Faculty Profiles - OKAUCHI Tatsuo

Papers - OKAUCHI Tatsuo

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A Convenient Method for Synthesizing 1-Alkyl-2-Acyl-sn-Glycero-3-Phosphoethanolamines Reviewed International journal

Okauchi T., Tsubaki K., Higuma Y., Shimooka H., Kitamura M.

Synthesis (Germany) 56 ( 11 ) 1787 - 1792 2024.02

KIT-13, a novel plasmalogen derivative, attenuates neuroinflammation and amplifies cognition Reviewed

Hossain M.S., Mawatari S., Honsho M., Okauchi T., Fujino T.

Frontiers in Cell and Developmental Biology 12 2024.01

Diazo-Transfer Reaction of Nonactivated Ketones with 2-Azido-1,3-bis(2,6-diisopropylphenyl)imidazolium Hexafluorophosphate (IPrAP) Reviewed International journal

Kitamura M., Ohtsuka K., Eto T., Tsuzaki M., Wada M., Shimooka H., Okauchi T.

Journal of Organic Chemistry 88 ( 21 ) 15494 - 15500 2023.11

Synthesis of an Ortho-Functionalized Tetrafluorinated Azobenzene Phosphoramidite for Incorporation into a Tetrafluorinated Azobenzene-Containing siRNA for Photocontrolled Gene Silencing Reviewed International journal

Hammill M.L.(Ontario Tech University), Tsubaki K., Kitamura M., Okauchi T., Desaulniers J.P.(Ontario Tech University)

Current Protocols 3 ( 10 ) e874 2023.10

Formal synthesis of isoquinocyclinone using ortho-alkoxycarbonylmethylation of anthranol via diazoquinone Reviewed International journal

Mitsuru Kitamura, Noriyuki Fukuzumi, Masayuki Shinagawa, Keiichiro Araki, Yutaro Shimizu, Shuhei Takahashi, Takumi Iwata, Hirokazu Shimooka, Tatsuo Okauchi

Tetrahedron Letters ( Elsevier ) 125 154618 2023.06

Conversion of η<sup>4</sup>-(Vinylketene)iron complexes to η<sup>4</sup>-(Vinylketenimine)iron complexes using titanium chloride and amines Reviewed International journal

Okauchi T., Teratani K., Nakagawa T., Ichimura T., Shimooka H., Kitamura M.

Journal of Organometallic Chemistry 990 2023.05

Synthesis of Dinucleotide Non-Symmetrical Triester Phosphate Phosphoramidites and Their Incorporation Within Oligonucleotides Reviewed International journal

Desaulniers, J.-P.(Ontario Tech University); Tsubaki, K.; Hammill, M. L.(Ontario Tech University); Kitamura, M.; Okauchi, T.

Current Protocols ( Willy ) 3 ( 5 ) e784 2023.05

Synthesis, Derivatization and Photochemical Control of an ortho-Functionalized Tetrafluorinated Azobenzene-Modified siRNA Reviewed International journal

Hammill M.L.(Ontario Tech University), Tsubaki K., Wang Y.(Ontario Tech University), Islam G.(Ontario Tech University), Kitamura M., Okauchi T., Desaulniers J.P.(Ontario Tech University)

ChemBioChem 23 ( 20 ) e202200386 2022.10

Formal Synthesis of Teadenols via Pd-catalyzed 6- endo Cyclization of Epoxyphenol Reviewed International journal

Kitamura M., Suetake H., Hoshino K., Higashijima Y., Kisanuki M., Yuasa R., Yamaguchi Y., Shimazu T., Koga N., Hamada H., Miyori N., Shimooka H., Okauchi T.

Synlett 33 ( 15 ) 1523 - 1526 2022.08

Synthesis of Diazoquinones and Azidophenols via Diazo-Transfer Reaction of Phenols Reviewed International journal

Mitsuru Kitamura, Takashi Eto, Kazushige Konai, Shuhei Takahashi, Hirokazu Shimooka, Tatsuo Okauchi

European Journal of Organic Chemistry 2022 ( 18 ) 2022.04

SiRNAs with Neutral Phosphate Triester Hydrocarbon Tails Exhibit Carrier-Free Gene-Silencing Activity Reviewed International journal

Matthew L. Hammill(Ontario Tech University), Kouta Tsubaki, Lidya Salim(Ontario Tech University), Andrew J. Varley(Ontario Tech University), Ifrodet Giorgees(Ontario Tech University), Mitsuru Kitamura, Tatsuo Okauchi, Jean-Paul Desaulniers(Ontario Tech University)

ACS Medicinal Chemistry Letters 13 ( 4 ) 695 - 700 2022.04

New Phosphorylating Agents for the Synthesis of Phosphatidylethanolamines Reviewed International journal

Tsubaki K., Yamanaka T., Hisamitsu T., Shimooka H., Kitamura M., Okauchi T.

