Updated on 2024/04/09

 
OTSUBO Yoshitaka
 
Scopus Paper Info  
Total Paper Count: 0  Total Citation Count: 0  h-index: 5

Citation count denotes the number of citations in papers published for a particular year.

Affiliation
Graduate School of Life Science and Systems Engineering Department of Human Intelligence Systems
Job
Associate Professor
External link

Degree

  • Kyushu Institute of Technology  -  Doctor of Information Engineering   2001.06

Biography in Kyutech

  • 2014.04
     

    Kyushu Institute of Technology   Graduate School of Life Science and Systems Engineering   Department of Human Intelligence Systems   Associate Professor  

  • 2012.04
    -
    2014.03
     

    Kyushu Institute of Technology   Graduate School of Life Science and Systems Engineering   Department of Brain Science and Engineering   Associate Professor  

  • 2007.04
    -
    2012.03
     

    Kyushu Institute of Technology   Graduate School of Life Science and Systems Engineering   Assistant Professor  

Academic Society Memberships

  • 2009.09   The Japanese Association for the Study of Taste and Smell   Japan

  • 2009.09   Physiological Society of Japan   Japan

  • 2007.07   The Japan Neuroscience Society   Japan

  • 2002.10   Society for Neuroscience   United States

Papers

  • Taste Receptor Cells Generate Oscillating Receptor Potentials by Activating G Protein-Coupled Taste Receptors Reviewed International journal

    Nakao Y., Tateno K., Ohtubo Y.

    Frontiers in Physiology   13   2022.05

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)

    DOI： 10.3389/fphys.2022.883372

    Scopus

    Other Link： https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85131946248&origin=inward

  • Slow recovery from the inactivation of voltage-gated sodium channel Nav1.3 in mouse taste receptor cells Reviewed International journal

    Ohtubo Y.

    Pflugers Archiv European Journal of Physiology   473 ( 6 )   953 - 968   2021.05

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)

    DOI： 10.1007/s00424-021-02563-w

    Scopus

    PubMed

    Other Link： https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85104945852&origin=inward

  • Characteristics of A-type voltage-gated K+ currents expressed on sour-sensing type III taste receptor cells in mice Reviewed International journal

    Moribayashi T., Nakao Y., Ohtubo Y.

    Cell and Tissue Research ( Springer )   2024.03

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    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)

    DOI： 10.1007/s00441-024-03887-6

    Scopus

    Other Link： https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85187940767&origin=inward

  • An electrophysiological method for evaluation of topical antipruritic drugs on itch-related neuronal activities in the spinal cord in hairless mice Reviewed International journal

    Ueda Y., Uta D., Furue H., Ohtubo Y.

    European Journal of Pharmacology   952   2023.08

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    Authorship：Last author   Language：English   Publishing type：Research paper (scientific journal)

    DOI： 10.1016/j.ejphar.2023.175798

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    Other Link： https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85160215870&origin=inward

  • Diurnal rhythm regulates the frequency of carbachol-induced beta oscillation via inhibitory neural system in rat hippocampus Reviewed International journal

    Shigemoto M., Nakatsuka H., Ohtubo Y., Natsume K.

    Cognitive Neurodynamics   16 ( 3 )   507 - 518   2022.06

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    Language：English   Publishing type：Research paper (scientific journal)

    DOI： 10.1007/s11571-021-09736-4

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    Other Link： https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85118865389&origin=inward

  • Age-related electrophysiological changes in mouse taste receptor cells Reviewed International journal

    Takeuchi K., Yoshii K., Ohtubo Y.

