研究者詳細 - 平　順一

論文 - 平　順一

分割表示57 件中 1 - 20 件目／全件表示 >>

Importance of isoleucine residue in ion channel formation ability of 11-residue peptaibols 査読有り国際誌

T. Nakatani, A. Koga, S. Goto, M. Inoue, K. Shigedomi, K. Seki, K. Araki, J. Taira, H. Kodama, S. Osada

Bioorg. Med. Chem. 110 117839 2024年08月

Role of tubulin C-terminal tail on mechanical properties of microtubule 査読有り国際誌

S. Nowroz, S.R. Nasrin, A.M.R. Kabir, T. Yamashita, T. Kusumoto, J. Taira, M. Tani, M. Ichikawa, K. Sada, Kazuki, A. Kakugo

Biochem. Biophys. Res. Commun. 706 149761 2024年04月

Computational Screening and Experimental Validation of Inhibitor Targeting the Complex Formation of Grb14 and Insulin Receptor 査読有り国際誌

Y. Ochi, T. Matsui, K. Inoue, K. Monobe, H. Sakamoto, S. Aoki, J. Taira

Molecules ( MDPI ) 29 198 2023年12月

Computer-assisted identification of inhibitor with novel pharmacophore targeting first kringle domain of hepatocyte growth factor 査読有り

J. Taira, M. Yamaguchi, A. Tashiro, A. Kida, K. Suzuki, K. Sakai, K. Matsumoto, S. Aoki

ChemistrySelect 8 ( 36 ) e202301577 2023年09月

Identification of novel inhibitors for mycobacterial polyketide synthase 13 via in silico drug screening assisted by the parallel compound screening with genetic algorithm-based programs 査読有り国際誌

Junichi Taira, Kahori Murakami, Kohei Monobe, Kohei Kuriki, Miu Fujita, Yosuke Ochi, Hiroshi Sakamoto, Shunsuke Aoki

The Journal of Antibiotics ( Springer Nature ) in press 2022年08月

Establishing a parallel compound screening method and identifying novel antimicrobial compounds targeting Staphylococcus aureus dihydrofolate reductase 査読有り国際誌

Junpei Nakashima, Masamune Takeuchi, Shuhei Kawamoto, Kohei Monobe, Junichi Taira, Shunsuke Aoki

Journal of Applied Pharmaceutical Science 12 ( 8 ) 036 - 047 2022年08月

Establishment of in silico prediction methods for potential bitter molecules using the human T2R14 homology-model structure 査読有り国際誌

K. Kuriki, R. Matsumoto, C. Ijichi, J. Taira, S. Aoki

Chem. Biol. Lett. 9 ( 3 ) 351 2022年05月

Computer‑Assisted Screening of Mycobacterial Growth Inhibitors: Exclusion of Frequent Hitters with the Assistance of the Multiple Target Screening Method 査読有り国際誌

Kohei Kuriki, Junichi Taira, Masato Kuroki, Hiroshi Sakamoto, Shunsuke Aoki

International Journal of Mycobacteriology 10 ( 3 ) 307 - 311 2021年09月

大学の枠を超えたオンライン生体分子デザインコンペティションの取り組み査読有り

村田智, 葛谷明紀, 藤原慶, 平順一, 川又生吹, 佐藤佑介, 瀧ノ上正浩, 野村 M. 慎一郎, 角五彰, 堀豊, 安部桂太

工学教育 ( 日本工業教育協会 ) 69 ( 4 ) 31 - 39 印刷中 2021年07月

Complex Formation of Heme Oxygenase-2 with Heme Is Competitively Inhibited by the Cytosolic Domain of Caveolin-1 査読有り

Misaki Takemoto, Hiroshi Sakamoto, Yuichiro Higashimoto, Junichi Taira

Biochemistry ( American Chemical Society ) 印刷中 2021年07月

Conformational Equilibrium of NADPH–Cytochrome P450 Oxidoreductase Is Essential for Heme Oxygenase Reaction 招待有り査読有り国際誌

1. M. Sugishima, J. Taira, T. Sagara, R. Nakao, H. Sato, M. Noguchi, K. Fukuyama, K. Yamamoto, T. Yasunaga, H. Sakamoto

Antioxidants 9 673 2020年07月

Improvement of the novel inhibitor for Mycobacterium enoyl-acyl carrier protein reductase (InhA): A structure–activity relationship study of KES4 assisted by in silico structure-based drug screening 査読有り国際誌

J. Taira, T. Umei, K. Inoue, M. Kitamura, F. Berenger, J. C. Sacchettini, H. Sakamoto, Shunsuke Aoki

J. Antibiot. 2020年03月

Structural modification of a novel inhibitor for Mycobacterium enoyl-acyl carrier protein reductase (InhA) assisted by in silico structure-based drug screening 査読有り国際誌

J. Taira, T. Nagano, M. Kitamura, M. Yamaguchi, H. Sakamoto, S. Aoki

Int. J. Mycobacteriol. 9 ( 1 ) 12 - 17 2020年03月

Dephosphorylation of clustered phosphoserine residues in human Grb14 by protein phosphatase 1 and its effect on insulin receptor complex formation 査読有り国際誌

J. Taira, K. Yoshida, M. Takemoto, K. Hanada, H. Sakamoto

J. Pept. Sci. 25 ( 10 ) e3207 2019年07月

Identification of Protein Phosphatase Involved in Dephosphorylation of Phosphoserines in Human Grb14 BPS Domain 査読有り

K. Yoshida, J. Taira, H. Komatsu, H. Sakamoto

Peptide Science 2018 33 2019年03月

Development of rat heme oxygenase-1 based gene encorded heme probe for intercellular heme detection

J. Taira, O. Nakashima, H. Komatsu, H. Sakamoto

Peptide Science 2017 156 - 157 2018年03月

Can peptide deformylase produce methionine aminopeptidase inhibitors from their formylated precursors?

