研究者詳細 - 城﨑　由紀

論文 - 城﨑　由紀

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特別解説“生体組織再生足場材料を目指したケイ素を含む有機−無機複合体” 招待有り

城﨑由紀

耐火物 77 ( 7 ) 292 - 297 2025年07月

Viral contamination in cell culture: Analyzing the impact of epstein barr virus and ovine herpesvirus 2 査読有り国際誌

Iman M. Bastawecy, Mohamed Abdelmonem, Ahmed Afify, Norazalina Saad, Yuki Shirosaki, Che Azurahanim Che Abdullah, Rania F. Al Naggar, Mohammed Rohaim, Muhammad Munir

Frontiers in Microbiology 16 2025年02月

Microwave plasma treated Sn/SnO2 and graphite nanocomposites to promote electrochemical sensing performance toward dopamine and uric acid synergistically 査読有り国際誌

Danang Tri Hartanto, Jui-Yu Tung, Galang Dhaifullah Abdul Aziz, Yuni Kusumastuti, Yuki Shirosaki, Meng-Jiy Wang

Analytica Chimica Acta 1343 343668 2025年01月

Initial bone tissue reactions of hydroxyapatite/collagen–(3-glycidoxypropyl)trimethoxysilane injectable bone paste 査読有り国際誌

Taira Sato, Yuki Shirosaki, Sho Oshima, Kanji Tsuru, Yoshihisa Koyama, Mamoru Aizawa, Masanori Kikuchi

Journal of Biomedical Materials Research: Part B 112 ( 8 ) 2024年07月

Exploring copper (II) porphyrin complexes and their derivatives for electrochemical analysis and biological assessment in the study of breast cancer (MCF-7) cell lines 査読有り国際誌

Supakorn Boonyuen, Shanmugam Paramasivam, Rajan Ramachandran, Tossapon Phromsatit, Thapong Teerawatananond, Supawan Tantayanon, Premjit Arpornmaeklong, Yuki Shirosaki

Environmental Research ( Science Direct ) 250 ( 1 ) 2024年02月

The impact of the molecular weight of degradation products with silicon from porous chitosan-siloxane hybrids on neuronal cell behavior 査読有り国際誌

Yuki Shirosaki, Federica Fregnan, Luisa Muratori, Saki Yasutomi, Stefano Geuna, Stefania Raimondo

Polymers ( MDPI ) 15 ( 15 ) 3272 - 3285 2023年08月

Effects of the silicon-containing chemical species dissolved from chitosan-siloxane hybrids on nerve cells 招待有り査読有り国際誌

Kosei Hattori, Satoshi Hayakawa, Yuki Shirosaki

Journal of Sol-Gel Science and Technology 104 ( 3 ) 606 - 616 2022年12月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

Silicic acid components from bioactive glass activate osteoblasts gene for bone generation. Many studies have been reported on osteoblast compatibility and bone regeneration using composites and hybrids, including silica or siloxane units. We previously synthesized chitosan−siloxane hybrids via a sol-gel method and observed bone and nerve regeneration. However, it is not clear the structure of molecules involving silicon atoms that has a more effective role in the cell activity and their mechanisms of cell activation. In this study, we prepared hybrid materials from chitosan and different types of alkoxysilane, 3-glycidoxypropyltrimethoxysilane (GPTMS), 3-glycidoxypropyldimethoxymethylsilane (GPDMS), and tetraethoxysilane (TEOS), and investigated the structures of the silicon-containing species dissolved from each hybrid and their effect on the proliferation of nerve cells. The silicon-containing species in the extraction were mainly 100–600 molecular weight, indicating they were chitin/chitosan units and monomeric hydrolyzed GPTMS, GPDMS, and TEOS. The nerve cell proliferation was inhibited by the chitosan–GPTMS and GPDMS hybrid extractions. The silicon-containing species were not taken up by the cells. The silicon-containing species dissolved from the hybrids were adsorbed to the cells or they inactivated biomolecules in the culture medium, suppressing cell proliferation. [Figure not available: see fulltext.]

DOI： 10.1007/s10971-022-05814-z

Scopus

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Preparation and drug release profile of chitosan–siloxane hybrid capsules coated with hydroxyapatite 査読有り国際誌

Yuki Shirosaki, Yasuyo Tsukatani, Kohei Okamoto, Satoshi Hayakawa, Akiyoshi Osaka

Pharmaceutics 14 ( 5 ) 1111 - 1120 2022年05月

Cocoa pod husks as precursors for biosynthesis of carbon dots as potential bioimaging tool 査読有り国際誌

Ashreen Norman, Ahmad Kamil Mohd, Jaaffar, Nazzatush Shimar Jamaludin, Yuki Shirosaki, Norazalina Saad, Che Azurahanim Che Abdullah

International Journal of Nanoscience and Nanotechnology 18 ( 1 ) 79 - 92 2022年03月

Preparation and characterization of encapsulated tamoxifen citrate-magnetite nanoparticle via oil in water emulsion evaporation technique 査読有り国際誌

Emmellie Laura Albert, Siti Norzulfikaini Yaacob, Ghazaleh Bahmanrokh, Toshiki Miyazaki, Yuki Shirosaki, Che Azurahanim Che Abdullah

