Kyushu Institute of Technology   Faculty of Computer Science and Systems Engineering   Department of Bioscience and Bioinformatics   Professor  

1994.01   The Protein Society   United States

1989.04   The Japanese Peptide Society   Japan

1989.04   日本化学会   Japan

1989.04   日本生化学会   Japan

Complex Formation of Heme Oxygenase-2 with Heme Is Competitively Inhibited by the Cytosolic Domain of Caveolin-1 Reviewed International journal

Takemoto M., Sakamoto H., Higashimoto Y., Taira J.

Biochemistry   60 ( 29 )   2300 - 2308   2021.07

Conformational equilibrium of NADPH–cytochrome P450 oxidoreductase is essential for heme oxygenase reaction Reviewed International journal

Sugishima M., Taira J., Sagara T., Nakao R., Sato H., Noguchi M., Fukuyama K., Yamamoto K., Yasunaga T., Sakamoto H.

Antioxidants   9 ( 8 )   1 - 13   2020.07

Structural modification of a novel inhibitor for mycobacterium enoyl-acyl carrier protein reductase assisted by in silico structure-based drug screening Reviewed International journal

Taira J., Nagano T., Kitamura M., Yamaguchi M., Sakamoto H., Aoki S.

International Journal of Mycobacteriology   9 ( 1 )   12 - 17   2020.01

Improvement of the novel inhibitor for Mycobacterium enoyl-acyl carrier protein reductase (InhA): a structure–activity relationship study of KES4 assisted by in silico structure-based drug screening Reviewed International journal

Taira J., Umei T., Inoue K., Kitamura M., Berenger F., Sacchettini J.C., Sakamoto H., Aoki S.

Journal of Antibiotics   73 ( 6 )   372 - 381   2020.01

Dephosphorylation of clustered phosphoserine residues in human Grb14 by protein phosphatase 1 and its effect on insulin receptor complex formation Reviewed

Junichi Taira, Keisuke Yoshida, Misaki Takemoto, Kousaku Hanada, Hiroshi Sakamoto

Journal of Peptide Science ( John Wiley & Sons, Inc. )   25 ( 10 )   e3207   e3207   2019.10

Development of Rat Heme Oxygenase-1 Based Gene Encoded Heme Probe for Intracellular Heme Detection Reviewed

Junichi Taira, Otomi Nakashima, Hideyuki Komatsu, Hiroshi Sakamoto

Peptide Science 2017   156 - 157   2018.03

Development of Fluorescent Protein-Fused Heme Oxygenase-1 as Intracellular Free Heme Detecing Probe Reviewed

Otomi Nakashima,Junichi Taira, Hideyuki Komatsu, Shinji Sueda, Hiroshi Sakamoto

Peptide Science 2016   181 - 182   2017.03

Effect of Surfactants on Quantification of Heme in Biological Samples using Heme Sensor Based on Fluorescently Labeld Heme Oxygenase-1 Reviewed

Takashi Yoshimura, Yukinori Nakashima, Junichi Taira, Hideyuki Komatsu, Nohito Tanioka, Hiroki Shimizu, Hiroshi Morimatsu, Hiroshi Sakamoto

Peptide Science 2016   177 - 178   2017.03

Phosphorylation of Serine Residues in Grb14 BPS Domain Involves in the Complex Forming of Grb14 with Insulin Receptor Reviewed

Junichi Taira, Kohei Inatomi, Hideyuki Komatsu, Hiroshi Sakamoto

Peptide Science 2016   175 - 176   2017.03

Surface Plasmon Resonance Study on the Interaction between the N-terminal Region of Heme Oxygenase-2 and NADPH-Cytochrome P450 Reductase Reviewed

Junichi Taira, Shota Wada, Yuya Fukushima, Shinji Sueda, Hideyuki Komatsu, Yuichiro Higashimoto, Hiroshi Sakamoto

Peptide Science 2015   157 - 158   2016.03

Improvement of heme oxygenase-1-based heme sensor for quantifying free heme in biological sample Reviewed

489   50 - 52   2015.08

Discovery of InhA inhibitors with anti-mycobacterial activity through a matched molecular pair approach Reviewed

Hironori Kanetaka, Yuji Koseki, Junichi Taira, Tomohiro Umei, Hideyuki Komatsu, Hiroshi Sakamoto, Gulcin Gulten, James C. Sacchettini, Mitsuru Kitamura, Shunsuke Aoki

European Journal of Medicinal Chemistry   94   378 - 385   2015.04

Application of the axial iron ligand-mutant heme oxygenase for heme-binding analysis Reviewed

Hideyuki Komatsu, Shinpei Yamamoto, Masataka Okuda, Hiroshi Sakamoto

Peptide Science 2014   185 - 186   2015.04

Development of a Heme Sensor Using Fluorescently Labeled Heme Oxygenase-1 Reviewed

433 ( 1 )   2 - 9   2013.02

Sensitive heme sensor using fluorescent-labeled heme oxygenase-1 "jointly worked" Reviewed

S. Koga, Y. Higashimoto,M. Noguchi,H. Komatsu,H. Sakamoto

Peptide Science 2010   2010   270 - 270   2011.03

Reduction of oxaporphyrin ring of CO-bound -verdoheme complexed with oxygenase-1 by NADPH-cytochrome P450 reductase Reviewed

