Faculty Profiles - PANDEY Shyam sudhir

Papers - PANDEY Shyam sudhir

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Fabrication of Nanobioengineered Interfaces Utilizing Quaternary Nanocomposite for Highly Efficient and Selective Electrochemical Biosensing of Urea Reviewed International journal

Krishna Kumar, Kshitij RB Singh, Ritu S. Rathour, Jay Singh, Subrato Bhattacharya, Shyam S. Pandey*

Langmuir ( American Chemical Society ) 2024.09

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

Nanobioengineered interfaces have gained attention owing to their small size and high surface area-to-volume ratio for utilization as a platform for highly selective and sensitive biosensing applications owing to the integration of biological molecules with engineered nanomaterials/nanocomposites. In this work, a novel Ag-complex, [(PPh3)2Ag(SCOf)]-based quaternary Ag–S–Zn–O nanocomposites (NCs), was synthesized through an environmentally-friendly process. The results revealed the formation of the NCs with an average crystallite size and particle size of 36.08 and 40.22 nm, respectively. In addition, this is the first study to utilize such NCs synthesized via a single-source precursor method, offering enhanced sensor performance due to their unique structural properties. Further, these NCs were used to fabricate a urease (Ur)/Ag–S–Zn–O NCs/ITO nanobioengineered electrode for precise and sensitive electrochemical biosensing of urea. The interfacial kinetic studies revealed quasi-reversible processes with high electron transfer rates and linear current responses, indicating efficient reaction dynamics. A high diffusion coefficient and low surface concentration suggested a fast diffusion-controlled process, affirming the electrode’s potential for rapid and sensitive urea detection. The biosensor demonstrated notable sensing properties such as high sensitivity (12.56 μA mM–1 cm–2) and a low detection limit (0.54 mM). The fabricated bioelectrode was highly selective and reproducible and demonstrated stability for up to 60 days. These results validate the potential of this nanobioengineered interface for next-generation biosensing applications, paving the way for advanced point-of-care diagnostics and real-time health monitoring.

DOI： 10.1021/acs.langmuir.4c02457

High-Density, Nonvolatile, Flexible Multilevel Organic Memristor Using Multilayered Polymer Semiconductors Reviewed International journal

Shubham Sharma*, Manish Pandey, Shuichi Nagamatsu, Hirofumi Tanaka, Kazuto Takashima Kazuto Takashima Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, 2-4 Hibikino, Wakamatsu, Kitakyushu 808-0196, Japan More by Kazuto Takashima , Masakazu Nakamura, and Shyam S. Pandey*

ACS Applied Materials and Interfaces ( American Chemical Society ) 16 ( 17 ) 22282 - 22293 2024.04

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

Nonvolatile organic memristors have emerged as promising candidates for next-generation electronics, emphasizingthe need for vertical device fabrication to attain a high density. Herein, we present a comprehensive investigation of high-performance organic memristors, fabricated in crossbar architecture with PTB7/Al-AlOx-nanocluster/PTB7 embedded between Alelectrodes. PTB7 films were fabricated using the Unidirectional Floating Film Transfer Method, enabling independent uniform filmfabrication in the Layer-by-Layer (LbL) configuration without disturbing underlying films. We examined the charge transportmechanism of our memristors using the Hubbard model highlighting the role of Al-AlOx-nanoclusters in switching-on the devices,due to the accumulation of bipolarons in the semiconducting layer. By varying the number of LbL films in the device architecture,the resistance of resistive states was systematically altered, enabling the fabrication of novel multilevel memristors. These multileveldevices exhibited excellent performance metrics, including enhanced memory density, high on−off ratio (>108), remarkable memoryretention (>105 s), high endurance (87 on−off cycles), and rapid switching (∼100 ns). Furthermore, flexible memristors werefabricated, demonstrating consistent performance even under bending conditions, with a radius of 2.78 mm for >104 bending cycles.This study not only demonstrates the fundamental understanding of charge transport in organic memristors but also introducesnovel device architectures with significant implications for high-density flexible applications.

