研究者詳細 - 平　順一

論文 - 平　順一

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Importance of isoleucine residue in ion channel formation ability of 11-residue peptaibols 査読有り国際誌

T. Nakatani, A. Koga, S. Goto, M. Inoue, K. Shigedomi, K. Seki, K. Araki, J. Taira, H. Kodama, S. Osada

Bioorg. Med. Chem. 110 117839 2024年08月

Role of tubulin C-terminal tail on mechanical properties of microtubule 査読有り国際誌

S. Nowroz, S.R. Nasrin, A.M.R. Kabir, T. Yamashita, T. Kusumoto, J. Taira, M. Tani, M. Ichikawa, K. Sada, Kazuki, A. Kakugo

Biochem. Biophys. Res. Commun. 706 149761 2024年04月

Computational Screening and Experimental Validation of Inhibitor Targeting the Complex Formation of Grb14 and Insulin Receptor 査読有り国際誌

Y. Ochi, T. Matsui, K. Inoue, K. Monobe, H. Sakamoto, S. Aoki, J. Taira

Molecules ( MDPI ) 29 198 2023年12月

Computer-assisted identification of inhibitor with novel pharmacophore targeting first kringle domain of hepatocyte growth factor 査読有り

J. Taira, M. Yamaguchi, A. Tashiro, A. Kida, K. Suzuki, K. Sakai, K. Matsumoto, S. Aoki

ChemistrySelect 8 ( 36 ) e202301577 2023年09月

Identification of novel inhibitors for mycobacterial polyketide synthase 13 via in silico drug screening assisted by the parallel compound screening with genetic algorithm-based programs 査読有り国際誌

Junichi Taira, Kahori Murakami, Kohei Monobe, Kohei Kuriki, Miu Fujita, Yosuke Ochi, Hiroshi Sakamoto, Shunsuke Aoki

The Journal of Antibiotics ( Springer Nature ) in press 2022年08月

Establishing a parallel compound screening method and identifying novel antimicrobial compounds targeting Staphylococcus aureus dihydrofolate reductase 査読有り国際誌

Junpei Nakashima, Masamune Takeuchi, Shuhei Kawamoto, Kohei Monobe, Junichi Taira, Shunsuke Aoki

Journal of Applied Pharmaceutical Science 12 ( 8 ) 036 - 047 2022年08月

Establishment of in silico prediction methods for potential bitter molecules using the human T2R14 homology-model structure 査読有り国際誌

K. Kuriki, R. Matsumoto, C. Ijichi, J. Taira, S. Aoki

Chem. Biol. Lett. 9 ( 3 ) 351 2022年05月

Computer‑Assisted Screening of Mycobacterial Growth Inhibitors: Exclusion of Frequent Hitters with the Assistance of the Multiple Target Screening Method 査読有り国際誌

Kohei Kuriki, Junichi Taira, Masato Kuroki, Hiroshi Sakamoto, Shunsuke Aoki

International Journal of Mycobacteriology 10 ( 3 ) 307 - 311 2021年09月

大学の枠を超えたオンライン生体分子デザインコンペティションの取り組み査読有り

村田智, 葛谷明紀, 藤原慶, 平順一, 川又生吹, 佐藤佑介, 瀧ノ上正浩, 野村 M. 慎一郎, 角五彰, 堀豊, 安部桂太

工学教育 ( 日本工業教育協会 ) 69 ( 4 ) 31 - 39 印刷中 2021年07月

Complex Formation of Heme Oxygenase-2 with Heme Is Competitively Inhibited by the Cytosolic Domain of Caveolin-1 査読有り

Misaki Takemoto, Hiroshi Sakamoto, Yuichiro Higashimoto, Junichi Taira

Biochemistry ( American Chemical Society ) 印刷中 2021年07月

Conformational Equilibrium of NADPH–Cytochrome P450 Oxidoreductase Is Essential for Heme Oxygenase Reaction 招待有り査読有り国際誌

1. M. Sugishima, J. Taira, T. Sagara, R. Nakao, H. Sato, M. Noguchi, K. Fukuyama, K. Yamamoto, T. Yasunaga, H. Sakamoto

Antioxidants 9 673 2020年07月

Improvement of the novel inhibitor for Mycobacterium enoyl-acyl carrier protein reductase (InhA): A structure–activity relationship study of KES4 assisted by in silico structure-based drug screening 査読有り国際誌

