Updated on 2024/05/14

写真a

 
SAKAMOTO Hiroshi
 
Scopus Paper Info  
Total Paper Count: 0  Total Citation Count: 0  h-index: 6

Citation count denotes the number of citations in papers published for a particular year.

Affiliation
Faculty of Computer Science and Systems Engineering Department of Bioscience and Bioinformatics
Job
Professor
E-mail
メールアドレス
Laboratory
680-4 Kawazu, Iizuka-shi, Fukuoka
Phone
+81-948-29-7815
Fax
+81-948-29-7801
External link

Research Interests

  • peptide

  • protein

  • enzyme

  • heme

  • structure-activity relationship

  • catalytic mechanism

Research Areas

  • Life Science / Structural biochemistry

  • Life Science / Functional biochemistry

  • Nanotechnology/Materials / Chemistry and chemical methodology of biomolecules

  • Nanotechnology/Materials / Bio chemistry

Degree

  • Kyushu University  -  Doctor of Science   1992.03

Biography in Kyutech

  • 2022.09
    -
    2024.03
     

    Kyushu Institute of Technology   Education Advancement Headquarters   Executive Vice President  

  • 2022.09
    -
    2024.03
     

    Kyushu Institute of Technology   Education Advancement Headquarters  

  • 2022.04
    -
    2024.03
     

    Kyushu Institute of Technology   Education Advancement Headquarters  

  • 2019.04
     

    Kyushu Institute of Technology   Faculty of Computer Science and Systems Engineering   Department of Bioscience and Bioinformatics   Professor  

  • 2016.04
     

    Kyushu Institute of Technology   Abolition organization   Learning & Teaching Center  

  • 2013.01
    -
    2019.03
     

    Kyushu Institute of Technology   Faculty of Computer Science and Systems Engineering   Department of Bioscience and Bioinformatics   Professor  

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Academic Society Memberships

  • 2011.05   日本生化学会九州支部例会   Japan

  • 2008.04   蛋白質と酵素の構造と機能に関する九州シンポジウム   Japan

  • 2007.04   泉屋コロキウム   Japan

  • 2004.04 - 2005.03   1st Asia-Pacific Internatinal Peptide Symposium/41th Japanese Peptide Symposium   Japan

  • 2000.01   フロンティア生命化学研究会   Japan

  • 1994.01   The Protein Society   United States

  • 1989.04   The Japanese Peptide Society   Japan

  • 1989.04   日本化学会   Japan

  • 1989.04   日本生化学会   Japan

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Papers

  • Establishment of an IR System for Institutional Decision-Making in Kyushu Institute of Technology Reviewed

    Oishi Tetsuya, Fukumaru Hirofumi, Hayashi Akihiro, Sakamoto Hiroshi

    IIAI Letters on Institutional Research ( International Institute of Applied Informatics )   3   1   2023.01

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)

    DOI: 10.52731/lir.v003.116

    CiNii Research

  • Identification of novel inhibitors for mycobacterial polyketide synthase 13 via in silico drug screening assisted by the parallel compound screening with genetic algorithm-based programs Reviewed International journal

    Junichi Taira, Kahori Murakami, Kohei Monobe, Kohei Kuriki, Miu Fujita, Yosuke Ochi, Hiroshi Sakamoto, Shunsuke Aoki

    The Journal of Antibiotics   2022.08

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    Language:English   Publishing type:Research paper (scientific journal)

    DOI: 10.1038/s41429- 022-00549-z

  • Computer‑Assisted Screening of Mycobacterial Growth Inhibitors: Exclusion of Frequent Hitters with the Assistance of the Multiple Target Screening Method Reviewed International journal

    Kohei Kuriki, Junichi Taira, Masato Kuroki, Hiroshi Sakamoto, Shunsuke Aoki

    International Journal of Mycobacteriology   10 ( 3 )   307 - 311   2021.09

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    Language:English   Publishing type:Research paper (scientific journal)

    Background: The emergence of frequent hitters (FHs) remains a challenge in drug discovery. We have previously used in silico structure‑based
    drug screening (SBDS) to identify antimycobacterial candidates. However, excluding FHs has not been integrated into the SBDS system.
    Methods: A dataset comprising 15,000 docking score (protein–compound affinity matrix) was constructed by multiple target screening (MTS):
    DOCK–GOLD two‑step docking simulations with 154,118 compounds versus the 30 target proteins essential for mycobacterial survival. After
    extraction of 141 compounds from the protein–compound affinity matrix, compounds determined to be FHs or false positives were excluded.
    Antimycobacterial properties of the top nine compounds selected through SBDS were experimentally evaluated. Results: Nine compounds
    designated KS1–KS9 were selected for experimental evaluation. Among the selected compounds, KS3, identified as adenosylhomocysteinase
    inhibitor, showed a potent inhibitory effect on antimycobacterial growth (inhibitory concentration [IC] 50 = 1.2 M). However, the compound
    also showed potent cytotoxicity. Conclusion: The MTS method is applicable in SBDS for the identification of enzyme‑specific inhibitors.

    DOI: 10.4103/ijmy.ijmy_137_21

  • Complex Formation of Heme Oxygenase-2 with Heme Is Competitively Inhibited by the Cytosolic Domain of Caveolin-1 Reviewed International journal

    Takemoto M., Sakamoto H., Higashimoto Y., Taira J.

    Biochemistry   60 ( 29 )   2300 - 2308   2021.07

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    Language:English   Publishing type:Research paper (scientific journal)

    DOI: 10.1021/acs.biochem.1c00247

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  • Conformational equilibrium of NADPH–cytochrome P450 oxidoreductase is essential for heme oxygenase reaction Reviewed International journal

    Sugishima M., Taira J., Sagara T., Nakao R., Sato H., Noguchi M., Fukuyama K., Yamamoto K., Yasunaga T., Sakamoto H.

    Antioxidants   9 ( 8 )   1 - 13   2020.07

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    DOI: 10.3390/antiox9080673

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  • Improvement of the novel inhibitor for Mycobacterium enoyl-acyl carrier protein reductase (InhA): a structure–activity relationship study of KES4 assisted by in silico structure-based drug screening Reviewed International journal

    Taira J., Umei T., Inoue K., Kitamura M., Berenger F., Sacchettini J.C., Sakamoto H., Aoki S.

    Journal of Antibiotics   73   372 - 381   2020.01

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    © 2020, The Author(s), under exclusive licence to the Japan Antibiotics Research Association. InhA or enoyl-acyl carrier protein reductase of Mycobacterium tuberculosis (mtInhA), which controls mycobacterial cell wall construction, has been targeted in the development of antituberculosis drugs. Previously, our in silico structure-based drug screening study identified a novel class of compounds (designated KES4), which is capable of inhibiting the enzymatic activity of mtInhA, as well as mycobacterial growth. The compounds are composed of four ring structures (A–D), and the MD simulation predicted specific interactions with mtInhA of the D-ring and methylene group between the B-ring and C-ring; however, there is still room for improvement in the A-ring structure. In this study, a structure–activity relationship study of the A-ring was attempted with the assistance of in silico docking simulations. In brief, the virtual chemical library of A-ring-modified KES4 was constructed and subjected to in silico docking simulation against mtInhA using the GOLD program. Among the selected candidates, we achieved synthesis of seven compounds, and the bioactivities (effects on InhA activity and mycobacterial growth and cytotoxicity) of the synthesized molecules were evaluated. Among the compounds tested, two candidates (compounds 3d and 3f) exhibited superior properties as mtInhA-targeted anti-infectives for mycobacteria than the lead compound KES4.

    DOI: 10.1038/s41429-020-0293-6

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  • Structural modification of a novel inhibitor for mycobacterium enoyl-acyl carrier protein reductase assisted by in silico structure-based drug screening Reviewed International journal

    Taira J., Nagano T., Kitamura M., Yamaguchi M., Sakamoto H., Aoki S.