    Experimental Physiology   106 ( 2 )   519 - 531   2021.02

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)

    DOI： 10.1113/EP089104

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    PubMed

    Other Link： https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85097000674&origin=inward

  • Cell-type-independent expression of inwardly rectifying potassium currents in mouse fungiform taste bud cells Reviewed International journal

    Yoshiki Nakao, Masahiro Koshimura, Takashi Yamasaki, Yoshitaka Ohtubo

    Physiological Research ( Institute of Physiology of the Czech Academy of Sciences )   69   501 - 510   2020.05

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)

    Inwardly rectifying potassium (Kir) channels play key roles in functions, including maintaining the resting membrane potential and regulating the action potential duration in excitable cells. Using in situ whole-cell recordings, we investigated Kir currents in mouse fungiform taste bud cells (TBCs) and immunologically identified the cell types (type I-III) expressing these currents. We demonstrated that Kir currents occur in a cell-type-independent manner. The activation potentials we measured were -80 to -90 mV, and the magnitude of the currents increased as the membrane potentials decreased, irrespective of the cell types. The maximum current densities at -120 mV showed no significant differences among cell types (p>0.05, one-way ANOVA). The density of Kir currents was not correlated with the density of either transient inward currents or outwardly rectifying currents, although there was significant correlation between transient inward and outwardly rectifying current densities (p<0.05, test for no correlation). RT-PCR studies employing total RNA extracted from peeled lingual epithelia detected mRNAs for Kir1, Kir2, Kir4, Kir6, and Kir7 families. These findings indicate that TBCs express several types of Kir channels functionally, which may contribute to regulation of the resting membrane potential and signal transduction of taste.

    DOI： 10.33549/physiolres.934331

    PubMed

  • Quantitative analysis of taste bud cell numbers in the circumvallate and foliate taste buds of mice Reviewed International journal

    Takahiro Ogata, Yoshitaka Ohtubo

    Chemical Senses ( Oxford University Press )   45 ( 4 )   261 - 273   2020.03

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    A mouse single taste bud contains 10–100 taste bud cells (TBCs) in which the elongated TBCs are classified into three cell types (types I–III) equipped with different taste receptors. Accordingly, differences in the cell numbers and ratios of respective cell types per taste bud may affect taste nerve responsiveness. Here we examined the numbers of each immunoreactive cell for the type II (sweet, bitter, or umami receptor cells) and type III (sour and/or salt receptor cells) markers per taste bud in the circumvallate and foliate papillae, and compared these numerical features of TBCs per taste bud to those in fungiform papilla and soft palate, which we previously reported. In circumvallate and foliate taste buds, the numbers of TBCs and immunoreactive cells per taste bud increased as a linear function of the maximal cross-sectional taste bud area. Type II cells made up approximately 25% of TBCs irrespective of the regions from which the TBCs arose. In contrast, type III cells in circumvallate and foliate taste buds made up approximately 11% of TBCs, which represented almost two-times higher than what was observed in the fungiform and soft palate taste buds. The densities (number of immunoreactive cells per taste bud divided by the maximal cross-sectional area of the taste bud) of types II and III cells per taste bud are significantly higher in the circumvallate papillae than in the other regions. The effects of these region-dependent differences on the taste response of the taste bud are discussed.

    DOI： 10.1093/chemse/bjaa017

    PubMed

    Other Link： https://doi.org/10.1093/chemse/bjaa017

  • A subset of taste receptor cells express biocytin-permeable channels activated by reducing extracellular Ca2+ concentration Reviewed

    Masafumi Iwamoto, Madoka Takashima, Yoshitaka Ohtubo

    European Journal of Neuroscience ( Blackwell Publishing Ltd )   51 ( 7 )   1605 - 1623   2020.01

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    Taste receptor cells (type II cells) transmit taste information to taste nerve fibres via ATP‐permeable channels, including calcium homeostasis modulator (CALHM), connexin and/or pannexin1 channels, via the paracrine release of adenosine triphosphate (ATP) as a predominant transmitter. In the present study, we demonstrate that extracellular Ca2+‐dependent biocytin‐permeable channels are present in a subset of type II cells in mouse fungiform taste buds using biocytin uptake, immunohistochemistry and in situ whole‐cell recordings. Type II cells were labelled with biocytin in an extracellular Ca2+ concentration ([Ca2+]out)‐sensitive manner. We found that the ratio of biocytin‐labelled type II cells to type II cells per taste bud was approximately 20% in 2 mM Ca2+ saline, and this ratio increased to approximately 50% in nominally Ca2+‐free saline. The addition of 300 µM GdCl3, which inhibits various channels including CALHM1 channels, significantly inhibited biocytin labelling in nominally Ca2+‐free saline, whereas the addition of 20 µM ruthenium red did not. Moreover, Cs+‐insensitive currents increased in nominally Ca2+‐free saline in approximately 40% of type II cells. These increased currents appeared at a potential of above −35 mV, reversed at approximately +10 mV and increased with depolarization. These results suggest that biocytin labels type II cells via ion channels activated by [Ca2+]out reduction, probably “CALHM‐like" channels, on the basolateral membrane and that taste receptor cells can be categorized into two groups based on differences in the expression levels of [Ca2+]out‐dependent biocytin‐permeable channels. These data indicate electrophysiological and pharmacologically relevant properties of biocytin‐permeable channels and suggest their contributions to taste signal transduction.