J. Taira, T. Umei, K. Inoue, M. Kitamura, F. Berenger, J. C. Sacchettini, H. Sakamoto, Shunsuke Aoki

J. Antibiot. 2020年03月

Structural modification of a novel inhibitor for Mycobacterium enoyl-acyl carrier protein reductase (InhA) assisted by in silico structure-based drug screening 査読有り国際誌

J. Taira, T. Nagano, M. Kitamura, M. Yamaguchi, H. Sakamoto, S. Aoki

Int. J. Mycobacteriol. 9 ( 1 ) 12 - 17 2020年03月

Dephosphorylation of clustered phosphoserine residues in human Grb14 by protein phosphatase 1 and its effect on insulin receptor complex formation 査読有り国際誌

J. Taira, K. Yoshida, M. Takemoto, K. Hanada, H. Sakamoto

J. Pept. Sci. 25 ( 10 ) e3207 2019年07月

Identification of Protein Phosphatase Involved in Dephosphorylation of Phosphoserines in Human Grb14 BPS Domain 査読有り

K. Yoshida, J. Taira, H. Komatsu, H. Sakamoto

Peptide Science 2018 33 2019年03月

Development of rat heme oxygenase-1 based gene encorded heme probe for intercellular heme detection

J. Taira, O. Nakashima, H. Komatsu, H. Sakamoto

Peptide Science 2017 156 - 157 2018年03月

Can peptide deformylase produce methionine aminopeptidase inhibitors from their formylated precursors?

Y. Oishi, Y. Takami, J. Taira, H. Kodama, S. Osada

Peptide Science 2017 106 - 107 2018年03月

Protective Role of PEDF-Derived Synthetic Peptide Against Experimental Diabetic Nephropathy 査読有り

Ishibashi Y., Matsui T., Taira J., Higashimoto Y., Yamagishi S.

Hormone and Metabolic Research 48 ( 9 ) 613 - 619 2016年09月

記述言語：英語掲載種別：研究論文（学術雑誌）

© Georg Thieme Verlag KG Stuttgart New York ISSN 0018-5043.Pigment epithelium-derived factor (PEDF) is a glycoprotein with complex neuroprotective, anti-angiogenic, and anti-inflammatory properties, all of which could potentially be exploited as a therapeutic option for vascular complications in diabetes. We have previously shown that PEDF-derived synthetic peptide, P5-3 (FIFVLRD) has a comparable ability with full PEDF protein to inhibit rat corneal neovascularization induced by chemical cauterization. However, the effects of PEDF peptide on experimental diabetic nephropathy remain unknown. To address the issue, we modified P5-3 to stabilize and administered the modified peptide (d-Lys-d-Lys-d-Lys-Gln-d-Pro-P5-3-Cys-amide, 0.2 nmol/day) or vehicle to streptozotocin-induced diabetic rats (STZ-rats) intraperitoneally by an osmotic mini pump for 2 weeks. We further examined the effects of modified peptide on human proximal tubular cells. Renal PEDF expression was decreased in STZ-rats. Although the peptide administration did not affect blood glucose or blood pressure, it decreased urinary excretion levels of 8-hydroxy-2′-deoxyguanosine, an oxidative stress marker, and reduced plasminogen activator inhibitor-1 (PAI-1) gene expression, and suppressed glomerular expansion in the diabetic kidneys. High glucose or advanced glycation end products stimulated oxidative stress generation and PAI-1 gene expression in tubular cells, all of which were significantly suppressed by 10 nM modified P5-3 peptide. Our present study suggests that PEDF-derived synthetic modified peptide could protect against experimental diabetic nephropathy and inhibit tubular cell damage under diabetes-like conditions through its anti-oxidative properties. Supplementation of modified P5-3 peptide may be a novel therapeutic strategy for diabetic nephropathy.

DOI： 10.1055/s-0042-108448

Scopus

その他リンク： https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84969927085&origin=inward

Coadministration of the fniii14 peptide synergistically augments the anti-cancer activity of chemotherapeutic drugs by activating pro-apoptotic bim 査読有り

Iyoda T., Iyoda T., Nagamine Y., Nakane Y., Tokita Y., Akari S., Otsuka K., Fujita M., Itagaki K., Takizawa Y., Orita H., Owaki T., Taira J., Hayashi R., Kodama H., Fukai F., Fukai F.