Nanomedicine Research Journal 6 ( 4 ) 337 - 346 2021年11月

Synthesis and cytotoxicity study of gold(III) porphyrin complexes and their derivative in breast cancer cells 査読有り国際誌

76. Tossapon Phromsatit, Premjit Arpornmaeklong, Yuki Shirosaki, Thapong Teerawatananond, Jundee Rabablert, Supakorn Boonyuen

Journal of Saudi Chemical Society 25 2021年10月

Antibacterial chitosan nanofiber thin films with bacitracin zinc salt 査読有り国際誌

Kazutaka Kumamoto, Toshinari Maeda, Satoshi Hayakawa, Nurul Asyifah Binti Mustapha, Meng-Jiy Wang, Yuki Shirosaki

Polymers 13 ( 7 ) 1104 2021年04月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

Chitosan nanofiber has a highly uniform structure of 20–50 nm in diameter and shows high dispersibility in water due to its submicron size and high surface-to-volume ratio. The stacked nanofibers film is useful for breathability because it has a gap with a size of several tens of nm or more. However, the chemical bonds between the nanofibers cannot be broken during use. In this study, the thin films were obtained by filtration of chitosan nanofibers and 3-glycidoxypropyltri-methoxysilane (GPTMS) mixture. The addition of GPTMS changed the wettability, mechanical property and stability in water of the thin films. Bacitracin zinc salt (BZ) has been used for the localized dermatological medicines and loaded in the films. BZ interacted electrostatically with the thin films matrix and the release of BZ was controlled by the amount of GPTMS. A higher released amount of BZ showed higher antibacterial effects toward S. aureus. The film was also tested their toxicity by L929 fibroblasts. The release of less than 11.9 μg of BZ showed antibacterial effects, but were not toxic for fibroblast cells.

DOI： 10.3390/polym13071104

Scopus

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Melt-vs. non-melt blending of complexly processable ultra-high molecular weight polyethylene/cellulose nanofiber bionanocomposite 査読有り国際誌

Nur Sharmila Sharip, Hidayah Ariffin, Tengku Arisyah Tengku Yasim-Anuar, Yoshito Andou, Yuki Shirosaki, Mohammad Jawaid, Paridah Md Tahir, Nor Azowa Ibrahim

Polymers 13 ( 3 ) 2021年01月

バイオセラミックス−身体の中で使用されるセラミックス− 招待有り

城﨑由紀

化学と教育 69 ( 1 ) 28 - 31 2021年01月

Silane Coupling Agent Modifies the Mechanical Properties of a Chitosan Microfiber 査読有り

Shirosaki Y., Okabayashi T., Yasutomi S.

Molecules (Basel, Switzerland) 25 ( 22 ) 2020年11月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

Chitosan microfibers are widely used in medical applications because they have favorable inherent properties. However, their mechanical properties require further improvement. In the present study, a trimethoxysilane aldehyde (TMSA) crosslinking agent was added to chitosan microfibers to improve their tensile strength. The chitosan microfibers were prepared using a coagulation method. The tensile strength of the chitosan microfibers was improved by crosslinking them with TMSA, even when only a small amount was used (less than 1%). TMSA did not change the orientation of the chitosan molecules. Furthermore, aldehyde derived from TMSA did not remain, and siloxane units were formed in the microfibers.

DOI： 10.3390/molecules25225292

Scopus

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Silane coupling agent modifies the mechanical properties of a chitosan microfiber 査読有り国際誌

Yuki Shirosaki, Toshinobu Okabayashi, Saki Yasutomi

Molecules 25 ( 22 ) 2020年11月

Process optimization of ultra-high molecularweight polyethylene/cellulose nanofiber bionanocomposites in triple screw kneading extruder by response surface methodology 査読有り

Sharip N.S., Ariffin H., Andou Y., Shirosaki Y., Bahrin E.K., Jawaid M., Tahir P.M., Ibrahim N.A.

Molecules 25 ( 19 ) 2020年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

© 2020 by the authors. Incorporation of nanocellulose could improve wear resistance of ultra-high molecular weight polyethylene (UHMWPE) for an artificial joint application. Yet, the extremely high melt viscosity of the polymer may constrict the mixing, leading to fillers agglomeration and poor mechanical properties. This study optimized the processing condition ofUHMWPE/cellulose nanofiber (CNF) bionanocomposite fabrication in triple screw kneading extruder by using response surface methodology (RSM). The effect of the process parameters-temperature (150-190°C), rotational speed (30-60 rpm), and mixing time (30-45 min)-on mechanical properties of the bionanocomposites was investigated. Homogenous filler distribution, as confirmed by scanning electron microscopy-energy dispersive spectroscopy (SEM-EDS) analysis, was obtained through the optimal processing condition of 150 °C, 60 rpm, and 45 min. TheUHMWPE/CNFbionanocomposites exhibited improved mechanical properties in terms of Young's and flexural modulus by 11% and 19%, respectively, as compared to neat UHMWPE. An insignificant effect was observed when maleic anhydride-grafted-polyethylene (MAPE) was added as compatibilizer. The obtained results proved that homogenous compounding of high melt viscosity UHMWPE with CNF was feasible by optimizing the melt blending processing condition in triple screw kneading extruder, which resulted in improved stiffness, a contributing factor for wear resistance.