    International Journal of Mycobacteriology   9 ( 1 )   12 - 17   2020.01

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    © 2020 Medknow. All rights reserved. Background: Mycobacterium tuberculosis enoyl-acyl carrier protein reductase (mtInhA) is involved in the biosynthesis of mycolic acids, a major component of mycobacterial cell walls, and has been targeted in the development of anti-tuberculosis (TB) drugs. In our previous in silico structure-based drug screening study, we identified KES4, a novel class of mtInhA inhibitor. KES4 is composed of four ring structures (A-D-rings) and molecular dynamic simulation predicted that the D-ring is essential for the interaction with mtInhA. Methods: The structure-activity relationship study of the D-ring was attempted and aided by in silico docking simulations to improve the mtInhA inhibitory activity of KES4. A virtual chemical library of the D-ring-modified KES4 was then constructed and subjected to in silico docking simulation against mtInhA using the GOLD program. The candidate compound showing the highest GOLD score, referred to as KEN1, was synthesized, and its biological properties were compared with those of the lead compound KES4. Results: We achieved the synthesis of KEN1 and evaluated its effects on InhA activity, mycobacterial growth, and cytotoxicity. The antimycobacterial activity of KEN1 was comparable to that of the lead compound (KES4), although it exhibited superior activity in mtInhA inhibition. \Conclusions: We obtained a KES4 derivative with high mtInhA inhibitory activity by in silico docking simulation with a chemical library consisting of a series of D-ring-modified KES4.

    DOI: 10.4103/ijmy.ijmy_184_19

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  • Dephosphorylation of clustered phosphoserine residues in human Grb14 by protein phosphatase 1 and its effect on insulin receptor complex formation Reviewed

    Junichi Taira, Keisuke Yoshida, Misaki Takemoto, Kousaku Hanada, Hiroshi Sakamoto

    Journal of Peptide Science ( John Wiley & Sons, Inc. )   25 ( 10 )   e3207   e3207   2019.10

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    DOI: 10.1002/psc.3207

    PubMed

  • Development of Rat Heme Oxygenase-1 Based Gene Encoded Heme Probe for Intracellular Heme Detection Reviewed

    Junichi Taira, Otomi Nakashima, Hideyuki Komatsu, Hiroshi Sakamoto

    Peptide Science 2017   156 - 157   2018.03

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    日本   堺   2017.11.20  -  2017.11.22

  • Development of Fluorescent Protein-Fused Heme Oxygenase-1 as Intracellular Free Heme Detecing Probe Reviewed

    Otomi Nakashima,Junichi Taira, Hideyuki Komatsu, Shinji Sueda, Hiroshi Sakamoto

    Peptide Science 2016   181 - 182   2017.03

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    日本   京都   2016.10.26  -  2016.10.28

  • Effect of Surfactants on Quantification of Heme in Biological Samples using Heme Sensor Based on Fluorescently Labeld Heme Oxygenase-1 Reviewed

    Takashi Yoshimura, Yukinori Nakashima, Junichi Taira, Hideyuki Komatsu, Nohito Tanioka, Hiroki Shimizu, Hiroshi Morimatsu, Hiroshi Sakamoto

    Peptide Science 2016   177 - 178   2017.03

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    日本   京都   2016.10.26  -  2016.10.28

  • Phosphorylation of Serine Residues in Grb14 BPS Domain Involves in the Complex Forming of Grb14 with Insulin Receptor Reviewed

    Junichi Taira, Kohei Inatomi, Hideyuki Komatsu, Hiroshi Sakamoto

    Peptide Science 2016   175 - 176   2017.03

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    日本   京都   2016.10.26  -  2016.10.28

  • Surface Plasmon Resonance Study on the Interaction between the N-terminal Region of Heme Oxygenase-2 and NADPH-Cytochrome P450 Reductase Reviewed

    Junichi Taira, Shota Wada, Yuya Fukushima, Shinji Sueda, Hideyuki Komatsu, Yuichiro Higashimoto, Hiroshi Sakamoto

    Peptide Science 2015   157 - 158   2016.03

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    日本   平塚   2015.11.16  -  2015.11.18

  • Improvement of heme oxygenase-1-based heme sensor for quantifying free heme in biological sample Reviewed

    489   50 - 52   2015.08

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    DOI: 10.1016/j.ab.2015.08.004

    Scopus

  • Discovery of InhA inhibitors with anti-mycobacterial activity through a matched molecular pair approach Reviewed

    Hironori Kanetaka, Yuji Koseki, Junichi Taira, Tomohiro Umei, Hideyuki Komatsu, Hiroshi Sakamoto, Gulcin Gulten, James C. Sacchettini, Mitsuru Kitamura, Shunsuke Aoki

    European Journal of Medicinal Chemistry   94   378 - 385   2015.04

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    DOI: 10.1016/j.ejmech.2015.02.062

    Scopus

  • Application of the axial iron ligand-mutant heme oxygenase for heme-binding analysis Reviewed

    Hideyuki Komatsu, Shinpei Yamamoto, Masataka Okuda, Hiroshi Sakamoto

    Peptide Science 2014   185 - 186   2015.04

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    日本   徳島   2014.10.22  -  2014.10.24

  • Development of a Heme Sensor Using Fluorescently Labeled Heme Oxygenase-1 Reviewed

    433 ( 1 )   2 - 9   2013.02

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    DOI: 10.1016/j.ab.2012.10.002

    Scopus

  • Sensitive heme sensor using fluorescent-labeled heme oxygenase-1 "jointly worked" Reviewed

    S. Koga, Y. Higashimoto,M. Noguchi,H. Komatsu,H. Sakamoto

    Peptide Science 2010   2010   270 - 270   2011.03

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    日本   京都   2010.12.04  -  2010.12.09

    CiNii Article

  • Reduction of oxaporphyrin ring of CO-bound -verdoheme complexed with oxygenase-1 by NADPH-cytochrome P450 reductase Reviewed

    H. Sato,Y. Higashimoto,H. Sakamoto,M. Sugishima,C. Shimokawa,J. Harada,G. Palmer,M. Noguchi

    Journal of Inorganic Biochemistry   105   289 - 296   2011.01

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    DOI: 10.1016/j.jinorgbio.2010.11.010

    Scopus

  • Heme Binding Analysis of Heme Regulatory Motifs of Rat Heme Oxygenase-2 Reviewed

    T. Ueda,S. Koga,Y. Higashimoto,M. Noguchi,H. Sakamoto

    Peptide Science 2009   2009   237 - 238   2010.02

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  • Crystal structure of rat heme oxygenase-1 in complex with ferrous verdoheme: presence of a hydrogen bond network on the distal side Reviewed

    H. Sato,M. Sugishima,H. Sakamoto,Y. Higashimoto,C. Shimokawa,K. Fukuyama,M. Noguchi

    Biochemical Journal   419   339 - 345   2009.04

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  • Functional Analysis of Heme Regulatory Motifs of Rat Heme Oxygenase-2 Reviewed

    S. Nakashima,Y. Higashimoto,M. Noguchi,H. Sakamoto

    Peptide Science 2008   217 - 220   2009.01

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  • Functional Analyses of Pseudomonas putida Benzoate Transporters Expressed in the Yeast Saccharomyces cerevisiae Reviewed

    Y. Nishikawa,Y. Yasumi,S. Noguchi,H. Sakamoto,J. Nikawa

    Biosci. Biotechnol. Biochem.   419 ( 8 )   2034 - 2038   2008.04

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  • Mass spectrometric identification of lysine residues of heme oxygenase-1 that are involved in its interaction with NADPH-cytochrome P450 reductase Reviewed