Synthesis ( Thieme ) 53 ( 20 ) 3827 - 3835 2021.10

Building siRNAs with Cubes: Synthesis and Evaluation of Cubane-Modified siRNAs Reviewed

Hammill M.L.(Ontario Tech University), Salim L.(Ontario Tech University), Tsubaki K., Varley A.J.(Ontario Tech University), Kitamura M., Okauchi T., Desaulniers J.P.(Ontario Tech University)

ChemBioChem 22 ( 20 ) 2981 - 2985 2021.10

Pyrrole Formation via Reactivity of η4-(Vinylketenimine)iron Complexes with Electron-Deficient Alkynes Reviewed International journal

Tatsuo Okauchi, Akihiro Urakawa, Nagomi Tabuchi, Miten Arai, Tomoya Nakagawa, Taiga Ichimura, Hirokazu Shimooka, Mitsuru Kitamura

Organometallics ( American Chemical Society ) 40 ( 17 ) 2929 - 2933 2021.08

PdBr<inf>2</inf>-Catalyzed Acetal Formation of Carbonyl Compounds Using Diazophenanthrenequinone: Utility of 9,10-Phenanthrenedioxyacetal Reviewed International journal

Kitamura M., Fujimura R., Nishimura T., Takahashi S., Shimooka H., Okauchi T.

European Journal of Organic Chemistry 2020 ( 33 ) 5319 - 5322 2020.09

Synthesis and Evaluation of Neutral Phosphate Triester Backbone-Modified siRNAs Reviewed International journal

Tsubaki K., Hammill M.L.(Ontario Tech University), Varley A.J.(Ontario Tech University), Kitamura M., Okauchi T., Desaulniers J.P.(Ontario Tech University)

ACS Medicinal Chemistry Letters 11 ( 7 ) 1457 - 1462 2020.07

Rh(II)-catalyzed formal [3+3] cycloaddition of diazonaphthoquinones and propargyl alcohols: Synthesis of 2,3-dihydronaphtho-1,4-dioxin derivatives Reviewed International journal

Kitamura M., Nishimura T., Otsuka K., Shimooka H., Okauchi T.

Tetrahedron Letters 61 ( 20 ) 2020.05

九州工業大学工学部応用化学科の化学実験教育 Reviewed

NAKATO Teruyuki, TAKENAKA Shigeori, OKAUCHI Tatsuo, YAMAMURA Masato, UEDA Kazushige

CHEMISTRY & EDUCATION ( The Chemical Society of Japan ) 68 ( 3 ) 114 - 117 2020.01

Selective Transesterification of 2,2,2-Trifluoroethyl Phosphates: Synthesis of Mixed Unsymmetrical Phosphates Reviewed International journal

Tsubaki K., Shimooka H., Kitamura M., Okauchi T.

Organic Letters 21 ( 23 ) 9779 - 9783 2019.12

高校生のためのクロスカップリング実験（共著）

岡内辰夫,北村充

化学と教育 ( 日本化学会 ) 67 ( 3 ) 130 - 133 2019.03

Pd-catalyzed cyclization of terminal alkynes using diazonaphthoquinones: Synthesis of naphtho[1,2-b]furans Reviewed International journal

48 ( 1 ) 28 - 31 2019.01

高校生のためのクロスカップリング実験:—ノーベル化学賞の鈴木-宮浦クロスカップリングを題材に— Reviewed

OKAUCHI Tatsuo, KITAMURA Mitsuru

CHEMISTRY & EDUCATION ( The Chemical Society of Japan ) 67 ( 3 ) 130 - 133 2019.01

Total Synthesis of Eleuthoside A; Application of Rh-Catalyzed Intramolecular Cyclization of Diazonaphthoquinone Reviewed International journal

Othman D.I.A., Otsuka K., Takahashi S., Selim K.B., El-Sayed M.A., Tantawy A.S., Okauchi T., Kitamura M.

Synlett 29 ( 4 ) 457 - 462 2018.03

Synthesis of 1,2-naphthalenediol derivatives by Rh-catalyzed intermolecular O[sbnd]H insertion reaction of 1,2-diazonaphthoquinones with water and alcohols Reviewed International journal

58 ( 36 ) 3508 - 3511 2017.09

Synthesis of (±)-myo-inositol 4-methylenephosphonate via Rh-Catalyzed hydrogenation of vinylphosphonate Reviewed International journal

Tatsuo Okauchi, Shuya Nakamura, Kouta Tsubaki, Momoko Asakawa, Mitsuru Kitamura

Carbohydrate Research 448 24 - 27 2017.08

Synthesis, characterization and air stable semiconductor properties of thiophene-condensed pyrene derivatives Reviewed

Moriguchi T., Higashi M., Yakeya D., Jalli V., Tsuge A., Okauchi T., Nagamatsu S., Takashima W.

Journal of Molecular Structure 1127 413 - 418 2017.01

Molecular structures of n-type semiconducting material 2,5-difluoro-1,4-phenylene-3,3′-bis{2-[(4-trifluoromethyl)phenyl]acrylonitrile} and its photo dimerization product Reviewed

Moriguchi T., Kitou N., Jalli V., Yoza K., Nagamatsu S., Okauchi T., Tsuge A., Takashima W.

Journal of Molecular Structure 1118 372 - 377 2016.08

Axially Chiral Bifunctional 8,8′-Biquinolyl: Synthesis of 7,7′-Dihydroxymethyl-8,8′-biquinolyl via Pd-Catalyzed Double C-H Oxidation of 7,7′-Dimethyl-8,8′-biquinolyl Reviewed

Kitamura M., Fukuma H., Kobayashi M., Okayama S., Okauchi T.