PLoS ONE 11 ( 9 ) 2016年09月

記述言語：英語掲載種別：研究論文（学術雑誌）

© 2016 Iyoda et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.The acquisition of drug resistance mediated by the interaction of tumor cells with the extracellular matrix (ECM), commonly referred to as cell adhesion-mediated drug resistance (CAM-DR), has been observed not only in hematopoietic tumor cells but also in solid tumor cells. We have previously demonstrated that a 22-mer peptide derived from fibronectin, FNIII14, can inhibit cell adhesion through the inactivation of β1 integrin; when coadministered with cytarabine, FNIII14 completely eradicates acute myelogenous leukemia by suppressing CAM-DR. In this study, we show that our FNIII14 peptide also enhances chemotherapy efficacy in solid tumors. Coadministration of FNIII14 synergistically enhances the cytotoxicity of doxorubicin and aclarubicin in mammary tumor and melanoma cells, respectively. The solid tumor cell chemosensitization induced by FNIII14 is dependent upon the upregulation and activation of the pro-apoptotic protein, Bim. Furthermore, the metastasis of tumor cells derived from ventrally transplanted mammary tumor grafts is suppressed by the coadministration of FNIII14 and doxorubicin. These results suggest that the coadministration of our FNIII14 peptide with chemotherapy could achieve efficient solid tumor eradication by increasing chemosensitivity and decreasing metastasis. The major causes of tumor recurrence are the existence of chemotherapy-resistant primary tumor cells and the establishment of secondary metastatic lesions. As such, coadministering FNIII14 with anti-cancer drugs could provide a promising new approach to improve the prognosis of patients with solid tumors.

DOI： 10.1371/journal.pone.0162525

Scopus

その他リンク： https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84990929246&origin=inward

EprS, an autotransporter serine protease, plays an important role in various pathogenic phenotypes of Pseudomonas aeruginosa 査読有り

Y. Kida, J. Taira, K. Kuwano

Microbiology 2015年12月

Improvement of heme oxygenase-1-based heme sensor for quantifying free heme in biological samples 査読有り

J. Taira, Y. Nakashima, S. Yoshihara, S. Koga, S. Sueda, H. Komatsu, Y. Higashimoto, T. Takahashi, N. Tanioka, H. Shimizu, H. Morimatsu, H. Sakamoto

Analytical Biochemistry 489 50 - 52 2015年11月

Pigment epithelium derived factor inhibits caveolin induced interleukin 8 gene expression and proliferation of human prostate cancer cells. 査読有り

T. Matsui, A. Ojima, Y. Higashimoto, J. Taira, K. Fukami, S. Yamagishi

Oncology Letters 10 2644 - 2648 2015年10月

Discovery of InhA inhibitors with anti-mycobacterial activity through a matched molecular pair approach 査読有り

4. H. Kanetaka, Y. Koseki, J. Taira, T. Umei, H. Komatsu, H. Sakamoto, G. Gulten, J. C. Sacchettini, M. Kitamura, S. Aoki

Eur. J. Med. Chem. 94 378 - 385 2015年04月

Effect of glycogen synthase kinase 3 on the complex forming between growth factor receptor bound protein 14 and insulin receptor

J. Taira, H. Sakamoto, Y. Higashimoto

Peptide Science 2014 187 - 190 2015年03月

Evaluation of in vitro Phosphorylation Properties of Predicted Kinase which Phosphorylate Serines in Nuclear Localization Signal 1 in High Mobility Group Box 1 査読有り

J. Taira, Y. Higashimoto

Journal of Peptide Science 20 ( 8 ) 613 - 617 2014年08月

Phosphorylation of Grb14 BPS Domain by GSK-3 Correlates with Complex Forming of Grb14 and Insulin Receptor 査読有り

J. Taira, Y. Higashimoto

The Journal of Biochemistry 155 ( 6 ) 353 - 360 2014年06月

Tenascin-C-derived Peptide TNIIIA2 Highly Enhances Cell Survival and PDGF-dependent Cell Proliferation through Potentiated and Sustained Activation of Integrin α5β1 査読有り

Tanaka R, Seki Y, Saito Y, Kamiya S, Fujita M, Okutsu H, Iyoda T, Takai T, Owaki T, Yajima H, Taira J, Hayashi R, Kodama H, Matsunaga T, Fukai F.