    Y. Higashimoto,M. Sugishima,H. Sato,H. Sakamoto,K. Fukuyama,G. Palmer,M. Noguchi

    Biochem. Biophys. Res. Commun.   367 ( 4 )   852 - 858   2008.03

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  • Interaction between Heme and Synthetic Peptides Containing Heme Regulatory Motifs of Rat Heme Oxygenase-2 Reviewed

    S. Nakashima,Y. Higashimoto,M. Sakamoto,H. Sakamoto

    Peptide Science 2007   249 - 250   2007.12

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  • ヘムの自己分解メカニズム-ヘム分解酵素ヘムオキシゲナーゼの触媒機構-

    坂本 寛

    化学と工業   60 ( 9 )   886 - 887   2007.09

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    代表的研究業績 日本化学会機関誌

  • X-ray crystallographic and biochemical characterization of the inhibitory action of an imidazole-dioxolane compound on heme oxygenase. Reviewed

    M. Sugishima,Y. Higashimoto,T. Oishi,H. Takahashi,H. Sakamoto,M. Noguchi,K. Fukuyama

    Biochemistry   46 ( 7 )   1860 - 1867   2007.04

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  • Alternative cyanide-binding modes to the haem iron in haem oxygenase. Reviewed

    M. Sugishima,K. Oda,T. Ogura,H. Sakamoto,M. Noguchi,K. Fukuyama

    Acta. Crystallogr. Sect. F Struct. Biol. Cryst. Commun.   63   471 - 477   2007.04

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  • Electrochemical reduction of ferrous alpha-verdoheme in complex with heme oxygenase-1. Reviewed

    H. Sato,Y. Higashimoto,H. Sakamoto,M. Sugishima,K. Takahashi,G. Palmer,M. Noguchi

    J Inorg Biochem.   101   1394 - 1399   2007.04

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  • The reactions of heme- and verdoheme-heme oxygenase-1 complexes with FMN-depleted NADPH-cytochrome P450 reductase-electrons required for verdoheme oxidation can be transferred through a pathway not involving FMN. Reviewed

    Y. Higashimoto,H. Sato,H. Sakamoto,K. Takahashi,G. Palmer,M. Noguchi

    J. Biol. Chem.   281 ( 42 )   31659 - 31667   2006.04

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  • Involvement of NADP(H) in the interaction between heme oxygenase-1 and cytochrome P450 reductase Reviewed

    Y. Higashimoto,H. Sakamoto,S. Hayashi,M. Sugishima,K. Fukuyama,G. Palmer,M. Noguchi

    Journal of Biological Chemistry   280   729 - 737   2005.04

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  • Neuroprotective mechanisms of lidocaine against in vitro ischemic insult of the rat hippocampal CA1 pyramidal neurons Reviewed

    S. Niiyama,E. Tanaka,S. Tsuji,Y. Murai,M. Satani,H. Sakamoto,K. Takahashi,M. Kuroiwa,A. Yamada,M. Noguchi,and H. Higashi.

    Neuroscience Research   53   271 - 278   2005.04

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  • A kinetic study of the mechanism of conversion of alpha-hydroxyheme to verdoheme while bound to heme oxygenase Reviewed

    H. Sakamoto,K. Takahashi,Y. Higashimoto,S. Harada,G. Palmer,M. Noguchi

    Biochemical and Biophysical Research Communications   338   578 - 583   2005.04

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  • Mechanism of heme binding in HO-1 inferred from structural comparison of the apo and heme complex forms Reviewed

    M. Sugishima,H. Sakamoto,Y. Kakuta,Y. Omata,M. Noguchi,and K. Fukuyama

    Biochemistry   41   7293 - 7300   2005.04

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  • ヘムオキシゲナーゼの立体構造からみた反応機構

    坂本寛,杉島正一,東元祐一郎,福山恵一,野口正人

    生化学   77 ( 7 )   634 - 638   2005.04

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    代表的研究業績 日本生化学会

  • Purification and characterization of human uroporphyrinogen III synthase expressed in Escherichia Coli Reviewed

    Y. Omata,H. Sakamoto,Y. Higashimoto,M. Satani,S. Hayashi,and M. Noguchi

    Journal of Biochemistry (Tokyo)   136   211 - 220   2004.04

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  • Hydroxylamine and hydrazine bind directly to the heme iron of the heme-heme oxygenase-1 complex Reviewed

    H. Sakamoto,Y. Higashimoto,S. Hayashi,M. Sugishima,K. Fukuyama,G. Palmer,and M. Noguchi

    Journal Inorganic Biochemistry   98   1223 - 1228   2004.04

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  • Characterization of rat heme oxygenase-3 gene. Implication of processed pseudogenes derived from heme oxygenase-2 Reviewed

    S. Hayashi,Y. Omata,H. Sakamoto,Y. Higashimoto,T. Hara,Y. ara,and M. Noguchi

    GENE   256   311 - 317   2004.04

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  • CO-trapping site in heme oxygenase revealed by photolysis of its CO-bound heme complex: mechanism of escaping from product inhibition Reviewed

    M. Sugishima,H. Sakamoto,M. Noguchi,K. Fukuyama

    Journal of Molecular Biology   341   7 - 13   2004.04

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  • Crystal structures of ferrous and CO-, CN--, and NO-bound forms of rat heme oxygenase (HO): implications for discrimination between CO and O2 in HO Reviewed

    H. Sakamoto,M. Sugishima,K. Fukuyama,M. Noguchi

    Biomolecular Chemistry -A Bridge for the Future- (Proceedings of the Fist International Symposium on Biomolecular Chemistry 2003)   196 - 197   2003.12

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    2003.12.02  -  2003.12.05

  • Crystal structures of ferrous and CO-, CN--, and NO-bound forms of rat heme oxygenase-1 (HO-1) in complex with heme: structural implications for discrimination between CO and O2 in HO-1 Reviewed

    M. Sugishima,H. Sakamoto,M. Noguchi,and K. Fukuyama

    Biochemistry   42   9898 - 9905   2003.04

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  • Expression and characterization of human bifunctional peptidylglycine alpha-amidating monooxygenase Reviewed

    M. Satani,K. Takahashi,H. Sakamoto,S. Harada,Y. Kaida,and M. Noguchi

    Protein Expression and Purification   28   293 - 302   2003.04

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  • Purification and characterization of a soluble form of rat liver NADPH-cytochrome P450 reductase highly expressed in Escherichia coli Reviewed

    S. Hayashi,Y. Omata,H. Sakamoto,T. Hara,and M. Noguchi

    Protein Expression and Purification   29   1 - 7   2003.04

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  • Crystal structure of rat heme oxygenase-1 in complex with biliverdin-iron chelate Reviewed

    M. Sugishima,H. Sakamoto,Y. Higashimoto,M. Noguchi,and K. Fukuyama

    Journal of Biological Chemistry   278   32352 - 32358   2003.04

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  • Crystal structure of rat heme oxygenase-1 in complex with heme Reviewed

    M. Sugishima,Y. Omata,Y. Kakuta,H. Sakamoto,M. Noguchi,and K. Fukuyama

    FEBS letters   471   61 - 66   2002.04

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  • Crystal structure of rat heme oxygenase-1 in complex with heme bound to azide: Implication for regiospecific hydroxylation of heme at the alpha-meso carbon Reviewed

    M. Sugishima,H. Sakamoto,Y. Higashimoto,Y. Omata,S. Hayashi,M. Noguchi,and K. Fukuyama

    Journal of Biological Chemistry   277   45086 - 45090   2002.04

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  • The reactivity of alpha-hydroxyheme and verdoheme bound to haem oxygenase-1 to dioxygen and sodium dithionite Reviewed

    H. Sakamoto,Y. Omata,S. Hayashi,S. Harada,G. Palmer,and M. Noguchi

    European Journal of Biochemistry   269   5231 - 5239   2002.04

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  • Structure and reaction mechanism of heme oxygenase-1 Reviewed

