Updated on 2023/06/01

写真a

 
KITADA Sakae
 
Scopus Paper Info  
Total Paper Count: 0  Total Citation Count: 0  h-index: 3

Citation count denotes the number of citations in papers published for a particular year.

Affiliation
Faculty of Computer Science and Systems Engineering Department of Bioscience and Bioinformatics
Job
Associate Professor
E-mail
メールアドレス
Phone
81-948-29-7847
External link

Research Interests

  • Biochemistry

Research Areas

  • Life Science / Applied microbiology

Undergraduate Education

  • 1991.03   Kyushu University   Faculty of Science   Graduated   Japan

Post Graduate Education

  • 1996.03   Kyushu University   Graduate School, Division of Natural Science   Doctoral Program   Accomplished Credits for Doctoral Program   Japan

Degree

  • Kyushu University  -  Doctor of Science   1997.03

Biography in Kyutech

  • 2019.04
     

    Kyushu Institute of Technology   Faculty of Computer Science and Systems Engineering   Department of Bioscience and Bioinformatics   Associate Professor  

  • 2010.04
    -
    2019.03
     

    Kyushu Institute of Technology   Faculty of Computer Science and Systems Engineering   Department of Bioscience and Bioinformatics   Associate Professor  

Biography before Kyutech

  • 1996.04 - 2007.03   Kyushu University   Research Assistant   Japan

  • 2007.04 - 2010.03   Kyushu University   Assistant Professor   Japan

Academic Society Memberships

  • 1991.04   The Japanese Biochemical Society   Japan

  • 2008.04   Society of invertebrate pathology   Japan

  • 2006.04   トキシンシンポジウム   Japan

  • 2006.04   パラスポリン命名委員会   Japan

  • 2008.04   パラスポリン研究会   Japan

Research Career

  • Molecular Mechanism of Tumor Specific Cell Death Induced by BT Toxin

    BT,Tumor,Cell Death,Toxin

    研究期間: 2000.04  - 

  • Molecular and cellular biology of Wolbachia

    Wolbachia Miochondria

    研究期間: 2011.04  - 

  • Biogenesis and evolution of organelle

    mitochondria,Hydrogenosome,evolution

    研究期間: 2000.04  - 

  • Processing of Mitochondrial Proteins

    Mitochondria,Protease,Processing

    研究期間: 1991.04  -  2008.03

Papers

  • Selection of the Bacillus thuringiensis Berliner strain to produce a parasporin with cytotoxic activity against MCF-7 breast cancer cells Reviewed

    Melo A.L.A., Kitada S.

    Breast Disease   39 ( 1 )   37 - 42   2020.01

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    Language:English   Publishing type:Research paper (scientific journal)

    DOI: 10.3233/BD-190405

    Scopus

    Other Link: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85079674620&origin=inward

  • Glycan region of GPI anchored-protein is required for cytocidal oligomerization of an anticancer parasporin-2, Cry46Aa1 protein, from Bacillus thuringiensis strain A1547 Invited Reviewed

    Abe Y., Inoue H., Ashida H., Maeda Y., Kinoshita T., Kitada S.

    Journal of Invertebrate Pathology   142   71 - 81   2017.01

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    Language:English   Publishing type:Research paper (scientific journal)

    DOI: 10.1016/j.jip.2016.11.008

    Scopus

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  • Response to leopoldo palma. Comments on ekino et al. Cloning and characterization of a unique cytotoxic protein parasporin-5 produced by bacillus thuringiensis a1100 strain. Toxins 2014, 6, 1882–1895 Reviewed

    Ekino K., Okumura S., Ishikawa T., Kitada S., Saitoh H., Akao T., Oka T., Nomura Y., Ohba M., Shin T., Mizuki E.

    Toxins   7 ( 12 )   5096 - 5097   2015.11

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    Language:English   Publishing type:Research paper (scientific journal)

    DOI: 10.3390/toxins7124866

    Scopus

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  • Parasporins as new natural anticancer agents: A review Invited Reviewed

    Okassov A., Nersesyan A., Kitada S., Ilin A.