Y. Oishi, Y. Takami, J. Taira, H. Kodama, S. Osada

Peptide Science 2017 106 - 107 2018年03月

Protective Role of PEDF-Derived Synthetic Peptide Against Experimental Diabetic Nephropathy 査読有り

Ishibashi Y., Matsui T., Taira J., Higashimoto Y., Yamagishi S.

Hormone and Metabolic Research 48 ( 9 ) 613 - 619 2016年09月

記述言語：英語掲載種別：研究論文（学術雑誌）

© Georg Thieme Verlag KG Stuttgart New York ISSN 0018-5043.Pigment epithelium-derived factor (PEDF) is a glycoprotein with complex neuroprotective, anti-angiogenic, and anti-inflammatory properties, all of which could potentially be exploited as a therapeutic option for vascular complications in diabetes. We have previously shown that PEDF-derived synthetic peptide, P5-3 (FIFVLRD) has a comparable ability with full PEDF protein to inhibit rat corneal neovascularization induced by chemical cauterization. However, the effects of PEDF peptide on experimental diabetic nephropathy remain unknown. To address the issue, we modified P5-3 to stabilize and administered the modified peptide (d-Lys-d-Lys-d-Lys-Gln-d-Pro-P5-3-Cys-amide, 0.2 nmol/day) or vehicle to streptozotocin-induced diabetic rats (STZ-rats) intraperitoneally by an osmotic mini pump for 2 weeks. We further examined the effects of modified peptide on human proximal tubular cells. Renal PEDF expression was decreased in STZ-rats. Although the peptide administration did not affect blood glucose or blood pressure, it decreased urinary excretion levels of 8-hydroxy-2′-deoxyguanosine, an oxidative stress marker, and reduced plasminogen activator inhibitor-1 (PAI-1) gene expression, and suppressed glomerular expansion in the diabetic kidneys. High glucose or advanced glycation end products stimulated oxidative stress generation and PAI-1 gene expression in tubular cells, all of which were significantly suppressed by 10 nM modified P5-3 peptide. Our present study suggests that PEDF-derived synthetic modified peptide could protect against experimental diabetic nephropathy and inhibit tubular cell damage under diabetes-like conditions through its anti-oxidative properties. Supplementation of modified P5-3 peptide may be a novel therapeutic strategy for diabetic nephropathy.

DOI： 10.1055/s-0042-108448

Scopus

その他リンク： https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84969927085&origin=inward

Coadministration of the fniii14 peptide synergistically augments the anti-cancer activity of chemotherapeutic drugs by activating pro-apoptotic bim 査読有り

Iyoda T., Iyoda T., Nagamine Y., Nakane Y., Tokita Y., Akari S., Otsuka K., Fujita M., Itagaki K., Takizawa Y., Orita H., Owaki T., Taira J., Hayashi R., Kodama H., Fukai F., Fukai F.

PLoS ONE 11 ( 9 ) 2016年09月

記述言語：英語掲載種別：研究論文（学術雑誌）

© 2016 Iyoda et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.The acquisition of drug resistance mediated by the interaction of tumor cells with the extracellular matrix (ECM), commonly referred to as cell adhesion-mediated drug resistance (CAM-DR), has been observed not only in hematopoietic tumor cells but also in solid tumor cells. We have previously demonstrated that a 22-mer peptide derived from fibronectin, FNIII14, can inhibit cell adhesion through the inactivation of β1 integrin; when coadministered with cytarabine, FNIII14 completely eradicates acute myelogenous leukemia by suppressing CAM-DR. In this study, we show that our FNIII14 peptide also enhances chemotherapy efficacy in solid tumors. Coadministration of FNIII14 synergistically enhances the cytotoxicity of doxorubicin and aclarubicin in mammary tumor and melanoma cells, respectively. The solid tumor cell chemosensitization induced by FNIII14 is dependent upon the upregulation and activation of the pro-apoptotic protein, Bim. Furthermore, the metastasis of tumor cells derived from ventrally transplanted mammary tumor grafts is suppressed by the coadministration of FNIII14 and doxorubicin. These results suggest that the coadministration of our FNIII14 peptide with chemotherapy could achieve efficient solid tumor eradication by increasing chemosensitivity and decreasing metastasis. The major causes of tumor recurrence are the existence of chemotherapy-resistant primary tumor cells and the establishment of secondary metastatic lesions. As such, coadministering FNIII14 with anti-cancer drugs could provide a promising new approach to improve the prognosis of patients with solid tumors.

DOI： 10.1371/journal.pone.0162525

Scopus

その他リンク： https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84990929246&origin=inward

EprS, an autotransporter serine protease, plays an important role in various pathogenic phenotypes of Pseudomonas aeruginosa 査読有り

Y. Kida, J. Taira, K. Kuwano

Microbiology 2015年12月

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