    H. Sakamoto,M. Sugishima,Y. Omata,Y. Kakuta,K. Fukuyama,G. Palmer,M. Noguchi

    177 - 183   2002.04

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    2002.04  -  2002.04

  • Study on the packing geometry, stoichiometery, and membrane interaction of three analogs related to a pore-forming small globular protein Reviewed

    E. Matsumoto,T. Kiyota,S. Lee,G. Sugihara,S. Yamashita,H. Meno,Y. Aso,H. Sakamoto,and H. M. Ellerby

    Biopolymers   56   96 - 108   2000.04

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  • Separation and identification of the regioisomers of verdoheme by reversed- phase ion-pair high-performance liquid chromatography, and characterization of their complexes with heme oxygenase Reviewed

    H. Sakamoto,Y. Omata,Y. Adachi,G. Palmer,and M. Noguchi

    Journal of Inorganic Biochemistry   82   113 - 121   2000.04

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  • Ferric alpha-hydroxyheme bound to heme oxygenase can be converted to verdoheme by dioxygen in the absence of added reducing equivalents Reviewed

    H. Sakamoto,Y. Omata,G. Palmer,and M. Noguchi

    Journal of Biological Chemistry   274   18196 - 18200   1999.04

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  • Crystallization and preliminary X-ray diffraction studies on the water-soluble form of rat heme oxygenase-1 in complex with heme Reviewed

    Y. Omata,S. Asada,H. Sakamoto,K. Fukuyama,and M. Noguchi

    Acta Crystallography Section D   54   1017 - 1019   1998.04

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  • Colocalization of heparin and receptor binding sites on keratinocyte growth factor Reviewed

    Kim,P. J.,Sakaguchi,K.,Sakamoto,H.,Saxinger,C.,Day,R.,McPhie,P.,Rubin,J.,and Bottaro,D. P.

    Biochemistry   37   8853 - 8862   1998.04

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    Language:English   Publishing type:Research paper (scientific journal)

  • Two distinct HLA- A*0101-specific submotifs illustrate alternative peptide binding modes Reviewed

    Kondo,A.,Sidney,J.,Southwood,S.,del Guercio,M. F.,Appella,E.,Sakamoto,H.,Grey,H. M.,Celis,E.,Chesnut,R.W.,Kubo,R. T.,and Sette,A.

    Immunogenetics   45   249 - 258   1997.04

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  • Architectural accommodation in the complex of four p53 DNA binding domain peptides with the p21/waf1/cip1 DNA response element Reviewed

    Sakaguchi,K.,Sakamoto,H.,Xie,D,Erickson,Lewis,M. S.,Anderson,C.W.,and Appella,E.

    Journal of Protein Chemistry   16   553 - 556   1997.04

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  • Phosphorylation of Serine 392 stabilizes the tetramer formation of tumor suppressor protein p53 Reviewed

    Sakaguchi,K.,Sakamoto,H.,Lewis,M. S.,Anderson,C. W.,Erickson,J. W.,Appella,E.,and Xie,D.

    Biochemistry   36   10117 - 10124   1997.04

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  • Architectural accommodation in the complex of four p53 DNA binding domain peptides with the p21/waf1/cip1 DNA response element Reviewed

    Nagaich,A. K.,Zhurkin,V. B.,Sakamoto,H.,Gorin,A. A.,Clore,G. M.,Gronenborn,A. M.,Appella,E.,and Harrington,R. E.

    Journal of Biological Chemistry   272   14830 - 14841   1997.04

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  • The negative signaling molecule SH2 domain- containing inositol-phosphate 5-phosphatase (SHIP) binds to the tyrosine- phosphorylated beta subunit of the high affinity IgE receptor Reviewed

    Kimura,T.,Sakamoto,H.,Appella,E.,and Siraganian,R. P.

    Journal of Biological Chemistry   272   13991 - 13996   1997.04

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  • Synthesis of oligomerization domain of p53 and its analogs and their association properties in buffer solution Reviewed

    Miyabe,M.,Lee,S.,Sugihara,G.,Sakamoto,H.,Meno,K.,Aso,Y.,and Sakaguchi,K

    Peptide Science Present and Future: Proceeding of the 1st International Peptide Symposium   1999   367 - 369   1997.04

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    京都   1997.04  -  1997.04

  • Chemical synthesis of phosphorylated peptides of the carboxy-terminal domain of human p53 by a segment condensation method Reviewed

    Sakamoto,H.,Kodama,H.,Higashimoto,Y.,Kondo,M.,Lewis,M. S.,Anderson,C. W.,Appella,E.,and Sakaguchi,K.

    International Journal of Peptide Protein Research   48   429 - 442   1996.04

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  • Therapy of murine tumors with p53 wild type and mutant sequence peptide-based vaccines Reviewed

    Mayordomo,J. I.,Loftus,D. J.,Sakamoto,H.,Lotze,M. T.,Storkus,W. J.,Appella,E.,and DeLeo,A. B.

    Journal of Experimental Medicine   183   1357 - 1365   1996.04

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  • Conformational changes induced in protein tyrosine kinase p72syk by tyrosine phosphorylation or by binding of phosphorylated ITAM peptides Reviewed

    Kimura,T.,Sakamoto,H.,Appella,E.,and Siraganian,R. P.

    Molecular and Cellular Biology   16   1471 - 1478   1996.04

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  • Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor Reviewed

    Kimura,T.,Kihara,H.,Bhattacharyya,S.,Sakamoto,H.,Appella,E.,and Siraganian,R. P.

    Journal of Biological Chemistry   271   27962 - 27968   1996.04

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  • Chymotripsin inhibitory conformation induced by ammino acid side chain-side chain intramolexular CH/pi interaction Reviewed

    Shimohigashi,Y.,Maeda,I.,Nose,T.,Ikesue,K.,Sakamoto,H.,Ogawa,T.,Ide,Y.,Kawahara,M.,Nezu,T.,Terada,Y.,Kawano,K.,and Ohno,M.

    Journal of Chemical Society: Perkin Transactions 1   20   2479 - 2485   1996.04

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  • The oligomerization domain of p53: Crystal structure of the trigonal form Reviewed

    Miller,M.,Lubkowski,J.,Rao,J. K. M.,Danishefsky,A. T.,Omichinski,J. G.,Sakaguchi,K.,Sakamoto,H.,Appella,E.,Gronenborn,A. M.,and Clore,G. M.

    FEBS letters   399   166 - 170   1996.04

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  • Interhelical angles in the solution structure of the oligomerization domain of p53: Correction Reviewed

    Clore,G. M.,Omichinski,J. G.,Sakaguchi,K.,Zambrano,N.,Sakamoto,H.,Appella,E.,and Gronenborn,A. M.

    Science   267   1515 - 1516   1995.04

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  • Prominent roles of secondary anchor residues in peptide binding to HLA-A24 human class I molecules Reviewed

    Kondo,A.,Sidney,J.,Southwood,S.,del Guercio,M-F.,Appella,E.,Sakamoto,H.,Celis,E.,Grey,H. M.,Chesnut,R. W.,Kubo,R. T.,and Sette,A.

    Journal of Immunology   155   4307 - 4312   1995.04

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  • Four p53 DNA binding domain peptides bind natural p53 response elements and bend the DNA Reviewed

    Balagurumoorthy,P.,Sakamoto,H.,Lewis,M. S.,Zambrano,N.,Clore,G. M.,Gronenborn,A. M.,Appella,E.,and Harrington,R. E.

    Proceedings of the National Academy of Sciences of the United States of America   92   8591 - 8595   1995.04

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  • Specific sequences from the carboxy terminus of human p53 gene product form anti-parallel teramers in solution Reviewed

    Sakamoto,H.,Lewis,M. S.,Kodama,H.,Appella,E.,and Sakaguchi,K.