DOI： 10.3390/molecules25194498

Scopus

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Process optimization of ultra-high molecular weight polyethylene/cellulose nanofiber bionanocomposites in triple screw kneading extruder by response surface methodology 査読有り国際誌

Nur Sharmila Sharip, Hidayah Ariffin, Yoshito Andou, Yuki Shirosaki, Ezyana Kamal Bahrin, Mohammad Jawaid, Paridah Md Tahir, Nor Azowa Ibrahim

Molecules 25 ( 19 ) 2020年09月

Microwave plasma treated composites of Cu/Cu<inf>2</inf>O nanoparticles on electrospun poly(N-vinylpyrrolidone) fibers as highly effective photocatalysts for reduction of organic dyes and 4-nitrophenol 査読有り

Muneekaew S., Chang K.C., Kurniawan A., Shirosaki Y., Wang M.J.

Journal of the Taiwan Institute of Chemical Engineers 107 171 - 181 2020年02月

記述言語：英語掲載種別：研究論文（学術雑誌）

© 2019 Taiwan Institute of Chemical Engineers Self-standing photocatalytic materials based on transition-metal decorated electrospun fiber mat have attracted considerable attention for photodegradation of toxic refractory organic pollutants in the environment. In this study, poly(N-vinylpyrrolidone)/copper(II) nitrate fibers (Cu/PVP-F) were prepared by electrospinning of PVP/Cu(NO3)2 solution followed by crosslinking using microwave-induced argon plasma (MAP) to produce Cu/Cu2O composites on the surface of fibers. The optimization for the electrospinning fibers was conducted such that the optimized electrospun composite fibers exhibited excellent visible light photocatalytic activity, corresponding to the narrowest band gap energy based on photoluminescence analyses. Moreover, the experimental results showed that the electro-spinning Cu/PVP-F fibers treated with MAP revealed the highest rate of photodegradation efficacy toward methyl orange (MO) and 4-nitrophenol (4- NP), that could be employed in the subsequent photocatalysis cycles with good recovery.

DOI： 10.1016/j.jtice.2019.11.008

Scopus

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Microwave plasma treated composites of Cu/Cu2O nanoparticles on electrospun poly(N-vinylpyrrolidone) fibers as highly effective photocatalysts for reduction of organic dyes and 4-nitrophenol 査読有り国際誌

Saitong Muneekaew, Kai-Cheng Chang, Alfin Kurniawan, Yuki Shirosaki, Meng-Jiy Wang

Journal of the Taiwan Institute of Chemical Engineers 107 171 - 181 2020年01月

Cytotoxicity of gold(III) polyphyrin complexes and their derivative of MCF7 cell lines 査読有り国際誌

Tossapon Phromsatit, Supakorn Boonyuen, Premjit Arpornmaeklong, Yuki Shirosaki

The 45th Congress on Science and Technology of Thailand (STT45), Proceedings Book 2019年10月

A new zinc(II) coordination polymer based on 5-nitroisophthalate; synthesis, crystal structure and highly sensitive fluorescence sensing propertis of small molecules and metal ions 査読有り国際誌

Pornsan Lueangseephet, Supakorn Boonyuen, Sukanya Mingphimai, Kittipong Chainok, Premjit Arpornmaeklong, Yuki Shirosaki

The 45th Congress on Science and Technology of Thailand (STT45), Proceedings Book 2019年10月

Cytocompatible and antibacterial properties of chitosan−siloxane hybrid spheres 査読有り国際誌

Yuki Shirosaki, Manato Nakatsukasa, Saki Yasutomi, Susana Cruz-Neves, Satoshi Hayakawa, Akiyoshi Osaka, Toshinari Maeda, Toshiki Miyazaki

Polymers 11 1676 - 1686 2019年10月

Control of crystalline phase and morphology pf calcium carbonate by electrolysis: effects of current and temperature 査読有り

Toshiki Miyazaki, Takashi Arii, Yuki Shirosaki

Ceramics International 45 14039 - 14044 2019年05月

In situ synthesis of magnetc iron oxide nanoparticles in chitosan hydrogels as a reaction field: effect of cross-linking density 査読有り

68. Toshiki Miyazaki, Akiko Iwanaga, Yuki Shirosaki, Masakazu Kawashita

Colloids and Surfaces B: Biointerfaces 179 334 - 339 2019年04月

Synthesis and characterization of graphene oxide functionalized with magnetic nanoparticle via simple emulsion method 査読有り

Emmellie Laura Albert, Che Azurahanim Che Abdullah, Yuki Shirosaki

Results in Physics 2018年11月

Preparation of anti-decay self-setting paste of hydroxyapatite/collagen utilizing (3-glycidoxypropyltrimethoxysilane) 査読有り

Taira Sato, Yuki Shirosaki, Masaki Nagaya, Yoshinori Asano, Kazuaki Nakano, Hiroshi Nagashima, Mamoru Aizawa, Masanori Kikuchi

Journal of Asian Ceramic Societies 6 ( 4 ) 322 - 331 2018年10月

Development of hafnium metal and titanium-hafnium alloys having apatite-forming ability by chemical surface modification 査読有り