Journal of Organic Chemistry 81 ( 9 ) 3956 - 3960 2016.05

Synthesis, structure, and reaction of chiral 2-azidoimidazolinium salts: (7aS)-3-azido-5,6,7,7a-tetrahydro-2-[(1R)-1-phenylethyl]-1H-pyrrolo[1,2-c]imidazolium hexafluorophosphate and 2-azido-1,3-bis[(S)-1-phenylethyl]imidazolinium hexafluorophosphate Reviewed

57 ( 16 ) 1794 - 1797 2016.04

Pinpoint-fluorinated phenanthrene synthesis based on C-F bond activation of difluoroalkenes Reviewed

Journal of Fluorine Chemistry 179 106 - 115 2015.11

Rh-Catalyzed Cyclization of 3-Aryloxycarbonyldiazonaphthoquinones for the Synthesis of beta-Phenylnaphthalene Lactones and Formal Synthesis of Pradimicinone Reviewed

The Journal of Organic Chemistry 80 ( 16 ) 8406 - 8416 2015.08

Thermodynamics and kinetic studies in the binding interaction of cyclic naphthalene diimide derivatives with double stranded DNAs Reviewed

23 ( 15 ) 4769 - 4776 2015.08

Synthesis of Diazonaphthoquinones from Naphthols by Diazo-Transfer Reaction Reviewed

Bulletin of the Chemical Society of Japan 88 ( 6 ) 824 - 833 2015.06

A Selective G-Quadruplex DNA-Stabilizing Ligand Based on a Cyclic Naphthalene Diimide Derivative Reviewed

20 ( 6 ) 10963 - 10979 2015.06

Unprecedented formation of hapto4-(vinylketene)iron complexes from hapto4-(diene)iron complexes and aromatic compounds in the presence of a Lewis acid Reviewed

Tatsuo Okauchi, Naoki Sata, Akihiro Urakawa, Mitsuru Kitamura

Chemical Communications 51 ( 40 ) 8454 - 8456 2015.05

Long-Term Air-Stable n-Channel Organic Thin-Film Transistors Using 2,5-Difluoro-1,4-phenylene-bis{2-[4-(trifluoromethyl)phenyl]acrylonitrile} Reviewed

Shuichi Nagamatsu, Shinya Oku, Kouji Kuramoto, Tetsuji Moriguchi, Wataru Takashima, Tatsuo Okauchi, Shuzi Hayase

ACS Applied Materials & Interfaces 6 3847 - 3852 2014.03

Pd(OAc)2-Catalyzed Macrocyclization of 1,2-Diazonaphthoquinones with Cyclic Ethers Reviewed

Mitsuru Kitamura, Masato Kisanuki, Koichi Kanemura, Tatsuo Okauchi

Organic Letters 16 ( 6 ) 1554 - 1557 2014.03

A reagent for safe and efficient diazo-transfer to primary amines: 2-azido-1,3-dimethylimidazolinium hexafluorophosphate Reviewed

Mitsuru Kitamura, So Kato, Masakazu Yano, Norifumi Tashiro, Yuichiro Shiratake, Mitsuyoshi Sandoa, Tatsuo Okauchi

Organic & Biomolecular Chemistry 12 ( 25 ) 4397 - 4406 2014.01

Rhodium-Catalyzed Reaction of Diazonaphthoquinones and Enol Ethers: Synthesis of Dihydronaphthofuran Derivatives and alpha-Naphthyl Esters Reviewed

Mitsuru Kitamura, Keiichiro Araki, Hiroki Matsuzaki, Tatsuo Okauchi

European Journal of Organic Chemistry 2013 ( 23 ) 5045 - 5049 2013.08

Synthesis of alpha-Arylcarboxylic Acid Amides from Silyl Enol Ether via Migratory Amidation with 2-Azido-1,3-dimethylimidazolinium Hexafluorophosphate Reviewed

Mitsuru Kitamura, Kento Murakami, Yuichiro Shiratake, Tatsuo Okauchi

Chemistry Letters 42 ( 7 ) 691 - 693 2013.07

Studies of inositol 1-phosphate analogues as inhibitors of the phosphatidylinositol phosphate synthase in mycobacteria Reviewed

H. Morii, T. Okauchi, H. Nomiya, M. Ogawa, K. Fukuda, H. Taniguchi

The Journal of Biochemistry 153 ( 3 ) 257 - 266 2013.03

Cu(OAc)2-Mediated Cross-Coupling Reaction of Benzophenone N,N,N-Trimethylhydrazonium Salts and Aryl Boronic Acids Reviewed

Mitsuru Kitamura, Yu Tokuda, Norifumi Tashiro, Tatsuo Okauchi

Australian Journal of Chemistry 65 ( 12 ) 1687 - 1690 2012.11

Direct Synthesis of Organic Azides from Alcohols Using 2-Azido-1,3-dimethylimidazolinium Hexafluorophosphate Reviewed

Mitsuru Kitamura, Tatsuya Koga, Masakazu Yano, Tatsuo Okauchi

Synlett ( 9 ) 1335 - 1338 2012.06

Synthesis of 1,2-Naphthalenediol Diacetates by Rhodium(II)-Catalyzed Reaction of 1,2-Diazonaphthoquinones with Acetic Anhydride Reviewed

European Journal of Organic Chemistry ( 5 ) 905 - 907 2012.02

Pd(II)-catalyzed Formal O-H Insertion Reactions of Diazonaphthoquinones to Acetic Acid: Synthesis of 1,2-Naphthalenediol Derivatives "jointly worked" Reviewed

Mitsuru Kitamura, Masato Kisanuki, Rie Sakata, Tatsuo Okauchi

Chemistry Letters 40 ( 10 ) 1129 - 1131 2011.10

Synthesis of pi-Conjugated Copolymers Composed of Benzo[2,1,3]thiadiazole and Thiophene Units Bearing Various Alkyl Groups and Their Application to Photovoltaic Cells "jointly worked" Reviewed

