O- and N-Selective Electrophilic Activation of Allylic Alcohols and Amines in Pd-Catalyzed Direct Alkylation Reviewed International journal

Lin L., Kataoka S., Hirayama K., Shibuya R., Watanabe K., Morimoto H., Ohshima T.

Chemical & pharmaceutical bulletin ( The Pharmaceutical Society of Japan )   71 ( 2 )   101 - 106   2023.01

One-Pot Catalytic Synthesis of α-Tetrasubstituted Amino Acid Derivatives via in Situ Generation of N-Unsubstituted Ketimines Reviewed International journal

Kondo Y., Hirazawa Y., Kadota T., Yamada K., Morisaki K., Morimoto H., Ohshima T.

Organic Letters   24 ( 36 )   6594 - 6598   2022.09

A TRPC3/6 Channel Inhibitor Promotes Arteriogenesis after Hind‐Limb Ischemia Reviewed International journal

Shimauchi T., Numaga‐tomita T., Kato Y., Morimoto H., Sakata K., Matsukane R., Nishimura A., Nishiyama K., Shibuta A., Horiuchi Y., Kurose H., Kim S.G., Urano Y., Ohshima T., Nishida M.

Cells   11 ( 13 )   2022.07

Development of Greener Catalytic Synthetic Methods of Nitrogen-Containing Compounds Using <i>N</i>-Unprotected Ketimines Invited Reviewed

Morimoto Hiroyuki

Journal of Synthetic Organic Chemistry, Japan ( The Society of Synthetic Organic Chemistry, Japan )   80 ( 1 )   2 - 13   2022.01

Catalytic Enantioselective Strecker Reaction of Isatin-Derived N-Unsubstituted Ketimines Reviewed International journal

Kadota T., Sawa M., Kondo Y., Morimoto H., Ohshima T.

Organic Letters   23 ( 12 )   4553 - 4558   2021.06

Development and Integration of New Green Reactions International journal

大嶋 孝志, 森本 浩之

Middle Molecular Strategy   15   275 - 295   2021.01

C-C Bond Cleavage of Unactivated 2-Acylimidazoles Reviewed International journal

Xin H.L., Pang B., Choi J., Akkad W., Morimoto H., Ohshima T.

Journal of Organic Chemistry   85 ( 18 )   11592 - 11606   2020.09

Recent Progress on Catalytic Addition Reactions to N-Unsubstituted Imines Reviewed International journal

Morisaki K., Morimoto H., Ohshima T.

ACS Catalysis   10 ( 12 )   6924 - 6951   2020.06

Recent progress towards the use of benzophenone imines as an ammonia equivalent Reviewed International journal

Kondo Y., Morimoto H., Ohshima T.

Chemistry Letters ( The Chemical Society of Japan )   49 ( 5 )   497 - 504   2020.05

Rhodium(I)/Chiral Diene-Catalyzed Enantioselective Addition of Boronic Acids to N-Unsubstituted Isatin-Derived Ketimines Reviewed International journal

Yonesaki R., Kusagawa I., Morimoto H., Hayashi T., Ohshima T.

Chemistry - An Asian Journal   15 ( 4 )   499 - 502   2020.02

Scandium(III) Triflate Catalyzed Direct Synthesis of N-Unprotected Ketimines Reviewed International journal

Kondo Y., Kadota T., Hirazawa Y., Morisaki K., Morimoto H., Ohshima T.

Organic Letters   22 ( 1 )   120 - 125   2020.01

Mechanistic studies of nickel(II)-catalyzed direct alcoholysis of 8-aminoquinoline amides Reviewed International journal

Morimoto H., Akkad W., Deguchi T., Ohshima T.

Heterocycles   101 ( 2 )   471 - 485   2020.01

Identification of candidate molecular targets of the novel antineoplastic antimitotic NP-10 Reviewed International journal

Yokoyama T., Yukuhiro M., Iwasaki Y., Tanaka C., Sankoda K., Fujiwara R., Shibuta A., Higashi T., Motoyama K., Arima H., Yoshida K., Sugimoto N., Morimoto H., Kosako H., Ohshima T., Fujita M.

Scientific Reports   9 ( 1 )   2019.12

A Convenient Preparation Method for Benzophenone Imine Catalyzed by Tetrabutylammonium Fluoride Reviewed International journal

Kondo Y., Morisaki K., Hirazawa Y., Morimoto H., Ohshima T.