H. Sato,Y. Higashimoto,H. Sakamoto,M. Sugishima,C. Shimokawa,J. Harada,G. Palmer,M. Noguchi

Journal of Inorganic Biochemistry   105   289 - 296   2011.01

Heme Binding Analysis of Heme Regulatory Motifs of Rat Heme Oxygenase-2 Reviewed

T. Ueda,S. Koga,Y. Higashimoto,M. Noguchi,H. Sakamoto

Peptide Science 2009   2009   237 - 238   2010.02

Crystal structure of rat heme oxygenase-1 in complex with ferrous verdoheme: presence of a hydrogen bond network on the distal side Reviewed

H. Sato,M. Sugishima,H. Sakamoto,Y. Higashimoto,C. Shimokawa,K. Fukuyama,M. Noguchi

Biochemical Journal   419   339 - 345   2009.04

Functional Analysis of Heme Regulatory Motifs of Rat Heme Oxygenase-2 Reviewed

S. Nakashima,Y. Higashimoto,M. Noguchi,H. Sakamoto

Peptide Science 2008   217 - 220   2009.01

Functional Analyses of Pseudomonas putida Benzoate Transporters Expressed in the Yeast Saccharomyces cerevisiae Reviewed

Y. Nishikawa,Y. Yasumi,S. Noguchi,H. Sakamoto,J. Nikawa

Biosci. Biotechnol. Biochem.   419 ( 8 )   2034 - 2038   2008.04

Mass spectrometric identification of lysine residues of heme oxygenase-1 that are involved in its interaction with NADPH-cytochrome P450 reductase Reviewed

Y. Higashimoto,M. Sugishima,H. Sato,H. Sakamoto,K. Fukuyama,G. Palmer,M. Noguchi

Biochem. Biophys. Res. Commun.   367 ( 4 )   852 - 858   2008.03

Interaction between Heme and Synthetic Peptides Containing Heme Regulatory Motifs of Rat Heme Oxygenase-2 Reviewed

S. Nakashima,Y. Higashimoto,M. Sakamoto,H. Sakamoto

Peptide Science 2007   249 - 250   2007.12

ヘムの自己分解メカニズム－ヘム分解酵素ヘムオキシゲナーゼの触媒機構－

坂本　寛

化学と工業   60 ( 9 )   886 - 887   2007.09

Alternative cyanide-binding modes to the haem iron in haem oxygenase. Reviewed

M. Sugishima,K. Oda,T. Ogura,H. Sakamoto,M. Noguchi,K. Fukuyama

Acta. Crystallogr. Sect. F Struct. Biol. Cryst. Commun.   63   471 - 477   2007.04

Electrochemical reduction of ferrous alpha-verdoheme in complex with heme oxygenase-1. Reviewed

H. Sato,Y. Higashimoto,H. Sakamoto,M. Sugishima,K. Takahashi,G. Palmer,M. Noguchi

J Inorg Biochem.   101   1394 - 1399   2007.04

X-ray crystallographic and biochemical characterization of the inhibitory action of an imidazole-dioxolane compound on heme oxygenase. Reviewed

M. Sugishima,Y. Higashimoto,T. Oishi,H. Takahashi,H. Sakamoto,M. Noguchi,K. Fukuyama

Biochemistry   46 ( 7 )   1860 - 1867   2007.04

The reactions of heme- and verdoheme-heme oxygenase-1 complexes with FMN-depleted NADPH-cytochrome P450 reductase-electrons required for verdoheme oxidation can be transferred through a pathway not involving FMN. Reviewed

Y. Higashimoto,H. Sato,H. Sakamoto,K. Takahashi,G. Palmer,M. Noguchi

J. Biol. Chem.   281 ( 42 )   31659 - 31667   2006.04

Neuroprotective mechanisms of lidocaine against in vitro ischemic insult of the rat hippocampal CA1 pyramidal neurons Reviewed

S. Niiyama,E. Tanaka,S. Tsuji,Y. Murai,M. Satani,H. Sakamoto,K. Takahashi,M. Kuroiwa,A. Yamada,M. Noguchi,and H. Higashi.

Neuroscience Research   53   271 - 278   2005.04

A kinetic study of the mechanism of conversion of alpha-hydroxyheme to verdoheme while bound to heme oxygenase Reviewed

H. Sakamoto,K. Takahashi,Y. Higashimoto,S. Harada,G. Palmer,M. Noguchi

Biochemical and Biophysical Research Communications   338   578 - 583   2005.04

Mechanism of heme binding in HO-1 inferred from structural comparison of the apo and heme complex forms Reviewed

M. Sugishima,H. Sakamoto,Y. Kakuta,Y. Omata,M. Noguchi,and K. Fukuyama

Biochemistry   41   7293 - 7300   2005.04

Involvement of NADP(H) in the interaction between heme oxygenase-1 and cytochrome P450 reductase Reviewed