    DOI： 10.1111/ejn.14672

    PubMed

    Other Link： https://doi.org/10.1111/ejn.14672

  • Counting algorithm for sequential optical images of immunoreactive mouse taste bud cells Reviewed

    Katsumi Tateno, Osamu Shiku, Yoshitaka Ohtubo

    ICIC Express Letters ( ICIC International )   14 ( 1 )   1 - 8   2020.01

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    We developed a counting algorithm for use with sequential optical images of immunoreactive mouse taste bud cells. To count the immunoreactive cells in serial thin sections, continuity of a cell through the sequential sections must be confirmed. For this purpose, we used the overlap ratio of the cell regions in given sections and the distance between the sections. Results show that the mean positive predictive value for mouse taste bud cells was 99%; the mean sensitivity was 73%. Gamma correction improved the mean sensitivity to 87% with a slight decrease in the mean positive predictive value (94%).

    DOI： 10.24507/icicel.14.01.1

  • Voltage-gated channels and neurotransmitter receptors in mouse taste bud cells Invited Reviewed

    25 ( 1 )   25 - 34   2018.04

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    Authorship：Corresponding author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (other)

  • Selective expression of muscarinic acetylcholine receptor subtype M3 by mouse type III taste bud cells Reviewed

    Yusuke Mori, Kohgaku Eguchi, Kiyonori Yoshii, and Yoshitaka Ohtubo

    Pflugers Archiv -European Journal of Physiology   468 ( 11 )   2053 - 2059   2016.11

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)

    DOI： 10.1007/s00424-016-1879-5

    Other Link： https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138268/

  • Neurophysiology of mammalian taste receptors Reviewed

    Kiyonori Yoshii, Yoshitaka Ohtubo, Takashi Kumazawa

    Journal of Life Science Research   13   5 - 8   2015.12

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    Language：Japanese   Publishing type：Research paper (scientific journal)

  • Neural impulse amplitude of taste nerve fiber branches depends on taste receptor sites in bullfrogs Reviewed

    Journal of Life Science Research   12   9 - 14   2014.12

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  • Time-dependent expression of hypertonic effects on bullfrog taste nerve responses to salts and bitter substances. Reviewed

    Brain Research   1556   1 - 9   2014.03

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    Language：English   Publishing type：Research paper (scientific journal)

    DOI： 10.1016/j.brainres.2014.02.006

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  • Cell-type-dependent action potentials and voltage-gated currents in mouse fungiform taste buds. Reviewed

    39 ( 1 )   24 - 34   2014.01

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    Language：English   Publishing type：Research paper (scientific journal)

    DOI： 10.1111/ejn.12388

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  • マウス味蕾の細胞型依存性から考える味情報処理

    立野勝巳、大坪義孝

    日本神経回路学会誌 ( 日本神経回路学会 )   20 ( 4 )   159 - 165   2013.12

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (other)

  • Subtype-dependent postnatal development of taste receptor cells in mouse fungiform taste buds. Reviewed

    Ohtubo Y, Iwamoto M, Yoshii K

    The European journal of neuroscience   35 ( 11 )   1661 - 1671   2012.06

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    Language：English   Publishing type：Research paper (scientific journal)