    Proceedings of the National Academy of Sciences of the United States of America   91   8974 - 8978   1994.04

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  • Interaction between cytochrome P450 2B1 and cytochrome b5: Inhibition by synthetic peptides indicates a role for P450 residues Lys-122 and Arg-125 Reviewed

    Omata,Y.,Sakamoto,H.,Robinson,R. C.,Pincus,M. R.,and Friedman,F. K.

    Biochemical and Biophysical Research Communications   210   428 - 433   1994.04

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  • High-resolution structure of the oligomerization domain of p53 by multidimensional NMR Reviewed

    Clore,G. M.,Omichinski,J. G.,Sakaguchi,K.,Zambrano,N.,Sakamoto,H.,Appella,E.,and Gronenborn,A. M.

    Science   265   386 - 391   1994.04

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  • Chymotrypsin inhibitory conformation of dipeptides constructed by side chain- side chain hydrophobic interactions Reviewed

    Sakamoto,H.,Shimohigashi,Y.,Maeda,I.,Nakashima,K.,Nakamura,I.,Ogawa,T.,Kawano,K.,and Ohno,M.

    Journal of Molecular Recognition   6   95 - 100   1993.04

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  • Interaction of gramicidin S by acylation of two ornithine residues with higher fatty acids Reviewed

    Shimohigashi,Y.,Ono,S.,Sakamoto,H.,Yoshitomi,H.,Waki,M.,and Ohno,M.

    Chemistry Letters   1993   671 - 672   1993.04

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  • Water soluble chymotrypsin specific inhibitors containing arginine Reviewed

    Maeda,I.,Shimohigashi,Y.,Nakamura,I.,Sakamoto,H.,Kawano,K.,and Ohno,M.

    Biochemical and Biophysical Research Communications   193   428 - 433   1993.04

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  • Discriminative affinity labelling of opioid receptors by enkephalin and morphiceptin analogs containing Npys-activated thiol residues Reviewed

    Shimohigashi,Y.,Takada,K.,Sakamoto,H.,Matsumoto,H.,Yasunaga,T.,Kondo,M.,and Ohno,M.

    Journal of Chromatography A   597   425 - 428   1992.04

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  • Receptor interactions of synthetic morphiceptin analogs containing phenylalanine homologs in position 4 Reviewed

    Sakaguchi,K.,Costa,T.,Sakamoto,H.,and Shimohigashi,Y.

    Bulletin of the Chemical Society of Japan   65   1052 - 1056   1992.04

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  • Dipeptide side chain-side chain hydrophobic interactions as conformational core for chymotrypsin inhibition. Reviewed

    Sakamoto,H.,Shimohigashi,Y.,Ogawa,T.,Kawano,K.,and Ohno,M.

    Bulletin of the Chemical Society of Japan   64   2519 - 2523   1991.04

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  • Opioid activities of morphiceptin-like peptide latent in various natural proteins Reviewed

    Shimohigashi,Y.,Sakaguchi,K.,Sakamoto,H.,Waki,M.,and Costa,T.

    Peptide Research   3   216 - 223   1990.04

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  • Specific inhibitory conformation of peptides for chymotrypsin Reviewed

    Shimohigashi,Y.,Ogawa,T.,Kodama,H.,Sakamoto,H.,Yoshitomi,H.,Waki,M.,and Ohno,M.

    Biochemical and Biophysical Research Communications   166   1460 - 1466   1990.04

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  • Opioid activities of morphiceptin analogs derived from beta-casein Reviewed

    Sakaguchi,K.,Sakamoto,H.,Tsubaki,Y.,Waki,M.,Costa,T.,and Shimohigashi,Y.

    Bulletin of the Chemical Society of Japan   63   1753 - 1757   1990.04

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▼display all

Conference Prsentations (Oral, Poster)

  • カベオリン-1によるヘムオキシゲナーゼ-2の酵素活性の競合阻害および超遠心分析による複合体形成の解析

    武本美沙希, 平順一, 東元祐一郎, 坂本寛

    蛋白質と酵素の構造と機能に関する九州シンポジウム 

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    Event date: 2019.09.05 - 2019.09.07   Language:Japanese  

  • 細胞内遊離ヘムの検出濃度レンジ拡大に向けたヘムバイオプローブの親和性の改変

    長濱和樹, 中島音海, 平順一, 小松英幸, 坂本寛

    蛋白質と酵素の構造と機能に関する九州シンポジウム 

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    Event date: 2019.09.05 - 2019.09.07   Language:Japanese  

  • 分析用超遠心を用いたヘムオキシゲナーゼ2とカベオリン1の細胞内領域の複合体形成の親和性解析

    武本美沙希, 平順一, 東元祐一郎, 坂本寛

    2019年度 日本生化学会九州支部例会  日本生化学会九州支部

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    Event date: 2019.06.08 - 2019.06.09   Language:Japanese  

  • Precise characterization of heme-binding thermodynamics of heme oxyganase by displacement isothermal calorimetry

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    Event date: 2012.12.14 - 2012.12.16   Language:Japanese  

  • Study of Interaction between Heme Oxygenase-2 and NADPH-Cytochrome P450 Reductase Using Surface Plasmon Resonance

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    Event date: 2012.12.14 - 2012.12.16   Language:Japanese  

  • ヘムオキシゲナーゼ-2由来HRMペプチドのPro残基における機能解析

    鶴澤怜也, 古賀真也, 東元祐一郎, 野口正人, 坂本寛

    第49回ペプチド討論会  日本ペプチド学会

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    Event date: 2012.11.07 - 2012.11.09   Language:Japanese  

  • 蛍光共鳴エネルギー移動によるヘムオキシゲナーゼ-1とシトクロムP450還元酵素間の親和性解析

    藤井涼, 古賀真也, 山崎一樹, 東元祐一郎, 野口正人, 小松英幸, 坂本寛

    第49回化学関連支部合同九州大会 

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    Event date: 2012.06.30   Language:Japanese  

  • ヘム定量に用いるセンサー蛋白質における蛍光色素の選定および導入箇所の検討

    坂東大輝, 古賀真也, 山崎一樹, 東元祐一郎, 野口正人, 小松英幸, 坂本寛

    第49回化学関連支部合同九州大会 

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    Event date: 2012.06.30   Language:Japanese  

  • 表面プラズモン共鳴法を用いたヘムオキシゲナーゼ-2変異体とシトクロームP450還元酵素との相互作用解析

    和田翔太,福嶋祐也,東元祐一郎,野口正人,末田慎二,小松英幸,坂本寛

    平成24年度日本生化学会九州支部例会 

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    Event date: 2012.05.26 - 2012.05.27   Language:Japanese  

  • ヘムオキシゲナーゼ-1とヘムとの結合における静電的相互作用の熱力学的解析

    山本真平, 奥田真孝, 山下耕平, 東元祐一郎, 野口正人, 小松英幸, 坂本寛

    平成24年度日本生化学会九州支部例会 

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    Event date: 2012.05.26 - 2012.05.27   Language:Japanese  

  • Development of enzyme-based sensor for free heme

    Hiroshi Sakamoto

    14th Peptide Forum 

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    Event date: 2011.12.06   Language:English  

  • ヘムオキシゲナーゼ-1 とヘムの結合の熱力学的解析静電相互作用と配位結合

    奥田真孝

    2011日本生物物理学会九州支部例会 

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    Event date: 2011.12.04   Language:Japanese  

  • 電子顕微鏡画像に基づいた制限付き分子動力学法を利用した、 シトクロムP450還元酵素・ヘムオキシゲナーゼ-1複合体の原子モデル構築

    山下理沙

    2011日本生物物理学会九州支部例会 

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    Event date: 2011.12.04   Language:Japanese  