Toshiki Miyazaki, Masaya Sueoka, Yuki Shirosaki, Nobuya Shinozaki, Takanobu Shiraishi

Journal of Biomedical Materials Research: Part B Applied Biomaterials 106B 2519 - 2523 2018年09月

Skull Bone Regeneration Using Chitosan–Siloxane Porous Hybrids—Long-Term Implantation 招待有り査読有り

Yuki Shirosaki Motomasa Furuse Takuji Asano Yoshihiko Kinoshita Toshihiko Kuroiwa

Pharmaceutics 10 ( 2 ) 70 - 78 2018年06月

Structural effects of dulfur-containing functional groups on apatite formation on Ca2+-modified copolymers in a simulated body environment 査読有り

Ryo Hamai, Yuki Shirosaki, Toshiki Miyazaki

ACS Omega 3 5627 - 5633 2018年05月

Drug release and kinetic study of tamoxifen citrate conjugated with magnetite nanoparticle for drug delivery application 査読有り

Emmellie Laura Albert, Yuki Shirosaki, Che Azurahanim Che Abdullah

International Journal of Applied Engineering Research 2018年04月

異なる立場での研究留学

城﨑由紀

表面と真空 ( 日本表面科学会 ) 61 ( 3 ) 1 - 2 2018年03月

有機−無機複合体の創製と医用分野への応用

城﨑由紀，Neves Susana，岡田拓磨，安冨沙紀

ナノ学会会報 ( ナノ学会 ) 16 ( 2 ) 1 - 5 2018年03月

Structural effects of phosphate groups on apatite formation in copolymer modified with Ca2+ in a simulated body fluid 査読有り

Ryo Hamai, Hirotaka Maeda, Hikaru Sawai, Yuki Shirosaki, Toshihiro Kasuga, Toshiki Miyazaki

Journal of Materials Chemistry B 6 ( 1 ) 174 - 182 2018年01月

Effect of metallographic structure and machining process on the apatite-forming ability of sodium hydroxide- and heat-treated titanium 査読有り

Toshiki Miyazakai, Takashi Sasaki, Yuki Shirosaki, Ken'ichi Yokoyama, Masakazu Kawashita

Bio-Medical Materials and Engineering 29 ( 1 ) 109 - 118 2018年01月

Apatite formation on a hydrogel containing sulfinic acid group under physiological conditions 査読有り

Ryo Hamai, Yuki Shirosaki, Toshiki Miyazaki

Journal of Biomedical Materials Research Part B: Applied Biomaterials 105B 1924 - 1929 2017年09月

Characterization and degradation study of chitosan-siloxane hybrid microspheres synthesized using a microfluidic approach 査読有り

Susana Neves, Yuki Shirosaki, Toshiki Miyazaki, Satoshi Hayakawa

Materials Science & Engineering C 81 571 - 579 2017年08月

Preparation of chitosan-hydroxyapatite composite mono-fiber using coagulation method and their mechanical properties 査読有り

Takuma Okada, Yuta Nobunaga, Toshiisa Konishi, Tomohiko Yoshioka, Satoshi Hayakawa, Maria A. Lopes, Toshiki Miyazaki, Yuki Shirosaki

Carbohydrate Polymers 175 355 - 360 2017年08月

Enhanced biosafety of silica coated gadolinium based nanoparticles 査読有り

Marta Laranjeira, Yuki Shirosaki, Saki Yoshimatsu Yasutomi, Toshiki Miyazaki, Fernando J. Monteiro

Journal of Materials Science: Materials in Medicine 2017年02月

Apatite-forming ability of vinylphosphonic acid-based copolymer in simulated body fluid: effects of phosphate group content 査読有り

Ryo Hamai, Yuki Shirosaki, Toshiki Miyazaki

Journal of Materials Science: Materials in Medicine 27 152 - 159 2016年09月

生体組織と人工材料間の接着および材料設計

城崎由紀

日本接着学会誌 ( 日本接着学会 ) 52 ( 4 ) 107 - 113 2016年04月

Biomineralization behavior of a vinylphosphonic acid-based copolymer added with polymerization accelerator in simulated body fluid 査読有り

Ryo Hamai, Yuki Shirosaki, Toshiki Miyazaki

Journal of Asian Ceramic Societies 3 407 - 411 2015年11月

Bioactive Co-Cr alloy for biomedical applications prepared by surface modification using self-assembled monolayers and poly-γ-glutamic acid 査読有り

Chao Liu, Chisato Matsunami, Yuki Shirosaki, Toshiki Miyazaki

Dental Materials Journal 34 ( 5 ) 707 - 712 2015年10月

Calcium phosphate crystallization on titania in Kokubo solution flowing throw narrow space 査読有り

Satoshi Hayakawa, Kanji Tsuru, Yuki Shirosaki, Keita Uetsuki, Keisuke Akasaka, Akiyoshi Osaka

Journal of Materials Science: Materials in Medicine 26 ( 8 ) 2015年08月

In vitro apatite formation on nano-crystalline titania layer aligned parallel to Ti6Al4V alloy substrates with sub-millimeter gap 査読有り