DOI： 10.1021/acsami.4c03111

Other Link： https://pubs.acs.org/doi/10.1021/acsami.4c03111

Photophysical Characterization and Biointeractions of NIR Squaraine Dyes for in Vitro and in Vivo Bioimaging Reviewed International journal

Sai Kiran Mavileti, Galyna Bila, Valentyn Utka, Evgenia Bila, Tamaki Kato, Rostyslav Bilyy, Shyam S Pandey

ACS Applied Biomaterials ( American Chemical Society ) 7 ( 1 ) 416 - 428 2023.12

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

The increasing demand for reliable near-infrared (NIR) probes exhibiting enduring fluorescence in living systems and facile compatibility with biomolecules such as peptides, antibodies or proteins is driven by the increasing use of NIR imaging in clinical diagnostics. To address this demand, a series of carboxy-functionalized unsymmetrical squaraine dyes (SQ-27, SQ-212, and SQ-215) along with non-carboxy-functionalized SQ-218 absorbing and emitting in the NIR wavelength range were designed and synthesized followed by photophysical characterization. This study focused on the impact of structural variations in the alkyl chain length, carboxy functionality positioning, and spacer chain length on dye aggregation and interaction with bovine serum albumin (BSA) as a model protein. In phosphate buffer (PB), the absorption intensity of the dyes markedly decreased accompanied by pronounced shoulders indicative of dye aggregation, and complete fluorescence quenching was seen in contrast to organic solvents. However, in the presence of BSA in PB, there was a enhancement in absorption intensity while regaining the fluorescence coupled with a remarkable increase in the intensity with increasing BSA concentrations, signifying the impact of dye–BSA interactions on preventing aggregation. Further analysis of Job’s plot unveiled a 2:1 interaction ratio between BSA and all dyes, while the binding studies revealed a robust binding affinity (Ka) in the order of 107/mol. SQ-212 and SQ-215 were further tested for their in vitro and in vivo imaging capabilities. Notably, SQ-212 demonstrated nonpermeability to cells, while SQ-215 exhibited easy penetration and prominent cytoplasmic localization in in vitro studies. Injection of the dyes into laboratory mice showcased their efficacy in visualization, displaying stable and intense fluorescence in tissues without toxicity, organ damage, or behavioral changes. Thus, SQ-212 and SQ-215 are promising candidates for imaging applications, holding potential for noninvasive cellular and diagnostic imaging as well as biomarker detection when coupled with specific vectors in living systems.

DOI： https://doi.org/10.1021/acsabm.3c00997

Other Link： https://pubs.acs.org/doi/10.1021/acsabm.3c00997

Fabrication of solid-state dye-sensitized solar cells by controlled evaporation of solvents for creation of facile charge transport pathway Reviewed International journal

Yuki Kurokawa, Takehito Kato, Shyam S. Pandey

Physica Status Solidi-A ( Wiley ) 220 ( 24 ) 2300116 (1) - 2300116 (7) 2023.08

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

Solid-state dye-sensitized solar cells (ss-DSSCs) based on MK-2 dye-sensitized TiO2 photoanode and the most commonly used I−/I3− redox electrolyte are successfully fabricated by the simple method of solidification of the injected liquid electrolyte under slow solvent evaporation. The use of the ionic liquid, which is solid at room temperature, and slow evaporation of solvent at low temperature is a key step for solidification toward the fabrication of ss-DSSCs. It has been demonstrated that ss-DSSCs thus fabricated not only retain about 80% of photoconversion efficiency (PCE) as compared to their liquid-state DSSCs counterpart but also maintain the device stability for more than 1000 h. PCE of the ss-DSSCs is found to increase as a function of the increasing concentration of the ionic liquid used for electrolyte preparation. In the case of ss-DSSCs with the ionic liquid concentration of 1.2 m, there is a good balance between PCE and durability leading to not only retention of about 70% of PCE as compared to its liquid-state DSSCs counterparts but also maintaining the stability of the solar cell for more than 1000 h stored at room temperature.

DOI： https://doi.org/10.1002/pssa.202300116

Kyutacar

Other Link： https://onlinelibrary.wiley.com/doi/10.1002/pssa.202300116

High field-effect mobility in oriented thin films of D-A type semiconducting polymers by engineering stable interfacial system Reviewed International journal

Shubham Sharma Ajendra K. Vats Linjun Tang Feng Kaishan Jumpei Toyoda Shuichi Nagamatsu Yoshito Ando Masaaki Tamagawa Hirofumi Tanaka Manish Pandey Shyam S. Pandey

