Updated on 2024/05/14

 
HIKIMA Tomohiro
 
Scopus Paper Info  
Total Paper Count: 0  Total Citation Count: 0  h-index: 4

Citation count denotes the number of citations in papers published for a particular year.

Affiliation
Faculty of Computer Science and Systems Engineering Department of Bioscience and Bioinformatics
Job
Associate Professor
E-mail
メールアドレス
Laboratory
680-4 Kawazu, Iizuka-shi, Fukuoka
Phone
+81-948-29-7836
Fax
+81-948-29-7801
External link

Research Interests

  • Drug Delivery System

  • Transdermal Therapeutic System

  • Ophthalmic Drug Delivery System

  • Cosmetics

  • Alternatives to Animal Experiments

  • Micro Electro Mechanical Systems

  • Drug Therapy

Research Areas

  • Life Science / Biomedical engineering

  • Life Science / Medical systems

  • Life Science / Pharmaceutical analytical chemistry and physicochemistry

  • Life Science / Biomaterials

Degree

  • Kyushu Institute of Technology  -  Doctor of Information Engineering   1996.03

Biography in Kyutech

  • 2019.04
     

    Kyushu Institute of Technology   Faculty of Computer Science and Systems Engineering   Department of Bioscience and Bioinformatics   Associate Professor  

  • 2014.02
    -
    2019.03
     

    Kyushu Institute of Technology   Faculty of Computer Science and Systems Engineering   Department of Bioscience and Bioinformatics   Associate Professor  

Biography before Kyutech

  • 2003.09 - 2004.09   University of Calfornia, San Francisco   Department of Dermatology   Visiting Research Associate   United States

  • 2000.08   University of California, San FRancisco   Research Fellow   United States

  • 1999.09 - 2000.08   University of California, San FRancisco   Department of Dermatology   Researcher   United States

  • 1996.10 - 1999.07   科学技術振興事業団   科学技術特別研究員   Japan

Academic Society Memberships

  • 1995.04   Controlled Release Society   United States

  • 1998.04   The Japan Society of Drug Delivery System   Japan

  • 1993.04   American Association of Pharmaceutical Scientists   United States

  • 1992.04   The Academy of Pharmaceutical Science and Technology, Japan   Japan

  • 1991.04   The Pharmaceutical Society of Japan   Japan

  • 2020.04 - 2022.03   The Academy of Pharmaceutical Science and Technology, Japan   Japan

  • 2016.02   The Society for Biotechnology, Japan   Japan

  • 2000.04   The Society of Chemical Engineers   Japan

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Research Career

  • Development of delivery system of biomedicine with high moleculear weight

    drug delivery system, biomedicine

    研究期間: 2012.04  - 

  • Development of drug delivery system using MEMS

    DDS, MEMS

    研究期間: 2008.04  - 

  • Development of drug carrier in drug delivery system

    biodegradable polymer,peptide

    研究期間: 2012.04  - 

  • Alternatives to animal testings for transdermal therapeutic system

    three-dimentional human cultured skin

    研究期間: 2010.04  - 

  • Local drug delivery into skin using pharmacokinetics

    transdermal therapy, local

    研究期間: 2004.04  - 

  • ヒト培養皮膚の経皮治療システムへの応用

    ヒト培養皮膚

    研究期間: 2006.04  - 

▼display all

Papers

  • Potential of TAK-593 ophthalmic emulsion for the treatment of age-related macular degeneration Reviewed International journal

    Yasuhiro MORI, Akifumi YAMAMOTO, Ayumi NAKAGAWA, Tomohiro HIKIMA, Akiharu ISOWAKI

    Biological and Pharmaceutical Bulletin ( The Pharmaceutical Society of Japan )   46 ( 7 )   921 - 928   2023.07

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    Language:English   Publishing type:Research paper (scientific journal)

    Intravitreal injection therapy of anti-vascular endothelial growth factor (VEGF) antibody or steroids is the mainstream for patients with age-related macular degeneration (AMD). However, since intravitreal injection is invasive administration, side effects such as endophthalmitis are major problems. In this study, we selected eye drops as a non-invasive treatment method, and aimed to develop eye drops that can deliver TAK-593 (VEGF receptor tyrosine kinase inhibitor) to the posterior segment of the eye. Since TAK-593 is a poorly water-soluble drug, the TAK-593 emulsion was formulated. The solubility of TAK-593 in various oils was measured, and the oil used for the emulsion was selected. Furthermore, viscosity enhancers were added to the emulsion in order to improve the drug delivery into the eye. As viscosity enhancer, xanthan gum was selected based on the properties and the viscosity of the emulsion. The delivery of TAK-593 to the posterior eye was increased by the formulation concentration and the addition of viscosity enhancers. In the laser-induced choroidal neovascularization model, TAK-593 emulsion eye drops showed the same angiogenesis-suppression efficacy as anti-VEGF antibody intravitreal injection. From these results, it was revealed that TAK-593 with an effective drug concentration can be delivered to the posterior eye by non-invasive eye drop administration.

    DOI: 10.1248/bpb.b23-00066

    Kyutacar

  • Predicting the safety of ocular iontophoresis using reconstructed human corneal epithelial cells. Reviewed International journal

    Tomohiro HIKIMA, Haruhiko EZAKI

    Biological and Pharmaceutical Bulletin ( The Pharmaceutical Society of Japan )   46 ( 7 )   1021 - 1023   2023.07

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)

    We aimed to investigate eye damage caused by ocular iontophoresis (IP) based on an in vitro eye irritation test using a reconstructed human corneal cell. In this study, the LabCyte CORNEA-MODEL was selected as the reconstructed corneal cell. The test procedure was performed according to Test Guideline No.492 of the Organisation for Economic Co-operation and Development, which was partially revised for the IP. From the relationship between the cell viability of the cornea model and the electric field intensity [current density (mA/cm2) × application time (min)] of the IP, we predicted that the intensity values of 465 mA/cm2 × min and 930 mA/cm2 × min caused reversible eye irritation and irreversible eye damage, respectively. However, further studies are required to improve the accuracy and reproducibility of the prediction. This report provides essential knowledge on the clinical safety of ocular IP.

