Establishing a parallel compound screening method and identifying novel antimicrobial compounds targeting Staphylococcus aureus dihydrofolate reductase Reviewed International journal

Junpei Nakashima, Masamune Takeuchi, Shuhei Kawamoto, Kohei Monobe, Junichi Taira, Shunsuke Aoki

Journal of Applied Pharmaceutical Science   12 ( 8 )   036 - 047   2022.08

Establishment of in silico prediction methods for potential bitter molecules using the human T2R14 homology-model structure Reviewed International journal

K. Kuriki, R. Matsumoto, C. Ijichi, J. Taira, S. Aoki

Chem. Biol. Lett.   9 ( 3 )   351   2022.05

Computer‑Assisted Screening of Mycobacterial Growth Inhibitors: Exclusion of Frequent Hitters with the Assistance of the Multiple Target Screening Method Reviewed International journal

Kohei Kuriki, Junichi Taira, Masato Kuroki, Hiroshi Sakamoto, Shunsuke Aoki

International Journal of Mycobacteriology   10 ( 3 )   307 - 311   2021.09

Online biomolecular design competition across university boundaries Reviewed

69 ( 4 )   31 - 39   印刷中   2021.07

Complex Formation of Heme Oxygenase-2 with Heme Is Competitively Inhibited by the Cytosolic Domain of Caveolin-1 Reviewed

Misaki Takemoto, Hiroshi Sakamoto, Yuichiro Higashimoto, Junichi Taira

Biochemistry ( American Chemical Society )   印刷中   2021.07

Conformational Equilibrium of NADPH–Cytochrome P450 Oxidoreductase Is Essential for Heme Oxygenase Reaction Invited Reviewed International journal

1. M. Sugishima, J. Taira, T. Sagara, R. Nakao, H. Sato, M. Noguchi, K. Fukuyama, K. Yamamoto, T. Yasunaga, H. Sakamoto

Antioxidants   9   673   2020.07

Improvement of the novel inhibitor for Mycobacterium enoyl-acyl carrier protein reductase (InhA): A structure–activity relationship study of KES4 assisted by in silico structure-based drug screening Reviewed International journal

J. Taira, T. Umei, K. Inoue, M. Kitamura, F. Berenger, J. C. Sacchettini, H. Sakamoto, Shunsuke Aoki

J. Antibiot.   2020.03

Structural modification of a novel inhibitor for Mycobacterium enoyl-acyl carrier protein reductase (InhA) assisted by in silico structure-based drug screening Reviewed International journal

J. Taira, T. Nagano, M. Kitamura, M. Yamaguchi, H. Sakamoto, S. Aoki

Int. J. Mycobacteriol.   9 ( 1 )   12 - 17   2020.03

Dephosphorylation of clustered phosphoserine residues in human Grb14 by protein phosphatase 1 and its effect on insulin receptor complex formation Reviewed International journal

J. Taira, K. Yoshida, M. Takemoto, K. Hanada, H. Sakamoto

J. Pept. Sci.   25 ( 10 )   e3207   2019.07

Identification of Protein Phosphatase Involved in Dephosphorylation of Phosphoserines in Human Grb14 BPS Domain Reviewed

K. Yoshida, J. Taira, H. Komatsu, H. Sakamoto

Peptide Science 2018   33   2019.03

Development of rat heme oxygenase-1 based gene encorded heme probe for intercellular heme detection

J. Taira, O. Nakashima, H. Komatsu, H. Sakamoto

Peptide Science 2017   156 - 157   2018.03

Can peptide deformylase produce methionine aminopeptidase inhibitors from their formylated precursors?

Y. Oishi, Y. Takami, J. Taira, H. Kodama, S. Osada

Peptide Science 2017   106 - 107   2018.03

Protective Role of PEDF-Derived Synthetic Peptide Against Experimental Diabetic Nephropathy Reviewed

48 ( 9 )   613 - 619   2016.09

Coadministration of the fniii14 peptide synergistically augments the anti-cancer activity of chemotherapeutic drugs by activating pro-apoptotic bim Reviewed

11 ( 9 )   2016.09

EprS, an autotransporter serine protease, plays an important role in various pathogenic phenotypes of Pseudomonas aeruginosa Reviewed

2015.12

Improvement of heme oxygenase-1-based heme sensor for quantifying free heme in biological samples Reviewed

489   50 - 52   2015.11

Pigment epithelium derived factor inhibits caveolin induced interleukin 8 gene expression and proliferation of human prostate cancer cells. Reviewed

10   2644 - 2648   2015.10

Discovery of InhA inhibitors with anti-mycobacterial activity through a matched molecular pair approach Reviewed

94   378 - 385   2015.04

Effect of glycogen synthase kinase 3 on the complex forming between growth factor receptor bound protein 14 and insulin receptor

187 - 190   2015.03

Evaluation of in vitro Phosphorylation Properties of Predicted Kinase which Phosphorylate Serines in Nuclear Localization Signal 1 in High Mobility Group Box 1 Reviewed

20 ( 8 )   613 - 617   2014.08

Phosphorylation of Grb14 BPS Domain by GSK-3 Correlates with Complex Forming of Grb14 and Insulin Receptor Reviewed

155 ( 6 )   353 - 360   2014.06

Tenascin-C-derived Peptide TNIIIA2 Highly Enhances Cell Survival and PDGF-dependent Cell Proliferation through Potentiated and Sustained Activation of Integrin α5β1 Reviewed