Y. Higashimoto,H. Sakamoto,S. Hayashi,M. Sugishima,K. Fukuyama,G. Palmer,M. Noguchi

Journal of Biological Chemistry   280   729 - 737   2005.04

ヘムオキシゲナーゼの立体構造からみた反応機構

坂本寛,杉島正一,東元祐一郎,福山恵一,野口正人

生化学   77 ( 7 )   634 - 638   2005.04

Hydroxylamine and hydrazine bind directly to the heme iron of the heme-heme oxygenase-1 complex Reviewed

H. Sakamoto,Y. Higashimoto,S. Hayashi,M. Sugishima,K. Fukuyama,G. Palmer,and M. Noguchi

Journal Inorganic Biochemistry   98   1223 - 1228   2004.04

Characterization of rat heme oxygenase-3 gene. Implication of processed pseudogenes derived from heme oxygenase-2 Reviewed

S. Hayashi,Y. Omata,H. Sakamoto,Y. Higashimoto,T. Hara,Y. ara,and M. Noguchi

GENE   256   311 - 317   2004.04

CO-trapping site in heme oxygenase revealed by photolysis of its CO-bound heme complex: mechanism of escaping from product inhibition Reviewed

M. Sugishima,H. Sakamoto,M. Noguchi,K. Fukuyama

Journal of Molecular Biology   341   7 - 13   2004.04

Purification and characterization of human uroporphyrinogen III synthase expressed in Escherichia Coli Reviewed

Y. Omata,H. Sakamoto,Y. Higashimoto,M. Satani,S. Hayashi,and M. Noguchi

Journal of Biochemistry (Tokyo)   136   211 - 220   2004.04

Crystal structures of ferrous and CO-, CN--, and NO-bound forms of rat heme oxygenase (HO): implications for discrimination between CO and O2 in HO Reviewed

H. Sakamoto,M. Sugishima,K. Fukuyama,M. Noguchi

Biomolecular Chemistry -A Bridge for the Future- (Proceedings of the Fist International Symposium on Biomolecular Chemistry 2003)   196 - 197   2003.12

Expression and characterization of human bifunctional peptidylglycine alpha-amidating monooxygenase Reviewed

M. Satani,K. Takahashi,H. Sakamoto,S. Harada,Y. Kaida,and M. Noguchi

Protein Expression and Purification   28   293 - 302   2003.04

Purification and characterization of a soluble form of rat liver NADPH-cytochrome P450 reductase highly expressed in Escherichia coli Reviewed

S. Hayashi,Y. Omata,H. Sakamoto,T. Hara,and M. Noguchi

Protein Expression and Purification   29   1 - 7   2003.04

Crystal structure of rat heme oxygenase-1 in complex with biliverdin-iron chelate Reviewed

M. Sugishima,H. Sakamoto,Y. Higashimoto,M. Noguchi,and K. Fukuyama

Journal of Biological Chemistry   278   32352 - 32358   2003.04

Crystal structures of ferrous and CO-, CN--, and NO-bound forms of rat heme oxygenase-1 (HO-1) in complex with heme: structural implications for discrimination between CO and O2 in HO-1 Reviewed

M. Sugishima,H. Sakamoto,M. Noguchi,and K. Fukuyama

Biochemistry   42   9898 - 9905   2003.04

Crystal structure of rat heme oxygenase-1 in complex with heme bound to azide: Implication for regiospecific hydroxylation of heme at the alpha-meso carbon Reviewed

M. Sugishima,H. Sakamoto,Y. Higashimoto,Y. Omata,S. Hayashi,M. Noguchi,and K. Fukuyama

Journal of Biological Chemistry   277   45086 - 45090   2002.04

The reactivity of alpha-hydroxyheme and verdoheme bound to haem oxygenase-1 to dioxygen and sodium dithionite Reviewed

H. Sakamoto,Y. Omata,S. Hayashi,S. Harada,G. Palmer,and M. Noguchi

European Journal of Biochemistry   269   5231 - 5239   2002.04

Crystal structure of rat heme oxygenase-1 in complex with heme Reviewed

M. Sugishima,Y. Omata,Y. Kakuta,H. Sakamoto,M. Noguchi,and K. Fukuyama

FEBS letters   471   61 - 66   2002.04

Structure and reaction mechanism of heme oxygenase-1 Reviewed

H. Sakamoto,M. Sugishima,Y. Omata,Y. Kakuta,K. Fukuyama,G. Palmer,M. Noguchi

177 - 183   2002.04

Separation and identification of the regioisomers of verdoheme by reversed- phase ion-pair high-performance liquid chromatography, and characterization of their complexes with heme oxygenase Reviewed

H. Sakamoto,Y. Omata,Y. Adachi,G. Palmer,and M. Noguchi

Journal of Inorganic Biochemistry   82   113 - 121   2000.04

Study on the packing geometry, stoichiometery, and membrane interaction of three analogs related to a pore-forming small globular protein Reviewed

E. Matsumoto,T. Kiyota,S. Lee,G. Sugihara,S. Yamashita,H. Meno,Y. Aso,H. Sakamoto,and H. M. Ellerby

Biopolymers   56   96 - 108   2000.04

Ferric alpha-hydroxyheme bound to heme oxygenase can be converted to verdoheme by dioxygen in the absence of added reducing equivalents Reviewed

H. Sakamoto,Y. Omata,G. Palmer,and M. Noguchi

Journal of Biological Chemistry   274   18196 - 18200   1999.04

Colocalization of heparin and receptor binding sites on keratinocyte growth factor Reviewed

Kim,P. J.,Sakaguchi,K.,Sakamoto,H.,Saxinger,C.,Day,R.,McPhie,P.,Rubin,J.,and Bottaro,D. P.