The Journal of Biological Chemistry 289 ( 25 ) 17699 - 17708 2014年05月

Pigment Epithelium-Derived Factor (PEDF) Binds to Caveolin-1 and Inhibits The Pro-Inflammatory Effects of Caveolin-1 in Endothelial Cells 査読有り

T. Matsui, Y. Higashimoto, J. Taira, S. Yamagishi

Biochemical and Biophysical Research Communications 2013年11月

EprS, an autotransporter protein of pseudomonas aeruginosa, possessing serine protease activity induces inflammatory responses through protease-activated receptors 査読有り

Y. Kida, J. Taira, T. Yamamoto, Y. Higashimoto, K. Kuwano

Cellular Microbiology 15 ( 7 ) 1168 - 1181 2013年07月

Protein phosphatase 2A dephosphorylates phosphoserines in nucleocytoplasmic shuttling and secretion of high mobility group box 1 査読有り

J. Taira, Y. Kida, K. Kuwano, Y. Higashimoto

The Journal of Biochemistry 154 ( 3 ) 299 - 308 2013年06月

Protein phosphatase 2A in macrophage dephosphorylates phosphoserines involved in nucleocytoplasmic shuttling and secretion of high mobility group box 1

J. Taira, Y. Kida, Y. Higashimoto

Peptide Science 2012 191 - 194 2013年03月

Caveolin-1 interacts with protein phosphatase 5 and modulates its activity in prostate cancer cells 査読有り

J. Taira, Y. Higashimoto

Biochemical and Biophysical Research Communications 434 ( 4 ) 724 - 728 2013年02月

Identification of essential amino acid residues involved in the interaction of heme oxygenase-1 with caveolin-1

J. Taira, M. Sugishima, Y. Kida, E. Oda, M. Noguchi, Y. Higashimoto

Peptide Science 2011 35 - 38 2012年03月

Caveolin-1 is a competitive inhibitor of heme oxygenase-1 (HO-1) with heme: identification of minimum sequence in caveolin-1 for binding to HO-1 査読有り

J. Taira, M. Sugishima, Y. Kida, E. Oda, M. Noguchi, Y. Higashimoto

Biochemistry 50 ( 32 ) 6824 - 6831 2011年08月

Structural modification of 2-aminoisobutylic acid containing peptides toward an acquiring of antimicrobial activities against pathogenic bacteria 査読有り

J. Taira, Y. Kida, H. Yamaguchi, K. Kuwano, Y. Higashimoto, H. Kodama

Peptide Science 2010 263 - 263 2011年03月

Peptaibol derived helix-Kink motif facilitates channel forming of the artificial α-aminoisobutyric acid rich helices 査読有り

J. Taira, M. Shibue, S. Osada, H. Kodama

International Journal of Peptide Research and Therapeutics International Journal of Peptide Research and Therapeutics 16 ( 4 ) 277 - 282 2010年12月

Modifications on amphiphilicity and cationicity of unnatural amino acid containing peptides for the improvement of antimicrobial activity against pathogenic bacteria 査読有り

J. Taira, Y. Kida, H. Yamaguchi, K. Kuwano, Y. Higashimoto, H. Kodama

Journal of Peptide Science 16 ( 17 ) 607 - 612 2010年11月

Trans-bilayer ion conduction by proline containing cyclic hexapeptides and effects of amino acid substitutions on ion conducting properties 査読有り

J. Taira, S. Osada, R. Hayashi, T. Ueda, M. Jelokhani-Niaraki, H. Aoyagi, H. Kodama

Bulletin of the Chemical Society of Japan 83 ( 6 ) 683 - 688 2010年06月

Apoptotic death of hematopoietic tumor cells through potentiated and sustained adhesion to fibronectin via VLA-4 査読有り

Y. Saito, T. Owaki, T. Matsunaga, M. Saze, S. Miura, M. Maeda, M. Eguchi, R. Tanaka, J. Taira, H. Kodama, S. Goto, Y. Niitsu, H. Terada, F. Fukai

The Journal of Biochemistry 285 ( 10 ) 7006 - 7015 2010年03月

Amino acid sequence dependence of ion channel activity by cyclic tetrapeptides

T. Suga, J. Taira, S. Osada, H. Kodama

Peptide Science 2009 195 - 198 2010年03月

Ion channel formation of dimeric peptide enhanced by electrostatic inter-helical interactions 査読有り