289 ( 25 )   17699 - 17708   2014.05

Pigment Epithelium-Derived Factor (PEDF) Binds to Caveolin-1 and Inhibits The Pro-Inflammatory Effects of Caveolin-1 in Endothelial Cells Reviewed

2013.11

EprS, an autotransporter protein of pseudomonas aeruginosa, possessing serine protease activity induces inflammatory responses through protease-activated receptors Reviewed

15 ( 7 )   1168 - 1181   2013.07

Protein phosphatase 2A dephosphorylates phosphoserines in nucleocytoplasmic shuttling and secretion of high mobility group box 1 Reviewed

154 ( 3 )   299 - 308   2013.06

Protein phosphatase 2A in macrophage dephosphorylates phosphoserines involved in nucleocytoplasmic shuttling and secretion of high mobility group box 1

191 - 194   2013.03

Caveolin-1 interacts with protein phosphatase 5 and modulates its activity in prostate cancer cells Reviewed

434 ( 4 )   724 - 728   2013.02

Identification of essential amino acid residues involved in the interaction of heme oxygenase-1 with caveolin-1

35 - 38   2012.03

Caveolin-1 is a competitive inhibitor of heme oxygenase-1 (HO-1) with heme: identification of minimum sequence in caveolin-1 for binding to HO-1 Reviewed

50 ( 32 )   6824 - 6831   2011.08

Structural modification of 2-aminoisobutylic acid containing peptides toward an acquiring of antimicrobial activities against pathogenic bacteria Reviewed

263 - 263   2011.03

Peptaibol derived helix-Kink motif facilitates channel forming of the artificial α-aminoisobutyric acid rich helices Reviewed

16 ( 4 )   277 - 282   2010.12

Modifications on amphiphilicity and cationicity of unnatural amino acid containing peptides for the improvement of antimicrobial activity against pathogenic bacteria Reviewed

16 ( 17 )   607 - 612   2010.11

Trans-bilayer ion conduction by proline containing cyclic hexapeptides and effects of amino acid substitutions on ion conducting properties Reviewed

83 ( 6 )   683 - 688   2010.06

Apoptotic death of hematopoietic tumor cells through potentiated and sustained adhesion to fibronectin via VLA-4 Reviewed

285 ( 10 )   7006 - 7015   2010.03

Amino acid sequence dependence of ion channel activity by cyclic tetrapeptides

195 - 198   2010.03

Ion channel formation of dimeric peptide enhanced by electrostatic inter-helical interactions Reviewed

611   321 - 322   2009.04

Conformational effects of cyclic hexapeptides for ion channel properties Reviewed

611   337 - 338   2009.04

Synthesis and biological activity of alamethicin analogs enhanced by electrostatic interaction

245 - 248   2009.03

Modifications of hydrophobic value and hydrophobic moment value of cationic model peptides for conversion of peptide-membrane interactions Reviewed

81 ( 6 )   733 - 739   2008.06

Ion channel formation assisted by electrostatic inter-helical interactions in covalently dimerized amphiphilic helical peptides Reviewed

47 ( 12 )   3705 - 3714   2008.03

Antiadhesive sites present in the fibronectin type III-like repeats of human plasma fibronectin

325 - 328   2008.03

Synthesis and ion conductance of cervinin peptides

277 - 280   2008.03

Enhancement of ion channel formation by electrostatic interaction incorporated in dimeric helical peptide

285 - 288   2008.03

Antiadhesive sites present in the fibronectin type III-like repeats of human plasma fibronectin Reviewed

30 ( 5 )   891 - 897   2007.05

Comparison study of ion channel activities of homo-dimerized and hetero-dimerized amphiphilic helical model peptides Reviewed

121 - 122   2006.11

Effect of ring size alteration for ion channel activities of cyclic peptides

245 - 248   2006.03

Synthesis and biological activities of proline rich cyclic heptapeptide hymenamide B analogs Reviewed

609 - 610   2005.06

Ion channel activities and mechanisms of ion conduction about cyclic hexapeptides Reviewed

607 - 608   2005.06

Ion-channel properties of cyclic hexapeptide cyclo(Pro-Xxx-Yyy)₂ Reviewed

531 - 534   2005.03

Solid-phase synthesis of tyrosine-containing cyclic peptides Reviewed

535 - 538   2005.03

Synthesis and biophysical properties of the transmembrane segments of the mitochondrial uncoupling proteins Reviewed

734 - 735   2004.11

Synthesis and ion-channel activity of assembled Aib-model peptides

327 - 330   2004.03

生体内遊離ヘムの濃度測定と動態解析

Grant number：15K01825  2015.04 - 2018.03   基盤研究(C)

リン酸化を介してHMGB1の分泌を制御する因子の探索と制御機構の解明

Grant number：25870990  2013.04 - 2016.03   若手研究(B)

受動性輸送体タンパク質の機能調節のための膜貫通セグメントの構造と機能に関する研究

Grant number：05J06431  2005.04 - 2008.03   特別研究員奨励費

Institution：杉森高等学校　看護専攻科

Project Award: Bronze

Annual biomolecular design competition for students (BIOMOD)   2019.10.28

優秀ポスター賞

第43回蛋白質と酵素の構造と機能に関する九州シンポジウム   2019.09.07

第３位（トラベルアワード）

分子ロボティクス研究会   2019.08.31