Satoshi Hayakawa, Yuko Matsumoto, Keita Uetsuki, Yuki Shirosaki, Akiyoshi Osaka

Journal of Materials Science: Materials in Medicine 26 2015年05月

Bioactive PMMA bone cement modified with combinations of phosphate group-containing monomers and calcium acetate 査読有り

Jinkun Liu, Yuki Shirosaki, Toshiki Miyazaki

Journal of Biomaterials Applications 29 ( 9 ) 1296 - 1303 2015年03月

Fabrication of calcium phosphate nanoparticles in a continuous flow tube reactor 査読有り

Eiji Fujii, Koji Kawabata, Yuki Shirosaki, Satoshi Hayakawa, Akiyoshi Osaka

Journal of the Ceramic Society of Japan 123 ( 1 ) 101 - 105 2015年03月

ほっとSpring“ガウディと生きるバルセロナの街”

城﨑由紀

セラミックス ( 日本セラミックス協会 ) 50 ( 2 ) 132 - 133 2015年01月

The role of hybrid chitosan membranes on scarring process following lumbar surgery: post-laminectomy experimental model 査読有り

Miguel Carvalho, Luís M. Costa, José E. Pereira, Yuki Shirosaki, Satoshi Hayakawa, José D. Santos, Stefano Geuna, Federica Fregnan, António M. Cabrita, Ana C. Maurício, Artur S. Varejão

Neurological Research 37 ( 1 ) 23 - 29 2015年01月

Preparation and in vitro cytocompatibility of chitosan-siloxane hybrid hydrogels 査読有り

Yuki Shirosaki, Masashi Hirai, Satoshi Hayakawa, Eiji Fujii, Maria A. Lopes, José D. Santos, Akiyoshi Osaka

Journal of Biomedical Materials Research PartA 103 ( 1 ) 289 - 299 2015年01月

Preparation of porous chitosan-siloxane hybrids coated with hydroxyapatite particles 査読有り

Yuki Shirosaki, Kohei Okamoto, Satoshi Hayakawa, Akiyoshi Osaka, Takuji Asano

BioMed Research International 2014 Article ID 392940 2014年11月

Yttrium phosphate microspheres with enriched phosphorus content prepared for radiotherapy of deep-seated cancer 査読有り

Toshiki Miyazaki, Toru Tanaka, Yuki Shirosaki, Masakazu Kawashita

Ceramics International 40 15259 - 15263 2014年07月

Challenges for nerve repair using chitosan-siloxane hybrid porous scaffolds 査読有り

Yuki Shirosaki, Satoshi Hayakawa, Akiyoshi Osaka, Maria A. Lopes, José D. Santos, Stefano Geuna, Ana C. Maurício

BioMed Research International 2014 2014年06月

Effects of organic polymer addition in magnetite synthesis on its crystalline structure 査読有り

Yoshimitsu Kuwahara, Toshiki Miyazaki, Yuki Shirosaki, Masakazu Kawashita

RSC Advances 4 23359 - 23363 2014年06月

TiO2-based superhydrophobic-superhydrophilic pattern with an extremely high wettability contrast 査読有り

Shunsuke Nishimoto, Michiaki Becchaku, Yoshikazu Kameshima, Yuki Shirosaki, Satoshi Hayakawa, Akiyoshi Osaka, Michihiro Miyake

Thins Solid Films 558 ( 2 ) 2014年02月

Liquid phase deposited titania coating to enable in vitro apatite formation on Ti6Al4V alloy 査読有り

37. Satoshi Hayakawa, Yoshitake Masuda, Keigo Okamoto, Yuki Shirosaki, Kazumi Kato, Akiyoshi Osaka

Journal of Materials Science: Materials in Medicine 25 375 - 381 2014年02月

Fabrication of yttrium phosphate microcapsules by an emulsion route for in situ cancer radiotherapy 査読有り

Toshiki Miyazaki, Takajin Suda, Yuki Shirosaki, Masakazu Kawashita

Journal of Medical and Biological Engineering 34 ( 1 ) 14 - 17 2014年02月

The role of the chemical composition of monetite on the synthesis and properties of α-tricalcium phosphate 査読有り

Jo Duncan, James F. MacDonald, John V. Hanna, Yuki Shirosaki, Satoshi Hayakawa, Akiyoshi Osaka, Janet M.S. Skakle, Iain R. Gibson

Materials Science and Engineering C 34 123 - 129 2014年01月

Organic-inorganic composites designed for biomedical applications 招待有り査読有り

Toshiki MIyazaki, Kunio Ishikawa, Yuki Shirosaki, Chikara Ohtsuki

Biological and Phrmaceutical Bulletin 36 ( 11 ) 1670 - 1675 2013年11月

Sol-gel-derived silicate nano-hybrids for biomedical applications 招待有り査読有り

Kanji Tsuru, Yuki Shirosaki, Satoshi Hayakawa, Akiyoshi Osaka

Biological and Phrmaceutical Bulletin 36 ( 11 ) 1683 - 1687 2013年11月

Preparation of injectable hydroxyapatite/collagen paste using sodium alginate and influence of additives 査読有り

Taira Sato, Akinori Kochi, Yuki Shirosaki, Satoshi Hayakawa, Mamoru Aizawa, Akiyoshi Osaka, Masanori Kikuchi