    Journal of B.U.ON.   20 ( 1 )   5 - 16   2015.01

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    Scopus

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  • Cloning and characterization of a unique cytotoxic protein parasporin-5 produced by Bacillus thuringiensis A1100 strain Reviewed

    6   2115 - 2126   2014.06

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    Language:English   Publishing type:Research paper (scientific journal)

    DOI: 10.3390/toxins6061882

    Scopus

  • FMP30 is required for the maintenance of a normal cardiolipin level and mitochondrial morphology in the absence of mitochondrial phosphatidylethanolamine synthesis. Reviewed

    Kuroda T,Tani M,Moriguchi A,Tokunaga S,Higuchi T,Kitada S,Kuge O.

    Mol. Microbiol.   80   2011.02

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    Language:English   Publishing type:Research paper (other academic)

    DOI: 10.1111/j.1365-2958.2011.07569.x

    Scopus

  • Mega Assemblages of Oligomeric Aerolysin-like Toxins Stabilized by Toxin-associating Membrane Proteins Reviewed

    Shimada,H,Kitada S.

    J. Biocem.   149   103 - 115   2011.01

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    Language:English   Publishing type:Research paper (scientific journal)

    DOI: 10.1093/jb/mvq124

    Scopus

  • Crystal Structure of the Parasporin-2 Bacillus thuringiensis Toxin That Recognizes Cancer Cells. Reviewed

    Akiba T.,Abe Y.,Kitada S.,Kusaka Y.,Ito A.,Ichimatsu T.,Katayama H.,Akao T.,Higuchi K.,Mizuki E.,Ohba M.,Kanai R.,Harata K.

    J. Mol. Biol   386   121 - 133   2009.04

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  • Purification and characterization of human phosphatidylserine synthase 1 and 2. Reviewed

    Tomohiro S.,Kawaguti A.,Kawabe Y.,Kitada S.,and Kuge O.

    Biochem. J.   418   421 - 429   2009.04

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  • Parasporin-2 requires GPI-anchored proteins for the efficient cytocidal action to human hepatoma cells. Reviewed

    Kitada,S.,Yuichi Abe,Maeda,T.,and Shimada H.

    Toxicology   264   80 - 88   2009.04

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  • 毒素が薬に食物に? 生命科学への応用について

    北田 栄、嶋田擴靖

    生物の科学 遺伝 ( エヌ・ティー・エス出版 )   2009.03

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    Authorship:Corresponding author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)

  • Raft-targeting and Oligomerization of Parasporin-2, a Bacillus thuringiensis Crystal Protein with Anti-tumor Activity Reviewed

    Abe,Y.,Shimada,Y.,and Kitada,S.

    J. Biochem.   143   269 - 275   2008.04

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  • Spatial orientation of mitochondrial processing peptidase and a preprotein revealed by fluorescence resonance energy transfer Reviewed

    Tomonori G. Nishino,T. G.,Katsuhiko. K.,Kojima,K.,Ogishima,T.,Ito,A.,and Kitada,S.

    J. Biochem   141   889 - 895   2007.04

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  • A Protein from a Parasitic Microorganism, Rickettsia prowazekii, Can Cleave the Signal Sequences of Proteins Targeting Mitochondria. Reviewed

    Kitada,S.,Uchiyama,T.,Funatsu,T.,Kitada,Y.,Ogishima,T.,and Ito,A.

    J Bacteriol.   189   844 - 850   2007.04

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  • Cytocidal Actions of Parasporin-2, an Anti-tumor Crystal Toxin from Bacillus thuringiensis. Reviewed

    Kitada,S.,Abe,Y.,Shimada,H.,Kusaka,K.,Matsuo,M.,Katayama,H.,Okumura,S.,Akao,T.,Mizuki,E.,Kuge,O.,Sasaguri,Y.,Ohba,M.,and Ito A.