Chemical Engineering Journal ( Elsevier ) 469 143932(1) - 143932(1) 2023.08

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

Conjugated polymers (CPs) have emerged as excellent organic semiconducting materials for flexible electronic applications. CPs exhibit a notably fast carrier transport along their main π-conjugated backbone followed by inter-chain hopping compelling the need to form large and ordered domains in thin films. Therefore, the formation of larger domains, along with their orientation, is critical in controlling the electrical properties of CP-based organic electronic devices. However, controlling the molecular ordering along with the formation of large aggregates is a challenge. In this work, the unidirectional floating film transfer method (UFTM) has been utilized to prepare oriented thin films of CPs, which is a highly facile, cost-effective and material utilization efficient technique. We have demonstrated that extent and direction of molecular orientation in the fabricated thin films can be tuned along with the higher degree of aggregation. The rheological aspects, especially viscosity, play a significant role in determining molecular ordering along with the formation of these large aggregates. Active control of viscosity to achieve a stable interfacial viscous system is paramount to achieving this, resulting in a very high mobility of 12.4 cm2V−1s−1.

DOI： 10.1016/j.cej.2023.143932

Kyutacar

Other Link： https://www.sciencedirect.com/science/article/pii/S1385894723026633

Smart Alginate Nanomaterials: Revolutionizing Food Across Delivery, Preservation, Packaging, Safety, and Waste Upcycling Reviewed International journal

Shweta Rathee, Kshitij RB Singh, Sadhucharan Mallick, Jay Singh, Shyam S. Pandey, Ankur Ojha, Ravindra Pratap Singh

Carbohydrate Polymer Technologies and Applications ( Elsevier ) 2024.09

Language：English Publishing type：Research paper (scientific journal)

As the global population grows, the demand for safe food security aligned with sustainable development objectives becomes increasingly critical. This review delves into the innovative design techniques of stimuli-responsive smart alginate nanomaterials. It focuses on smart alginate hybrid nanomaterials and their nanocomposites that react to external stimuli. pH-responsive smart alginate hybrid nanomaterials are effectively utilized for the targeted delivery of bioactive components. Conversely, pH, temperature, specific analytes, and ionic strength-responsive smart alginate nanocomposites have food preservation, packaging, safety, and waste upcycling applications. This paper provides an in-depth examination of recent advancements in pH-responsive smart alginate hybrid nanomaterials, emphasizing targeted distribution systems, including nanoparticles, nanoliposome complexes, high internal phase Pickering emulsions, emulgels, nanogels, nanobioaerogels, and electrospun nanofibers. Moreover, the review highlights how smart alginate nanocomposites contribute to sustainable food preservation and upcycling of food waste, enhancing food safety. Detailed discussions on commercialization regulations underscore the importance of regulatory compliance and safety in deploying these advanced materials.

DOI： https://doi.org/10.1016/j.carpta.2024.100568

Other Link： https://www.sciencedirect.com/science/article/pii/S2666893924001488?via%3Dihub

Probing heavy metals in tropospheric particulate matter – An approach towards sustainability Reviewed International journal

Abel Inobeme, Arunadevi Natarajan, Safalmani Pradhan, Charles Oluwaseun Adetunji, Ariola Devolli, Chetan Chauhan, John Tsado Mathew, Jonathan Inobeme, Kaushik Pal, Kshitij RB Singh, Shyam S. Pandey*

Journal of Molecular Liquids ( Elsevier ) 412 125822(1) - 125822(13) 2024.08

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

Various organic and inorganic contaminants are increasingly found in the atmosphere due to several anthropogenic sources of alarming concern. Amongst the various classes of pollutants, heavy metals (HMs) have drawn global attention due to their bioaccumulation and biomagnification potential in cellular and sub-cellular structures of living organisms. In comparison to other media of dispersion of HMs, the mechanism involved in particulate matter (PM) in the atmosphere makes it easier for the transport of HMs over long distances at a global and regional scale due to the non-confinement of air masses. The transport of HMs through atmospheric PM requires close assessment and monitoring. At present, there is limited literature focusing on heavy metals in aerosols and dust. Most of the available studies have emphasized heavy metals in soil and water. The current review comprehensively highlights the various aspects of HMs including the sources, recent trends, and investigation models explored for the assessment and monitoring of HMs in PM and atmospheric aerosols, which will further help in achieving sustainable environmental monitoring aspects more precisely.