Journal of the Ceramic Society of Japan 121 ( 9 ) 775 - 781 2013年09月

Biomineralization on chemically synthesized collagen containing immobilized poly-γ-glutamic acid 査読有り

Toshiki Miyazaki, Akimasa Kuramoto, Atsuhide Hirakawa, Yuki Shirosaki, Chikara Ohtsuki

Dental Materials Journal 30 ( 4 ) 544 - 549 2013年08月

In vitro bioactivity and MG63 cytocompatibility of chitosan-silicate hybrids 招待有り査読有り

Yuki Shirosaki, Tomoyuki Okayama, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka

International Journal of Materials and Chemistry 3 ( 3A ) 1 - 7 2013年06月

The investigation of bioactivity and mechanical properties of glass ionomer cements prepared from Al2O3-SiO2 glass and poly(γ-glutamic acid) 査読有り

Jinkun Liu, Yoshimitsu Kuwahara, Yuki Shirosaki, Toshiki Miyazaki

Journal of Nanomaterials 2013 2013年06月

Nucleation and growth of apatite on an anatase layer irradiated with UV light under different environmental conditions 査読有り

Keita Uetsuki, Shinsuke Nakai, Yuki Shirosaki, Satoshi Hayakawa, Akiyoshi Osaka

Journal of Biomedical Materials Research A 101A ( 3 ) 712 - 719 2013年03月

Revisiting structure of silica gels from water glass: an 1H and 29Si MAS and CP-MAS NMR study 査読有り

Jie Li, Satoshi Hayakawa, Yuki Shirosaki, Akiyoshi Osaka

Journal of Sol-Gel Science and Technology 65 ( 2 ) 135 - 142 2013年03月

Heterogeneous structure and in vitro degradation behavior of wet-chemically derived nanocrystalline silicon-containing hydroxyapatite particles 査読有り

Satoshi Hayakawa, Tomoko Kanaya, Kanji Tsuru, Yuki Shirosaki, Akiyoshi Osaka, Eiji Fujii, Koji Kawabata, Georgiana Gasqueres, Christian Bonhomme, Florence Babonneau, Christian Jäger, Hans-Joachim Kleebe

Acta Biomaterialia 9 ( 1 ) 4856 - 4867 2013年01月

Preparation of organic-inorganic hybrids with silicate network for the medical applications 査読有り

Shirosaki Y.

Nippon Seramikkusu Kyokai Gakujutsu Ronbunshi/Journal of the Ceramic Society of Japan 120 ( 1408 ) 555 - 559 2012年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

Novel strategies for regenerating or reconstructing damaged bone tissues are of urgent necessity, because of limitations in conventional therapies for trauma, congenital defects, cancer, and other bone diseases. The tissue engineering approach to repair and regeneration is founded upon the use of biodegradable polymer scaffolds, which may manipulate bone cell functions, encourage the migration of bone cells from border areas to the defect site, and provide a source of inductive factors to support bone cell differentiation. During the past decades, scaffolds from natural biodegradable polymers such as collagen, gelatin, fibrin, and alginates, or synthetic biodegradable polymers such as polyglycolide, polylactides, and copolymers of glycolide with lactides have been extensively explored. On the other hand, it has been confirmed that the bonelike apatite layer, deposited spontaneously on the biomaterial surfaces, can enhance osteoconductivity. The presence of such bone-like apatite layers is also believed to be a prerequisite to conduction of osteogenic cells into various porous scaffolds or onto the surface of bioactive glasses. The formation of such bone-like apatite is favored by the cooperative behavior of a hydrated silica or titania gel surface SiOH or TiOH groups as well as calcium ions to be released into the body fluid when implanted. Thus, hybrid materials derived from the integration of biodegradable polymers with bioactive inorganic species may construct a new group of scaffolds appropriate for tissue engineering. Moreover, tissue engineering approach depends on the use of porous scaffolds that serve to support and reinforce the regenerating tissue. Controlled porous structures of these scaffolds allow cell attachment, and migration, tissue generation, or vascularization. The synthesis of novel chitosan-silicate hybrids derived from the integration of chitosan and γ-glycidoxypropyltrimethoxysilane (GPTMS) has been studied. Some of the results on this hybrid for biomedical application are introduced. © 2012 The Ceramic Society of Japan.

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Science and Technology of Advanced Materials 12 2011年12月

ガラスやガラスセラミックの生体安全性

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Apatite nano-rods array grown on glass substrates in aqueous systems 査読有り

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Biomaterials Science: Processing, Properties, and Applications, edited by Roger Narayan, Amit Bandyopadhyay, and Susmita Bose, The American Ceramic Society, Ceramic Transactions 228 83 - 88 2011年10月

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Preparation and protein adsorption of silica-based composite particles for blood purification therapy 招待有り査読有り

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Effect of disordered structure of boron-containing calcium phosphates on their in vitro biodegradability 査読有り

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Journal of American Ceramics Society 94 ( 8 ) 2656 - 2662 2011年08月

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Lívia Santos, Maria Pia Ferraz, Yuki Shirosaki, Maria Ascensão Lopes, Maria Helena Fernandes, Akiyoshi Osaka, José Santos