Lee, Kwang-Hoi)Ho-Jin Lee, K, Kouji Kuramoto, Yohei Tanaka, Kazuhide Morino, Atsushi Sudo, Tatsuo Okauchi, Akihiko Tsuge, Takeshi Endo

Journal of Polymer Science Part A-Polymer Chemistry 49 ( 16 ) 3543 - 3549 2011.08

Synthesis of π-conjugated copolymers composed of benzo[2,1,3]thiadiazole and thiophene units bearing various alkyl groups and their application to photovoltaic cells Reviewed

49 ( 16 ) 3543 - 3549 2011.08

Synthesis of alpha,alpha-diarylacetamides from benzyl aryl ketones using 2-azido-1,3-dimethylimidazolinium hexafluorophosphate "jointly worked" Reviewed

Mitsuru Kitamura, Satoshi Miyagawa, Tatsuo Okauchi

Tetrahedron Letters 52 ( 24 ) 3158 - 3161 2011.06

Synthesis of α,α-diarylacetamides from benzyl aryl ketones using 2-azido-1,3-dimethylimidazolinium hexafluorophosphate Reviewed

52 ( 24 ) 3158 - 3161 2011.06

Palladium-catalyzed cross-coupling reactions of 2-diazonaphthoquinones with arylboronic acids "jointly worked" Reviewed

Mitsuru Kitamura, Rie Sakata, Tatsuo Okauchi

Tetrahedron Letters 52 ( 16 ) 1931 - 1933 2011.04

2-Azido-1,3-dimethylimidazolinium Salts: Efficient Diazo-Transfer Reagents for 1,3-Dicarbonyl Compounds "jointly worked" Reviewed

Mitsuru Kitamura, Norifumi Tashiro, Satoshi Miyagawa, Tatsuo Okauchi

Synthesis ( 7 ) 1037 - 1044 2011.04

Synthesis of Isoindole Derivatives by Palladium-Catalyzed Domino Reaction of (2-Alkynyl)phenylketone O-Pentafluorobenzoyloximes "jointly worked" Reviewed

Mitsuru Kitamura, Yohei Moriyasu, Tatsuo Okauchi

Synlett ( 5 ) 643 - 646 2011.03

Polythiophenes Bearing Electron-Withdrawing Groups in the Side Chain and Their Application to Bulk Heterojunction Solar Cells"jointly worked" Reviewed

Kwang-Hoi Lee, Ho-Jin Lee, Kouji Kuramoto, Yohei Tanaka, Kazuhide Morino, Atsushi Sudo, Tatsuo Okauchi, Akihiko Tsuge, Takeshi Endo

Journal of Polymer Science Part A-Polymer Chemistry 49 ( 1 ) 234 - 241 2011.01

Facile Preparation of Aryl Sulfides Using Palladium Catalysis under Mild Conditions "jointly worked" Reviewed

Tatsuo Okauchi, Kouji Kuramoto, Mitsuru Kitamura

Synlett ( 19 ) 2891 - 2894 2010.12

Synthesis of Diazonaphthoquinones from Naphthols by Diazo-Transfer Reaction with 2-Azido-1,3-dimethylimidazolinium Chloride "jointly worked" Reviewed

Mitsuru Kitamura, Norifumi Tashiro, Rie Sakata, Tatsuo Okauchi

Synlett ( 16 ) 2503 - 2505 2010.10

Low-valent zirconocene-mediated cyclization of gamma,delta-unsaturated oximes "jointly worked" Reviewed

Mitsuru Kitamura, Yuki Shintaku, Daisuke Kudo, Tatsuo Okauchi

Tetrahedron Letters 51 ( 37 ) 4890 - 4893 2010.09

Enantioselective Synthesis of alpha-Benzylalanine Using trans-3,4-Dihydro-3,4-diaryldibenzo[c,g]phenanthrene-3,4-diols "jointly worked" Reviewed

Mitsuru Kitamura, Daisuke Kitahara, Tatsuo Okauchi

Synlett ( 14 ) 2097 - 2100 2010.09

Direct Synthesis of Acyl Azides from Carboxylic Acids Using 2-Azido-1,3-dimethylimidazolinium Chloride "jointly worked" Reviewed

Mitsuru Kitamura, Norifumi Tashiro, Yusuke Takamoto, Tatsuo Okauchi

Chemistry Letters 39 ( 7 ) 732 - 733 2010.07

2-azido-1,3-dimethylimidazolinium chloride: An efficient diazo transfer reagent for 1,3-dicarbonyl compounds Reviewed

Kitamura M., Tashiro N., Okauchi T.

Synlett ( 18 ) 2943 - 2944 2009.12

2-Azido-1,3-dimethylimidazolinium Chloride: An Efficient Diazo Transfer Reagent for 1,3-Dicarbonyl Compounds "jointly worked" Reviewed

Mitsuru Kitamura, Norifumi Tashiro, Tatsuo Okauchi

Synlett ( 18 ) 2943 - 2944 2009.11

A Steady Operation of n-Type Organic Thin-Film Transistors with Cyano-Substituted Distyrylbenzene Derivative "jointly worked" Reviewed

Shuichi Nagamatsu, Tetsuji Moriguchi, Toshiya Nagase, Shinya Oku, Kouji Kuramoto, Wataru Takashima, Tatsuo Okauchi, Katsuhiro Mizoguchi, Shuji Hayase, Keiichi Kaneto

Applied Physics Express 2 ( 10 ) 101502 2009.10

A steady operation of n-type organic thin-film transistors with cyano-substituted distyrylbenzene derivative Reviewed

Nagamatsu S., Moriguchi T., Nagase T., Oku S., Kuramoto K., Takashima W., Okauchi T., Mizoguchi K., Hayase S., Kaneto K.