Biochemistry   37   8853 - 8862   1998.04

Crystallization and preliminary X-ray diffraction studies on the water-soluble form of rat heme oxygenase-1 in complex with heme Reviewed

Y. Omata,S. Asada,H. Sakamoto,K. Fukuyama,and M. Noguchi

Acta Crystallography Section D   54   1017 - 1019   1998.04

Architectural accommodation in the complex of four p53 DNA binding domain peptides with the p21/waf1/cip1 DNA response element Reviewed

Sakaguchi,K.,Sakamoto,H.,Xie,D,Erickson,Lewis,M. S.,Anderson,C.W.,and Appella,E.

Journal of Protein Chemistry   16   553 - 556   1997.04

Phosphorylation of Serine 392 stabilizes the tetramer formation of tumor suppressor protein p53 Reviewed

Sakaguchi,K.,Sakamoto,H.,Lewis,M. S.,Anderson,C. W.,Erickson,J. W.,Appella,E.,and Xie,D.

Biochemistry   36   10117 - 10124   1997.04

Architectural accommodation in the complex of four p53 DNA binding domain peptides with the p21/waf1/cip1 DNA response element Reviewed

Nagaich,A. K.,Zhurkin,V. B.,Sakamoto,H.,Gorin,A. A.,Clore,G. M.,Gronenborn,A. M.,Appella,E.,and Harrington,R. E.

Journal of Biological Chemistry   272   14830 - 14841   1997.04

The negative signaling molecule SH2 domain- containing inositol-phosphate 5-phosphatase (SHIP) binds to the tyrosine- phosphorylated beta subunit of the high affinity IgE receptor Reviewed

Kimura,T.,Sakamoto,H.,Appella,E.,and Siraganian,R. P.

Journal of Biological Chemistry   272   13991 - 13996   1997.04

Two distinct HLA- A*0101-specific submotifs illustrate alternative peptide binding modes Reviewed

Kondo,A.,Sidney,J.,Southwood,S.,del Guercio,M. F.,Appella,E.,Sakamoto,H.,Grey,H. M.,Celis,E.,Chesnut,R.W.,Kubo,R. T.,and Sette,A.

Immunogenetics   45   249 - 258   1997.04

Synthesis of oligomerization domain of p53 and its analogs and their association properties in buffer solution Reviewed

Miyabe,M.,Lee,S.,Sugihara,G.,Sakamoto,H.,Meno,K.,Aso,Y.,and Sakaguchi,K

Peptide Science Present and Future: Proceeding of the 1st International Peptide Symposium   1999   367 - 369   1997.04

Therapy of murine tumors with p53 wild type and mutant sequence peptide-based vaccines Reviewed

Mayordomo,J. I.,Loftus,D. J.,Sakamoto,H.,Lotze,M. T.,Storkus,W. J.,Appella,E.,and DeLeo,A. B.

Journal of Experimental Medicine   183   1357 - 1365   1996.04

Conformational changes induced in protein tyrosine kinase p72syk by tyrosine phosphorylation or by binding of phosphorylated ITAM peptides Reviewed

Kimura,T.,Sakamoto,H.,Appella,E.,and Siraganian,R. P.

Molecular and Cellular Biology   16   1471 - 1478   1996.04

Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor Reviewed

Kimura,T.,Kihara,H.,Bhattacharyya,S.,Sakamoto,H.,Appella,E.,and Siraganian,R. P.

Journal of Biological Chemistry   271   27962 - 27968   1996.04

Chymotripsin inhibitory conformation induced by ammino acid side chain-side chain intramolexular CH/pi interaction Reviewed

Shimohigashi,Y.,Maeda,I.,Nose,T.,Ikesue,K.,Sakamoto,H.,Ogawa,T.,Ide,Y.,Kawahara,M.,Nezu,T.,Terada,Y.,Kawano,K.,and Ohno,M.

Journal of Chemical Society: Perkin Transactions 1   20   2479 - 2485   1996.04

The oligomerization domain of p53: Crystal structure of the trigonal form Reviewed

Miller,M.,Lubkowski,J.,Rao,J. K. M.,Danishefsky,A. T.,Omichinski,J. G.,Sakaguchi,K.,Sakamoto,H.,Appella,E.,Gronenborn,A. M.,and Clore,G. M.

FEBS letters   399   166 - 170   1996.04

Chemical synthesis of phosphorylated peptides of the carboxy-terminal domain of human p53 by a segment condensation method Reviewed

Sakamoto,H.,Kodama,H.,Higashimoto,Y.,Kondo,M.,Lewis,M. S.,Anderson,C. W.,Appella,E.,and Sakaguchi,K.

International Journal of Peptide Protein Research   48   429 - 442   1996.04

Prominent roles of secondary anchor residues in peptide binding to HLA-A24 human class I molecules Reviewed

Kondo,A.,Sidney,J.,Southwood,S.,del Guercio,M-F.,Appella,E.,Sakamoto,H.,Celis,E.,Grey,H. M.,Chesnut,R. W.,Kubo,R. T.,and Sette,A.