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空間デザインと熱酸化による骨親和性の向上

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Fabrication of hydroxyapatite with controlled morphology in a micro-reactor 査読有り

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Journal of the Ceramic Society of Japan 119 ( 2 ) 116 - 119 2011年02月

Effects of Si(IV) released from chitosan-silicate hybrids on proliferation and differentiation of MG63 osteoblast cells 査読有り

Yuki Shirosaki, Kanji Tsuru, Satoshi Hayakawa, Yuri Nakamura, Iain R. Gibson, Akiyoshi Osaka

Bioceramics Development and Applications 2 2011年02月

Contrary effects of UV-irradiation on in vitro apatite-forming ability of TiO2 layer in simulated body fluid 査読有り

Keita Uetsuki, Yuki Shirosaki, Satoshi Hayakawa, Akiyoshi Osaka

Bioceramics Development and Applications 1 2011年02月

A novel method of preparing a nanometer-scale rod array of hydroxyapatite crystals 査読有り

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Bioceramics Development and Applications 1 2011年02月

In vitro and in vivo chitosan membranes testing for peripheral nerve reconstruction 査読有り

Maria J. Simões, Andrea Gärtner, Yuki Shirosaki, Rui M. Gil da Costa, Paulo P. Cortez, Fátima Gärtner, José D. Santos, Maria A. Lopes, Stefano Geuna, António P. Veloso, Artur S.P. Varejão, Ana C. Maurício

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Effect of UV-irradiation environment on induction time for apatite nucleation on TiO2 layer 査読有り

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Effects of UV-irradiation on in vitro apatite-forming ability of TiO2 layers 査読有り

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Cell proliferation on nano-structured titanium oxide layer prepared on titanium substrates 査読有り

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Journal of Materials Chemistry 20 ( 35 ) 7337 - 7339 2010年07月

Enhancement of apatite-forming ability of parallely aligned Ti-substrates with optimum gaps by autoclaving 査読有り

Yoko Nakao, Atsushi Sugino, Kanji Tsuru, Keita Uetsuki, Yuki Shirosaki, Satoshi Hayakawa, Akiyoshi Osaka

Journal of the Ceramic Society of Japan 118 ( 6 ) 483 - 486 2010年06月

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GRAPE® technology improves apatite-formation on thermally derived titania layer 査読有り

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Apatite-forming ability on spatial design enhanced by autoclaving 査読有り

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One-step preparation of organosiloxane-derived silica particles 査読有り

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Song Chen, Satoshi Hayakawa, Yuki Shirosaki, Eiji Fujii, Koji Kawabata, Kanji Tsuru, Akiyoshi Osaka

Journal of American Ceramic Society 96 ( 9 ) 2074 - 2082 2009年09月

Synthesis and characterization of chitosan-silicate hydrogel as resorbable vehicle for Bonelike® bone graft 査読有り

Yuki Shirosaki, Cláudia M. Botelho, Maria A. Lopes, José D. Santos

Journal of Nanoscience and Nanotechnology 9 ( 6 ) 3714 - 3719 2009年06月

XPS study on potential suppression factors of suppressing in vitro apatite formation on anatase films prepared on various substrates 査読有り

Tetsuya Shozui, Kanji Tsuru, Satoshi Hayakawa, Yuki Shirosaki, Akiyoshi Osaka

Surface & Coatings Technology 203 ( 16 ) 2181 - 2185 2009年05月

医用金属チタンの生体親和性の制御

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未来材料 ( （株）エヌ・ティー・エス ) 9 ( 5 ) 38 - 44 2009年05月

Structure and morphology of aminopropyltriethoxysilane-modified TiO2 nano-particles derived from sol-gel processing of tetraethylorthotitanate 査読有り

Song Chen, Akiyoshi Osaka, Satoshi Hayakawa, Yuki Shirosaki, Eiji Fujii, Koji Kawabata, Kanji Tsuru

Journal of the Ceramic Society of Japan 117 ( 4 ) 537 - 541 2009年04月

Physical, chemical and in vitro biological profile of chitosan hybrid membrane as a function of organosiloxane concentration 査読有り

Yuki Shirosaki, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka, Maria Ascensão Lopes, José Domingos Santos, Maria Adeliana Costa, Maria Helena Fernandes

Acta Biomaterialia 5 ( 1 ) 346 - 355 2009年01月

生体用結晶化ガラス

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セラミックス ( 公益法人日本セラミックス協会 ) 43 ( 12 ) 1055 - 1061 2008年12月

Use of hybrid chitosan membranes and N1E-115 cells for promoting nerve regeneration in an axonotmesis rat model 査読有り

Sandra Amado, Maria J. Simões, Paulo Armada-da Silva, Ana L. Luís, Yuki Shirosaki, Maria A. Lopes, José D. Santos, Federica Fregnan, G. Gambarotta, S. Raimondo, M. Fornaro, António P. Veloso, S.P. Varejão, Ana C. Maurício, Stefano Geuna

Biomaterials 29 ( 33 ) 4409 - 4419 2008年11月

UV irradiation enhanced in vitro apatite-forming ability of the sol-gel derived titania on Ti, SUS, alumina, and Na-Ca glass substrates 査読有り