    J. Biol. Chem.   281   26350 - 26360   2006.04

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    Language:English   Publishing type:Research paper (scientific journal)

  • Molecular identification and cytocidal action of parasporin, a protein group of novel crystal

    2005.11

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    Authorship:Corresponding author   Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)

  • Bacillus thuringiensis から発見された新しい結晶性毒素タンパク質(パラスポリン2)

    北田 栄、阿部雄一、嶋田擴靖、片山秀樹、赤尾哲之、水城英一、大庭道夫、久下 理、伊藤明夫

    第52回毒素シンポジウム ( 毒素シンポジウム )   2005.07

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    Authorship:Corresponding author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (other)

  • Recognition and processing of a nuclear-encoded polyprotein precursor by mitochondrial processing peptidase. Reviewed

    Oshima,T.,Yamasaki,E.,Ogishima,T.,Kadowaki,K.,Ito A.,and Kitada S.

    Biochem. J.   385   55 - 761   2005.04

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  • Molecular identification and cytocidal action of parasporin, a protein group of novel crystal toxins targeting to human cells Reviewed

    Sakae Kitada,Yuichi Abe,Akio Ito,Osamu Kuge,Testuyuki Akao,Eiichi Mizuki,and Michio Ohba

    Proceedings of the 6th Pacific Rim Conference. In Biotechnology of Bacillus thuringiensis and Its Environmental Impact., Victria BC 23-27 (2005) review (Côtè, J.-C., Otvos, I.S., Schwartz, J.-L. and Vincent, C. eds.).   2005.04

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    Canada   Victria   2005.04  -  2005.04

  • Oligomerization of parasporin-2, a new crystal protein from non-insecticidal Bacillus thuringiensis, in lipid rafts. Reviewed

    Abe,Y.,Kitada S.,Kuge,O.,Ohba M.,and Ito,A

    Proceedings of the 6th Pacific Rim Conference. In Biotechnology of Bacillus thuringiensis and Its Environmental Impact., Victria BC(Côtè, J.-C., Otvos, I.S., Schwartz, J.-L. and Vincent, C. eds.).   2005.04

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    2005.04  -  2005.04

  • Crystallization of parasporin-2, a Bacillus thuringiensis crystal protein with selective cytocidal activity against human cells. Reviewed

    Akiba,T.,Abe,Y.,Kitada,S.,Kusaka,Y.,Ito,A.,Ichimatsu T.,KatayamaH.,AkaoT.,Higuch,K.,Mizuki E.,Ohba M.,Kanai R.,and Harata K.

    Acta Cryst. D   60   2355 - 2357   2004.04

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  • A Bacillus thuringiensis Crystal Protein with Selective Cytocidal Action to Human Cells. Reviewed

    Ito,A.,Sasaguri,Y.,Kitada,S.,Kusaka,Y.,Kuwano,K.,Masutomi,K.,Mizuki,E.,Akao,T.,Ohba,M.

    J. Biol. Chem.   279   21282 - 21286.   2004.04

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  • Molecular Recognition and Clea vage of Presequence by Mitochondrial Processing Peptidase

    2003.12

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    Authorship:Corresponding author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (other)

  • Determination of the cleavage site of the presequence by mitochondrial processing peptidase on the substrate binding scaffold and the multiple-subsite inside a molecular cavity Reviewed

    Kitada S.,Yamasaki E.,Kojima K.,Ito A.

    J. Biol. Chem   vol278   pp1879 - 1885.   2003.04

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  • Molecular Recognition and Cleavage of Presequence by Mitochondrial Processing Peptidase Reviewed

    Seikagaku   vol. 75 pp1439-1444   2003.04

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    2003.04  -  2003.04

  • RI標識で観るミトコンドリアタンパク質の一生 ~成熟編~

    北田 栄

    九州大学RIセンターニュース ( 九州大学RIセンター )   2003.03

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  • A proposed common structure of substrates bound to mitochondrial processing peptidase. Reviewed

    Kojima K.,Kitada S.,Ogishima T.,and Ito A.