  • Role of proline in heme regulatory motifs of heme oxygenase-2

    R. Tsurusawa

    第48回ペプチド討論会 

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    Event date: 2011.09.27 - 2011.09.29   Language:English  

  • ヘムオキシゲナーゼ-2とシトクロムP450還元酵素の相互作用の検討

    福嶋祐也

    第84回日本生化学会大会 

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    Event date: 2011.09.21 - 2011.09.24   Language:Japanese  

  • ナノメータ分解の3次元電子顕微鏡マップからのシトクロムP450還元酵素・ヘムオキシゲナーゼ-1複合体の原子モデル構築

    山下理沙

    第84回日本生化学会大会 

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    Event date: 2011.09.21 - 2011.09.24   Language:Japanese  

  • ヘムオキシゲナーゼ-2のヘム調節モチーフの合成と機能解析

    鶴澤怜也

    第48回化学関連支部合同九州大会 

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    Event date: 2011.07.09   Language:Japanese  

  • ヘムオキシゲナーゼ-1・NADPH-シトクロムP450還元酵素複合体の電子顕微鏡3次元増からの原子モデル構築

    山下理沙

    平成23年度日本生化学会九州支部例会  日本生化学会九州支部

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    Event date: 2011.05.21 - 2011.05.22   Language:Japanese  

  • ヘムオキシゲナーゼ-1のヘム結合における静電的相互作用の熱量解析

    奥田真孝

    平成23年度日本生化学会九州支部例会  日本生化学会九州支部

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    Event date: 2011.05.21 - 2011.05.22   Language:Japanese  

  • ヘム分解活性をもたないバイオヘムセンサーの設計と開発

    義原俊

    平成23年度日本生化学会九州支部例会  日本生化学会九州支部

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    Event date: 2011.05.21 - 2011.05.22   Language:Japanese  

  • バイオヘムセンサーを用いたヘムタンパク質の新規スクリーニング定量法の提案

    情報科学専攻 古賀真也

    BMB2010第33回日本分子生物学会年会第83回日本生化学会大会合同大会 

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    Event date: 2010.12.07 - 2010.12.10   Language:Japanese  

  • Sensitive heme sensor using fluorescent-labeled heme oxygenase-1

    情報科学専攻 古賀真也

    5th International Peptide Symposium inconjunction with 47th Japanese Peptide Symposium 

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    Event date: 2010.12.04 - 2010.12.09   Language:Japanese  

  • 蛍光検出型バイオセンサーを用いたヘムの新規定量法の開発

    情報科学専攻 古賀真也

    第34回蛋白質と酵素の構造と機能に関する九州シンポジウム 

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    Event date: 2010.09.09 - 2010.09.11   Language:Japanese  

  • 蛍光ラベル化HO-1を用いたヘムセンサーにおける蛍光導入箇所の検討

    情報科学専攻 山崎一樹

    平成22年度日本生化学会九州支部例会 プログラム講演要旨集 

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    Event date: 2010.05.22 - 2010.05.23   Language:Japanese  

  • ヘムオキシゲナーゼ-2とシトクロムP450還元酵素の結合様式の検討

    情報科学専攻 福嶋祐也

    平成22年度日本生化学会九州支部例会 プログラム講演要旨集 

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    Event date: 2010.05.22 - 2010.05.23   Language:Japanese  

  • 微量ヘム定量法に向けたバイオセンサーの開発

    情報科学専攻 古賀真也

    第82回日本生化学会大会プログラム・講演要旨集CD 

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    Event date: 2009.10.21 - 2009.10.24   Language:Japanese  

  • ラットヘムオキシゲナーゼ-1と基質ヘムとの結合における誘導適合モデルのカロリメトリー解析

    情報科学専攻 岩崎浩之

    第82回日本生化学会大会プログラム・講演要旨集CD 

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    Event date: 2009.10.21 - 2009.10.24   Language:Japanese  

  • ヘムオキシゲナーゼ-2とシトクロムP450還元酵素との相互作用におけるヘムとNADP(H)の影響

    情報科学専攻 吉永篤史

    第82回日本生化学会大会プログラム・講演要旨集CD 

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    Event date: 2009.10.21 - 2009.10.24   Language:Japanese  

  • ヘム分解酵素ヘムオキシゲナーゼのヘム結合解析とヘムセンサーとしての応用

    本人

    第58回高分子討論会予稿集 

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    Event date: 2009.09.16 - 2009.09.18   Language:Japanese  

  • α-ベルドヘム-ヘムオキシゲナーゼ-1複合体の結晶構造

    久留米大学 佐藤秀明

    平成21年度日本生化学会九州支部例会プログラム講演要旨集 

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    Event date: 2009.05.16 - 2009.05.17   Language:Japanese  

  • 新規ヘム定量法に向けたバイオヘムセンサーの開発

    情報科学専攻 古賀真也

    平成21年度日本生化学会九州支部例会プログラム講演要旨集 

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    Event date: 2009.05.16 - 2009.05.17   Language:Japanese  

  • 等温滴定カロリメトリーによるラットヘムオキシゲナーゼ-1の基質結合における誘導適合モデルの検討

    情報科学専攻 岩崎浩之

    平成21年度日本生化学会九州支部例会プログラム講演要旨集 

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    Event date: 2009.05.16 - 2009.05.17   Language:Japanese  

  • 表面プラズモン共鳴法によるヘムオキシゲナーゼ-2とシトクロムP450還元酵素の相互作用解析

    本人

    平成21年度日本生化学会九州支部例会プログラム講演要旨集 

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    Event date: 2009.05.16 - 2009.05.17   Language:Japanese  

  • CO配位型ベルドヘム-ヘムオキシゲナーゼ複合体のオキサポルフィリン環の還元

    久留米大学 佐藤秀明

    第31回日本分子生物学会・第81回日本生化学大会合同大会(BMB2008)講演要旨集 

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    Event date: 2008.12.09 - 2008.12.12   Language:Japanese  

  • ラットHeme Oxygenase-1のヘム結合の熱力学的特性にイオン強度変化が及ぼす影響

    情報科学専攻 岩崎浩之

    第31回日本分子生物学会・第81回日本生化学大会合同大会(BMB2008)講演要旨集 

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    Event date: 2008.12.09 - 2008.12.12   Language:Japanese  

  • ラットヘムオキシゲナーゼ-2由来HRMペプチドのヘム相互作用

    情報科学専攻 中島正太

    第31回日本分子生物学会・第81回日本生化学大会合同大会(BMB2008)講演要旨集 

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    Event date: 2008.12.09 - 2008.12.12   Language:Japanese  

  • Crystal structure of rat verdoheme-heme oxygenase-1 complex

    久留米大学 杉島正一

    第31回日本分子生物学会・第81回日本生化学大会合同大会(BMB2008)講演要旨集 

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    Event date: 2008.12.09 - 2008.12.12   Language:Japanese  

  • ヘムオキシゲナーゼ-1を応用した新型バイオヘムセンサーの開発

    情報科学専攻 古賀真也

    第31回日本分子生物学会・第81回日本生化学大会合同大会(BMB2008)講演要旨集 

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    Event date: 2008.12.09 - 2008.12.12   Language:Japanese  

  • 質量分析法によるヘムオキシゲナーゼとNADPH-シトクロムP450還元酵素、ビリベルジン還元酵素との相互作用

    久留米大学 東元祐一郎

    第31回日本分子生物学会・第81回日本生化学大会合同大会(BMB2008)講演要旨集 

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    Event date: 2008.12.09 - 2008.12.12   Language:Japanese  

  • Heme binding analysis of heme regulatory motifs of rat heme oxygenase-2

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    Event date: 2008.11.04 - 2008.11.06   Language:English  

  • unctional analysis of heme regulatory motifs of rat heme oxygenase-2

    Shota Nakashima

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    Event date: 2008.10.29 - 2008.10.31   Language:English  

  • Surface plasmon resonance and mass spectrometric analysis of protein interaction in heme catabolism

    MPSA2008 (17th Meeting of Methods in Protein Structure Analysis) Chemical and Structural Proteomics: The Solution to Biological Problems! 