    DOI： 10.1111/j.1460-9568.2012.08068.x

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  • Hypertonicity augments bullfrog taste nerve responses to inorganic salts. Reviewed

    Beppu N, Higure Y, Mashiyama K, Ohtubo Y, Kumazawa T, Yoshii K

    Pflugers Archiv : European journal of physiology   463 ( 6 )   845 - 851   2012.06

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    Language：English   Publishing type：Research paper (scientific journal)

    DOI： 10.1007/s00424-012-1097-8

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  • Network model of chemical-sensing system inspired by mouse taste buds Reviewed

    Tateno K, Igarashi J, Ohtubo Y, Nakada K, Miki T, Yoshii K

    Biological Cybermetics   105 ( 1 )   21 - 27   2011.07

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    Language：English   Publishing type：Research paper (scientific journal)

    DOI： 10.1007/s00422-011-0447-5

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  • Dye-permeable, voltage-gated channel on mouse fungiform taste bud cells. Reviewed

    K. Takeuchi,Y. Seto,Y. Ohtubo,K. Yoshii

    Brain Research   1373   17 - 24   2011.02

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    Language：English   Publishing type：Research paper (scientific journal)

    DOI： 10.1016/j.brainres.2010.12.019

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  • Quantitative analysis of taste bud cell numbers in fungiform and soft palate taste buds of mice. Reviewed

    Y. Ohtubo,K. Yoshii

    Brain Research   1367   13 - 21   2011.01

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    Language：English   Publishing type：Research paper (scientific journal)

    DOI： 10.1016/j.brainres.2010.10.060

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  • 哺乳類味蕾細胞の電位依存性Naチャネル

    大坪義孝

    日本味と匂学会誌 ( 未設定 )   17 ( 1 )   21 - 27   2010.04

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    Authorship：Corresponding author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (other)

  • Signal detection inspired by mouse taste receptor cells. Reviewed

    K. Tateno,J. Igarashi,K. Nakada,T. Miki,Y. Ohtubo,K. Yoshi

    NOLTA2009   2009.10

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    Language：English   Publishing type：Research paper (international conference proceedings)

    2009.10.18  -  2009.10.21

  • Functional expression of M3, a muscarinic acetylcholine receptor subtype, in taste bud cells of mouse fungiform papillae Reviewed

    K. EGUCHI,Y. OHTUBO,K. YOSHII

    Chemical senses   33 ( 1 )   47 - 55   2008.01

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  • A chemical sensor array inspired by mouse taste buds Reviewed

    Jun Igarashi,Katsumi Tateno,Kazuki Nakada,Tsutomu Miki,Yoshitaka Ohtubo,Kiyonori Yoshii

    Abstracts of the Brain-inspired Information Technology (BrainIT2007)   34 - 75   2007.11

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    Language：English   Publishing type：Research paper (international conference proceedings)

    北九州   2007.11.14  -  2007.11.16

  • Functional expression of ionotropic purinergic receptors on mouse taste bud cells Reviewed

    R. HAYATO,Y. OHTUBO,K. YOSHII

    The Journal of physiology   584 ( 2 )   473 - 473   2007.10

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  • 味蕾内の味情報伝達機構

    吉井清哲,大坪義孝,熊澤隆

    日本味と匂学会誌 ( 未設定 )   14 ( 2 )   171 - 178   2007.08

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (other)

  • A network model toward a taste bud inspired sensor. Reviewed

    K. Tateno,K. Yoshii,Y. Ohtubo,and Tsutomu Miki

    Brain-Inspired IT III   3   52 - 55   2007.01

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    Language：English   Publishing type：Research paper (other academic)

  • Quantitative study on cell types in adult mouse taste buds. Reviewed

    Brain-Inspired IT III   3   250 - 253   2007.01

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  • Electrophysiological identification of mouse taste bud cells. Reviewed

    Kimura K,Ohtubo Y,Kumazawa T,Yoshii K

    Brain-Inspired IT III   3   254 - 257   2007.01

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  • Functional expression of muscarinic acetylcholine receptors in mouse taste buds. Reviewed