Applied Physics Express 2 ( 10 ) 2009.10

Preparation of colloidal silica grafted with iron(0) carbonyl complex/polymer and formation of colloidal crystals in organic solvents Reviewed

Nakano M., Mouri E., Karakawa H., Okauchi T., Yoshinaga K., Nakai A.

Polymer Preprints, Japan 55 ( 1 ) 2006.10

Chlamydocin analogs bearing carbonyl group as possible ligand toward zinc atom in histone deacetylases Reviewed

M. P.I. Bhuiyan,T. Kato,T. Okauchi,N. Nishino,S. Maeda,T. G. Nishino,M. Yoshida

Bioorganic & Medicinal Chemistry 14 ( 10 ) 3438 - 3446 2006.05

Facile Synthesis of Modified Cyclic Imino Acids with Methyl and Hydroxyl Groups Reviewed

BHUIYAN Mohammed P. I., WATANABE Louis A., IKEDA Satoshi, JUNG An-Na, KATO Tamaki, OKAUCHI Tatsuo, NISHINO Norikazu

Peptide science : proceedings of the ... Japanese Peptide Symposium 2005 15 - 18 2006.03

Generation of alpha-phosphonovinyl radicals and development of a new route to highly functionalized vinylphosphonates and vinylphosphonate-incorporated carbocyclic or heterocyclic compounds via a radical trapping sequence Reviewed

Takafumi Ageno,Tatsuo Okauchi,Toru Minami,Masaru Ishida

Organic and Biomolecular Chemistry 3 ( 5 ) 924 - 931 2005.04

Generation of α-phosphonovinyl radicals and development of a new route to highly functionalized vinylphosphonates and vinylphosphonate- incorporated carbocyclic or heterocyclic compounds via a radical trapping sequence Reviewed

Ageno T., Okauchi T., Minami T., Ishida M.

Organic and Biomolecular Chemistry 3 ( 5 ) 924 - 931 2005.03

Vinyl-and arylphosphorus derivatives Reviewed

Minami T., Okauchi T.

Comprehensive Organic Functional Group Transformations II 2 853 - 907 2004.12

Acid-promoted reaction of trimethylsilylketene bis(ethylthio)acetal with imines. Synthesis of γ,γ-bis(ethylthio)allylamines Reviewed

Yahiro S., Shibata K., Saito T., Okauchi T., Minami T.

Journal of Organic Chemistry 68 ( 12 ) 4947 - 4950 2003.06

New synthesis of gem-bis(phosphono)ethylenes and their applications Reviewed

Inoue S., Okauchi T., Minami T.

Synthesis ( 13 ) 1971 - 1976 2003.01

The first synthesis of phosphonoacrolein Reviewed

Arimori S., Kouno R., Okauchi T., Minami T.

Phosphorus, Sulfur and Silicon and Related Elements 177 ( 8-9 ) 1953 - 1954 2002.11

The first synthesis of phosphonoacrolein. Application to Diels-Alder reaction as heterodiene Reviewed

Arimori S., Kouno R., Okauchi T., Minami T.

Journal of Organic Chemistry 67 ( 21 ) 7303 - 7308 2002.10

Synthesis and biological evaluation of N-(7-indolyl)-3-pyridinesulfonamide derivatives as potent antitumor agents Reviewed

Owa T., Yoshino H., Okauchi T., Okabe T., Ozawa Y., Hata Sugi N., Yoshimatsu K., Nagasu T., Koyanagi N., Kitoh K.

Bioorganic and Medicinal Chemistry Letters 12 ( 16 ) 2097 - 2100 2002.08

Synthesis and Biological Evaluation of N-(7-Indolyl)-3-Phridinesulfonamide Derivatives as Potent Antitumor Agents Reviewed

岡内　辰夫

Biolrganic & Medicinal Chemistry Letters 12 ( 16 ) 2097 - 2100 2002.04

The First Synthesis of Phosphonoacrolein. Application to Diels-Alder Reaction as Heterodiene Reviewed

The Journal of Organic Chemistry 67 ( 21 ) 7303 - 7308 2002.04

Synthesis and Biological Evaluation of N-(7-Indolyl)-3-Phridinesulfonamide Derivatives as Potent Antitumor Agents Reviewed

Biolrganic & Medicinal Chemistry Letters 12 ( 16 ) 2097 - 2100 2002.04

The First Synthesis of Phosphonoacrolein. Application to Diels-Alder Reaction as Heterodiene Reviewed

岡内　辰夫

The Journal of Organic Chemistr 67 ( 21 ) 7303 - 7308 2002.04

Regioselective proton abstraction and 1,3-migration of a phosphorus group in 1,3-dienes by iron coordination: A new method for the synthesis of α-phosphono-α,β-unsaturated ketones [17] Reviewed

Okauchi T., Teshima T., Hayashi K., Suetsugu N., Minami T.