    DOI: 10.1248/bpb.b23-00096

    Kyutacar

  • Suitability of high-molecular-weight tissue-derived elastin polypeptides and their particles as cosmetic biomaterials Reviewed International journal

    Toma SAKAI, Nanami SODEMOTO, Asako INOUE, Suguru TANIGUCHI, Iori MAEDA, Tomohiro HIKIMA

    Journal of Peptide Science ( European Peptide Society and John Wiley & Sons, Ltd. )   46 ( 7 )   え3472   2022.12

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)

    We aimed to determine the coacervation properties of high-molecular-weight (HMW) tissue-derived elastin (TDE) and to examine the potential use of TDE particles as a cosmetic biomaterial. TDE solutions were filtered and divided into three fractions (1–3) according to the molecular weight of the elastin. The turbidity of fraction 2, which contained a large portion (58%) of HMW elastin polypeptides (>100 kDa), was measured under several pH values (3.0–11.0) and NaCl concentrations (0–1000 mM) to examine its coacervation ability. HMW TDE exhibited coacervation under the physiological conditions (temperature, pH, and NaCl concentration) of the skin surface. We performed inclusion and release experiments using three model chemicals with different molecular weights and measured the size and zeta potential of the fraction 3 particles to investigate the suitability of HMW elastin polypeptides. Fraction 3, which contained a larger portion (64%) of HMW elastin polypeptides, displayed a strong coacervation property at a phase transition temperature of 19.8 ± 0.1°C. The inclusion ratio of the model chemical Biebrich Scarlet (BS) with a molecular weight of <600 was approximately 92.1 ± 0.7%. The release profiles of BS from the particles linearly increased and reached a plateau after 15 days. Moreover, the average size of the particles with BS was 474.2 ± 24.6 nm. The low-molecular-weight (LMW) elastin peptides have moisturizing and whitening functions for the skin. We concluded that TDE, as a mixture of HMW polypeptides and LMW peptides, can potentially serve as a multifunctional and effective cosmetic biomaterial.

    DOI: 10.1002/psc.3472

    Kyutacar

  • Microneedle array for medical application Reviewed

    Kawabata Kazuki, Matushima Syunya, Mizuguchi Ryou, Ito Takahiro, Hikima Tomohiro, Murakami Sunao, Matsuo Masaaki, Tashiro Yasunori, Hara Masaya, Tsubaki Hirotada

    Proceedings of JSPE Semestrial Meeting ( The Japan Society for Precision Engineering )   2021A ( 0 )   387 - 388   2021.09

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    Language:Japanese   Publishing type:Research paper (other academic)

    DOI: 10.11522/pscjspe.2021a.0_387

    CiNii Research

  • Fabrication of novel-shaped microneedles to overcome the disadvantages of solid microneedles for the transdermal delivery of insulin Reviewed International journal

    Mizuno Y., Takasawa K., Hanada T., Nakamura K., Yamada K., Tsubaki H., Hara M., Tashiro Y., Matsuo M., Ito T., Hikima T.

    Biomedical Microdevices   23 ( 3 )   38   2021.09

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)

    DOI: 10.1007/s10544-021-00576-x

    Kyutacar

    Scopus

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  • A phase I study of high dose camostat mesylate in healthy adults provides a rationale to repurpose the TMPRSS2 inhibitor for the treatment of COVID-19 Reviewed International journal

    Kitagawa J., Arai H., Iida H., Mukai J., Furukawa K., Ohtsu S., Nakade S., Hikima T., Haranaka M., Uemura N.

    Clinical and Translational Science   14 ( 5 )   1967 - 1976   2021.09

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    Language:English   Publishing type:Research paper (scientific journal)

    DOI: 10.1111/cts.13052

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  • Microneedle array for medical application Reviewed

    Yamada Kazuya, Matsushima Shunya, Mizuno Yuki, Fukuda Tatsuya, Takasawa Kanae, Ito Takahiro, Hikima Tomohiro, Murakami Sunao, Tsubaki Hirotada, Hara Masaya, Tashiro Yasunori, Matsuo Masaaki

    Proceedings of JSPE Semestrial Meeting ( The Japan Society for Precision Engineering )   2020A ( 0 )   472 - 473   2020.08

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    Language:Japanese   Publishing type:Research paper (other academic)

    DOI: 10.11522/pscjspe.2020a.0_472

    CiNii Article

    CiNii Research

  • 九州工業大学におけるマイクロニードルの研究開発 Invited

    引間知広

    三島光産技報   2020.04

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    Authorship:Lead author, Corresponding author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)

  • Trans-scleral iontophoresis delivery of a compound with high molecular weight into the posterior segment of the eys Reviewed

    Journal of Eye   36 ( 9 )   1149 - 1147   2019.09

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    Authorship:Lead author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)

  • Microneedle array for medical application Reviewed

    Matsushima Shunya, Yamada Kazuya, Fukuda Tatsuya, Mizuno Yuki, Ito Takahiro, Hikima Tomohiro, Murakami Sunao, Tsubaki Hirotada, Tashiro Yasunori, Hara Masaya, Matsuo Masaaki

    Proceedings of JSPE Semestrial Meeting ( The Japan Society for Precision Engineering )   2019A ( 0 )   478 - 479   2019.08

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    Language:Japanese   Publishing type:Research paper (other academic)

    DOI: 10.11522/pscjspe.2019a.0_478

    CiNii Article

    CiNii Research

  • 乾燥肌に対するビート由来グルコシルセラミド含有物の効果 Reviewed

    引間 知広, 木下 真梨子

    Fragrance Journal ( フレグランスジャーナル社 )   ( 7月 )   82 - 85   2019.07

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    Authorship:Lead author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)

  • Microneedle array for medical application Reviewed

    Yamada Kazuya, Hanada Taichi, Ito Takahiro, Hikima Tomohiro, Murakami Sunao, Tsubaki Hirotada, Fukuda Tatsuya, Hara Masaya, Tashiro Yasunori, Matsuo Masaaki

    Proceedings of JSPE Semestrial Meeting ( The Japan Society for Precision Engineering )   2019S ( 0 )   879 - 879   2019.03

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    Language:Japanese   Publishing type:Research paper (other academic)

    DOI: 10.11522/pscjspe.2019s.0_879

    CiNii Article

    CiNii Research

  • Microneedle array for medical application Reviewed

    HANADA Taichi, ITO Takahiro, HIKIMA Tomohiro, FUKUDA Tatsuya, MURAKAMI Sunao, TSUBAKI Hirotada, HARA Masaya, TASHIRO Yasunori, MATSUO Masaaki

    Proceedings of JSPE Semestrial Meeting ( The Japan Society for Precision Engineering )   2018A ( 0 )   819 - 819   2018.08

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    Language:Japanese   Publishing type:Research paper (other academic)

    DOI: 10.11522/pscjspe.2018a.0_819

    CiNii Article

    CiNii Research

  • Characterization of an in vitro penetration system for ocular iontophoresis Reviewed International journal

    Hikima Tomohiro, Kawakami Masatoshi, Tojo Kakuji

    JOURNAL OF CHEMICAL ENGINEERING OF JAPAN ( The Society of Chemical Engineers, Japan )   51 ( 5 )   418 - 422   2018.01

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    Authorship:Lead author, Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)