    J. Biol. Chem.   276   2115 - 2121   2001.04

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  • Glu(191) and Asp(195) in rat mitochondrial processing peptidase beta subunit are involved in effective cleavage of precursor protein through interaction with the proximal arginine. Reviewed

    Kitada S.,Kojima K.,Ito A.

    Biochem. Biophys. Res. Commun.   .. 287   594 - 599   2001.04

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  • Electrostatic recognition of matrix targeting signal by mitochondrial Processing Peptidase Reviewed

    Journal of Biochemistry   129   155 - 161   2001.04

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  • Mitochondrial Processing Peptidase Reveal the Mode for Specific Cleavage of Import Signal Sequence Reviewed

    Taylor A. B.,Smith B. S.,Kitada S.,Kojima K.,Miyaura H.,Otwinowski Z.,Ito A.,Deisenhofer J.

    Structure   9   615 - 625   2001.04

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  • Characterization of rat TOM40, a central component of the preprotein translocase of the mitochondrial outer membrane. Reviewed

    Suzuki H.,Okazawa Y.,Komiya T.,Saeki K.,Mekada E.,Kitada S.,Ito A.,Mihara K.

    J. Biol. Chem.   275   37930 - 37936   2000.04

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  • Glycine-rich Region of Mitochondrial Processing Peptidase α-Subunit is Essential for Binding and Cleavage of the Precursor Proteins Reviewed

    Nagao Y.,Kitada S.,Kojima K.,Toh H.,Kuhara S.,Ogishima T.,Ito A.

    The Journal of Biological Chemistry   275   34552 - 34556   2000.04

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  • Cooperative Formation of Substrate-Binding Pocket by α-and β-subunit of Mitochondrial Processing Peptidase Reviewed

    Kojima K.,Kitada S.,Shimokata K.,Ogishima T.,Ito A.

    The Journal of Biological Chemistry   273   25158 - 15163   1998.04

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  • Glutamate Residues Required for Substrate Binding and Cleavage Activity in Mitochondrial Processing Peptidase Reviewed

    Kitada S.,Kojima K.,Shimokata K.,Ogishima T.,Ito A.

    The Journal of Biological Chemistry   273   32547 - 32553   1998.04

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  • Role of α-Subunit of Mitochondrial Processing Peptidase in Substrate Recogrition Reviewed

    Shimokata K.,Kitada S.,Ogishima T.,Ito A.

    The Journal of Biological Chemistry   273   25158 - 25163   1998.04

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  • ミトコンドリアタンパク質のプロセシング プロテオリシス「タンパク質分解の分子機構と

    伊藤明夫、荻島 正、北田 栄

    蛋白質 核酸 酵素 ( 共立出版 )   1997.05

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  • Substrate recognition by mitochondrial processing peptidase toward the malate dehydrogenase precursor. Reviewed

    Shimokata K.,Nishio T.,Song M.C.,Kitada S.,Ogishima T.,and Ito A.

    122   2362 - 2367   1997.04

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  • Recognition of the Precursor Proteins by the Mitochondrial Processing Peptidase Reviewed

    Ito,A.,Ogishima,T.,Niidome,T.,Kitada,S.,Shimokata,K.

    "Proteolysis and Cell Functions" (ed. by Hopsu-Havu et al.) IOS Press   332 - 339   1997.04

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    Language:English   Publishing type:Research paper (international conference proceedings)

    Finland   1997.04  -  1997.04

  • Role of basic amino acids in the cleavage of synthetic peptide substrates by mitochondrial processing peptidase. Reviewed

    Song M.C.,Shimokata K.,Kitada S.,Ogishima T.,Ito A.

    J. Biochem.   120   1163 - 1166   1996.04

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  • Analysis of elements in the substrate required for processing by mitochondrial processing peptidase. Reviewed

    Ogishima T.,Niidome T.,Shimokata K.,Kitada S.,Ito A.