J. Taira, S. Osada, M. Jelokhani-Niaraki, T. Ehara, H. Kodama

Advances in Experimental Medicine and Biology 611 321 - 322 2009年04月

Conformational effects of cyclic hexapeptides for ion channel properties 査読有り

J. Taira, S. Imamura, S. Osada, M. Jelokhani-Niaraki, T. Ehara, H. Kodama

Advances in Experimental Medicine and Biology 611 337 - 338 2009年04月

Synthesis and biological activity of alamethicin analogs enhanced by electrostatic interaction

S. Imamura, J. Taira, T. Suga, S. Osada, H. Kodama

Peptide Science 2008 245 - 248 2009年03月

Modifications of hydrophobic value and hydrophobic moment value of cationic model peptides for conversion of peptide-membrane interactions 査読有り

J. Taira, S. Furukawa, T. Hatakeyama, H. Aoyagi, H. Kodama

Bulletin of the Chemical Society of Japan 81 ( 6 ) 733 - 739 2008年06月

Ion channel formation assisted by electrostatic inter-helical interactions in covalently dimerized amphiphilic helical peptides 査読有り

J. Taira, M. Jelokhani-Niaraki, S. Osada, F. Kato, H. Kodama

Biochemistry 47 ( 12 ) 3705 - 3714 2008年03月

Antiadhesive sites present in the fibronectin type III-like repeats of human plasma fibronectin

T. Naito, S. Miura, Y. Saito, T. Owaki, R. Hayashi, J. Taira, H. Kodama, M. Ueki, H. Sugimoto, F. Fukai

Peptide Science 2007 325 - 328 2008年03月

Synthesis and ion conductance of cervinin peptides

J. Ito, J. Taira, S. Osada, F. Kato, and H. Kodama

Peptide Science 2007 277 - 280 2008年03月

Enhancement of ion channel formation by electrostatic interaction incorporated in dimeric helical peptide

J. Taira, S. Osada, M. Jelokhani-Niaraki, T. Ehara, H. Kodama

Peptide Science 2007 285 - 288 2008年03月

Antiadhesive sites present in the fibronectin type III-like repeats of human plasma fibronectin 査読有り

S. Miura, S. Kamiya, Y. Saito, S. Wada, R. Hayashi, J. Taira, H. Kodama, H. Yajima, M. Ueki, F. Fukai

Biological and Pharmaceutical Bulletin 30 ( 5 ) 891 - 897 2007年05月

Comparison study of ion channel activities of homo-dimerized and hetero-dimerized amphiphilic helical model peptides 査読有り

J. Taira, S. Osada, M. Jelokhani-Niaraki, T. Ehara, H. Kodama

Peptide Science 2006 121 - 122 2006年11月

Effect of ring size alteration for ion channel activities of cyclic peptides

J. Taira, S. Osada, M. Jelokhani-Niaraki, T. Ehara, H. Kodama

Peptide Science 2005 245 - 248 2006年03月

Synthesis and biological activities of proline rich cyclic heptapeptide hymenamide B analogs 査読有り

Y. Shiki, J. Taira, A. Nakamura, S. Osada, T. Ehara, H. Kodama

Understanding Biology Using Peptides 609 - 610 2005年06月

Ion channel activities and mechanisms of ion conduction about cyclic hexapeptides 査読有り

Y. Shiki, J. Taira, A. Nakamura, S. Osada, T. Ehara, H. Kodama

Understanding Biology Using Peptides 607 - 608 2005年06月

Ion-channel properties of cyclic hexapeptide cyclo(Pro-Xxx-Yyy)#D2#DR 査読有り

J. Taira, M. Sugishima, Y. Kida, E. Oda, M. Noguchi, Y. Higashimoto

Peptide Science 2004 531 - 534 2005年03月

Solid-phase synthesis of tyrosine-containing cyclic peptides 査読有り

J. Taira, M. Sugishima, Y. Kida, E. Oda, M. Noguchi, Y. Higashimoto

Peptide Science 2004 535 - 538 2005年03月

Synthesis and biophysical properties of the transmembrane segments of the mitochondrial uncoupling proteins 査読有り

M. Jelokhani-Niaraki, H. Yamaguchi, J. Taira, H. Kodama

Peptide 2004 734 - 735 2004年11月

Synthesis and ion-channel activity of assembled Aib-model peptides

J. Taira, S. Osada, M. Jelokhani-Niaraki, H. Kodama

Peptide Science 2003 327 - 330 2004年03月

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