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    Event date: 2008.08.26 - 2008.08.29   Language:English  

  • 質量分析法によるヘムオキシゲナーゼとNADPH-シトクロムP450還元酵素,ビリベルジン還元酵素との相互作用解析

    平成20年度日本生化学会九州支部例会 プログラム・講演要旨集 

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    Event date: 2008.05.17 - 2008.05.18   Language:Japanese  

  • ラット由来ヘムオキシゲナーゼ-2が持つヘム調節モチーフの機能解析

    中島正太

    平成20年度日本生化学会九州支部例会 プログラム・講演要旨集 

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    Event date: 2008.05.17 - 2008.05.18   Language:Japanese  

  • ラットHeme oxygenase-1のヘム結合の熱力学的特性に与えるイオン強度変化の影響

    大村昇

    平成20年度日本生化学会九州支部例会 プログラム・講演要旨集 

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    Event date: 2008.05.17 - 2008.05.18   Language:Japanese  

  • 蛍光ラベル化Heme oxygenase-1を利用したヘムセンサーの開発

    鈴居詠之郎

    平成20年度日本生化学会九州支部例会 プログラム・講演要旨集 

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    Event date: 2008.05.17 - 2008.05.18   Language:Japanese  

  • ヒトHeme oxygenase-1遺伝子のSNPsによるアミノ酸置換が酵素機能に与える影響

    堤 由佳

    平成20年度日本生化学会九州支部例会 プログラム・講演要旨集 

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    Event date: 2008.05.17 - 2008.05.18   Language:Japanese  

  • ヘムオキシゲナーゼのヘム結合能の解析とヘムセンサーへの応用

    本人

    第10回生命化学研究会シンポジウム・熊本(2008) 

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    Event date: 2008.01.11   Language:Japanese  

  • クライオ電子顕微鏡法によるヘムオキシゲナーゼ-1・シトクロムP450還元酵素複合体の結合様式の解明

    第45回日本生物物理学会年会要旨集 

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    Event date: 2007.12.21 - 2007.12.22   Language:Japanese  

  • ラットヘムオキシゲナーゼ-2のヘム調節モチーフ含有ペプチドとの相互作用

    中島正太

    BMB2007(第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会) 

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    Event date: 2007.12.11 - 2007.12.15   Language:Japanese  

  • Electrochemical reduction of ferrous alpha-verdoheme-rat heme oxygenase-1 complex

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    Event date: 2007.12.11 - 2007.12.15   Language:English  

  • ラットヘムオキシゲナーゼ-1によるヘム結合のカロリメトリー解析

    大村昇

    BMB2007(第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会) 

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    Event date: 2007.12.11 - 2007.12.15   Language:Japanese  

  • ヒトheme oxygenase-1のヘム分解活性および立体構造に対するアミノ酸置換をともなうSNPsの影響

    堤 由佳

    BMB2007(第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会) 

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    Event date: 2007.12.11 - 2007.12.15   Language:Japanese  

  • Interaction between heme and synthetic peptides containing heme regulatory motifs of rat heme oxygenase-2

    Shota Nakashima

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    Event date: 2007.11.07 - 2007.11.09   Language:English  

  • ヘム分解酵素ヘムオキシゲナーゼの構造・反応・相互作用

    本人

    第31回蛋白質と酵素の構造と機能に関する九州シンポジウム 

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    Event date: 2007.09.20 - 2007.09.22   Language:Japanese  

  • ヒトheme oxygenase-1遺伝子のSNPsによるアミノ酸置換がヘム分解活性と立体構造に与える影響

    堤 由佳

    平成19年度日本生化学会九州支部例会 

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    Event date: 2007.05.19 - 2007.05.20   Language:Japanese  

  • ラットヘムオキシゲナーゼ-2のヘム調節モチーフの合成とヘムとの相互作用

    中島正太

    平成19年度日本生化学会九州支部例会 プログラム・講演要旨集 

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    Event date: 2007.05.19 - 2007.05.20   Language:Japanese  

  • イミダゾール-ジオキソレン化合物によるヘムオキシゲナーゼの阻害機構

    久留米大・医 杉島正一

    平成19年度日本生化学会九州支部例会 

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    Event date: 2007.05.19 - 2007.05.20   Language:Japanese  

  • ベルドヘム-ヘムオキシゲナーゼ複合体の電気化学的還元

    久留米大医 佐藤秀明

    平成19年度日本生化学会九州支部例会 

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    Event date: 2007.05.19 - 2007.05.20   Language:Japanese  

  • クライオ電子顕微鏡法によるヘムオキシゲナーゼ-1・シトクロムP450還元酵素複合体の結合様式の解明

    中尾亮太

    平成19年度日本生化学会九州支部例会 

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    Event date: 2007.05.19 - 2007.05.20   Language:Japanese  

  • ラットヘムオキシゲナーゼ-1によるヘム結合の熱測定

    大村昇

    平成19年度日本生化学会九州支部例会 

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    Event date: 2007.05.19 - 2007.05.20   Language:Japanese  

  • Kinetic Analysis of Conversion of alpha-Hydroxyheme to Verdoheme in Heme Oxygenase

    20th IUBMB International Congress of Biochemistry and Molecular Biology 

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    Event date: 2006.06.18 - 2006.06.23   Language:English  

  • Degradation of Ferriprotoporphyrin IX Dimethyl Ester by Rat Heme Oxygenase-1

    20th IUBMB International Congress of Biochemistry and Molecular Biology 

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    Event date: 2006.06.18 - 2006.06.23   Language:English  

  • ヘムオキシゲナーゼ反応第2中間ステップのストップト・フロー解析

    本人

    平成18年度日本生化学会九州支部例会 

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    Event date: 2006.05.20 - 2006.05.21   Language:Japanese  

  • FMN欠失NADPHシトクロムP450還元酵素を用いたヘムオキシゲナーゼ反応における電子授受機構の検討

    平成18年度日本生化学会九州支部例会 

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    Event date: 2006.05.20   Language:Japanese  

  • Kinetic study of the conversion of alpha-hydroxyheme to verdoheme while bound to heme oxygenase-1

    The 14th Takeda Science Foundation Symposium on BioscienceThe 50th Anniversary of OxygenasesAdvances and Reflections 

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    Event date: 2006.04.10 - 2006.04.12   Language:English  

  • NADP(H) enhances the interaction between heme oxygenase-1 and cytochrome P450 reductase

    International symposium on regulation of protein function through post-translational modifications: new technologies and application to biomedical systems 

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    Event date: 2006.03.16 - 2006.03.17   Language:English  

  • NADP(H)-mediated association of heme oxygenase-1 with cytochrome P450 reductase

    2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) 

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    Event date: 2005.12.15 - 2005.12.20   Language:English  

  • Involvement of NADP(H) in the interaction between heme oxygenase-1 and cytochrome P450 reductase.