    J. Biol. Chem.   270   30322 - 30326   1995.04

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  • A Putative Metal-Binding Site in the β Subunit of Rat Mitochondrial Processing Peptidase Is Essential for Its Catalytic Activity Reviewed

    Kitada S.,Shimokata K.,Niidome T.,Ogishima T.,Ito A.

    Journal of Biochemistry   117   1148 - 1150   1995.04

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  • The Structure of Extension Peptide Recognized by Mitochondrial Processing Peptidase. Reviewed

    Niidome,T.,Kitada,S.,Shimokata,K.,Ogishima T,Ito A.

    Peptide Chemistry   65 - 68   1995.04

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    China   1995.04  -  1995.04

  • Rat Liver Mitochondrial Processing Peptidase: Primary Structure and Putative Active Site. Reviewed

    Kitada S.,Shimokata K.,Song M.C.,Niidome T.,Ogishima T.,Ito A.

    "Frontiers in Protein Chemistry and Biotechnology" (ed. by Wang Zongmu and Li Wei) CPH Press   193 - 197   1995.04

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    1995.04  -  1995.04

  • Structural requirement for recognition of the precursor proteins by the mitochondrial processing peptidase. Reviewed

    Ou W.J.,Kumamoto T.,Mihara K.,Kitada S.,Niidome T.,Ito A.,Omura T.

    J. Biol. Chem.   269   24673 - 24678   1994.04

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  • Arginine residues in the extension peptide are required for cleavage of a precursor by mitochondrial processing peptidase. Demonstration using synthetic peptide as a substrate. Reviewed

    Niidome T.,Kitada S.,Shimokata K.,Ogishima T.,Ito A.

    J. Biol. Chem.   269   24719 - 24722   1994.04

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  • Molecular cloning of the Smaller Subunit(P52)of Rat Liver Mitochondrial Processing Protease. Reviewed

    Biochemical and Biophysical Research Communications   190 - 190   1993.04

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Conference Prsentations (Oral, Poster)

  • 微生物毒素パラスポリン2の細胞認識を利用した生体での抗癌効果と作用解明 (若手奨励賞受賞)

    本村恭平、麻﨑一哉、岩崎新司、木村雄作、日下雅友、北田 栄

    第61回トキシンシンポジウム 

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    Event date: 2014.09.03 - 2014.09.05   Language:Japanese  

  • 直腸がん移植マウスに対するパラスポリン2腹腔内投与の抗がん効果

    岩崎新司、大林隆志、木村雄作、麻崎一哉、北田有美子、北田 栄

    第5回パラスポリン研究会 

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    Event date: 2012.12.08   Language:Japanese  

  • がん移植マウスに対するparasporin-2の局所投与による抗がん作用

    麻﨑一哉、大林隆志、北田有美子、北田 栄

    第5回パラスポリン研究会 

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    Event date: 2012.12.08   Language:English  

  • トリパノソーマに対するパラスポリン2の毒性作用

    浦 渉太、杉原 真、鮫島結香、井上雅広、北田 栄

    第5回パラスポリン研究会 

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    Event date: 2012.12.08   Language:Japanese  

  • 細胞膜傷害を示すパラスポリン2複合体の構造決定に向けた解析

    吉田裕介、嶋田拡靖、北田 栄

    第5回パラスポリン研究会 

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    Event date: 2012.12.08   Language:Japanese  

  • 抗がん性タンパク質パラスポリン2のマウスに対する毒性の解明

    木村雄作、北田有美子、日下雅友、北田 栄

    第5回パラスポリン研究会 

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    Event date: 2012.12.08   Language:Japanese  

  • ヒトすい臓がん細胞に作用する新規パラスポリン産生Bt菌株のスクリーニング

    狩野貴之、鮫島結香、斉藤浩之、水城英一、北田 栄

    第5回パラスポリン研究会 

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    Event date: 2012.10.08   Language:Japanese  