Organic Process Research and Development   23 ( 8 )   1718 - 1724   2019.08

Ammonium Salt-Accelerated Hydrazinolysis of Unactivated Amides: Mechanistic Investigation and Application to a Microwave Flow Process Reviewed International journal

Noshita M., Shimizu Y., Morimoto H., Akai S., Hamashima Y., Ohneda N., Odajima H., Ohshima T.

Organic Process Research and Development   23 ( 4 )   588 - 594   2019.04

窒素上無保護ケチミンに対する触媒的不斉求核付加反応の開発――四置換炭素含有アミノ酸の環境調和型新規合成手法への展開 Invited Reviewed

森本 浩之

化学と工業   72   780 - 781   2019.01

有機触媒による窒素上無保護α－ケチミノエステルに対する直接的不斉求核付加反応の開発 Invited Reviewed

森本 浩之

化学工業（化学工業社）   70   668 - 672   2019.01

3-Mono-Substituted BINOL Phosphoric Acids as Effective Organocatalysts in Direct Enantioselective Friedel–Crafts-Type Alkylation of N-Unprotected α-Ketiminoester Reviewed International journal

Yonesaki R., Kondo Y., Akkad W., Sawa M., Morisaki K., Morimoto H., Ohshima T.

Chemistry - A European Journal   24 ( 57 )   15211 - 15214   2018.10

Catalytic Enantioselective Decarboxylative Mannich-Type Reaction of N-Unprotected Isatin-Derived Ketimines Reviewed International journal

Sawa M., Miyazaki S., Yonesaki R., Morimoto H., Ohshima T.

Organic Letters   20 ( 17 )   5393 - 5397   2018.09

Development of direct enantioselective alkynylation of αketoester and α-ketiminoesters catalyzed by phenylbis(oxazoline)Rh(III) complexes Reviewed

Morisaki K., Morimoto H., Mashima K., Ohshima T.

Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry ( The Society of Synthetic Organic Chemistry, Japan )   76 ( 3 )   226 - 240   2018.01

Direct Access to N-Unprotected α- and/or β-Tetrasubstituted Amino Acid Esters via Direct Catalytic Mannich-Type Reactions Using N-Unprotected Trifluoromethyl Ketimines Reviewed International journal

Sawa M., Morisaki K., Kondo Y., Morimoto H., Ohshima T.

Chemistry - A European Journal   23 ( 67 )   17022 - 17028   2017.12

Boronic Acid Accelerated Three-Component Reaction for the Synthesis of α-Sulfanyl-Substituted Indole-3-acetic Acids Reviewed

Das A., Watanabe K., Morimoto H., Ohshima T.

Organic Letters   19 ( 21 )   5794 - 5797   2017.11

Direct Catalytic Alcoholysis of Unactivated 8-Aminoquinoline Amides Reviewed International journal

Deguchi T., Xin H.L., Morimoto H., Ohshima T.

ACS Catalysis   7 ( 5 )   3157 - 3161   2017.05

Direct enantioselective alkynylation of α-ketoesters and α-ketiminoesters catalyzed by [bis(oxazoline)phenyl]rhodium(III) complexes Reviewed International journal

Morisaki K., Morimoto H., Mashima K., Ohshima T.

Heterocycles   95 ( 2 )   637 - 661   2017.01

Direct access to: N -unprotected tetrasubstituted propargylamines via direct catalytic alkynylation of N -unprotected trifluoromethyl ketimines Reviewed International journal

Morisaki K., Morimoto H., Ohshima T.

Chemical Communications   53 ( 47 )   6319 - 6322   2017.01

Synthesis of 1-tetrasubstituted 2,2,2-trifluoroethylamine derivatives via palladium-catalyzed allylation of sp³ C–H bonds Reviewed International journal

Morisaki K., Kondo Y., Sawa M., Morimoto H., Ohshima T.

Chemical and Pharmaceutical Bulletin ( The Pharmaceutical Society of Japan )   65 ( 11 )   1089 - 1092   2017.01

Diethylenetriamine-Mediated Direct Cleavage of Unactivated Carbamates and Ureas Reviewed International journal

Noshita M., Shimizu Y., Morimoto H., Ohshima T.

Organic Letters   18 ( 23 )   6062 - 6065   2016.12

Mechanistic Studies and Expansion of the Substrate Scope of Direct Enantioselective Alkynylation of α-Ketiminoesters Catalyzed by Adaptable (Phebox)Rhodium(III) Complexes Reviewed International journal

Morisaki K., Sawa M., Yonesaki R., Morimoto H., Mashima K., Ohshima T.