Journal of Immunology   155   4307 - 4312   1995.04

Four p53 DNA binding domain peptides bind natural p53 response elements and bend the DNA Reviewed

Balagurumoorthy,P.,Sakamoto,H.,Lewis,M. S.,Zambrano,N.,Clore,G. M.,Gronenborn,A. M.,Appella,E.,and Harrington,R. E.

Proceedings of the National Academy of Sciences of the United States of America   92   8591 - 8595   1995.04

Interhelical angles in the solution structure of the oligomerization domain of p53: Correction Reviewed

Clore,G. M.,Omichinski,J. G.,Sakaguchi,K.,Zambrano,N.,Sakamoto,H.,Appella,E.,and Gronenborn,A. M.

Science   267   1515 - 1516   1995.04

Interaction between cytochrome P450 2B1 and cytochrome b5: Inhibition by synthetic peptides indicates a role for P450 residues Lys-122 and Arg-125 Reviewed

Omata,Y.,Sakamoto,H.,Robinson,R. C.,Pincus,M. R.,and Friedman,F. K.

Biochemical and Biophysical Research Communications   210   428 - 433   1994.04

High-resolution structure of the oligomerization domain of p53 by multidimensional NMR Reviewed

Clore,G. M.,Omichinski,J. G.,Sakaguchi,K.,Zambrano,N.,Sakamoto,H.,Appella,E.,and Gronenborn,A. M.

Science   265   386 - 391   1994.04

Specific sequences from the carboxy terminus of human p53 gene product form anti-parallel teramers in solution Reviewed

Sakamoto,H.,Lewis,M. S.,Kodama,H.,Appella,E.,and Sakaguchi,K.

Proceedings of the National Academy of Sciences of the United States of America   91   8974 - 8978   1994.04

Interaction of gramicidin S by acylation of two ornithine residues with higher fatty acids Reviewed

Shimohigashi,Y.,Ono,S.,Sakamoto,H.,Yoshitomi,H.,Waki,M.,and Ohno,M.

Chemistry Letters   1993   671 - 672   1993.04

Water soluble chymotrypsin specific inhibitors containing arginine Reviewed

Maeda,I.,Shimohigashi,Y.,Nakamura,I.,Sakamoto,H.,Kawano,K.,and Ohno,M.

Biochemical and Biophysical Research Communications   193   428 - 433   1993.04

Chymotrypsin inhibitory conformation of dipeptides constructed by side chain- side chain hydrophobic interactions Reviewed

Sakamoto,H.,Shimohigashi,Y.,Maeda,I.,Nakashima,K.,Nakamura,I.,Ogawa,T.,Kawano,K.,and Ohno,M.

Journal of Molecular Recognition   6   95 - 100   1993.04

Receptor interactions of synthetic morphiceptin analogs containing phenylalanine homologs in position 4 Reviewed

Sakaguchi,K.,Costa,T.,Sakamoto,H.,and Shimohigashi,Y.

Bulletin of the Chemical Society of Japan   65   1052 - 1056   1992.04

Discriminative affinity labelling of opioid receptors by enkephalin and morphiceptin analogs containing Npys-activated thiol residues Reviewed

Shimohigashi,Y.,Takada,K.,Sakamoto,H.,Matsumoto,H.,Yasunaga,T.,Kondo,M.,and Ohno,M.

Journal of Chromatography A   597   425 - 428   1992.04

Dipeptide side chain-side chain hydrophobic interactions as conformational core for chymotrypsin inhibition. Reviewed

Sakamoto,H.,Shimohigashi,Y.,Ogawa,T.,Kawano,K.,and Ohno,M.

Bulletin of the Chemical Society of Japan   64   2519 - 2523   1991.04

Specific inhibitory conformation of peptides for chymotrypsin Reviewed

Shimohigashi,Y.,Ogawa,T.,Kodama,H.,Sakamoto,H.,Yoshitomi,H.,Waki,M.,and Ohno,M.

Biochemical and Biophysical Research Communications   166   1460 - 1466   1990.04

Opioid activities of morphiceptin analogs derived from beta-casein Reviewed

Sakaguchi,K.,Sakamoto,H.,Tsubaki,Y.,Waki,M.,Costa,T.,and Shimohigashi,Y.

Bulletin of the Chemical Society of Japan   63   1753 - 1757   1990.04

Opioid activities of morphiceptin-like peptide latent in various natural proteins Reviewed

Shimohigashi,Y.,Sakaguchi,K.,Sakamoto,H.,Waki,M.,and Costa,T.