    Eguchi K,Ohtubo Y,Yoshii K

    Brain-Inspired IT III   3   246 - 249   2007.01

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  • Functional expression of muscarinic acetylcholine receptors in mouse taste buds Reviewed

    K. Eguchi,Y. Ohtubo,K. Yoshii

    Brain-Inspired IT III   2006.09

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    北九州   2006.09.27  -  2006.09.27

  • Quantitative study on cell types in adult mouse taste buds Reviewed

    Y. Ohtubo,K Yoshii

    Brain-Inspired IT III   2006.09

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    北九州   2006.09.27  -  2006.09.27

  • Electrophysiological identification of mouse taste bud cells Reviewed

    K. Kimura,Y. Ohtubo,T. Kumazawa,K. Yoshii

    Brain-Inspired IT III   2006.09

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    北九州   2006.09.27  -  2006.09.27

  • A network model toward a taste bud inspired sensor Reviewed

    K. Tateno,K. Yoshii,Y. Ohtubo,T. Miki

    Brain-Inspired IT III   2006.09

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    北九州   2006.09.27  -  2006.09.27

  • Expression of purinergic receptors in mouse taste buds. Reviewed

    Hayato R,Ohtubo Y,Yoshii K

    Brain-Inspired IT II   2   81 - 84   2006.01

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  • Expression patterns of taste transduction-related proteins during development in mouse taste buds. Reviewed

    Brain-Inspired IT II   2   85 - 88   2006.01

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  • Expression of purinergic receptor in mouse taste buds Reviewed

    R. Hayato,Y. Ohtubo,K. Yoshii

    Brain-Inspired IT II   2005.10

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    北九州   2005.10.07  -  2005.10.07

  • Expression patterns of taste transduction-related proteins during development in mouse taste buds Reviewed

    Brain-Inspired IT II   2005.10

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    北九州   2005.10.07  -  2005.10.07

  • 味蕾細胞間情報伝達

    吉井清哲,大坪義孝,熊澤隆

    生体の化学 ( 未設定 )   56 ( 2 )   85 - 89   2005.04

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (other)

  • マウス味蕾細胞ネットワーク

    吉井清哲,大坪義孝,熊澤隆

    生物物理 ( 未設定 )   44 ( 1 )   21 - 25   2004.04

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  • Cell-networks in mouse taste buds. Reviewed

    R. HAYATO,T. KITABORI,M. MIYAJIMA,Y. HIGURE,Y. OHTUBO,T. KUMAZAWA AND K. YOSHII

    Brain-Inspired IT first edition   2004.04

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    Language：English   Publishing type：Research paper (international conference proceedings)

    北九州   2004.04  -  2004.04

  • Cell-networks in mouse taste buds. Reviewed

    Hayato R,Kitabori T,Miyajima M,Higure Y,Ohtubo Y,Kumazawa T,Yoshii K

    Brain-Inspired IT   1   2004.01

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  • Effects of endomorphin on substantia gelatinosa neuronsin rat spinal cordslices Reviewed

    S.Y. WU,Y. OHTUBO,G.C. BRAILOIU,N.J. DUN.

    British journal of pharmacology   140   1088 - 1096   2003.04

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  • Lucifer Yellow slows voltage-gated Na+ current inactivation in a light-dependent manner in mice Reviewed

    Y. HIGURE.,Y. KATAYAMA,K. TAKEUCHI,Y. OHTUBO,K. YOSHII

    The Journal of Physiology   550   159 - 167   2003.04

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  • Optical recordings of taste responses from fungiform papillae of mouse in situ Reviewed

    Y. OHTUBO,T. SUEMITSU,S. SHIOBARA,T. MATSUMOTO,T. KUMAZAWA,K. YOSHII

    The Journal of Physiology   530   287 - 293   2001.04

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  • 画像解析に便利なソフトーNIH imageの使い方ー

    大坪義孝,吉井清哲

    日本味と匂学会 ( 未設定 )   7 ( 1 )   97 - 100   2000.04

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  • Open channel block of NMDA receptors by conformationally restricted analogs of milnacipran and their protective effect against NMDA-induced neurotoxicity Reviewed