Journal of the American Chemical Society 123 ( 48 ) 12117 - 12118 2001.12

Lewis acid-promoted deoxygenative di[β,β-bis(ethylthio)]vinylation of aldehydes with trimethylsilylketene bis(ethylthio)acetal Reviewed

Okauchi T., Tanaka T., Minami T.

Journal of Organic Chemistry 66 ( 11 ) 3924 - 3929 2001.06

Intramolecular Cyclizations of ο-substituted β,β-Difluorostyrenes: Synthesis of 3-Fluorinated Isochromenes and Isotheiochromenes Reviewed

Wada Yukinori, Ichikawa Junji, Katsume Tadayuki, NOHIRO Tomoko, OKAUCHI Tatsuo, MINAMI Toru

Bulletin of the Chemical Society of Japan 74 ( 5 ) 971 - 977 2001.05

Regioselective Proton Abstraction and 1.3-Migration of a Phosphorus Group in 1.3-Dienes by Iron Coordination: A New Method for the Synthesis of α-Phosphono-α,β-Unsaturated Ketores. Reviewed

岡内　辰夫

Journal of the American Chemical Society 123 ( 48 ) 12117 - 12118 2001.04

Regioselective Proton Abstraction and 1.3-Migration of a Phosphorus Group in 1.3-Dienes by Iron Coordination: A New Method for the Synthesis of α-Phosphono-α,β-Unsaturated Ketores. Reviewed

Journal of the American Chemical Society 123 ( 48 ) 12117 - 12118 2001.04

α-Phosphonovinyl Carbanions in Organic Synthesis Reviewed

Synthesis ( 3 ) 349 - 357 2001.04

Lewis Acid-promoted Deoxygenative Di[β, β-bis(ethylthio)]vinylation of Aldehydes with Trimethylsilylketene Bis(ethylthio)acetal Reviewed

The Journal of Organic Chemistry 66 ( 11 ) 3924 - 3929 2001.04

Regioselective Nucleophilic Additions to Cross-Conjugated Dienone System Bearing β-Fluorine : A Versatile Approach to Highly Substituted 2-Cyclopentenones Reviewed

Organic Letters 3 ( 15 ) 2345 - 2348 2001.04

Intramolecular Cyclizations of o-Substituted β, β-Difluorostyrenes : Synthesis of 3-Fluorinated Isochromenes and Isothiochromenes Reviewed

Bulletin of the Chemical Society of Japan 74 ( 5 ) 971 - 977 2001.04

The nucleophilic 5-endo-trig cyclization of gem-difluoroolefins with homoallylic functional groups: Syntheses of ring-fluorinated dihydroheteroaromatics Reviewed

Ichikawa J., Fujiwara M., Wada Y., Okauchi T., Minami T.

Chemical Communications ( 19 ) 1887 - 1888 2000.10

Synthesis and synthetic application of α-formylvinylphosphonates. Facile synthesis of phosphono-substituted heterocyclic compounds Reviewed

Kouno R., Tsubota T., Okauchi T., Minami T.

Journal of Organic Chemistry 65 ( 14 ) 4326 - 4332 2000.07

A focused compound library of novel N-(7-indolyl)benzenesulfonamides for the discovery of potent cell cycle inhibitors Reviewed

Owa T., Okauchi T., Yoshimatsu K., Sugi N., Ozawa Y., Nagasu T., Koyanagi N., Okabe T., Kitoh K., Yoshino H.

Bioorganic and Medicinal Chemistry Letters 10 ( 11 ) 1223 - 1226 2000.06

Language：English Publishing type：Research paper (scientific journal)

A series of compounds containing an N-(7-indolyl)benzenesulfonamide pharmacophore was synthesized and evaluated as a potential antitumor agent. Cell cycle analysis with P388 murine leukemia cells revealed that there were two different classes of potent cell cycle inhibitors; one disrupted mitosis and the other caused G1 accumulation. Herein described is the SAR summary of the substituent patterns on this pharmacophore template. (C) 2000 Elsevier Science Ltd. All rights reserved.

DOI： 10.1016/S0960-894X(00)00219-5

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A general method for acylation of ndoles at the 3-position with Acyl chlorides in the presence of dialkylaluminum chloride Reviewed

Okauchi T., Itonaga M., Minami T., Takashi O., Kitoh K., Yoshino H.

Organic Letters 2 ( 10 ) 1485 - 1487 2000.05

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

(Matrix presented) Indoles are selectively acylated at the 3-position in high yields on treatment with a wide variety of acyl chlorides in CH2CI2 in the presence of diethylaluminum chloride or dimethylaluminum chloride. The reaction proceeds under mild conditions and is applicable to indoles bearing various functional groups without NH protection.

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Asymmetric allylic alkylation of cycloalkenediol diacetates using a chiral phosphine ligand bearing a carboxyl group Reviewed

Okauchi T., Fujita K., Ohtaguro T., Ohshima S., Minami T.