  • 効率的なBt菌判別法の検討と新規のBt菌株の探索

    前田健佑、鮫島結香、齊藤浩之、水城英一、北田 栄

    第84回日本生化学会大会 

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    Event date: 2011.09.21 - 2011.09.24   Language:English  

  • 抗がん性タンパク質パラスポリン-2のマウスに対する毒性の解明

    木村雄作、北田有美子、日下雅友、北田 栄

    第84回日本生化学会大会 

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    Event date: 2011.09.21 - 2011.09.24   Language:Japanese  

  • がん移植マウスに対するparasporin-2の抗がん作用

    麻崎一哉、北田有美子、日下雅友、北田 栄

    第84回日本生化学大会  

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    Event date: 2011.09.21 - 2011.09.23   Language:Japanese  

  • 抗がん性微生物毒素Parasporin-2のKLN206がん移植マウスにおける生体内挙動

    未入力 

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    Event date: 2010.11.27   Language:Japanese  

  • パラスポリン-2の結腸がん細胞移植マウスに対する抗腫瘍効果

    第4回パラスポリン研究会 

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    Event date: 2010.11.27   Language:Japanese  

  • Mega complex of anti-tumor cry toxin parasporin-2 in hepatoma cell membrane.

    6TH Annual Pacific Rim Conference on the Biotechnology of Bacillus thuringiensis and its Enviromental Impact  

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    Event date: 2009.11.26   Language:English  

  • 北田 栄,新奇細胞毒素を利用したBt菌バイオ研究新領域への総合展開

    特定領域研究「統合がん」報告会 

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    Event date: 2009.09.17   Language:Japanese  

  • 膜孔形成オリゴマー化毒素は細胞膜で巨大な毒素複合体を形成する

    第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会 

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    Event date: 2008.12.10   Language:Japanese  

  • 脂質ラフトを標的とし多量体化する毒素parasporin-2は細胞膜中で超分子複合体を形成する

    第3回パラスポリン研究会 

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    Event date: 2008.10   Language:Japanese  

  • 微生物毒素パラスポリン2のがん細胞破壊作用におけるGPIアンカー型タンパク質の関与

    第30回日本分子生物学会年会、第80回日本生化学会大会、合同大会 

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    Event date: 2007.12   Language:Japanese  

  • Mega assemblage of a mammalian cell-targeting and pore-forming toxin parasporin-2 from Bacillus thuringiensis

    40th Annual Meeting of the SIP and 1st IFENSB 

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    Event date: 2007.08   Language:English  

  • Cell-binding and oligomerization of parasporin-2 are mediated by glycosylphosphatidylinositol -anchored proteins

    40th Annual Meeting of the Society for Invertebrate Pathology 

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    Event date: 2007.08   Language:English  

  • Cytocidal actions of parasporin-2, a novel crystal toxin targeting human cancer cells from Bacillus thuringiensis

    IX International Colloquium on Invertebrate Pathology 

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    Event date: 2006.08   Language:English  

  • Parasporin, an anti-tumor crystal toxin from Bacillus thuringiensis.

    GEPROM conferences  

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    Event date: 2006.04   Language:English  

  • BT菌から発見された新しい結晶性毒素タンパク質「パラスポリン2の細胞認識と毒性」

    微研セミナー 

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    Event date: 2006.03   Language:Japanese  

  • Bacillus thuringiensis から発見された新しい結晶性毒素タンパク質(パラスポリン2)の細胞破壊機構

    第52回毒素シンポジウム 

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    Event date: 2005.07   Language:Japanese  

  • 腫瘍結晶性毒素パラスポリン-2はGPIアンカータンパク質を認識し脂質ラフトでオリゴマーを形成する

    第5回日本蛋白質科学会年会 

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    Event date: 2005.06   Language:Japanese  

  • Molecular identification and cytocidal action of parasporin, a protein group of novel crystal toxins targeting to human cells