DOI： 10.1016/j.molliq.2024.125822

Other Link： https://www.sciencedirect.com/science/article/pii/S0167732224018816?via%3Dihub

Study on the charge transport behaviour of MXene- polymer nanocomposite-based self-assembled floating films at the air-liquid interface Reviewed International journal

Radhe Shyam, Shubham Sharma, Shyam S. Pandey, Takaaki Manaka, Rajiv Prakash

Materials Today Electronics ( Elsevier ) 9 100112(1) - 100112(11) 2024.08

Language：English Publishing type：Research paper (scientific journal)

This study explores the fabrication and charge transport behavior of MXene-polymer nanocomposite-based self-assembled floating films at the air-liquid interface. Utilizing ultrasonic dispersion of MXene nanosheets was integrated into a DPP-TTT polymer matrix, significantly enhancing the alignment and crystallization of the polymer chains. The films were fabricated using a unidirectional floating film transfer method (UFTM), which proved to be both simple and cost-effective. UV–visible and grazing incidence X-ray diffraction (GIXD) analyses confirmed increased π–π stacking and improved structural arrangement within the nanocomposites. Organic field-effect transistors (OFETs) fabricated from these films demonstrated that a 3% MXene inclusion resulted in the highest mobility, measuring 3.1 cm2V-1s-1 with an on-off ratio in the order of 104, compared to 1.3 cm2V-1s-1 in pristine DPP-TTT films. However, further increases in MXene content reduced mobility, emphasizing the importance of precise compositional tunin

DOI： 10.1016/j.mtelec.2024.100112

Other Link： https://www.sciencedirect.com/science/article/pii/S277294942400024X?via%3Dihub

Synthesis and Characterization of Multifunctional Symmetrical Squaraine Dyes for Molecular Photovoltaics by Terminal Alkyl Chain Modifications Reviewed International journal

Kota Mori, Yuki Kurokawa and Shyam S. Pandey*

Colorants ( MDPI ) 3 ( 3 ) 198 - 216 2024.07

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

Novel far-red sensitive symmetric squaraine (SQ) dyes with terminal alkyl chain modifications were designed, synthesized, and characterized, aiming towards imparting multifunctionalities such as photosensitization, dye aggregation prevention, and source of electrolyte components. The dye sensitizer SQ-80 with alkyl chain terminal modifications consisting of 1-methylimidazolium iodide was designed and synthesized as a new dye sensitizer for DSSCs based on symmetric SQ-4 without any terminal modification used as reference. Upon adsorption on the mesoporous TiO2 surface, SQ-80 demonstrated reduced dye aggregation and stronger binding to the TiO2 surface, leading to enhanced durability of DSSCs. Apart from the most common photosensitization behavior, the newly designed dye demonstrated multifunctionalities such as aggregation prevention and electrolyte functionality, utilizing iodine-based redox electrolytes in the presence and absence of I2 and LiI additives. In the absence of LiI and I2, a mixture of SQ-77 with alkyl chain terminal modifications consisting of iodide and SQ-80 demonstrated a photoconversion efficiency of 1.54% under simulated solar irradiation, which was about six times higher compared with the reference dye SQ-4 (0.24%) (having no alkyl chain terminal modification).

DOI： 10.3390/colorants3030014

Kyutacar

Other Link： https://www.mdpi.com/2079-6447/3/3/14

Synthesis and advances of smart heteroatom-sited coatings for anticorrosion applications Reviewed

M. Swathika, Sharmila Chandran, Kshitij RB Singh, Ravindra Pratap Singh, Shyam S. Pandey, Arunadevi Natarajan

Journal of the Taiwan Institute of Chemical Engineers ( Elsevier ) 105639(1) - 105639(14) 2024.07

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

Highlights
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Novel coating material for bore water, soil, and bacterial corrosion.

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A microphotograph of steel substrate immersed in bore water and soil reveals the anticorrosion behavior.

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Early-stage recognition of corrosion with highly pigmented metal oxides.

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Highest anticorrosive property was shown by epoxy-CoO nanomaterial.