Tetrahedron Asymmetry 11 ( 6 ) 1397 - 1403 2000.04

Asymmetric Allylic Alkylation of Cycloalkenediol Diacetates Using a Chiral Phosphine Ligand Bearing a Carbonyl Group Reviewed

Tetrahedron : Asymmetry 11 ( 6 ) 1397 - 1403 2000.04

The Nucleophilic 5-endo-trig Cyclization of gem-Difluoroolefins with Homoallylic Functional Group : Syntheses of Ring-fluorinated Dihydroheteroaromatics Reviewed

Chemical Communications ( 19 ) 1887 - 1888 2000.04

A Focused Compound Library of Novel N-(7-Indolyl)benzenesulfonamides for the Discovery of Potent Cell Cycle Inhibitors Reviewed

Bioorganic & Medicinal Chemistry Letters 10 ( 11 ) 1223 - 1226 2000.04

Synthesis and Synthetic Application of α-Formylvinylphosphonates. Facile Synthesis of Phosphono-Substituted Heterocyclic Compounds Reviewed

The Journal of Organic Chemistry 65 ( 14 ) 4326 - 4332 2000.04

Synthesis of 5-Diphenylphosphinolyl-2, 3-dihydropyran-4-ones Reviewed

Heterocycles 53 ( 3 ) 1393 - 1398 2000.04

General Method for Acylation of Indoles at 3-Position with Acyl Chlorides in the Presence of Dialkylaluminum Chloride Reviewed

Organic Letters 2 ( 10 ) 1485 - 1487 2000.04

Synthesis of 5-diphenylphosphinoyl-2,3-dihydropyran-4-ones Reviewed

Okauchi T., Nagamori H., Kouno R., Ichikawa J., Minami T.

Heterocycles 52 ( 3 ) 1393 - 1398 2000.03

Vinylic C-F bond activation with low-valent zirconocene: The generation and cross-coupling reactions of 1-fluorovinylzirconocene Reviewed

Fujiwara M., Ichikawa J., Okauchi T., Minami T.

Tetrahedron Letters 40 ( 40 ) 7261 - 7265 1999.10

α-Phosphonovinyl Nonaflate : Their Synthesis and Cross-Coupling Reactions Reviewed

Tetrahedron Letters 40 ( 29 ) 5337 - 5340 1999.04

A Facile Synthesis of 1-H-2, 2-Difluorovinylphosphorus Compounds from 2, 2, 2-Trifluoroethyl Trifluoromethanesulfonate and Substitutions of Their Vinylic Fluorines Reviewed

Journal of Fluorine Chemistry 97 ( 1-2 ) 109 - 114 1999.04

Vinylic C-F Bond Activation : Generation and Cross-Coupling Reactions of 1-Fluorovinylzirconocene Reviewed

Tetrahedron Letters 40 ( 40 ) 7261 - 7265 1999.04

Synthetic Utilization of α-Phosphonovinyl Anions Reviewed

Phosphorus, Sulfur and Silicon 144-146 689 - 692 1999.04

Discovery of Novel Antitumor Sulfonamides Targeting G1 Phase of the Cell Cycle Reviewed

Journal of Medicinal Chemistry 42 ( 19 ) 3789 - 3799 1999.04

Synthetic utilization of α-phosphonovinyl anions Reviewed

Minami T., Kouno R., Okauchi T., Nakamura M., Ichikawa J.

Phosphorus, Sulfur and Silicon and Related Elements 144-146 689 - 692 1999.01

Synthesis and Synthetic Utilization of α-Functionalized Vinylphosphonates Bearing β-Oxy or β-Thio Substituents Reviewed

Kouno R., Okauchi T., Nakamura M., Ichikawa J., Minami T.

Journal of Organic Chemistry 63 ( 18 ) 6239 - 6246 1998.09

Fluorine-directed Nazarov cyclizations 2: Regioselective synthesis of 5-trifluoromethyl-2-Cyclopentenones Reviewed

Ichikawa J., Fujiwara M., Okauchi T., Minami T.

Synlett ( 8 ) 927 - 929 1998.08

Fluorine-Directed Nazarov Cyclizations 2 : Regioselective Synthesis of 5-Trifluoromethyl-2-2cyclopentenones Reviewed

Synlett ( 8 ) 927 - 929 1998.04

Synthesis and Synthetic Utilization of α-Functionalized Vinylphosphonates Bearing β-Oxy or β-Thio Substituents Reviewed

The Journal of Organic Chemistry 63 ( 18 ) 6239 - 6246 1998.04

Lewis Acid-Catalyzed Intramodecular [2+2]Cydoaddition of α-Ester-Substituted Conjugated Dienyl and Trienylphosphonates. New Synthesis of Functionalized Cydic Terpenoids Reviewed

The Journal of Organic Chemistry 62 ( 24 ) 8419 - 8424 1997.04

5-endo-Trigonal Cyclization of o-Substituted gem-Difluorostyrenes : Syntheses of 2-Fluorinated Indoles, Benzo[b]furans, and Benzo[b]thiophenes Reviewed

Chemical Communications ( 16 ) 1537 - 1538 1997.04

2-Phosphono-1,1,4,4-tetrathio-1,3-butadienes. Synthesis and Synthetic Application to Highly Functionalized Dienes and Heterocycles Reviewed

Bulletin des Soci(]J1117[)t(]J1117[)s Chimique Belges 106 ( 9-10 ) 525 - 532 1997.04

5-endo-Trigonal cyclization of o-substituted gem-difluorostyrenes: Syntheses of 2-fluorinated indoles, benzo[b]furans and benzo[b]thiophenes Reviewed

Ichikawa J., Wada Y., Okauchi T., Minami T.

Chemical Communications ( 16 ) 1537 - 1538 1997.01

Lewis Acid-Catalyzed Intramolecular [2 + 2] Cycloaddition of α-Ester-Substituted Conjugated Dienyl- And Trienylphosphonates. New Synthesis of Functionalized Cyclic Terpenoids Reviewed

Okauchi T., Kakiuchi T., Kitamura N., Utsunomiya T., Ichikawa J., Minami T.