    <p>We have developed an <i>in vitro</i> penetration cell for transcorneal iontophoretic delivery. The thickness of the diffusion boundary layer δ of this <i>in vitro</i> system was evaluated by benzoic acid dissolution experiments under several mixing conditions of receptor solution. The δ under the condition of magnetic stirrer at 300 rpm in the receptor solution for the present KK cell was 201.0±20.4 µm, which is thinner than that for a Franz diffusion cell (323 µm). Moreover, the mass transfer coefficient <i>k</i><sub><i>m</i></sub> (=<i>D</i>/δ) was calculated by <i>Sh</i>=2+3.45<i>Re</i><sup>0.11</sup><i>Sc</i><sup>0.33</sup>; this equation gave the <i>k</i><sub><i>m</i></sub> and δ for the KK cell if the value of the diffusion coefficient <i>D</i>, viscosity μ, and density ρ of receptor solution were known. The penetration rate across cornea from pig <i>in vitro</i> was proportional to the voltage applied to the cornea during iontophoresis. The effect of iontophoresis on the penetration rate was quantitatively investigated after taking into consideration the hydrodynamic diffusion boundary layer.</p>

    DOI: 10.1252/jcej.17we084

    Scopus

    CiNii Article

    CiNii Research

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  • Microneedle array for medical application Reviewed

    Hanada Taichi, Ito Takahiro, Hikima Tomohiro, Murakami Sunao, Tsubaki Hirotada, Hara Masaya, Kuroki Junji, Tashiro Yasunori, Matsuo Masaaki

    Proceedings of JSPE Semestrial Meeting ( The Japan Society for Precision Engineering )   2017A ( 0 )   287 - 288   2017.01

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    Language:Japanese   Publishing type:Research paper (other academic)

    DOI: 10.11522/pscjspe.2017a.0_287

    CiNii Article

    CiNii Research

  • Investigation of water-soluble elastin as a multifunctional cosmetic material: Moisturizing and whitening effects Reviewed International journal

    Inoue A., Hikima T., Taniguchi S., Nose T., Maeda I.

    Journal of Cosmetic Science   68 ( 1 )   11 - 23   2017.01

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    Language:English   Publishing type:Research paper (scientific journal)

    Scopus

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  • Improvement/enhancement of transdermal absorption using microneedles and other methods

    Tomohiro Hikima

    Fragrance Journal ( Fragrance Journal Ltd. )   ( 1月 )   12 - 19   2015.01

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    Authorship:Corresponding author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)

  • 経皮治療システムの現状と微細加工技術の応用 Invited

    引間知広

    三島光産技報 ( 三島光産 )   35   15 - 20   2014.01

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    Authorship:Corresponding author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)

  • Effect of diffusive direction across the skin on the penetration profile of chemicals in vitro Reviewed

    36 ( 11 )   1760 - 1765   2013.11

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)

    DOI: 10.1248/bpb.b13-00331

    Scopus

    CiNii Article

  • 経皮吸収に関する研究

    引間知広

    Cosme Tech Japan ( 株式会社じほう )   2013.08

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    Authorship:Corresponding author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)

  • Prediction of percutaneous absorption in human of nicotine from marketed TTS using three-dimensional human cultured epidermis Reviewed

    2013.06

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (international conference proceedings)

  • Skin accumulation and penetration of a hydrophilic compound by a novel gemini surfactant, sodium dilauramidoglutamide lysine. Reviewed

    Tomohiro HIKIMA, Yoshinaga TAMURA, Yukio YAMAWAKI, Masashi YAMAMOTO, Kakuji TOJO

    International Journal of Pharmaceutics   443 ( 1-2 )   288 - 292   2013.02

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)

    DOI: 10.1016/j.ijpharm.2012.12.034

    Scopus

  • Prediction of percutaneous absorption in human using three-dimensional human cultureed epidermis LabCyte EPI-MODEL Reviewed

    Tomohiro Hikima, Noriaki Kaneda, kyouhei Matsuo, Kakuji Tojo

    Biological & Pharmaceutical Bulletin   35 ( 3 )   362 - 368   2012.03

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)

    DOI: 10.1248/bpb.35.362

    Scopus

    CiNii Article

  • 経皮治療システムにおける透過促進剤

    引間知広,冨永健治

    Cosmetic Stage ( 技術情報協会 )   ( 7 )   10 - 13   2010.07

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    Authorship:Corresponding author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)

  • 経皮治療システムにおける物理的透過促進法

    引間知広,冨永健治

    Cosmetic Stage ( 技術情報協会 )   ( 7 )   14 - 18   2010.07

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    Authorship:Corresponding author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)

  • Mechanism of the synergistic skin penetration by sonophoresis and iontophoresis. Reviewed

    Tomohiro Hikima,Shinya Ohsumi,Kenta Shirouzu,Kakuji Tojo

    Biological & Pharmaceutical Bulletin   32 ( 5 )   905 - 909   2009.05

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  • Control of barrier capacity of stratum corneum by microdermabrasion. Reviewed

    Kouhei Shirakami,Tomohiro Hikima,Kakuji Tojo

    Journal of Chemical Engineering of Japan   41 ( 12 )   1123 - 1126   2008.12

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)

  • Synergistic effect of sonophoresis and iontophoresis in transdermal drug delivery Reviewed

    Kenta Shirouzu,Tetsuya Nishiyama,Tomohiro Hikima,Kakuji Tojo

    Journal of Chemical Engineering of Japan   42 ( 4 )   300 - 305   2008.04

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)

  • Bioequivalence of marketed transdermal delivery systems for tulobuterol Reviewed

    Kakuji Tojo,Tomohiro Hikima

    Biological & Pharmaceutical Bulletin   30 ( 8 )   1576 - 1579   2007.04

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  • 経皮治療システム用貼付剤製造装置の開発 Invited Reviewed

    引間知広,因昭一,中村昭範,東條角治

    膜   32 ( 2 )   116 - 119   2007.04

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    Authorship:Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)

  • Effect of molecular weight of penetrants on iontophortic transdermal delivery in vitro Reviewed

    Takamitsu Miyagi,Tomohiro Hikima,Kakuji Tojo

    American Institute of Chemical Engineers   2006.11

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    Language:English   Publishing type:Research paper (international conference proceedings)

    U.S.A.   San Francisco   2006.11.12  -  2006.11.12

  • Skin enzymes distribution in transdermal drug delivery Reviewed

    Tomohiro Hikima,Howard I. Maibach,Kakuji Tojo

    American Institute of Chemical Engineers   2006.11

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (international conference proceedings)

    U.S.A.   San Francisco   2006.11.12  -  2006.11.12

  • Effect of molecular weight of penetrants on iontophoretic transdermal delivery in vitro Reviewed

    Takamitsu Miyagi,Tomohiro Hikima,Kakuji Tojo

    Journal of Chemical Engineering of Japan   39 ( 3 )   360 - 365   2006.04

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  • Skin penetration flux and lag-time of steroids across hydrated and dehydrated human skin in vitro Reviewed