Journal of the American Chemical Society   138 ( 19 )   6194 - 6203   2016.05

A novel anti-microtubule agent with carbazole and benzohydrazide structures suppresses tumor cell growth in vivo Reviewed International journal

Ohira M., Iwasaki Y., Tanaka C., Kuroki M., Matsuo N., Kitamura T., Yukuhiro M., Morimoto H., Pang N., Liu B., Kiyono T., Amemiya M., Tanaka K., Yoshida K., Sugimoto N., Ohshima T., Fujita M.

Biochimica et Biophysica Acta - General Subjects   1850 ( 9 )   1676 - 1684   2015.05

Direct catalytic anti-Markovnikov addition reactions of oxygen nucleophiles to simple Alkenes Reviewed

Morimoto H.

Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry   72 ( 12 )   1402 - 1403   2014.12

A short scalable route to (-)-α-kainic acid using Pt-catalyzed direct allylic amination Reviewed International journal

Zhang M., Watanabe K., Tsukamoto M., Shibuya R., Morimoto H., Ohshima T.

Chemistry - A European Journal   21 ( 10 )   3937 - 3941   2014.10

Cleavage of unactivated amide bonds by ammonium salt-accelerated hydrazinolysis Reviewed International journal

Shimizu Y., Noshita M., Mukai Y., Morimoto H., Ohshima T.

Chemical Communications   50 ( 84 )   12623 - 12625   2014.09

Lanthanum(III) triflate catalyzed direct amidation of esters Reviewed International journal

Morimoto H., Fujiwara R., Shimizu Y., Morisaki K., Ohshima T.

Organic Letters   16 ( 7 )   2018 - 2021   2014.04

Rh-catalyzed direct enantioselective alkynylation of α-ketiminoesters Reviewed International journal

Morisaki K., Sawa M., Nomaguchi J.Y., Morimoto H., Takeuchi Y., Mashima K., Ohshima T.

Chemistry - A European Journal   19 ( 26 )   8417 - 8420   2013.06

Microwave-assisted deacylation of unactivated amides using ammonium-salt-accelerated transamidation Reviewed International journal

Shimizu Y., Morimoto H., Zhang M., Ohshima T.

Angewandte Chemie - International Edition   51 ( 34 )   8564 - 8567   2012.08

Stereodivergent direct catalytic asymmetric mannich-type reactions of α-isothiocyanato ester with ketimines Reviewed International journal

Lu G., Yoshino T., Morimoto H., Matsunaga S., Shibasaki M.

Angewandte Chemie - International Edition   50 ( 19 )   4382 - 4385   2011.05

A broadly applicable copper reagent for trifluoromethylations and perfluoroalkylations of aryl iodides and bromides Reviewed International journal

Morimoto H., Tsubogo T., Litvinas N., Hartwig J.

Angewandte Chemie - International Edition   50 ( 16 )   3793 - 3798   2011.04

Catalytic asymmetricaza-Morita-Baylis-Hillman reaction of methyl acrylate: Role of a bifunctional La(O- i Pr)<inf>3</inf>/linked-BINOL complex Reviewed International journal

Yukawa T., Seelig B., Xu Y., Morimoto H., Matsunaga S., Berkessel A., Shibasaki M.

Journal of the American Chemical Society   132 ( 34 )   11988 - 11992   2010.09

Construction of contiguous tetrasubstituted chiral carbon stereocenters via direct catalytic asymmetric aldol reaction of α-isothiocyanato esters with ketones Reviewed International journal

Yoshino T., Morimoto H., Lu G., Matsunaga S., Shibasaki M.

Journal of the American Chemical Society   131 ( 47 )   17082 - 17083   2009.12

Mixed La-Li heterobimetallic complexes for tertiary nitroaldol resolution Reviewed International journal

Hara K., Tosaki S., Gnanadesikan V., Morimoto H., Harada S., Sugita M., Yamagiwa N., Matsunaga S., Shibasaki M.

Tetrahedron   65 ( 26 )   5030 - 5036   2009.06

Lewis base assisted Brønsted base catalysis: Bidentate phosphine oxides as activators and modulators of brønsted basic lanthanum-aryloxides Reviewed International journal

Morimoto H., Yoshino T., Yukawa T., Lu G., Matsunaga S., Shibasaki M.