Peptide Research   3   216 - 223   1990.04

ヘムオキシゲナーゼ-2由来HRMペプチドのPro残基における機能解析

鶴澤怜也, 古賀真也, 東元祐一郎, 野口正人, 坂本寛

第49回ペプチド討論会  日本ペプチド学会

蛍光共鳴エネルギー移動によるヘムオキシゲナーゼ-1とシトクロムP450還元酵素間の親和性解析

藤井涼, 古賀真也, 山崎一樹, 東元祐一郎, 野口正人, 小松英幸, 坂本寛

第49回化学関連支部合同九州大会 

ヘム定量に用いるセンサー蛋白質における蛍光色素の選定および導入箇所の検討

坂東大輝, 古賀真也, 山崎一樹, 東元祐一郎, 野口正人, 小松英幸, 坂本寛

第49回化学関連支部合同九州大会 

表面プラズモン共鳴法を用いたヘムオキシゲナーゼ-2変異体とシトクロームP450還元酵素との相互作用解析

和田翔太,福嶋祐也,東元祐一郎,野口正人,末田慎二,小松英幸,坂本寛

平成24年度日本生化学会九州支部例会 

ヘムオキシゲナーゼ-1とヘムとの結合における静電的相互作用の熱力学的解析

山本真平, 奥田真孝, 山下耕平, 東元祐一郎, 野口正人, 小松英幸, 坂本寛

平成24年度日本生化学会九州支部例会 

Development of enzyme-based sensor for free heme

Hiroshi Sakamoto

14th Peptide Forum 

ヘムオキシゲナーゼ-1 とヘムの結合の熱力学的解析静電相互作用と配位結合

奥田真孝

2011日本生物物理学会九州支部例会 

電子顕微鏡画像に基づいた制限付き分子動力学法を利用した、 シトクロムP450還元酵素・ヘムオキシゲナーゼ-1複合体の原子モデル構築

山下理沙

2011日本生物物理学会九州支部例会 

Role of proline in heme regulatory motifs of heme oxygenase-2

R. Tsurusawa

第48回ペプチド討論会 

ヘムオキシゲナーゼ-2とシトクロムP450還元酵素の相互作用の検討

福嶋祐也

第84回日本生化学会大会 

ナノメータ分解の３次元電子顕微鏡マップからのシトクロムP450還元酵素・ヘムオキシゲナーゼ-1複合体の原子モデル構築

山下理沙

第84回日本生化学会大会 

ヘムオキシゲナーゼ-2のヘム調節モチーフの合成と機能解析

鶴澤怜也

第48回化学関連支部合同九州大会 

ヘムオキシゲナーゼ-1・NADPH-シトクロムP450還元酵素複合体の電子顕微鏡３次元増からの原子モデル構築

山下理沙

平成２３年度日本生化学会九州支部例会  日本生化学会九州支部

ヘムオキシゲナーゼ-1のヘム結合における静電的相互作用の熱量解析

奥田真孝

平成２３年度日本生化学会九州支部例会  日本生化学会九州支部

ヘム分解活性をもたないバイオヘムセンサーの設計と開発

義原俊

平成２３年度日本生化学会九州支部例会  日本生化学会九州支部

バイオヘムセンサーを用いたヘムタンパク質の新規スクリーニング定量法の提案

情報科学専攻　古賀真也

BMB2010第33回日本分子生物学会年会第83回日本生化学会大会合同大会 

Sensitive heme sensor using fluorescent-labeled heme oxygenase-1

情報科学専攻　古賀真也

5th International Peptide Symposium inconjunction with 47th Japanese Peptide Symposium 