    Tomohiro Hikima,Howard I. Maibach

    Biological & Pharmaceutical Bulltein   29 ( 11 )   2270 - 2273   2006.04

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  • Gender differences of enzymatic activity and distribution of 17s-hydroxysteroid dehydrogenase in human skin in vitro Reviewed

    Tomohiro Hikima,Howard I. Maibach

    Skin Pharmacology and Physiology   20 ( 4 )   168 - 174   2006.04

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  • Effect of molecular weight of FITC-dextrans on iontophoretic transdermaldelivery in vitro Reviewed

    Takamitsu Miyagi,Tomohiro Hikima,Kakuji Tojo

    The aaps Journal (AAPS Natonal Biotechnology Conference)   7 ( S1 )   2005.06

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    Language:English   Publishing type:Research paper (scientific journal)

    U.S.A   San Francisco   2005.06  -  2005.06

  • Age and gender differences of enzymes distrbution and activity in human skin Reviewed

    Tomohiro Hikima,Howard I.Maibach,KakujiTojo

    The AAPS Journal (AAPS National Biotechnoligy Conference)   7 ( S1 )   2005.06

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    U.S.A.   San Francisco   2005.06  -  2005.06

  • Skin metabolism in transdermal therapeutic systems

    Skin Pharmacology and Physiology   18 ( 4 )   153 - 159   2005.04

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    Authorship:Corresponding author   Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)

  • Skin penetration enhancement by synergistic effect of supersaturated dissolution and chemical enhancers Reviewed

    Qing Wang,Tomohiro Hikima,Kakuji Tojo

    Journal of Chemical Engineering of Japan   36 ( 1 )   92 - 97   2003.04

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  • In vivo evaluation of skin permeability using microdermabration system Reviewed

    29th International Symposium on Controlled Release of Bioactive Materials   20 - 25   2002.07

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    Seaul, Korea   2002.07.20  -  2002.07.25

  • Comparison of Skin Distribution of Hydrolytic Activity for Bioconversion of β-Estradiol 17-Acetate Between Man and Several Animals in Vitro. Reviewed

    Tomohiro Hikima,Kayoko Yamada,Tohru Kimura,Howard I. Maibach,Kakuji Tojo

    European Journal of Pharmaceutics and Biopharmaceutics   54 ( 2 )   155 - 160   2002.04

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  • Studies on the synergistic enhancement of supersaturated dissolution and enhancer in matrix transdermal drug delivery system Reviewed

    Qing Wang,Tomohiro Hikima,Kakuji Tojo

    Journal of Chemical Engineering of Japan   35 ( 8 )   771 - 777   2002.04

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  • 薬物の皮膚透過と皮膚代謝に及ぼす超音波の影響 Invited

    引間知広,東條角治

    超音波テクノ   14 ( 1 )   51 - 54   2002.01

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    Authorship:Corresponding author   Language:Japanese   Publishing type:Research paper (other academic)

  • Bioconversion of beta-estradiol 17-acetate in skin: distribution of hydrolytic activity in human and animal skin Reviewed

    Tomohiro HIKIMA,Kayoko YAMADA,Tohru KIMURA,Howard I. MAIBACH,Kakuji TOJO

    28th International Symposium on Controlled Release of Bioactive Materials   2001.06

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (other academic)

    San Deigo, USA   2001.06.23  -  2001.06.27

  • 経皮治療システム研究における皮膚モデル Reviewed

    引間知広,東條角治

    Drug Delivery System   16 ( 3 )   179 - 181   2001.05

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    Authorship:Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)

  • Metabolism of prednisolone 21-acetate in hairless mouse skin Reviewed

    Tomohiro Hikima,Yasuo Ohno,Howard I. Maibach

    Skin Pharmacology and Applied Skin Physiology   14 ( 4 )   203 - 209   2001.04

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  • Distribution of hydrolytic activity catalyze the biotransformation of prednisolone 21-acetate in human skin Reviewed

    Tomohiro Hikima,Howard I. Maibach

    Skin Pharmacology and Applied Skin Physiology   14 ( 4 )   196 - 202   2001.04

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  • 薬物の皮膚透過および皮膚内代謝活性のヘアレスマウス系統による差異 Reviewed

    引間知広,東條角治

    Drug Delivery System   15 ( 3 )   203 - 207   2000.04

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  • Effect of intensity and duration of ultrasound application on skin metabolism of prednisolone 21-acetate Reviewed

    T. Hikima,K. Yamada,K. Tojo

    The 25th International Symposium on Controlled Release of Bioactive Materials   1998.06

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    U.S.A.   1998.06  -  1998.06

  • Effect of ultrasound application on skin metabolism of prednsisolone 21-acetate Reviewed

    Tomohiro HIkima,Yoshiaki Hirai,Kakuji Tojo

    Pharmaceutical Research   15 ( 11 )   1680 - 1683   1998.04

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    Language:English   Publishing type:Research paper (scientific journal)

  • Binding of prednisolone and its ester prodrugs in the skin Reviewed

    Tomohiro Hikima,Kakuji Tojo

    Pharmaceutical Research   14 ( 2 )   197 - 202   1997.04

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    Language:English   Publishing type:Research paper (scientific journal)

  • Effect of ultrasound application on skin metabolism and penetration of prednisolone acetate Reviewed

    T. Hikima,Y. Hirai,K. Tojo

    AAPS Annual Meetings   1996.11

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    Language:English   Publishing type:Research paper (other academic)

    U.S.A.   1996.11  -  1996.11

  • Percutaneous absorption of drugs: Diffusion, binding and metabolism Reviewed

    1995.12

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    Language:English   Publishing type:Research paper (international conference proceedings)

  • Topical delivery of prednisolone using prodrugs Reviewed

    T. Hikima,K. Yamada,K. Tojo

    The 22th International Symposium on Controlled Release of Bioactive Materials   1995.07

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    Language:English   Publishing type:Research paper (international conference proceedings)

    1995.07.30  -  1995.07.30

  • 結合と代謝をともなう薬物の皮膚吸収 Reviewed

    引間知広,東條角治

    薬剤学   55   122 - 126   1995.04

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    Language:Japanese   Publishing type:Research paper (scientific journal)

  • Diffusion and metabolism of prednisolone farnesylate in the stripped skin Reviewed

    Kakuji Tojo,Kayoko Yamada,Tomohiro Hikima

    Pharmaceutical Research   11 ( 3 )   393 - 397   1994.04

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    Language:English   Publishing type:Research paper (scientific journal)

  • Diffusion and metabolism of prednisolone farnesylate in the hairless mouse skin. Reviewed

    Tomohiro Hikima,Kayoko Yamada,Kakuji Tojo

    AAPS Annual Meetings   1993.11

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    Language:English   Publishing type:Research paper (other academic)