Journal of Organic Chemistry 62 ( 24 ) 8419 - 8424 1997.01

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

α-Ester-substituted 1,3-dienylphosphonates 7 and 8, prepared by the Knoevenagel condensation, underwent intramolecular [2 + 2] cycloaddition in the presence of Lewis acid to form bicyclo[4.2.0] (26-57% yield) and bicyclo[3.2.0]skeleton (14-38% yield), respectively. Similar treatment of homologous 1,3-dienylphosphonate 11 and 1,3,5-trienylphosphonate 12 resulted in the formation of ionone derivatives (30-94% yield). The intramolecular cycloaddition reaction was applicable to several conjugated dienes bearing an ester group.

DOI： 10.1021/jo971153g

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Other Link： https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0000736055&origin=inward

Synthesis and synthetic application of phosphonoketene dithioacetals. New synthesis of dithioallenes and (α-dithiocarboxyvinyl)phosphonates Reviewed

Minami T., Okauchi T., Matsuki H., Nakamura M., Ichikawa J., Ishida M.

Journal of Organic Chemistry 61 ( 23 ) 8132 - 8140 1996.11

Development of Chiral Phosphine Ligands Bearing a Carboxyl Group and Their Application to Catalytic Asymmetric Reaction Reviewed

Tetrahedron : Asymmetry 6 ( 10 ) 2469 - 2474 1996.04

Novel 2, 2-Difluorovinylzirconocene : A Facile Synthesis of Monosubstituted gem-Difluoroolefins via Its Cross-Coupling Reaction Reviewed

Tetrahedron Letters 37 ( 48 ) 8799 - 8802 1996.04

synthesis and Synthetic Application of Phosphonoketene Dithioacetals. New Synthesis of Dithioallenes and (α-Dithio carboxyvinyl) phosphonatis. Reviewed

The Journal of Organic Chemistry 23 ( 61 ) 8132 - 8140 1996.04

Development of chiral phosphine ligands bearing a carboxyl group and their application to catalytic asymmetric reaction Reviewed

Minami T., Okada Y., Otaguro T., Tawaraya S., Furuichi T., Okauchi T.

Tetrahedron: Asymmetry 6 ( 10 ) 2469 - 2474 1995.10

Novel 6-5 Fused Ring Heterocycle Antifolates with Potent Antitumor Activity : Bridge Modifications and Heterocyclic Benzoyl Isosters of 2, 4-Diamino-6, 7-dihydro-5H-cyclopenta[d]pyrimidine Antifolate Reviewed

Chemical & Pharmaceutical Bulletin 43 ( 5 ) 829 - 841 1995.04

Novel 6–5 Fused Ring Heterocycle Antifolates with Potent Antitumor Activity: Bridge Modifications and Heterocyclic Benzoyl Isosters of 2,4-Diamino-6,7-dihydro-5H-cyclopenta[d] pyrimidine Antifolate Reviewed

Kotake Y., Okauchi T., Iijima A., Yoshimatsu K., Nomura H.

Chemical and Pharmaceutical Bulletin 43 ( 5 ) 829 - 841 1995.01

Oxydative Generation of Thioalkyl Cation from 2-Tributylstannyl-1, 3-ditianes and 1-(Tributylstannnyl)alkyl Sulfides and Their Reactions with Olefinic Nucleophiles Reviewed

Bulletin of the Chemical Society of Japan 66 ( 10 ) 2995 - 3003 1993.04

Generation of Cation Radicals from 2-Tributylstannyl-1, 3-dithianes and Their Reaction with Olefins Reviewed

Chemistry Letters ( 7 ) 1229 - 1232 1992.04

Generation of Cation Radicals from Enamines and Their Reactions with Olefins Reviewed

Chemistry Letters ( 10 ) 2099 - 2102 1992.04

Addition Reactions of Cation Radicals of Nitroalkanes to Olefinic Compounds by the Use of Manganese((]G0003[))2-Pyridinecarboxylate Reviewed

Chemistry Letters ( 3 ) 423 - 426 1991.04

Generation of Cation Radicals from Allylic Sulfides and Their Reactions with Silyl Enol Ethers by the Use of Cerium(IV)Ammonium Nitrate Reviewed

Chemistry Letters ( 3 ) 515 - 518 1991.04

Stereoselective β-C-and β-S-Glycosylation of 2-Deoxyribofuranose Derivatives Controlled by the 3-Hydroxy Protecrive Group Reviewed

Bulletin of the Chemical Society of Japan 62 ( 3 ) 845 - 852 1989.04

The Addition Reaction of β-Keto Carboxylic Acids to Olefinic Compounds by the Use of Mn((]G0003[))Tris(2-pyridinecarboxylate)as an Oxidant Reviewed

Chemistry Letters ( 12 ) 2169 - 2172 1989.04

Synthesis of β-2-Deoxyribonucleosides from 1-O-Acetyl-3-O-[2-(methylsulfinyl)ethyl]-2-deoxyribose Reviewed

Chemistry Letters ( 5 ) 801 - 804 1989.04

The Trityl Cation Mediated Michael Reaction of Ethylthioketene Dithioacetals with Silyl Enol Ethers Reviewed

Chemistry Letters ( 9 ) 1691 - 1694 1987.04

The Trityl Cation Catalyzed Michael Type Reaction of Stannylated Nucleophiles with Ethylthioketene Dithioacetals Reviewed

Chemistry Letters ( 9 ) 1695 - 1698 1987.04

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