680-4 Kawazu, Iizuka-shi, Fukuoka

Research Fields, Keywords

Control engineering, Molecular robotics, Systems biology

Scopus Paper Info  
Total Paper Count: 0  Total Citation Count: 0  h-index: 6

Citation count denotes the number of citations in papers published for a particular year.

Undergraduate Education 【 display / non-display

  • 1997.03   Sophia University   Faculty of Science and Engineering   Graduated   JAPAN

Post Graduate Education 【 display / non-display

  • 2006.03  Sophia University  Graduate School, Division of Science and Engineering  Doctoral Program  Completed  JAPAN

  • 1999.03  Sophia University  Graduate School, Division of Science and Engineering  Master's Course  Completed  JAPAN

Degree 【 display / non-display

  • Sophia University -  Doctor of Engineering  2006.03

Biography in Kyutech 【 display / non-display

  • 2019.04

    Kyushu Institute of TechnologyFaculty of Computer Science and Systems Engineering   Department of Intelligent and Control Systems   Professor  

  • 2019.03

    Kyushu Institute of TechnologyFaculty of Computer Science and Systems Engineering   Department of Systems Design and Informatics   Professor  

  • 2013.04

    Kyushu Institute of TechnologyFaculty of Computer Science and Systems Engineering   Department of Systems Design and Informatics   Associate Professor  

Biography before Kyutech 【 display / non-display

  • 2012.04

      Associate Professor   JAPAN

  • 2009.04

      Lecturer   JAPAN

  • 2008.04

      Researcher   JAPAN

  • 2006.04

      Researcher   JAPAN

  • 1999.04

      Technical Support Staff   JAPAN

Academic Society Memberships 【 display / non-display

  • 2018.01

    IFAC Technical Committee 8.4 on Bioprocesses and Biosystems  JAPAN

Specialized Field (scientific research fund) 【 display / non-display

  • Life / Health / Medical informatics

  • Control engineering/System engineering


Publications (Article) 【 display / non-display

  • Design method for biomolecular circuit with plasticity (Accepted)

    Kenta Hidaka, Takashi Nakakuki

    Proc of 2021 The 21th International Conference on Control, Automation and Systems (ICCAS2021)      2021.10  [Refereed]

  • New Approach to Frequency Response Analysis of Biomolecular Circuits (Accepted)

    Keitaro Koga, Takashi Nakakuki

    Proc of SICE Annual Conference (SICE2021)      2021.09  [Refereed]

  • Renewable implementation of rational biomolecular systems design

    Tamba M., Nakakuki T.

    2020 59th Annual Conference of the Society of Instrument and Control Engineers of Japan, SICE 2020      300 - 307   2020.09  [Refereed]

     View Summary

    Recently, a rationally designed method enabling the development of large-scale biomolecular circuits by combining three basic elements (catalysis, degradation, and annihilation mechanisms) like a Lego block was established. Although this method is instrumental in forming a functional biomolecular circuit, the circuit can operate normally only for a limited amount of time, which is a serious limitation in the field of DNA computing. In this study, we developed a conventional method of biomolecular implementation to make linear input-to-output systems renewable.

    DOI Scopus

  • Analysis of finite-time regulation property of biomolecular PI controller

    Rong P., Nakakuki T.

    Control Theory and Technology    18 ( 2 ) 135 - 142   2020.05  [Refereed]

     View Summary

    © 2020, South China University of Technology, Academy of Mathematics and Systems Science, CAS and Springer-Verlag GmbH Germany, part of Springer Nature. In practical applications of dynamic DNA nanotechnology, a biomolecular controller is required for maintaining the operation of the molecular actuator at a desired condition based on the information from molecular sensors. By making use of the DNA strand displacement mechanism as a “programming language” in the controller design, a biomolecular PI controller has been proposed. However, this PI control system has been verified only at the simulation level, and a theoretical regulation analysis is still required. Accordingly, in this study, we perform a rigorous regulation analysis of the biomolecular PI control system. Specifically, we theoretically prove that the output signal approaches the target level at a quasi-steady state. To this end, we apply the concept of finite-time regulation property to the biomolecular PI control system.

    repository DOI Scopus

  • Finite-time regulation property of DNA feedback regulator

    Nakakuki T., Imura J.

    Automatica    114   2020.04  [Refereed]

     View Summary

    © 2020 Elsevier Ltd In dynamic DNA nanotechnology, the DNA strand displacement technique provides the cornerstone for the bottom-up design of a man-made DNA molecular system. Practically, a feedback controller for regulating the concentration of a target DNA strand to the desired level is indispensable for mediating the kinetic momentum of a molecular actuator. However, such a regulator system operates by consuming fuel strands and requires sufficient supplies of these consumables for its normal execution, indicating that, in practice, optimal controller design requires the period of time during which the regulator proceeds with normal operation to be as long as possible. The fact that the system is naturally high dimensional and nonlinear complicates the analysis of properties emerging during a finite-time period in terms of their theoretical aspects. In this paper, we first define the new concept of a “finite-time regulation property” of DNA systems in the regulation problem. Then, to theoretically analyze this regulation property, we present two-time-scale modeling based on the difference in the initial distribution of the abundance of DNA strands. Focusing on the fast mode as a subsystem with a positive quadratic structure, we propose a new method for analyzing the regulation property observed in a finite period of time.

    DOI Scopus

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Publications (Books) 【 display / non-display

Conference Prsentations (Oral, Poster) 【 display / non-display

  • 光反応制御を用いた 濃度レギュレータに関する研究


    第4回分子ロボティクス年次大会  2020.11  -  2020.11 

  • 周波数特性からみるDNA回路の新設計の提案

    古賀 啓太郎,中茎隆

    第4回分子ロボティクス年次大会  2020.11  -  2020.11 

  • 光応答分子アゾベンゼンを利用した再利用可能なDNA回路の設計法


    第4回分子ロボティクス年次大会  2020.11  -  2020.11 

  • 光反応制御を利用した再生可能な濃度レギュレータに関する研究

    秋田実, 中茎隆

    計測自動制御学会 システム・情報部門 学術講演会 2019  (千葉大学)  2019.11  -  2019.11  計測自動制御学会

  • 国際生体分子デザインコンテストBIOMODを活用したGCE教育への試み


    第70回BMIRC教育研究成果報告会  2019.03  -  2019.03 

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Lectures 【 display / non-display

  • プログラミング教育とGIGAスクール構想が描く未来

    筑豊地区教育研究所連絡協議会教育実践発表会 ( 飯塚市コスモスコモンズ )  2021.08.05 

  • 飯塚市立小・中学校のICT教育推進にかかわって

    2021年度飯塚市立小・中学校管理職春季研修会   2021.04.14 

  • 飯塚市の産学連携によるプログラミング教育の取り組み

    平成29年度飯塚市学力向上フォーラム「子どもたちの未来をひらくプログラミング教育」   2018.01.21 

  • 分子ロボティクスの教育〜BIOMODの取り組み〜

    新学術領域研究 分子ロボティクス 最終公開シンポジウム   2017.07.15 

  • Integrative analyses of ErbB receptor signaling and transcriptional network

    FEBS SysBio2007 ( Gosau, Austria )  2007.03