    1993.11  -  1993.11

  • 薬物の皮膚代謝におよぼす透過促進剤の影響 Reviewed

    引間知広,東條角治

    Drug Delivery System   8   291 - 295   1993.04

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    Language:Japanese   Publishing type:Research paper (scientific journal)

  • 代謝をともなう薬物の皮膚透過 Reviewed

    引間知広,山田佳世子,山下明泰,東條角治

    Drug Delivery System   7   453 - 457   1992.04

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▼display all

Publications (Books)

  • Combined use of iontophoresis and other physical methods

    (Joint author)

    2017.05  ( ISBN:9783662532737

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    Language:English

    Scopus

  • MEMSを利用した薬物送達システムの開発事例

    引間知広(Sole author)

    株式会社技術情報協会  2013.03 

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    Language:Japanese

  • 物理的促進法の最新技術概論

    引間知広,東條角治(Joint author)

    シーエムシー出版  2011.07 

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    Language:Japanese

  • ホットメルト 材料および装置、製品の最新技術と使い方ノウハウ

    引間知広(Sole author ,  試料作成装置用途として)

    (株)技術情報協会  2011.01 

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Conference Prsentations (Oral, Poster)

  • 脂溶性薬物の皮膚透過性および皮膚滞留性に関する検討

    大谷早紀, 引間知広

    第39回日本DDS学会学術集会  2023.07  日本DDS学会

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    Event date: 2023.07.27 - 2023.07.28   Language:Japanese  

  • ナイアシンアミドの安定性及び皮膚透過性評価

    薄田育美, 引間知広

    第39回日本DDS学会学術集会  2023.07  日本DDS学会

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    Event date: 2023.07.27 - 2023.07.28   Language:Japanese  

  • ナノ水による親水性化合物の皮膚透過挙動と角層含水量への影響

    竹下真由, 小渕杏乃, 井上慎介, 平野明良, 重森康司, 引間知広

    第39回日本DDS学会学術集会  2023.07  日本DDS学会

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    Event date: 2023.07.27 - 2023.07.28   Language:Japanese  

  • 油中ナノ粒子分散体に包含した親水性高分子化合物の皮膚透過促進に関する研究

    袖本菜々美, 井上亜沙子, 佐藤宏晶, 引間知広

    日本薬学会第143年会  2023.03  日本薬学会

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    Event date: 2023.03.25 - 2023.03.28   Language:Japanese  

  • 電場を用いた高分子医薬品の眼内薬物送達促進

    金丸貴俊, 有田昂平, 島村佳久, 岩瀬陽一郎, 引間知広

    日本薬学会第143年会  2023.03  日本薬学会

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    Event date: 2023.03.25 - 2023.03.28   Language:Japanese  

  • New shape coated microneedle array for medical application

    H. Takei, S. Matsushima, K. Kawabata, T. Ito, R. Mizuguchi, T. Hikima, H. Tsubaki, M. Hara, Y. Tashiro, T. Oniki, M. Matsuo

    The 19th International Conference on Precision Engineerin  2022.12  The Japan Society for Precision Engineering

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    Event date: 2022.11.28 - 2022.12.02   Language:English  

  • 医療用マイクロニードルの研究

    川端一輝, 松島俊也, 水口凌, 伊藤高廣, 引間知広, 村上直, 松尾正昭, 田代康典, 原正哉, 椿浩忠

    2021年度精密工学会秋季大会学術講演会  精密工学会

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    Event date: 2021.09.21 - 2021.09.27   Language:Japanese  

  • 烏口型マイクロニードルのニードル本数による経皮薬物送達促進への影響に関する研究

    水口凌, 水野有希, 山田一也, 松島俊也, 田代康典, 松尾正昭, 伊藤高廣, 引間知広

    第37回日本DDS学会学術集会  日本DDS学会

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    Event date: 2021.06.29 - 2021.06.30   Language:Japanese  

  • 油中ナノ粒子分散体による親水性高分子の皮膚透過促進メカニズムの解明

    袖本菜々美, 井上亜沙子, 佐藤宏晶, 引間知広

    第37回日本DDS学会学術集会  日本DDS学会

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    Event date: 2021.06.29 - 2021.06.30   Language:Japanese  

  • A Phase I study to evaluate safety, tolerability and pharmacokinetics of high doses of camostat mesylate in healthy subjects provides a rationale to repurpose the TMPRSS2 inhibitor for the treatment of COVID-19

    Junsaku KITAGAWA, Hayato ARAI, Hiroyuki IIDA, Jiro MUKAI, Kenji FURUKAWA, Seitaro OHTSU, Susumu NAKADE, Tomohiro HIKIMA, Miwa HARANAKA, Naoto UEMURA

    ASCPT 2021 Annual Meeting  American Society for Clinical Pharmacology & Therapeutics

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    Event date: 2021.03   Language:English  

  • 医療用マイクロニードルの研究

    山田一也、松島俊也, 水野有希, 福田龍彌, 高澤香奈衣, 伊藤高廣, 引間知広, 村上直, 椿浩忠, 原正哉, 田代康典, 松尾正昭

    2020年度精密工学会秋季大会学術講演会  精密工学会

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    Event date: 2020.09.01 - 2020.09.07   Language:Japanese  

  • イオントフォレシスによる荷電性薬物の後眼部への送達促進

    武内宏樹, 江崎晴彦, 引間知広

    第36回日本DDS学会学術集会  日本DDS学会

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    Event date: 2020.08.28 - 2020.08.29   Language:Japanese  

  • 医療用マイクロニードルアレイの研究 −新規形状の提案と評価 –

    松島俊也, 山田一也, 伊藤高廣, 引間知広, 福田龍彌, 水野有希, 村上直, 椿浩忠, 原正哉, 田代康典, 松尾正昭

    2019年度精密工学会秋季大会学術講演会  精密工学会

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    Event date: 2019.09.04 - 2019.09.06   Language:Japanese  

  • 新規形状のコーティング型マイクロニードルの開発

    水野有希, 福田龍彌, 原正哉, 田代康典, 松尾正昭, 伊藤高廣, 引間知広

    第35回日本DDS学会学術集会  日本DDS学会

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    Event date: 2019.07.04 - 2019.07.05   Language:Japanese  

  • イオントフォレシスによる眼球内への高分子薬物送達における薬物分子量の影響

    江﨑晴彦, 井上茉莉, 、引間知広

    第35回日本DDS学会学術集会  日本DDS学会

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    Event date: 2019.07.04 - 2019.07.05   Language:Japanese  

  • 医療用マイクロニードルアレイの研究

    山田一也, 花田大知, 伊藤高廣, 引間知広, 福田龍彌, 村上直, 椿浩忠, 原正哉, 田代康典, 松尾正昭

    2019年度精密工学会春季大会  精密工学会

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    Event date: 2019.03.13 - 2019.03.15   Language:Japanese  