    T. NOGUCHI,K. ISHII,Y. OHTUBO,S. SATOSHI,O. SHIZUKA,A. MATSUDA,K. YOSHII

    Synapse   31   87 - 96   1999.04

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  • Phenytoin protected mouse cortical cell cultures against neurotoxicity induced by kaiate but not by NMDA Reviewed

    H. FURUE,N. FUDAMOTO,Y. OHTUBO,K. YOSHII

    Amino Acids   12   179 - 184   1997.04

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Conference Prsentations (Oral, Poster)

  • Quantitative analysis of biocytin-labeled taste cell numbers in response to sweet substances

    Katsuhiro Kaetsu, Yoshiki Nakao, Hiroyuki Nakagawa, Yoshitaka Ohtubo

    The 101st Annual Meeting of the Physiological Society of Japan  2024.03 

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    Event date： 2024.03.28 - 2024.03.30   Language：English   Country：Japan  

  • The carbachol-induced beta oscillation causes the decrease in frequency by disinhibition at the midnight phase

    Masaya Shigemoto, Yoshitaka Ohtubo, Kiyohisa Natsume

    Neuro2021 

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    Event date： 2021.07.28 - 2021.07.31   Language：English  

  • ラット海馬におけるカルバコール誘導ベータ振動の概日調節メカニズムには抑制性神経が関与している

    重本 昌也，大坪 義孝，夏目季代久

    MEとバイオサイバネティックス研究会 

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    Event date： 2021.06.25   Language：Japanese  

  • Circadian / diurnal modulation of carbachol-induced beta oscillations in rat hippocampal slices

    Masaya Shigemoto, Yoshitaka Ohtubo, Kiyohisa Natsume

    Neuro2020 

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    Event date： 2020.07.29 - 2020.08.01   Language：English  

  • カルバコール誘導β振動周波数の概日調節と抑制性神経機構の関連性

    重本 昌也，大坪 義孝，夏目季代久

    非線形問題研究会 

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    Event date： 2020.05.15   Language：Japanese  

  • Immunohistostaining and Ca2+-imaging of tracheal solitary chemosensory cells in mice

    Ohtubo Yoshitaka, Miyazaki Aiko

    第97回日本生理学会大会  日本生理学会

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    Event date： 2020.03.17 - 2020.03.19   Language：English  

  • Numerical studies on the expression of cell type marker proteins in mouse circumvallate taste buds.

    The 48th Annual Meeting of the Japanese Association for the Study of Taste and Smell 

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    Event date： 2014.10.02 - 2014.10.04   Language：English  

  • Density of taste receptor cell types in mouse circumvallate taste buds.

    Ohtubo Y

    XXIVth International Conference of European Chemoreception Research Organization 

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    Event date： 2014.09.10 - 2014.09.13   Language：English  

  • Aging-dependent changes in the ratio between taste receptor cells in ~20-month-old mice

    Y. Higure, Y. Ohtubo, K. Yoshii

    FENS Featured Regional Meeting 

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    Event date： 2013.09.11 - 2013.09.14   Language：English  

  • Aging effects on electrophysiological properties of taste receptor cells in ~20-month-old mice.

    K. Takeuchi, Y. Ohtubo, K. Yoshii

    FENS Featured Regional Meeting 

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    Event date： 2013.09.11 - 2013.09.14   Language：English  

  • Action potential shapes for a change in TEA-insensitive current ratio in mouse taste bud cell model.

    K. Tateno

    FENS Featured Regional Meeting 

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    Event date： 2013.09.11 - 2013.09.14   Language：English  

  • Postnatal development of taste receptor cells in mouse soft palate taste buds.

    Y. Ohtubo

    FENS Featured Regional Meeting 

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    Event date： 2013.09.11 - 2013.09.14   Language：English  

  • Aging of voltage-gated currents in mouse fungiform taste bud cells.