Tetsuya Shozui, Kanji Tsuru, Satoshi Hayakawa, Yuki Shirosaki, Akiyoshi Osaka

Archieves of Bio Ceramics Research 8 85 - 88 2008年11月

Synthesis and cytocompatibility of porous chitosan-silicate hybrids for tissue engineering scaffold application 査読有り

Yuki Shirosaki, Tomoyuki Okayama, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka

Chemical Engineering Journal 137 ( 1 ) 122 - 128 2008年03月

Biodegradable chitosan-silicate porous hybrids for drug delivery 査読有り

Yuki Shirosaki, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka, Maria Ascensão Lopes, José Domingos Santos, Maria Helena Fernandes

Key Engineering Materials 361-363 1219 - 1222 2008年02月

Hybrid chitosan membranes tested in sheep for guided tissue regeneration 査読有り

Paulo P. Cortez, Yuki Shirosaki, Claudia M. Botelho, Maria J. Simões, Fátima Gärtner, Rui M. Gil da Costa, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka, Maria A. Lopes, José D. Santos, Ana C. Maurício

Key Engineering Materials 361-363 1265 - 1268 2008年02月

Sol-gel synthesis and in vitro cell compatibility analysis of silicate-containing biodegradable hybrid gels 査読有り

Kanji Tsuru, Zoe Robertson, Basil Annaz, Iain R. Gibson, Serena M. Best, Satoshi Hayakawa, Yuki Shirosaki, Akiyoshi Osaka

Key Engineering Materials 361-363 447 - 450 2008年02月

Use of PLGA 90:10 scaffolds enriched with in vitro-differentiated neural cells for repairing rat sciatic nerve defects 査読有り

Ana L. Luís, Jorge M. Rodrigues, Stefano Geuna, Sandra Amado, Yuki Shirosaki, Jennifer M. Lee, Federica Fregnan, Maria A. Lopes, António P. Veloso, António J. Ferreira, José D. Santos, Paulo Armada-da Silva, Artur S.P. Varejão, Ana C. Maurício

Tissue Engineering PartA 14 ( 6 ) 1 - 15 2008年01月

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Key Engineering Materials 330-332 1177 - 1180 2007年02月

Cytocompatibility of silicone elastomer grafted with γ-methacryloxypropyltrimethoxysilane 査読有り

Yuki Shirosaki, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka, Seisuke Takashima

Journal of the Ceramic Society of Japan 114 ( 1 ) 72 - 76 2006年01月

In vitro apatite formation on organic polymers modified with a silane coupling reagent 査読有り

Yuki Shirosaki, Masaaki Kubo, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka, Seisuke Takashima

Journal of the Royal Society Interface 2 ( 4 ) 335 - 340 2005年09月

In vitro cytocompatibility of MG63 cells on chitosan-organosiloxane hybrid membranes 査読有り

Yuki Shirosaki, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka, Maria Ascensão Lopes, José Domingos Santos, Maria Helena Fernandes

Biomaterials 26 ( 5 ) 485 - 493 2005年02月

In vitro biodegradability of chitosan-organosiloxane hybrid membrane 査読有り

Kanji Tsuru, Yuki Shirosaki, Satoshi Hayakawa, Akiyoshi Osaka, Maria Ascensão Lopes, José Domingos Santos, Maria Helena Fernandes

Key Engineering Materials 284-286 823 - 826 2005年02月

In vitro biological reactivity of porous chitosan-organosiloxane hybrids

Yuki Shirosaki, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka

The 20th International Congress on Glass 2004年10月

Preparation of chitosan-silicate hybrid for bone formation 査読有り

Yuki Shirosaki, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka

53rd SPSJ Symposium on Macromolecules, Polymer Preprints 53 ( 2 ) 3698 - 3699 2004年09月

In vitro cytocompatibility of osteoblastic cells cultured on chitosan-organosiloxane hybrid membrane 査読有り

Yuki Shirosaki, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka, Maria Ascensão Lopes, José Domingos Santos, Maria Helena Fernandes

Key Engineering Materials 254-256 857 - 860 2004年02月

Cytocompatibility on silicone modified with organoalkoxysilane due to emulsion polymerization 査読有り

Yuki Shirosaki, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka, Seisuke Takashima

Key Engineering Materials 240-242 687 - 690 2003年02月

Response to osteoblastic cell of the organic-inorganic hybrid 査読有り

Yasushi Aburatani, Takako Uchida, Yuki Shirosaki, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka

Key Engineering Materials 240-242 683 - 686 2003年02月

Improvement of biocompatibility of silicone elastomer by surface modification

Yuki Shirosaki, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka, Seisuke Takashima

Memoirs of Faculty of Engineering, Okayama University 36 ( 1 ) 117 - 121 2001年12月

Cytocompatibility of silicone elastomer treated with hydrogen-peroxide containing tantalum chloride

Satoshi Hayakawa, Yuki Shirosaki, Takeshi Yabuta, Kanji Tsuru, Chikara Otsuki, Akiyoshi Osaka

Memoirs of Faculty of Engineering, Okayama University 34 ( 1 ) 39 - 43 2000年03月

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