  • 医療用マイクロニードルの作製

    花田大知,伊藤高廣,引間知広,福田龍彌,村上直,椿浩忠,原正哉,田代康典,松尾正昭

    2018年度精密工学会秋季大会  精密工学会

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    Event date: 2018.09.05 - 2018.09.07   Language:Japanese  

  • 薬物キャリアとしての生体由来エラスチン

    引間知広,坂井透麻,井上亜沙子,谷口卓,前田衣織

    第34回日本DDS学会学術集会  日本DDS学会

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    Event date: 2018.06.21 - 2018.06.22   Language:Japanese  

  • Microneedle array for medical application

    Proceedings of JSPE Semestrial Meeting 

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    Event date: 2017.09.20   Language:Japanese  

    CiNii Article

  • 疑似中空型マイクロニードルの作成並びに高分子薬物の経皮吸収促進

    高澤香奈衣,中村響,黒木潤二,原正哉,田代康典,伊藤高廣,引間知広

    第33回日本DDS学会学術集会  日本DDS学会

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    Event date: 2017.07.06 - 2017.07.07   Language:Japanese  

  • エラスチン微粒子からの化合物放出挙動に対するpHの影響

    松下幹司,坂井透麻,前田衣織,引間知広

    第33回日本DDS学会学術集会  日本DDS学会

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    Event date: 2017.07.06 - 2017.07.07   Language:Japanese  

  • 生体由来エラスチンの自己集合能及びその応用に関する研究

    坂井透麻,松下幹司,谷口卓,井上亜沙子,前田衣織,引間知広

    第23回日本生物工学会九州支部飯塚大会  日本生物工学会九州支部

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    Event date: 2016.12.03   Language:Japanese  

  • 低周波超音波と直流パルス電流の併用による高分子化合物の経皮透過促進

    増田貴仁,引間知広

    第23回日本生物工学会九州支部飯塚大会  日本生物工学会九州支部

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    Event date: 2016.12.03   Language:Japanese  

  • 経皮吸収型製剤における添加剤が及ぼす薬物皮膚透過パラメータへの影響

    高澤香奈衣,引間知広

    第32回日本DDS学会学術集会  日本DDS学会

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    Event date: 2016.06.30 - 2016.07.01   Language:Japanese  

  • 生体由来エラスチンの薬物キャリアとしての可能性に関する検討

    坂井透麻,引間知広

    第32回日本DDS学会学術集会  日本DDS学会

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    Event date: 2016.06.30 - 2016.07.01   Language:Japanese  

  • イオントフォレシスによる後眼部への高分子化合物の送達促進

    井上茉莉,引間知広

    第31回日本DDS学会  日本DDS学会

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    Event date: 2015.07.02 - 2015.07.03   Language:Japanese  

  • パルス直流電流イオントフォレシスを用いた高分子化合物の経皮送達促進

    増田貴仁,引間知広

    第31回日本DDS学会  日本DDS学会

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    Event date: 2015.07.02 - 2015.07.03   Language:Japanese  

  • エラスチン由来ペプチドのヒト3次元培養皮膚に対する効果

    井上亜沙子,引間知広,野瀬健,前田衣織

    第31回日本DDS学会  日本DDS学会

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    Event date: 2015.07.02 - 2015.07.03   Language:Japanese  

  • 後眼部への薬物送達促進

    井上茉莉,引間知広

    第21回日本生物工学会九州支部熊本大会  日本生物工学会九州支部

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    Event date: 2014.12.06   Language:Japanese  

  • 電場による両性界面活性剤の皮膚透過促進

    松田洋輔,増田貴仁,引間知広

    第21回日本生物工学会九州支部熊本大会  日本生物工学会九州支部

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    Event date: 2014.12.06   Language:Japanese  

  • 培養皮膚を用いた経皮吸収製剤の評価

    石井信弥,白尾嘉郎,引間知広

    第21回日本生物工学会九州支部熊本大会  日本生物工学会九州支部

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    Event date: 2014.12.06   Language:Japanese  

  • ジェミニ型両親媒性化合物による薬物の皮膚内貯留メカニズムの解明

    原田篤知,引間知広

    第30回日本DDS学会  日本DDS学会

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    Event date: 2014.07.30 - 2014.07.31   Language:Japanese  

  • 経皮吸収型製剤のin vitro-in silico血中濃度予測法

    森大輔,釘宮健,原田篤知,引間知広

    第30回日本DDS学会  日本DDS学会

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    Event date: 2014.07.30 - 2014.07.31   Language:Japanese  

  • 剤形の違いによる薬物皮膚透過挙動への影響

    釘宮健,引間知広

    第30回日本DDS学会  日本DDS学会

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    Event date: 2014.07.30 - 2014.07.31   Language:Japanese  

  • In vitro動物皮膚透過データに基づいたヒト経皮吸収シミュレーション

    森大輔,釘宮健,原田篤知,引間知広

    日本薬剤学会第29年会  日本薬剤学会

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    Event date: 2014.05.20 - 2014.05.22   Language:Japanese  

  • マイクロデバイスを用いた経皮治療システムの開発

    中島広嗣,吉田昂広,岡部英明,成瀬早矢加,東條角治,引間知広

    第20回日本生物工学会九州支部佐賀大会  日本生物工学会九州支部

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    Event date: 2013.12.07   Language:Japanese  

  • 培養皮膚の経皮治療システムへの応用

    原田篤知,釘宮健,引間知広

    第20回日本生物工学会九州支部佐賀大会  日本生物工学会九州支部

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    Event date: 2013.12.07   Language:Japanese  

  • Microneedle arrayによる皮膚透過促進とその予測

    引間知広,吉田昂広,岡部英明,伊藤高廣,東條角治

    日本DDS学会 

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    Event date: 2012.07.04 - 2012.07.05   Language:Japanese  

  • 皮膚透過促進に及ぼすMicroneedle Arrayの構造の影響

    情報科学専攻,岡部英明

    化学工学会 

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    Event date: 2011.03.22 - 2011.03.24   Language:Japanese  

  • 薬物の皮膚透過速度に及ぼす拡散方向の影響

    諸藤遼

    日本DDS学会 

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    Event date: 2010.06.17 - 2010.06.18   Language:Japanese  

  • 皮膚透過促進法におけるLabCtye EPI-MODELのヒト代替皮膚モデルとしての有用性

    本人

    日本DDS学会 

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    Event date: 2010.06.17 - 2010.06.18   Language:Japanese  

  • 新規ジェミニ型界面活性剤の皮膚透過促進剤としての作用機序

    本人

    日本薬剤学会 

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    Event date: 2010.05.12 - 2010.05.14   Language:Japanese  