Angewandte Chemie - International Edition   47 ( 47 )   9125 - 9129   2008.11

Chiral γ-amino amide synthesis by heterobimetallic lanthanum/lithium/pybox-catalyzed direct asymmetric Mannich-type reactions of α-keto anilides Reviewed International journal

Lu G., Morimoto H., Matsunaga S., Shibasaki M.

Angewandte Chemie - International Edition   47 ( 36 )   6847 - 6850   2008.08

A bench-stable homodinuclear Ni<inf>2</inf>-Schiff base complex for catalytic asymmetric synthesis of α-tetrasubstituted anti-α,β- diamino acid surrogates Reviewed International journal

Chen Z., Morimoto H., Matsunaga S., Shibasaki M.

Journal of the American Chemical Society   130 ( 7 )   2170 - 2171   2008.02

Organolithiums and lithium 2,2,6,6-tetramethylpiperidide in reductive alkylation of epoxides: Synthesis of (E)-alkenes [(E)-2-methyltetradeca-1,3-diene] International journal

Hodgson D.M., Humphreys P.G., Fleming M.J., Morimoto H., Mihara H., Shibasaki M.

Organic Syntheses   85   1 - 9   2008.01

Lanthanum aryloxide/pybox-catalyzed direct asymmetric mannich-type reactions using a trichloromethyl ketone as a propionate equivalent donor Reviewed International journal

Morimoto H., Lu G., Aoyama N., Matsunaga S., Shibasaki M.

Journal of the American Chemical Society   129 ( 31 )   9588 - 9589   2007.08

Catalytic asymmetric epoxidation of α,β-unsaturated esters with chiral yttrium-biaryldiol complexes Reviewed International journal

Kakei H., Tsuji R., Ohshima T., Morimoto H., Matsunaga S., Shibasaki M.

Chemistry - An Asian Journal   2 ( 2 )   257 - 264   2007.07

Catalytic asymmetric Michael reactions of dibenzyl malonate to α,β-unsaturated N-acylpyrroles using a La(O-iPr)<inf>3</inf>/Ph-linked-BINOL complex Reviewed International journal

Park S.Y., Morimoto H., Matsunaga S., Shibasaki M.

Tetrahedron Letters   48 ( 16 )   2815 - 2818   2007.04

Catalytic asymmetric epoxidation of α-methyl α,β- unsaturated anilides as ester surrogates Reviewed International journal

Chen Z., Morimoto H., Matsunaga S., Shibasaki M.

Synlett   ( 20 )   3529 - 3532   2006.12

Mixed La-Li heterobimetallic complexes for tertiary nitroaldol resolution Reviewed International journal

Tosaki S., Hara K., Gnanadesikan V., Morimoto H., Harada S., Sugita M., Yamagiwa N., Matsunaga S., Shibasaki M.

Journal of the American Chemical Society   128 ( 36 )   11776 - 11777   2006.09

Trichloromethyl ketones as synthetically versatile donors: Application in direct catalytic mannich-type reactions and the stereoselective synthesis of azetidines Reviewed International journal

Morimoto H., Wiedemann S., Yamaguchi A., Harada S., Chen Z., Matsunaga S., Shibasaki M.

Angewandte Chemie - International Edition   45 ( 19 )   3146 - 3150   2006.05

Non-C<inf>2</inf>-symmetric, chirally economical, and readily tunable linked-binols: Design and application in a direct catalytic asymmetric mannich-type reaction Reviewed International journal

Yoshida T., Morimoto H., Kumagai N., Matsunaga S., Shibasaki M.

Angewandte Chemie - International Edition   44 ( 22 )   3470 - 3474   2005.05

Direct catalytic asymmetric Mannich-type reaction of hydroxyketone using a Et<inf>2</inf>Zn/linked-BINOL complex: Synthesis of either anti- or syn-β-amino alcohols Reviewed International journal

Matsunaga S., Yoshida T., Morimoto H., Kumagai N., Shibasaki M.

Journal of the American Chemical Society   126 ( 28 )   8777 - 8785   2004.07

新規エステル等価体を活用した触媒的多不斉中心同時構築法の開発と医薬化学への応用

Grant number：06J11617  2006.04 - 2009.03   特別研究員奨励費

窒素上無保護アミン類の環境調和型立体選択的直接合成法の開発

2017.08 - 2020.05

2017年度薬学系研究助成