    Yoshitaka Ohtubo

    第90回日本生理学会大会 

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    Event date： 2013.03.27 - 2013.03.29   Language：English  

  • Bullfrog taste nerve responses under hyperosmotic conditions

    8th FENS Forum of Neuroscience 

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    Event date： 2012.07.14 - 2012.07.18   Language：English  

  • Action potentials and voltage-gated currents of mouse taste bud cells

    8th FENS Forum of Neuroscience 

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    Event date： 2012.07.14 - 2012.07.18   Language：English  

  • Cell type dependence of voltage-gated sodium channel currents in fungiform taste bud cells

    8th FENS Forum of Neuroscience 

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    Event date： 2012.07.14 - 2012.07.18   Language：English  

  • Pharmacology and expression of a dye-permeable voltage-gated channel on mouse taste bud cells

    20th congress of the European chemoreception research organization 

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    Event date： 2010.09.14 - 2010.09.19   Language：English  

  • The number of taste bud cells that belongs to each cell type is in equilibrium in fungiform and soft palate taste buds of mice

    20th congress of the European chemoreception research organization 

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    Event date： 2010.09.14 - 2010.09.19   Language：English  

  • マウス味蕾細胞に発現する色素透過性イオンチャネルの性質

    本人

    日本味と匂学会　第44回大会 

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    Event date： 2010.09.08 - 2010.09.10   Language：Japanese  

  • マウス味蕾細胞のsingle cell RT-PCR

    本人

    第12回　ブレインサイエンス研究会 

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    Event date： 2010.05.29 - 2010.05.30   Language：Japanese  

  • 味蕾細胞電位依存性ナトリウムチャネルの電気生理学的・分子生物学的研究

    本人

    第60回西日本生理学会 

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    Event date： 2009.11.06 - 2009.11.07   Language：Japanese  

  • Voltage-gated sodium currents of cell types in mouse taste bud cells

    The 7th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception 

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    Event date： 2009.11.03 - 2009.11.04   Language：English  

  • 味蕾細胞の電位依存性ナトリウムチャネル

    本人

    日本味と匂学会　第４３回大会 

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    Event date： 2009.09.02 - 2009.09.04   Language：Japanese  

  • VOLTAGE-GATED Na+ CURRENTS OF EACH CELL TYPE IN MOUSE TASTE BUDS

    18th congress of the European chemoreception research organization 

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    Event date： 2008.09.03 - 2008.09.07   Language：English  

  • Search of mouse soft palate taste bud cells for neurotransmitter receptors

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    Event date： 2008.03.25 - 2008.03.27   Language：English  

  • Identification and characterization of voltage-gated Na channels in mouse taste bud cells

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    Event date： 2008.03.25 - 2008.03.27   Language：English  

  • Voltage-gated currents of taste bud cells in infant mice

    Neuro2007 

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    Event date： 2007.09.10 - 2007.09.12   Language：English  

  • Quantitative differences between taste buds in mouse fungiform papillae and soft palates

    Neuro2007 

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    Event date： 2007.09.10 - 2007.09.12   Language：English  

  • Functional expression of M3, a muscarinic acetylcholine receptor subtype, in taste bud cells of mouse fungiform papillae

    The 84th Annual Meeting of the Physiological Society of Japan 

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    Event date： 2007.04   Language：English  

  • P2 receptors on mouse taste bud cells in fungiform papillae

    The 84th Annual Meeting of the Physiological Society of Japan 

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    Event date： 2007.03.20 - 2007.03.22   Language：English  

  • The number of each cell type in mouse single fungiform taste buds

    17th congress of the European chemoreception research organization 

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    Event date： 2006.09.04 - 2006.09.08   Language：English  

  • Electrophysiological identification of mouse taste bud cell types

    17th congress of the European chemoreception research organization 

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    Event date： 2006.09.04 - 2006.09.08   Language：English  

  • Immunoreactivity and voltage-gated channels of mouse taste bud cells

    The 29th Annual Meeting of the Japan Neuroscience Society 

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    Event date： 2006.04   Language：English  

  • Developmental changes in expression of taste transduction-related proteins within single taste buds in mouse

    In 35th Annual Meeting, Society for Neuroscience 

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    Event date： 2005.11   Language：English  