  • ヒト3次元培養表皮モデルLabCtye EPI-MODELを用いた薬物の皮膚透過性の評価

    日本医工学治療学会 

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    Event date: 2009.04   Language:Japanese  

  • 超音波と電場による皮膚透過促進の相乗効果メカニズム

    本人

    日本DDS学会 

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    Event date: 2008.06   Language:Japanese  

  • ヒト3次元培養表皮モデルLabCyte EPI-MODELを用いた薬物透過性の評価

    松尾恭平

    化学工学会第73年会 

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    Event date: 2008.03.17 - 2008.03.19   Language:Japanese  

  • 超音波と電場を用いた薬物皮膚透過速度制御

    本人

    第23回日本DDS学会 

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    Event date: 2007.06.14 - 2007.06.15   Language:Japanese  

  • ツロブテロール貼付薬の生物学的同等性の評価-皮膚透過性の観点から-

    東條角治

    第19回日本アレルギー学会春季臨床大会 

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    Event date: 2007.06.10   Language:Japanese  

  • 薬物皮膚透過促進における電場と超音波の相乗効果

    白水健太

    日本薬剤学会第22年会 

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    Event date: 2007.05   Language:Japanese  

  • 経皮吸収型ツロブテロール製剤の生物学的同等性評価-皮膚透過性の観点から-

    東條角治

    日本薬剤学会第22年会 

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    Event date: 2007.05   Language:Japanese  

  • マイクロダーマブレーションによる角質層剥離制御

    白神浩平

    日本薬剤学会第22年会 

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    Event date: 2007.05   Language:Japanese  

  • 生分解性埋め込み製剤の作成方法および剤型による放出挙動とそのメカニズム

    本田尚

    化学工学会第38回秋季大会, 

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    Event date: 2006.09.16   Language:Japanese  

  • 電場と超音波を併用した薬物皮膚吸収促進

    白水健太

    化学工学会第38回秋季大会 

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    Event date: 2006.09.16   Language:Japanese  

  • 皮膚表層部での薬物貯留を目指した経皮投与のin-vitro実験での検討

    本人

    日本薬剤学会第20年会 

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    Event date: 2005.03   Language:Japanese  

  • マトリクス製剤中薬物の再結晶に及ぼすPVPの抑制作用とそのメカニズム

    化学工学会 第35回秋季大会 

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    Event date: 2002.09.20   Language:Japanese  

  • 代謝を伴う薬物の経皮吸収におけるヒト代替皮膚を用いる臨床性能の予測

    古賀徹

    化学工学会 第35回秋季大会 

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    Event date: 2002.09.20   Language:Japanese  

  • 経皮及び眼科薬物送達における電場の利用

    川上雅智

    化学工学会 第35回秋季大会 

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    Event date: 2002.09.20   Language:Japanese  

  • イオン電気導入法による眼科薬物の角膜透過促進

    立川久

    化学工学会第67年会 

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    Event date: 2002.03.27 - 2002.03.29   Language:Japanese  

  • 皮膚内代謝機能を利用する薬物の皮膚吸収促進

    古賀徹

    化学工学会第67年会 

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    Event date: 2002.03.27 - 2002.03.29   Language:Japanese  

  • 生体リズムを考慮した経皮治療システム

    森大輔

    化学工学会第67年会 

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    Event date: 2002.03.27 - 2002.03.29   Language:Japanese  

  • ポリ乳酸ロッドDDSからの生理活性物質の時間制御

    藤川佳子

    化学工学会第67年会 

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    Event date: 2002.03.27 - 2002.03.29   Language:Japanese  

  • Synergistic enhancement in transdermal penetration of 17-β-estradiol by supersaturated dissolution and chemical enhancer

    汪晴

    化学工学会第67年会 

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    Event date: 2002.03.27 - 2002.03.29   Language:Japanese  

  • 生分解性埋め込みDDSにおける超音波による薬物放出時間制御

    高崎宏

    化学工学会第67年会 

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    Event date: 2002.03.27 - 2002.03.29   Language:Japanese  

  • マイクロピーリングシステムを利用した薬物皮膚吸収速度の評価法

    藤本朋子

    化学工学会第67年会 

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    Event date: 2002.03.27 - 2002.03.29   Language:Japanese  

  • コンビネーション型経皮吸収製剤における薬物相互作用

    宮城孝満

    化学工学会第67年会 

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    Event date: 2002.03.27 - 2002.03.29   Language:Japanese  

  • 新規マトリクス型エストラジオ-ル経皮吸収製剤の開発

    宮城孝満

    第17回日本DDS学会 

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    Event date: 2001.07.12 - 2001.07.13   Language:Japanese  

  • 経皮吸収製剤の臨床性能予測法

    東條角治

    第17回日本DDS学会 

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    Event date: 2001.07.12 - 2001.07.13   Language:Japanese  

  • 薬物の基剤中過飽和溶解による皮膚透過促進

    汪晴

    第17回日本DDS学会 

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    Event date: 2001.07.12 - 2001.07.13   Language:Japanese  

  • 麻薬系鎮痛剤による痛みの時間治療システム

    森大輔

    化学工学会第66年会 

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    Event date: 2001.04.02 - 2001.04.04   Language:Japanese  

  • 代謝を伴う薬物の皮膚吸収モデル

    本人

    化学工学会第66年会 

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    Event date: 2001.04.02 - 2001.04.04   Language:Japanese  

  • Effect of ultrasound on rate of penetration and metabolism of drugs in the skin

    Tojo Kakuji

    The 2nd International Symposium on Sonodynamic Therapy 

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    Event date: 2001.03.30   Language:English  

  • 2-Mercaptobenzimidazole(MBI)およびそのメチル誘導体のラット肝薬物代謝酵素系に及ぼす影響について

    宮島敦子,簾内桃子,引間知広,酒見和枝,津田充宥,大野泰雄

    第26回トキシコロジ−学会 

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    Event date: 1999.07   Language:Japanese  

  • In vitroおよびIn vivo皮膚透過実験におけるモデル動物としてのヘアレスドッグの有用性

    引間知広,木村透,東條角治

    日本薬剤学会 第14年会 

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    Event date: 1999.03.26 - 1999.03.28   Language:Japanese  

  • ジフェニルのラットおよびBDF1マウスでの代謝(1)

    紅林秀雄,小澤正吾,宮島敦子,簾内桃子,韓晶,引間知広,酒見和枝,津田充宥,大野泰雄

    第115回 日本薬学会年会 

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    Event date: 1998.03.31 - 1998.04.02   Language:Japanese  

  • Influence of application of ultrasound on enzymatic metabolism in the skin

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    Event date: 1996.07.07 - 1996.07.08   Language:English  