蛍光検出型バイオセンサーを用いたヘムの新規定量法の開発

情報科学専攻　古賀真也

第34回蛋白質と酵素の構造と機能に関する九州シンポジウム 

蛍光ラベル化HO-1を用いたヘムセンサーにおける蛍光導入箇所の検討

情報科学専攻　山崎一樹

平成22年度日本生化学会九州支部例会　プログラム講演要旨集 

ヘムオキシゲナーゼ-2とシトクロムP450還元酵素の結合様式の検討

情報科学専攻　福嶋祐也

平成22年度日本生化学会九州支部例会　プログラム講演要旨集 

ヘムオキシゲナーゼ-2とシトクロムP450還元酵素との相互作用におけるヘムとNADP(H)の影響

情報科学専攻　吉永篤史

第82回日本生化学会大会プログラム・講演要旨集CD 

微量ヘム定量法に向けたバイオセンサーの開発

情報科学専攻　古賀真也

第82回日本生化学会大会プログラム・講演要旨集CD 

ラットヘムオキシゲナーゼ-1と基質ヘムとの結合における誘導適合モデルのカロリメトリー解析

情報科学専攻　岩崎浩之

第82回日本生化学会大会プログラム・講演要旨集CD 

ヘム分解酵素ヘムオキシゲナーゼのヘム結合解析とヘムセンサーとしての応用

本人

第58回高分子討論会予稿集 

α-ベルドヘム-ヘムオキシゲナーゼ-1複合体の結晶構造

久留米大学　佐藤秀明

平成21年度日本生化学会九州支部例会プログラム講演要旨集 

新規ヘム定量法に向けたバイオヘムセンサーの開発

情報科学専攻　古賀真也

平成21年度日本生化学会九州支部例会プログラム講演要旨集 

等温滴定カロリメトリーによるラットヘムオキシゲナーゼ-1の基質結合における誘導適合モデルの検討

情報科学専攻　岩崎浩之

平成21年度日本生化学会九州支部例会プログラム講演要旨集 

表面プラズモン共鳴法によるヘムオキシゲナーゼ-2とシトクロムP450還元酵素の相互作用解析

本人

平成21年度日本生化学会九州支部例会プログラム講演要旨集 

質量分析法によるヘムオキシゲナーゼとNADPH-シトクロムP450還元酵素、ビリベルジン還元酵素との相互作用

久留米大学　東元祐一郎

第31回日本分子生物学会・第81回日本生化学大会合同大会（BMB2008）講演要旨集 

CO配位型ベルドヘム-ヘムオキシゲナーゼ複合体のオキサポルフィリン環の還元

久留米大学　佐藤秀明

第31回日本分子生物学会・第81回日本生化学大会合同大会（BMB2008）講演要旨集 

ラットHeme Oxygenase-1のヘム結合の熱力学的特性にイオン強度変化が及ぼす影響

情報科学専攻　岩崎浩之

第31回日本分子生物学会・第81回日本生化学大会合同大会（BMB2008）講演要旨集 

ラットヘムオキシゲナーゼ-2由来HRMペプチドのヘム相互作用

情報科学専攻　中島正太

第31回日本分子生物学会・第81回日本生化学大会合同大会（BMB2008）講演要旨集 

Crystal structure of rat verdoheme-heme oxygenase-1 complex

久留米大学　杉島正一

第31回日本分子生物学会・第81回日本生化学大会合同大会（BMB2008）講演要旨集 

ヘムオキシゲナーゼ-1を応用した新型バイオヘムセンサーの開発

情報科学専攻　古賀真也

第31回日本分子生物学会・第81回日本生化学大会合同大会（BMB2008）講演要旨集 

Heme binding analysis of heme regulatory motifs of rat heme oxygenase-2

unctional analysis of heme regulatory motifs of rat heme oxygenase-2

Shota Nakashima

Surface plasmon resonance and mass spectrometric analysis of protein interaction in heme catabolism

MPSA2008 (17th Meeting of Methods in Protein Structure Analysis) Chemical and Structural Proteomics: The Solution to Biological Problems! 

質量分析法によるヘムオキシゲナーゼとNADPH-シトクロムP450還元酵素，ビリベルジン還元酵素との相互作用解析

平成20年度日本生化学会九州支部例会　プログラム・講演要旨集 

ラット由来ヘムオキシゲナーゼ-2が持つヘム調節モチーフの機能解析

中島正太

平成20年度日本生化学会九州支部例会　プログラム・講演要旨集 

ラットHeme oxygenase-1のヘム結合の熱力学的特性に与えるイオン強度変化の影響

大村昇

平成20年度日本生化学会九州支部例会　プログラム・講演要旨集 

蛍光ラベル化Heme oxygenase-1を利用したヘムセンサーの開発

鈴居詠之郎

平成20年度日本生化学会九州支部例会　プログラム・講演要旨集 

ヒトHeme oxygenase-1遺伝子のSNPsによるアミノ酸置換が酵素機能に与える影響

堤　由佳

平成20年度日本生化学会九州支部例会　プログラム・講演要旨集 

ヘムオキシゲナーゼのヘム結合能の解析とヘムセンサーへの応用

本人

第10回生命化学研究会シンポジウム・熊本（2008） 

クライオ電子顕微鏡法によるヘムオキシゲナーゼ-1・シトクロムP450還元酵素複合体の結合様式の解明

第45回日本生物物理学会年会要旨集 

ヒトheme oxygenase-1のヘム分解活性および立体構造に対するアミノ酸置換をともなうSNPsの影響

堤　由佳

BMB2007（第30回日本分子生物学会年会・第80回日本生化学会大会　合同大会） 

ラットヘムオキシゲナーゼ-2のヘム調節モチーフ含有ペプチドとの相互作用

中島正太

BMB2007（第30回日本分子生物学会年会・第80回日本生化学会大会　合同大会） 

Electrochemical reduction of ferrous alpha-verdoheme-rat heme oxygenase-1 complex

ラットヘムオキシゲナーゼ-1によるヘム結合のカロリメトリー解析

大村昇

BMB2007（第30回日本分子生物学会年会・第80回日本生化学会大会　合同大会） 

Interaction between heme and synthetic peptides containing heme regulatory motifs of rat heme oxygenase-2

Shota Nakashima

ヘム分解酵素ヘムオキシゲナーゼの構造・反応・相互作用

本人

第３１回蛋白質と酵素の構造と機能に関する九州シンポジウム 

ラットヘムオキシゲナーゼ-1によるヘム結合の熱測定

大村昇

平成19年度日本生化学会九州支部例会 

クライオ電子顕微鏡法によるヘムオキシゲナーゼ-1・シトクロムP450還元酵素複合体の結合様式の解明

中尾亮太

平成19年度日本生化学会九州支部例会 

ヒトheme oxygenase-1遺伝子のSNPsによるアミノ酸置換がヘム分解活性と立体構造に与える影響

堤　由佳

平成19年度日本生化学会九州支部例会 

ラットヘムオキシゲナーゼ-2のヘム調節モチーフの合成とヘムとの相互作用

中島正太

平成19年度日本生化学会九州支部例会　プログラム・講演要旨集 

イミダゾール-ジオキソレン化合物によるヘムオキシゲナーゼの阻害機構

久留米大・医　杉島正一

平成19年度日本生化学会九州支部例会 

ベルドヘム－ヘムオキシゲナーゼ複合体の電気化学的還元

久留米大医　佐藤秀明

平成19年度日本生化学会九州支部例会 

Degradation of Ferriprotoporphyrin IX Dimethyl Ester by Rat Heme Oxygenase-1

20th IUBMB International Congress of Biochemistry and Molecular Biology 

Kinetic Analysis of Conversion of alpha-Hydroxyheme to Verdoheme in Heme Oxygenase