  • Effect of endomorphins on neurons of the ratsubstntia gelatinosa

    In 32st Annual Meeting, Society For Neuroscience 

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    Event date： 2002.04   Language：English  

  • Lucifer yellow inhibited the inactivation process of voltage-gated sodium currents

    In 31st Annual Meeting, Society For Neuroscience  

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    Event date： 2001.04   Language：English  

  • In situ imaging of cytosolic calcium in mouse taste bud cells

    In 31st Annual Meeting, Society For Neuroscience  

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    Event date： 2001.04   Language：English  

  • Optical and electrophysiological recordings of mouse taste cell responses in situ

    In 30th Annual Meeting, Society For Neuroscience 

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    Event date： 2000.04   Language：English  

  • Optical recordings of mouse taste receptor potentials in situ

    In 29th Annual Meeting, Society For Neuroscience 

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    Event date： 1999.04   Language：English  

  • In-situ optical recordings of cytosolic Ca2+ concentration in mouse taste bud cells

    In 29th Annual Meeting, Society For Neuroscience 

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    Event date： 1999.04   Language：English  

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Honors and Awards

  • 平成２９年度 日本味と匂学会 研究奨励賞

    日本味と匂学会   2017.09.26

    大坪義孝

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    Country：Japan

  • Outstanding Poster Award

    2006.09.08

    K. Kimura,Y. Ohtubo,T. Kumazawa and K. Yoshii

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    Country：Spain

Grants-in-Aid for Scientific Research

  • 味蕾細胞と味神経終末の味蕾内分布に基づく細胞ネットワークの構造的機能的解析

    Grant number：15K07053  2015.04 - 2018.03   基盤研究(C)

  • 活動電位と起動電位の動的関係に基づく味物質濃度検出機構

    Grant number：23700469  2011.04 - 2014.03   若手研究(B)

  • 味蕾細胞間相互作用の機能解明

    Grant number：20770124  2008.04 - 2010.03   若手研究(B)

Contracts

  • 味蕾細胞ネットワークによる情報処理機構の統合的解析および 数理モデルの構築

    2016.04 - 2017.03

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    Grant type：Other joint research

    味覚器を構成する味蕾細胞は、興奮性に加え抑制性神経伝達物質の合成・放出機構を有し、更にそれら受容体を発現する。従って、味情報は従来の定説とは異なり、まず味蕾細胞ネットワークで修飾・統合されると考えられている。しかし、この末梢組織で修飾・統合された情報が中枢へどのように伝達されるか不明である。味情報の中枢への入り口である延髄孤束核からin vivoで記録を行い、味蕾ネットワーク処理機構の統合的解明、およびその数理モデルを構築する

Other External Funds

  • 味蕾細胞におけるＡＴＰ放出機構の電気生理学的研究

    2009.09 - 2010.08

    成茂神経科学研究助成金  

Charge of off-campus class subject

  • 2022.08   Institution：福岡大学

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    Level：postgraduate_courses  Country：Japan

    地球圏の生物は、生存するために化学物質を検出し、その化学情報を生体情報に変換後、脳で処理し、適切な行動を引き起こす。本講義では、化学受容器官における化学物質の検出機構、生体情報への変換機構、神経細胞への情報伝達機構について解説する。まず、基礎的な知識として神経細胞の電気的性質および細胞間の情報伝達方法などを概説する。その後、細胞の研究手法を測定原理から解析方法まで説明する。最後に、化学受容細胞（嗅覚、味覚）における生体情報変換機構を解説する。

Activities of Academic societies and Committees

  • The Japanese Association for the Study of Taste and Smell  

    2018.01 - 2020.12

  • The Japanese Association for the Study of Taste and Smell  

    2015.01 - 2017.12

  • The Japanese Association for the Study of Taste and Smell  

    2014.04

Social activity outside the university

  • どうして、いろいろ感じたり、動いたり出来るの？－感覚・行動と脳の関係－

    Role(s)：Lecturer

    九州大学工業大学  飯塚高等学校  2023.03.13

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    Audience： High school students

    Type：Visiting lecture