DOI： 10.1016/j.jtice.2024.105639

Developing In2S3 upon Modified MgTiO3 Anchored on Nitrogen-doped CNT for Sustainable Sensing and Removal of Toxic Insecticide Clothianidin Reviewed International journal

Soumya Ranjan Mishra, Vishal Gadore, Kshitij RB Singh, Shyam S. Pandey, Md. Ahmaruzzaman

Environmental Research ( Elsevier ) 259 119435(1) - 119435(23) 2024.06

Language：English Publishing type：Research paper (scientific journal)

Herein, the study introduces a novel bifunctional In2S3/MgTiO3/TiO2@N-CNT (IMTNC) nanocomposite, which is poised to revolutionize the detection and removal of clothianidin (CLD) from aquatic environments by synergistic adsorption and photodegradation. Confirmation of the material’s synthesis was done using structural, optical, morphological, and chemical characterizations. An outstanding sensitivity of 2.168 μA/nM.cm2 with a linear range of 4–100 nM and a LOD of 0.04 nM, along with an exceptional elimination efficiency of 98.06 ± 0.84% for about 10 ppm CLD within 18 min was demonstrated by the IMTNC nanocomposite. Extensive studies were carried out to appraise the material’s effectiveness in the presence of various interfering species, such as cations, anions, organic compounds, and different water matrices, and a comprehensive assessment of its stability throughout several cycles was made. Response Surface Methodology (RSM) study was used to determine the ideal removal conditions for improved performance. In addition, the catalytic performance in removing various other pollutants was also analyzed. Adding In2S3 and developing N-doped Carbon Nanotubes (N-CNT) increased conductivity and higher electrochemical sensing skills, improving charge transfer and increasing photocatalytic activity. This research underscores the potential of the IMTNC nanocomposite as a promising candidate for advanced environmental sensing and remediation applications.

DOI： 10.1016/j.envres.2024.119435

Other Link： https://www.sciencedirect.com/science/article/pii/S0013935124013409?via%3Dihub

Role of Si and SiO2 in Optoelectronic Device Fabrication Reviewed International journal

Harshita Rai , Kshitij RB Singh , Shyam S. Pandey, Arunadevi Natarajan

Journal of Molecular Structure ( Elsevier ) 1316 138994(1) - 138994(9 2024.06

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

Silicon and its oxide deliver a dextrous way for engineering the successors of optoelectronic/photonic devices, by integrating fabrication techniques with heterostructured material possessing tuneable properties. Besides comprehensive knowledge, a collection of functional materials with device fabrication should be amplified. In general, silicon-based allied compounds can co-form with other materials like polymers, nanometal oxides, and organic/inorganic hybrid materials to deliver multiple electronic characteristics. A noteworthy and excellent performance of Si and its oxide secures a prominent position in the realm of the optoelectronics field. This study deliberates an exhaustive overview of advances in fabrication strategies, characteristics, Si/SiO2-based optoelectronic devices, and new materials used in this field. Additionally, this investigation spotlights the potential of Si/SiO2 in accentuating diverse applications like light-emitting diodes, solar cells, photodiodes, and phototransistors. In brief, this article will expose novel pathways of research and peregrination in this mushrooming field.

DOI： 10.1016/j.molstruc.2024.138994

Kyutacar

Other Link： https://www.sciencedirect.com/science/article/pii/S0022286024015126?via%3Dihub

Advancing dye-sensitized solar cell performance with bifacial illumination: A novel Stack Formation Framework approach Reviewed

Hussein A. AlSultan, Suhaidi Shafie, Mohd Nizar Hamidon, Ismayadi Ismail, Shyam S. Pandey, Fauzan Ahmad

Optical Materials ( Elsevier ) 153 115535(1) - 115535(10) 2024.05

Language：English Publishing type：Research paper (scientific journal)

Dye-sensitized solar cells (DSSCs) are considered to be one of the promising photovoltaic devices in terms of low cost, low toxicity, and versatility. However, the issue of low power conversion efficiency (PCE) is still a main issue of those devices, especially in low light harvesting and the issue of electron–hole recombination that hinders the PCE of the device. This study aims to enhance the PCE by maximizing the light-harvesting without sacrificing the electron–hole separation by a novel approach of the Stack Formation Framework (SFF) for multi-layered Titanium Dioxide (TiO
) photoanodes in DSSCs by integrating bifacial illumination capabilities. The SFF method, leveraging both commercial and synthesized TiO
pastes, now considers light absorption from both the front and rear sides of the device, aiming to harness the full potential of ambient light sources. Comparative analyses under varying illumination conditions reveal the T/sp-P25-T/sp (TPT) configuration’s superior efficiency (6.1%) and (3.8%) PCE in front and back respectively, with a notable increase in overall theoretical photocurrent (J
) to (15.99 mA) and (9.32 mA) in front and back illumination respectively. When both sides are utilized using a reflective mirror, the PCE reaches (9.9%). This work underscores the potential of bifacial DSSCs in maximizing energy capture and conversion, setting a new benchmark for photoanode performance in photovoltaic applications.