20th IUBMB International Congress of Biochemistry and Molecular Biology 

ヘムオキシゲナーゼ反応第２中間ステップのストップト・フロー解析

本人

平成18年度日本生化学会九州支部例会 

FMN欠失NADPHシトクロムP450還元酵素を用いたヘムオキシゲナーゼ反応における電子授受機構の検討

平成18年度日本生化学会九州支部例会 

Kinetic study of the conversion of alpha-hydroxyheme to verdoheme while bound to heme oxygenase-1

The 14th Takeda Science Foundation Symposium on BioscienceThe 50th Anniversary of OxygenasesAdvances and Reflections 

NADP(H) enhances the interaction between heme oxygenase-1 and cytochrome P450 reductase

International symposium on regulation of protein function through post-translational modifications: new technologies and application to biomedical systems 

NADP(H)-mediated association of heme oxygenase-1 with cytochrome P450 reductase

2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) 

Involvement of NADP(H) in the interaction between heme oxygenase-1 and cytochrome P450 reductase.

Y. Higashimoto

HO conference 2005, The 4th International Congress 

Binding study of heme oxygenase with NADPH-cytochrome P450 reductase by surface plasmon resonance measurement

Amino acid residues crucial for uroporphyrinogen III synthase activity

生化学（第77回日本生化学会） 

Characterization of rat heme oxygenase-3 gene

ヘムヘムオキシゲナーゼ-1複合体へのヒドロキシルアミンの結合

第５４回錯体化学討論会講演要旨集 

NADP(H)-mediated association of the heme oxygenase with NADPH-cytochrome P450 reductase

Protein Science (The 18th Symposium of the Protein Society) 

表面プラズモン共鳴法によるヘムオキシゲナーゼとNADPH-シトクロムP450還元酵素との相互作用の検討

生化学（平成16年度日本生化学会九州支部例会） 

Crystal structure of rat heme oxygenase-1 in complex with biliverdin-iron chelate - implications for product release.

The 1st Pacific-Rim International Conference on Protein Science 

Binding study of heme oxygenase with NADPH-cytochrome P450 reductase by surface plasmon resonance measurements

The 1st Pacific-Rim International Conference on Protein Science 

Structural basis for discrimination between CO and O2 in heme oxygenase

The 1st Pacific-Rim International Conference on Protein Science 

Crystal structure of ferrous and CO-, CN--, and NO-bound forms of rat heme oxygenase(HO): implications for discrimination between CO and O2 in HO

The First International Symposium on Biomolecular Chemistry(ISBC 2003) 

Crystal structure of rat heme oxygenase-1 in complex with biliverdin-iron chelate

Heme Oxygenase: Regulation, Function and Clinical Application 

Amino acid residues involved in the activity of uroporphyrinogen III synthase

The 1st Pacific-Rim International Conference on Protein Science 

ESR・NMR分光及び結晶構造に基づくヘムオキシゲナーゼによるヘム分解機構の検討

Grant number：12670125  2000.04 - 2003.03   基盤研究(C)

日本生物工学会   九州支部　評議員  

2017.04

泉屋コロキウム   会長  

2017.04

日本生化学会   九州支部　評議員  

2014.05

日本生化学会九州支部例会   平成２３年度実行委員  

2011.05

蛋白質と酵素の構造と機能に関する九州シンポジウム   第34回　実行委員長  

2010.09

The Japanese Peptide Society  

2009.11

The Japanese Peptide Society  

2009.11

The Japanese Peptide Society  

2009.01

蛋白質と酵素の構造と機能に関する九州シンポジウム   地区世話人  

2008.04 - 2021.04

The Japanese Peptide Society   PEPTIDE NEWSLETTER JAPAN editorial member  

2008.04 - 2014.03

泉屋コロキウム   組織委員  

2007.04 - 2017.03

1st Asia-Pacific Internatinal Peptide Symposium/41th Japanese Peptide Symposium  

2004.11

eポートフォリオによる学修成果の可視化コンソーシアム第１回定例研究会

Role(s)：Presenter

2022.08.29

生命体工学研究科FD研修会「大学院生の研究計画・報告管理に伴う大学院版学修自己評価システムの構築」

Role(s)：Lecturer

学習教育センター  令和3年度第2回生命体工学研究科FD研修会  2022.01.27

情報工学府FD研修会「大学院生の研究計画・報告管理に伴う大学院生版学修自己評価システムの構築」

Role(s)：Lecturer

2022.01.27

教育フォーラム・文部科学省GPフォーラム「大学教育におけるパラダイムシフトと新機軸」「学修自己評価システムによる学修意識改革の取り組み」

2012.03.07