    6TH Annual Pacific Rim Conference on the Biotechnology of Bacillus thuringiensis and its Enviromental Impact 

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    Event date: 2005.04   Language:English  

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Lectures

  • Molecular basis of parasporin-2 action toward cancer cells

    47th Annual Meeting of the Society for Invertebrate Pathology   2014.08 

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    Event date: 2014.08.03 - 2014.08.07   Language:English   Presentation type:Special lecture  

  • 凝集性毒素パラスポリン2によるがん細胞認識と作用の分子機構と抗がん作用への応用

    第35回 蛋白質と酵素の構造と機能に関する九州シンポジウム  2011.09 

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    Event date: 2011.09.30 - 2011.10.01   Language:Japanese   Presentation type:Special lecture  

  • パラスポリン2のin vitroとin vivoでの抗がん作用とその利用

    第84回日本生化学会大会 シンポジウム  2011.09 

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    Event date: 2011.09.21 - 2011.09.23   Language:Japanese   Presentation type:Special lecture  

Press

  • Bt菌毒素でがん細胞を死滅させる

    北田栄

    西日本新聞  2010.07.08

  • 抗がんたんぱく質立証

    北田栄

    読売新聞  2009.02.26

  • 正常細胞ダメージ少なくガン細胞を狙い撃ち

    北田栄

    科学新聞  2009.02.20

  • がん攻撃の新規たん白

    北田栄

    化学工業新聞  2009.02.06

Grants-in-Aid for Scientific Research

  • 細胞内共生細菌から探るミトコンドリアの進化的形成

    Grant number:26650061  2014.04 - 2016.03   挑戦的萌芽研究

  • チューリンジェンシス菌からの新しい抗病原体活性物質の大規模検索とその作用

    Grant number:25292052  2013.04 - 2018.03   基盤研究(B)

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    10,000株のチューリンジェンシス菌から、がん・病原異性物・ウイルスなどの病原体に作用する新規毒素タンパク質とその遺伝子を同定する。それらの分子作用を解明しバイオ分野への基礎とする。

  • 細胞内共生細菌ボルバキアのオルガネラコミュニケーション

    Grant number:23657133  2011.04 - 2013.03   挑戦的萌芽研究

  • 細胞毒素を利用した制がん研究への総合展開

    Grant number:20011007  2008.04 - 2010.03   特定領域研究

  • 脂質ラフトを標的とする毒素の細胞認識とオリゴマーの分子機構

    Grant number:18687007  2006.04 - 2009.03   若手研究(A)

  • 微生物毒素の生体膜侵入と複合体形成

    Grant number:17053019  2005.04 - 2006.03   特定領域研究

  • 微生物毒素による選択的細胞認識の分子機構

    Grant number:16770077  2004.04 - 2006.03   若手研究(B)

  • ミトコンドリアからの情報発信(ミトコンドリアストレスに対する細胞応答)

    Grant number:14658233  2002.04 - 2004.03   萌芽研究・萌芽的研究

  • 構造生物学に基づいたミトコンドリア標的化シグナル認識の分子メカニズム

    Grant number:12780455  2000.04 - 2002.03   奨励研究(A)

  • ミトコンドリアプロセシングペプチダ-ゼαサブユニットの機能と基質認識機構

    Grant number:09780577  1997.04 - 1999.03   奨励研究(A)

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Contracts

  • Bt菌新規生物活性因子探索

    2013.04

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    Grant type:Other joint research

  • すい臓がんに作用する微生物毒素の探索

    2012.11 - 2013.10

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    Grant type:Consigned research

  • パラスポリン2の膜作用における電気生理学的解析

    2005.09

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    Grant type:Other joint research

  • structure of mitochondrial processing peptidase

    2000.04 - 2001.03

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    Grant type:Other joint research

Activities of Academic societies and Committees

  • The Japanese Biochemical Society  

    2011.09

  • パラスポリン命名委員会   委員  

    2006.04