DOI： 10.1016/j.optmat.2024.115535

Kyutacar

Other Link： https://www.sciencedirect.com/science/article/pii/S0925346724007183?via%3Dihub

Clarifying the Dominant Role of Crystallinity and Molecular Orientation in Differently Processed Thin Films of Regioregular Poly(3-hexylthiophene) Reviewed International journal

Kumar Vivek Gaurav, Harshita Rai, Kshitij RB Singh, Shubham Sharma,Yoshito Ando, and Shyam S. Pandey*

Micromachine ( MDPI ) 15 ( 6 ) 677(1) - 677(16) 2024.05

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

Conjugated polymers (CPs) offer the potential for sustainable semiconductor devices due to their low cost and inherent molecular self-assembly. Enhanced crystallinity and molecular orientation in thin films of solution-processable CPs have significantly improved organic electronic device performance. In this work, three methods, namely spin coating, dip coating, and unidirectional floating-film transfer method (UFTM), were utilized with their parametric optimization for fabricating RR-P3HT films. These films were then utilized for their characterization via optical and microstructural analysis to elucidate dominant roles of molecular orientation and crystallinity in controlling charge transport in organic field-effect transistors (OFETs). OFETs fabricated by RR-P3HT thin films using spin coating and dip coating displayed field-effect mobility (μ) of 8.0 × 10−4 cm2V−1s−1 and 1.3 × 10−3 cm2V−1s−1, respectively. This two-time enhancement in µ for dip-coated films was attributed to its enhanced crystallinity. Interestingly, UFTM film-based OFETs demonstrated μ of 7.0 × 10−2 cm2V−1s−1, >100 times increment as compared to its spin-coated counterpart. This superior device performance is attributed to the synergistic influence of higher crystallinity and molecular orientation. Since the crystallinity of dip-coated and UFTM-thin films are similar, ~50 times improved µ of UFTM thin films, this suggests a dominant role of molecular orientation as compared to crystallinity in controlling the charge transport.

DOI： 10.3390/mi15060677

Kyutacar

Proliferating optoelectronic properties of doped ZnO nanoparticles Reviewed International journal

Sharmila Chandran, Arthi Priscilla Ganesan, Nidhi Asthana, Shyam S. Pandey, Kshitij RB Singh, Arunadevi Natarajan

Journal of Molecular Structure ( Elsevier ) 1311 138310(1) - 138310(8)) 2024.04

Language：English Publishing type：Research paper (scientific journal)

Ag-doped ZnO nanocomposites were synthesized precisely by adopting a wet chemical method to explore their optoelectronic characteristics for LED applications. Characterization studies have progressed for substantiation of its structural, and functional characteristics in conjugation with the optical properties of nanocomposites before and after doping. The metal-oxygen bonding was affirmed from IR spectra and excitation characteristics were detailed from UV–visible absorption spectra. The SEM images along with Energy dispersive X-ray analysis deliberates hexagonal morphology for pure ZnO which was surprisingly reformed into poly hexagon structures after doping with silver ions. The pertinence of the target material for LED application was verified by performing photoluminescence and charge density measurements. The doping of silver ions into ZnO presents a novel avenue in the field of optronics and serves as appropriate phosphors for light-emitting diodes. The application of the title compound was established by providing nano coating to LED bulb and emission efficiencies was recorded before and after coating. The present research recommends a unique method of nanocoating of LED bulb for efficient light intensity.

DOI： https://doi.org/10.1016/j.molstruc.2024.138310

Kyutacar

Other Link： https://www.sciencedirect.com/science/article/pii/S0022286024008305?via%3Dihub

Clarifying the Role of Carboxyl Functionality in Squaraine towards Aggregation and Self-assembly through Photophysical Characterization and BSA Interactions. Reviewed International journal

