研究者詳細 - 平　順一

論文 - 平　順一

分割表示62 件中 21 - 40 件目／全件表示 >>

Establishing a parallel compound screening method and identifying novel antimicrobial compounds targeting Staphylococcus aureus dihydrofolate reductase 査読有り国際誌

Junpei Nakashima, Masamune Takeuchi, Shuhei Kawamoto, Kohei Monobe, Junichi Taira, Shunsuke Aoki

Journal of Applied Pharmaceutical Science 12 ( 8 ) 036 - 047 2022年08月

Establishment of in silico prediction methods for potential bitter molecules using the human T2R14 homology-model structure 査読有り国際誌

K. Kuriki, R. Matsumoto, C. Ijichi, J. Taira, S. Aoki

Chem. Biol. Lett. 9 ( 3 ) 351 2022年05月

Computer‑Assisted Screening of Mycobacterial Growth Inhibitors: Exclusion of Frequent Hitters with the Assistance of the Multiple Target Screening Method 査読有り国際誌

Kohei Kuriki, Junichi Taira, Masato Kuroki, Hiroshi Sakamoto, Shunsuke Aoki

International Journal of Mycobacteriology 10 ( 3 ) 307 - 311 2021年09月

大学の枠を超えたオンライン生体分子デザインコンペティションの取り組み査読有り

村田智, 葛谷明紀, 藤原慶, 平順一, 川又生吹, 佐藤佑介, 瀧ノ上正浩, 野村 M. 慎一郎, 角五彰, 堀豊, 安部桂太

工学教育 ( 日本工業教育協会 ) 69 ( 4 ) 31 - 39 印刷中 2021年07月

Structural modification of a novel inhibitor for Mycobacterium enoyl-acyl carrier protein reductase (InhA) assisted by in silico structure-based drug screening 査読有り国際誌

J. Taira, T. Nagano, M. Kitamura, M. Yamaguchi, H. Sakamoto, S. Aoki

Int. J. Mycobacteriol. 9 ( 1 ) 12 - 17 2020年03月

Identification of Protein Phosphatase Involved in Dephosphorylation of Phosphoserines in Human Grb14 BPS Domain 査読有り

K. Yoshida, J. Taira, H. Komatsu, H. Sakamoto

Peptide Science 2018 33 2019年03月

Development of rat heme oxygenase-1 based gene encorded heme probe for intercellular heme detection

J. Taira, O. Nakashima, H. Komatsu, H. Sakamoto

Peptide Science 2017 156 - 157 2018年03月

Can peptide deformylase produce methionine aminopeptidase inhibitors from their formylated precursors?

Y. Oishi, Y. Takami, J. Taira, H. Kodama, S. Osada

Peptide Science 2017 106 - 107 2018年03月

Protective Role of PEDF-Derived Synthetic Peptide Against Experimental Diabetic Nephropathy 査読有り

Ishibashi Y., Matsui T., Taira J., Higashimoto Y., Yamagishi S.

Hormone and Metabolic Research 48 ( 9 ) 613 - 619 2016年09月

記述言語：英語掲載種別：研究論文（学術雑誌）

© Georg Thieme Verlag KG Stuttgart New York ISSN 0018-5043.Pigment epithelium-derived factor (PEDF) is a glycoprotein with complex neuroprotective, anti-angiogenic, and anti-inflammatory properties, all of which could potentially be exploited as a therapeutic option for vascular complications in diabetes. We have previously shown that PEDF-derived synthetic peptide, P5-3 (FIFVLRD) has a comparable ability with full PEDF protein to inhibit rat corneal neovascularization induced by chemical cauterization. However, the effects of PEDF peptide on experimental diabetic nephropathy remain unknown. To address the issue, we modified P5-3 to stabilize and administered the modified peptide (d-Lys-d-Lys-d-Lys-Gln-d-Pro-P5-3-Cys-amide, 0.2 nmol/day) or vehicle to streptozotocin-induced diabetic rats (STZ-rats) intraperitoneally by an osmotic mini pump for 2 weeks. We further examined the effects of modified peptide on human proximal tubular cells. Renal PEDF expression was decreased in STZ-rats. Although the peptide administration did not affect blood glucose or blood pressure, it decreased urinary excretion levels of 8-hydroxy-2′-deoxyguanosine, an oxidative stress marker, and reduced plasminogen activator inhibitor-1 (PAI-1) gene expression, and suppressed glomerular expansion in the diabetic kidneys. High glucose or advanced glycation end products stimulated oxidative stress generation and PAI-1 gene expression in tubular cells, all of which were significantly suppressed by 10 nM modified P5-3 peptide. Our present study suggests that PEDF-derived synthetic modified peptide could protect against experimental diabetic nephropathy and inhibit tubular cell damage under diabetes-like conditions through its anti-oxidative properties. Supplementation of modified P5-3 peptide may be a novel therapeutic strategy for diabetic nephropathy.

DOI： 10.1055/s-0042-108448

Scopus

その他リンク： https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84969927085&origin=inward

Coadministration of the fniii14 peptide synergistically augments the anti-cancer activity of chemotherapeutic drugs by activating pro-apoptotic bim 査読有り

Iyoda T., Iyoda T., Nagamine Y., Nakane Y., Tokita Y., Akari S., Otsuka K., Fujita M., Itagaki K., Takizawa Y., Orita H., Owaki T., Taira J., Hayashi R., Kodama H., Fukai F., Fukai F.