    Y. Higashimoto

    HO conference 2005, The 4th International Congress 

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    Event date: 2005.10.06 - 2005.10.09   Language:English  

  • Binding study of heme oxygenase with NADPH-cytochrome P450 reductase by surface plasmon resonance measurement

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    Event date: 2004.10.13 - 2004.10.16   Language:English  

  • Amino acid residues crucial for uroporphyrinogen III synthase activity

    生化学(第77回日本生化学会) 

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    Event date: 2004.10.13 - 2004.10.16   Language:Japanese  

  • Characterization of rat heme oxygenase-3 gene

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    Event date: 2004.10.12 - 2004.10.16   Language:English  

  • ヘムヘムオキシゲナーゼ-1複合体へのヒドロキシルアミンの結合

    第54回錯体化学討論会講演要旨集 

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    Event date: 2004.09.23 - 2004.09.25   Language:Japanese  

  • NADP(H)-mediated association of the heme oxygenase with NADPH-cytochrome P450 reductase

    Protein Science (The 18th Symposium of the Protein Society) 

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    Event date: 2004.08.14 - 2004.08.18   Language:English  

  • 表面プラズモン共鳴法によるヘムオキシゲナーゼとNADPH-シトクロムP450還元酵素との相互作用の検討

    生化学(平成16年度日本生化学会九州支部例会) 

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    Event date: 2004.05.29 - 2004.05.30   Language:Japanese  

  • Structural basis for discrimination between CO and O2 in heme oxygenase

    The 1st Pacific-Rim International Conference on Protein Science 

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    Event date: 2004.04.14 - 2004.04.18   Language:English  

  • Crystal structure of rat heme oxygenase-1 in complex with biliverdin-iron chelate - implications for product release.

    The 1st Pacific-Rim International Conference on Protein Science 

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    Event date: 2004.04.14 - 2004.04.18   Language:English  

  • Binding study of heme oxygenase with NADPH-cytochrome P450 reductase by surface plasmon resonance measurements

    The 1st Pacific-Rim International Conference on Protein Science 

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    Event date: 2004.04.14 - 2004.04.18   Language:English  

  • Crystal structure of ferrous and CO-, CN--, and NO-bound forms of rat heme oxygenase(HO): implications for discrimination between CO and O2 in HO

    The First International Symposium on Biomolecular Chemistry(ISBC 2003) 

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    Event date: 2003.12.02 - 2003.12.05   Language:English  

  • Crystal structure of rat heme oxygenase-1 in complex with biliverdin-iron chelate

    Heme Oxygenase: Regulation, Function and Clinical Application 

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    Event date: 2003.09 - 2003.10.03   Language:English  

  • Amino acid residues involved in the activity of uroporphyrinogen III synthase

    The 1st Pacific-Rim International Conference on Protein Science 

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    Event date: 2003.04.14 - 2003.04.18   Language:English  

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Industrial Property

  • 金属プロトポルフィリン錯体の定量方法およびそれに用いる酵素センサー

    坂本寛,古賀真也,小松英幸

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    Application no:2009-129822  Date applied:2009.05.29

    Patent/Registration no:05761660  Date registered:2015.06.19 

Lectures

  • e ポートフォリオによる学修成果の可視化の事例報告

    大学 e ラーニング協議会 / 日本リメディアル教育学会 合同フォーラム 2019  2020.03  大学eラーニング協議会

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    Event date: 2020.03.09   Language:Japanese   Presentation type:Special lecture  

  • eポートフォリオによる学修成果の可視化ー教育の質保証と産学連携を基礎とした人材育成を目指してー

    大学教育再生加速プログラム(AP)成果報告会  2019.11  公立千歳科学技術大学

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    Language:Japanese   Presentation type:Keynote lecture   Venue:公立千歳科学技術大学 B102講義室  

  • ヘム分解系酵素の反応機構と相互作用

    平成23年度日本生化学会九州支部例会シンポジウム「生命応答を制御するヘム結合タンパク質」  2011.05 

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    Presentation type:Invited lecture   Venue:久留米  

Grants-in-Aid for Scientific Research

  • ヘムオキシゲナーゼ反応の中間過程および電子授受機構の解明

    Grant number:21590321  2009.04 - 2012.03   基盤研究(C)

  • ヘムオキシゲナーゼによるヘム分解中間過程とCOのガス状伝達物質としての意義

    Grant number:18590278  2006.04 - 2009.03   基盤研究(C)

  • ヘムオキシゲナーゼの酵素化学的検討とヘム分解系マシーナリーへの展開

    Grant number:18550153  2006.04 - 2009.03   基盤研究(C)

  • 結晶構造に基づくヘムオキシゲナーゼによるヘム分解機構の検討

    Grant number:15590260  2003.04 - 2006.03   基盤研究(C)

  • ヘムは如何に壊れるのか-結晶構造に基づくヘムオキシゲナーゼの触媒機構の解明-

    Grant number:15550155  2003.04 - 2006.03   基盤研究(C)

  • ESR・NMR分光及び結晶構造に基づくヘムオキシゲナーゼによるヘム分解機構の検討

    Grant number:12670125  2000.04 - 2003.03   基盤研究(C)

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Award for Educational Activities

  • 学生優秀ポスター賞

    第43回蛋白質と酵素の構造と機能に関する九州シンポジウム   2019.09.07

Activities of Academic societies and Committees

  • 日本生物工学会   支部編集委員  

    2023.06 - 2025.05

  • 日本生物工学会   代議員(九州支部)  

    2023.04 - 2025.03

  • 日本生物工学会   支部編集委員  

    2021.06 - 2023.05

  • 日本生物工学会   代議員(九州支部)  

    2021.04 - 2023.03

  • 蛋白質と酵素の構造と機能に関する九州シンポジウム   第43回 実行委員長  

    2019.09

  • 日本生物工学会   九州支部 評議員  

    2017.04

  • 泉屋コロキウム   会長  

    2017.04

  • 日本生化学会   九州支部 評議員  

    2014.05

  • 日本生化学会九州支部例会   平成23年度実行委員  

    2011.05

  • 蛋白質と酵素の構造と機能に関する九州シンポジウム   第34回 実行委員長  

    2010.09

  • The Japanese Peptide Society  

    2009.11

  • The Japanese Peptide Society  

    2009.11

  • The Japanese Peptide Society  

    2009.01

  • 蛋白質と酵素の構造と機能に関する九州シンポジウム   地区世話人  

    2008.04 - 2021.04

  • The Japanese Peptide Society   PEPTIDE NEWSLETTER JAPAN editorial member  

    2008.04 - 2014.03

  • 泉屋コロキウム   組織委員  

    2007.04 - 2017.03

  • 1st Asia-Pacific Internatinal Peptide Symposium/41th Japanese Peptide Symposium  

    2004.11

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Social activity outside the university

  • 九州工業大学におけるeポートフォリオによる学修成果の可視化の取組

    Role(s):Lecturer

    岡山大学  岡山大学 令和3年度第4回大学教育リデザイン研究会  2022.03.14

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    Audience: Teachers, Researchesrs

    Type:Seminar, workshop

  • eポートフォリオによる学修成果の可視化コンソーシアム 第2回フォーラム

    Role(s):Presenter

    2023.03.22

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    Audience: Teachers, General

    Type:Lecture

  • オンライン保護者説明会

    Role(s):Lecturer

    九州工業大学 教育高度化本部 教育連携・連携PF推進本部  2022.12.27

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    Type:Lecture

  • eポートフォリオによる学修成果の可視化コンソーシアム第2回定例研究会

    Role(s):Presenter

    2022.10.27

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    Audience: Teachers

    Type:Lecture

  • eポートフォリオによる学修成果の可視化コンソーシアム第1回定例研究会

    Role(s):Presenter

    2022.08.29

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    Audience: Teachers

    Type:Lecture

  • 生命体工学研究科FD研修会「大学院生の研究計画・報告管理に伴う大学院版学修自己評価システムの構築」

    Role(s):Lecturer

    学習教育センター  令和3年度第2回生命体工学研究科FD研修会  2022.01.27

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    Audience: Teachers

    Type:Lecture

  • 情報工学府FD研修会「大学院生の研究計画・報告管理に伴う大学院生版学修自己評価システムの構築」

    Role(s):Lecturer

    2022.01.27

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    Audience: Teachers

    Type:Lecture

  • 教育フォーラム・文部科学省GPフォーラム「大学教育におけるパラダイムシフトと新機軸」「学修自己評価システムによる学修意識改革の取り組み」

    2012.03.07

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    Type:Seminar, workshop

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