Sai Kiran Mavileti, Tamaki Kato, Shyam S. Pandey

Journal of Molecular Structure ( Elsevier ) 1309 138226(1) - 138226(9) 2024.04

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

The demand for near-infrared (NIR) probes with robust and stable fluorescence signals has surged, driven by their applications in optical sensing and bioimaging. Squraine dyes as NIR fluorescent probes have gained significant traction. However, understanding their behavior in aqueous media is important for their successful application. Herein we report the synthesis and photophysical characterization of carboxy-functionalized unsymmetrical squaraine dyes capable of light absorption and emission in the near-infrared (NIR) wavelength region. Structural variations in alkyl chain length, and spacer chain length between the primary chromophore and –COOH group were systematically introduced to investigate their impact on self-assembly in aqueous media leading to dye aggregation and their differential interactions with Bovine Serum Albumin (BSA) as a model protein. In phosphate buffer (PB) the absorption intensity decreased drastically along with pronounced shoulders due to dye aggregation leading to complete fluorescence quenching. However, in the presence of BSA, the intensity of shoulder bands reduced coupled with a sharp increase in the absorption associated with monomeric dye with the increasing concentration of BSA, indicating the prevention of dye aggregation owing to dye-BSA interactions. The prevention of dye aggregation due to dye-BSA interaction also led to a tremendous increase in the fluorescence intensities as a function of the increasing BSA concentrations. Site-selective study off BSA showed that these dyes bind preferably at Site-II using hydrophilic interactions. Thus, these dyes show great potential as FRET or fluorescent on/off probes for biosensing, non-covalent labeling of proteins, and fluorescent probes for bioimaging.

DOI： https://doi.org/10.1016/j.molstruc.2024.138226

Other Link： https://www.sciencedirect.com/science/article/pii/S0022286024007464?via%3Dihub

Targeted elimination of heavy metals from industrial wastewater: Synergistic effect of nano metal oxides Reviewed International journal

Manoharan Swathika, Narasimhan Muthulakshmi Andal, Sivasubramaniam Dharani, Jay Singh, Shyam S. Pandey, Kshitij RB Singh, Arunadevi Natarajan

Journal of the Taiwan Institute of Chemical Engineers ( Elsevier ) 105485(1) - 105485(10) 2024.03

Language：English Publishing type：Research paper (scientific journal)

Design and synthesis of pro-active nano metal oxides.

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Advanced and cost-effective process for water treatment.

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Comparative study probed the efficacies of target compound in heavy metal removal.

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Upscaling the lab result to field samples to batch (96 %) and column method (98 %).

DOI： https://doi.org/10.1016/j.jtice.2024.105485

Other Link： https://www.sciencedirect.com/science/article/pii/S1876107024001433?via%3Dihub

A Biocompatible NIR Squaraine Dye and Dye-Antibody Conjugates for Versatile Long-term In Vivo Fluorescence Bioimaging Reviewed International journal

Priyanka Balyan, Galyna Bila, Sai Kiran Mavileti, Evgenia Bila, Nazar Negrych, Shekhar Gupta, Linjun Tang, Rostyslav Bilyy, Shyam S. Pandey, Tamaki Kato

Materials Advances ( RSC ) 5 3940 - 3949 2024.03

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

The demand for dependable near-infrared (NIR) probes, capable of sustained fluorescence within living systems and facile conjugation with biomolecules like antibodies and proteins, has been significantly on the rise, attributed to the substantial rise in the use of NIR imaging techniques and devices, with extensive integration into clinical diagnostics. Antibody conjugates are vital for targeted and selective bioimaging, enabling precise visualization of specific biomolecules within complex biological systems. Their multiplexing capability allows simultaneous detection of multiple targets, while their dynamic imaging capability enables real-time monitoring of cellular processes. Clinically, antibody conjugates have significant applications in disease prognosis, diagnosis, and monitoring. In this work, we report the synthesis of a new symmetrical NIR squaraine dye (SQ-58) with multiple carboxy anchoring groups for ease of coupling with antibodies. The dye showed decreased absorption and fluorescence intensity in phosphate buffer (PB) due to enhanced dye-aggregate formation. However, in the presence of bovine serum albumin (BSA) in PB, SQ-58 showed an enhanced fluorescence signal along concentrations of BSA. SQ-58 showed no cytotoxicity when tested in white laboratory mice while providing strong fluorescence when injected in vivo. Conjugation of SQ-58 through the carboxylic groups to the isotypic mouse IgG antibodies (IgG-SQ-58) resulted in uniform distribution of the targeted molecule in the whole cardiovascular system. The NIR signal of IgG-SQ-58 was stable for at least 7 days allowing the possibility of long-term imaging. Conjugation of SQ-58 to antibodies raised against NK-Ly lymphoma tumor cells allowed efficient discrimination of tumor cells grown in the abdomen of laboratory mice. Thus, to the best of our knowledge, we report for the first time a biocompatible NIR dye, SQ-58, that can be easily conjugatable to biomolecules, and its antibody conjugates for a wide range of bioimaging applications.