PLoS ONE 11 ( 9 ) 2016年09月

記述言語：英語掲載種別：研究論文（学術雑誌）

© 2016 Iyoda et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.The acquisition of drug resistance mediated by the interaction of tumor cells with the extracellular matrix (ECM), commonly referred to as cell adhesion-mediated drug resistance (CAM-DR), has been observed not only in hematopoietic tumor cells but also in solid tumor cells. We have previously demonstrated that a 22-mer peptide derived from fibronectin, FNIII14, can inhibit cell adhesion through the inactivation of β1 integrin; when coadministered with cytarabine, FNIII14 completely eradicates acute myelogenous leukemia by suppressing CAM-DR. In this study, we show that our FNIII14 peptide also enhances chemotherapy efficacy in solid tumors. Coadministration of FNIII14 synergistically enhances the cytotoxicity of doxorubicin and aclarubicin in mammary tumor and melanoma cells, respectively. The solid tumor cell chemosensitization induced by FNIII14 is dependent upon the upregulation and activation of the pro-apoptotic protein, Bim. Furthermore, the metastasis of tumor cells derived from ventrally transplanted mammary tumor grafts is suppressed by the coadministration of FNIII14 and doxorubicin. These results suggest that the coadministration of our FNIII14 peptide with chemotherapy could achieve efficient solid tumor eradication by increasing chemosensitivity and decreasing metastasis. The major causes of tumor recurrence are the existence of chemotherapy-resistant primary tumor cells and the establishment of secondary metastatic lesions. As such, coadministering FNIII14 with anti-cancer drugs could provide a promising new approach to improve the prognosis of patients with solid tumors.

DOI： 10.1371/journal.pone.0162525

Scopus

その他リンク： https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84990929246&origin=inward

EprS, an autotransporter serine protease, plays an important role in various pathogenic phenotypes of Pseudomonas aeruginosa 査読有り

Y. Kida, J. Taira, K. Kuwano

Microbiology 2015年12月

Pigment epithelium derived factor inhibits caveolin induced interleukin 8 gene expression and proliferation of human prostate cancer cells. 査読有り

T. Matsui, A. Ojima, Y. Higashimoto, J. Taira, K. Fukami, S. Yamagishi

Oncology Letters 10 2644 - 2648 2015年10月

Discovery of InhA inhibitors with anti-mycobacterial activity through a matched molecular pair approach 査読有り

4. H. Kanetaka, Y. Koseki, J. Taira, T. Umei, H. Komatsu, H. Sakamoto, G. Gulten, J. C. Sacchettini, M. Kitamura, S. Aoki

Eur. J. Med. Chem. 94 378 - 385 2015年04月

Effect of glycogen synthase kinase 3 on the complex forming between growth factor receptor bound protein 14 and insulin receptor

J. Taira, H. Sakamoto, Y. Higashimoto

Peptide Science 2014 187 - 190 2015年03月

Evaluation of in vitro Phosphorylation Properties of Predicted Kinase which Phosphorylate Serines in Nuclear Localization Signal 1 in High Mobility Group Box 1 査読有り

J. Taira, Y. Higashimoto

Journal of Peptide Science 20 ( 8 ) 613 - 617 2014年08月

Tenascin-C-derived Peptide TNIIIA2 Highly Enhances Cell Survival and PDGF-dependent Cell Proliferation through Potentiated and Sustained Activation of Integrin α5β1 査読有り

Tanaka R, Seki Y, Saito Y, Kamiya S, Fujita M, Okutsu H, Iyoda T, Takai T, Owaki T, Yajima H, Taira J, Hayashi R, Kodama H, Matsunaga T, Fukai F.

The Journal of Biological Chemistry 289 ( 25 ) 17699 - 17708 2014年05月

Pigment Epithelium-Derived Factor (PEDF) Binds to Caveolin-1 and Inhibits The Pro-Inflammatory Effects of Caveolin-1 in Endothelial Cells 査読有り

T. Matsui, Y. Higashimoto, J. Taira, S. Yamagishi

Biochemical and Biophysical Research Communications 2013年11月

EprS, an autotransporter protein of pseudomonas aeruginosa, possessing serine protease activity induces inflammatory responses through protease-activated receptors 査読有り

Y. Kida, J. Taira, T. Yamamoto, Y. Higashimoto, K. Kuwano

Cellular Microbiology 15 ( 7 ) 1168 - 1181 2013年07月

Protein phosphatase 2A in macrophage dephosphorylates phosphoserines involved in nucleocytoplasmic shuttling and secretion of high mobility group box 1

J. Taira, Y. Kida, Y. Higashimoto

Peptide Science 2012 191 - 194 2013年03月

Identification of essential amino acid residues involved in the interaction of heme oxygenase-1 with caveolin-1

J. Taira, M. Sugishima, Y. Kida, E. Oda, M. Noguchi, Y. Higashimoto

Peptide Science 2011 35 - 38 2012年03月

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