DOI： https://doi.org/10.1039/d4ma00212a

Other Link： https://pubs.rsc.org/en/content/articlelanding/2024/ma/d4ma00212a

Design and Synthesis of Novel Squaraine-Based Fluorescent Probe for Far-Red Detection of Chymotrypsin Enzyme Reviewed International journal

Shekhar Gupta, Priyanka, Sai Kiran Mavileti, Shyam S. Pandey, Tamaki Kato

Molecules ( MDPI ) 29 ( 6 ) 1282(1) - 1282(14) 2024.03

Language：English Publishing type：Research paper (scientific journal)

Chymotrypsin, a crucial enzyme in human digestion, catalyzes the breakdown of milk proteins, underscoring its significance in both health diagnostics and dairy quality assurance. Addressing the critical need for rapid, cost-effective detection methods, we introduce a groundbreaking approach utilizing far-red technology and HOMO-Förster resonance energy transfer (FRET). Our novel probe, SQ-122 PC, features a unique molecular design that includes a squaraine dye (SQ), a peptide linker, and SQ moieties synthesized through solid-phase peptide synthesis. Demonstrating a remarkable quenching efficiency of 93.75% in a tailored H2O:DMSO (7:3) solvent system, our probe exhibits absorption and emission properties within the far-red spectrum, with an unprecedented detection limit of 0.130 nM. Importantly, our method offers unparalleled selectivity towards chymotrypsin, ensuring robust and accurate enzyme detection. This pioneering work underscores the immense potential of far-red-based homo-FRET systems in enabling the sensitive and specific detection of chymotrypsin enzyme activity. By bridging the gap between cutting-edge technology and biomedical diagnostics, our findings herald a new era of enzyme sensing, promising transformative advancements in disease diagnosis and dairy quality control.

DOI： https://doi.org/10.3390/molecules29061282

Other Link： https://www.mdpi.com/1420-3049/29/6/1282

The Influence of a Microstructural Conformation of Oriented Floating Films of Semiconducting Polymers on Organic Device Performance Reviewed International journal

Shubham Sharma, Kumar Vivek Gaurav, Shuichi Nagamatsu, Shyam S. Pandey

Polymers ( MDPI ) 16 ( 5 ) 710(1) - 710(13) 2024.03

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

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Open AccessArticle
The Influence of a Microstructural Conformation of Oriented Floating Films of Semiconducting Polymers on Organic Device Performance
by Shubham Sharma 1,*ORCID,Kumar Vivek Gaurav 1ORCID,Shuichi Nagamatsu 2 andShyam S. Pandey 1,*ORCID
1
Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, 2-4 Hibikino, Wakamatsu, Kitakyushu 808-0196, Japan
2
Department of Computer Science and Electronics, Kyushu Institute of Technology, 680-4 Kawazu, Iizuka 820-8502, Japan
*
Authors to whom correspondence should be addressed.
Polymers 2024, 16(5), 710; https://doi.org/10.3390/polym16050710
Submission received: 24 January 2024 / Revised: 27 February 2024 / Accepted: 4 March 2024 / Published: 5 March 2024
(This article belongs to the Special Issue New Progress in Semiconducting Polymer Nanoparticles)
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Abstract
Extended π-conjugation with backbone-planarity-driven π-π stacking dominates charge transport in semiconducting polymers (SCPs). The roles of SCP film morphology and macromolecular conformation concerning the substrate in influencing charge transport and its impact on device performance have been a subject of extensive debate. Face-on SCPs promote out-of-plane charge transport primarily through π-π stacking, with conjugated polymeric chains assisting transport in connecting crystalline domains, whereas edge-on SCPs promote in-plane charge transport primarily through conjugation and π-π stacking. In this work, we fabricated three different types of devices, namely, organic field effect transistors, organic Schottky diodes, and organic bistable memristors, as representatives of planar and vertical devices. We demonstrate that a planar device, i.e., an organic field effect transistor, performs well in an edge-on conformation exhibiting a field-effect mobility of 0.12 cm2V−1s−1 and on/off ratio >104, whereas vertical devices, i.e., organic Schottky diodes and organic memristors, perform well in a face-on conformation, exhibiting exceptionally high on/off ratios of ~107 and 106, respectively.

DOI： https://doi.org/10.3390/polym16050710

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Other Link： https://www.mdpi.com/2073-4360/16/5/710

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