  • 埋め込み型シリコーンロッドからの薬物制御放出

    古川芳子,平井良明,引間知広,東條角治

    第12回 日本薬学会九州支部大会 

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    Event date: 1995.12.02 - 1995.12.03   Language:Japanese  

  • 代謝と結合をともなうプレドニゾロンエステルの皮膚吸収

    引間知広,東條角治

    日本薬剤学会 第11年会 

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    Event date: 1995.09.11 - 1995.09.13   Language:Japanese  

  • プレドニゾロンエステルの皮膚内結合性:皮下組織への薬物送達

    引間知広,東條角治

    第11回 DDS 学会 

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    Event date: 1995.07.06 - 1995.07.07   Language:Japanese  

  • Transdermal estradiol delivery by prodrug bioconversion

    The Seventh Symposium on Chemical Engineering Kyushu-Taejon/ Chungnam 

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    Event date: 1994.12.15 - 1994.12.16   Language:English  

  • 代謝と結合をともなう薬物の皮膚透過

    引間知広,山田佳世子,東條角治

    第11回日本薬学会九州支部大会 

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    Event date: 1994.11.26 - 1994.11.27   Language:Japanese  

  • 薬物の経皮吸収における超音波の透過促進効果

    平井良明,引間知広,山下明泰,東條角治

    第27回化学工学会秋季大会 

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    Event date: 1994.09.27 - 1994.09.29   Language:Japanese  

  • 結合をともなう薬物の皮膚吸収

    畠山直久,引間知広,山下明泰,東條角治

    日本膜学会 第16年会 

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    Event date: 1994.05.18 - 1994.05.19   Language:Japanese  

  • 代謝をともなうエストラジオールエステルの皮膚吸収

    山田佳世子,引間知広,東條角治

    日本膜学会 第16年会 

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    Event date: 1994.05.18 - 1994.05.19   Language:Japanese  

  • ファルネシル酸の皮膚透過および皮膚内結合

    引間知広,畠山直久,東條角治

    第10回 日本薬学会九州支部大会 

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    Event date: 1993.11.27 - 1993.11.28   Language:Japanese  

  • エストラジオールエステルの皮膚内代謝速度分布

    山田佳世子,引間知広,東條角治

    第10回 日本薬学会九州支部大会 

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    Event date: 1993.11.27 - 1993.11.28   Language:Japanese  

  • 透過促進剤の皮膚代謝におよぼす影響

    引間知広,東條角治

    日本薬学会 第113年会 

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    Event date: 1993.03.29 - 1993.03.31   Language:Japanese  

  • 代謝反応をともなう薬物の皮膚吸収:拡散モデルによる理論的考察

    山田佳世子,引間知広,山下明泰,東條角治

    第9回 日本薬学会九州支部大会 

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    Event date: 1992.11.28 - 1992.11.29   Language:Japanese  

  • Viable skin 内代謝と結合をともなう薬物の皮膚吸収:in vitro 実験

    引間知広,東條角治

    第9回 日本薬学会九州支部大会 

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    Event date: 1992.11.28 - 1992.11.29   Language:Japanese  

  • 経皮薬物送達システムと物質移動

    東條角治,引間知広,山田佳世子,山下明泰

    化学工学会東海支部浜松大会 

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    Event date: 1992.11.21 - 1992.11.22   Language:Japanese  

  • 代謝をともなう薬物の皮膚透過

    引間知広,山田佳世子,山下明泰,東條角治

    日本薬剤学会第8年会 

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    Event date: 1992.09.24 - 1992.09.26   Language:Japanese  

  • Computer simulation of transdermal drug delivery

    K.Tojo, A.Yamashita, T.Hikima, Y.W. Chien

    International Symposia on Information Sciences 

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    Event date: 1992.07.13 - 1992.07.15   Language:English  

  • 薬物皮膚透過の温度依存性

    引間知広,大鳥聡,山下明泰,東條角治

    日本薬学会第112年会 

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    Event date: 1992.03.29 - 1992.03.31   Language:Japanese  

  • 薬物皮膚透過におよぼす温度の影響 -In vitro実験による評価-

    山下明泰,引間知広,大鳥聡,東條角治

    第6回 経皮吸収型製剤シンポジウム 

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    Event date: 1992.02.25   Language:Japanese  

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Industrial Property

  • 溶解型マイクロニードルアレイの製造方法

    引間知広, 伊藤高廣

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    Application no:2023-140376  Date applied:2023.08.30

  • マイクロニードル用振動型アプリケータ

    東島敦弘,松尾正昭,田代康典,中野姫香,鬼木喬玄,伊藤高廣,引間知広,富永建治,宮城孝満

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    Application no:2023-0022629  Date applied:2023.02.16

  • マイクロニードルアレイ

    中利明,松尾正昭,田代康典,原正哉,伊藤高廣,引間知広

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    Application no:2021-14454  Date applied:2021.02.01

    Announcement no:2022-117769  Date announced:2022.08.12

  • Microneedle Array

    Toshiaki Atari, Masaaki Matsuo, Yasuhiro Tashiro, Masaaki Hara, Junji Kuroki, Takahiro Ito, Tomohiro Hikima

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    Application no:16/957,172  Date applied:2020.06.23

  • マイクロニードルアレイ

    中利明,松尾正昭,田代康典,原正哉,黒木潤二,伊藤高廣,引間知広

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    Application no:2017-249120  Date applied:2017.12.26

    Patent/Registration no:特許6375435  Date registered:2018.07.27 

  • マイクロニードルアレイ

    中利明,松尾正昭,田代康典,原正哉,黒木潤二,伊藤高廣,引間知広

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    Application no:2017-088392  Date applied:2017.04.17

    Patent/Registration no:特許6261795  Date registered:2017.12.22 

  • マイクロニードルアレイ

    原正哉,黒木潤二,谷口史樹,小寺啓二,中利明,東島敦弘,松尾正昭,田代康典,伊藤高廣,引間知広,高田正人

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    Application no:2016-112572  Date applied:2016.07.04

    Patent/Registration no:特許第6608336号 

  • 経皮吸収素材、並びに、経皮吸収式化粧品、及び、経皮吸収式薬剤

    前田衣織,引間知広,野瀬健

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    Application no:特願2015-25675  Date applied:2015.02.12

    Patent/Registration no:6736036  Date registered:2016.08.16 

  • 透過促進剤

    山本政嗣,山脇幸男,田村幸永,引間知広

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    Application no:特願2010-111118  Date applied:2010.05.13

    Announcement no:特開2011-236179  Date announced:2011.11.24

    Patent/Registration no:特開2011-236179  Date registered:2011.11.24 

  • Microneedle Array (China, United States of America)

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    Patent/Registration no:WO2019130640 (A1) 

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Lectures

  • MEMS/射出成型/切削機械加工などの種々の微細加工技術によるものづくりについて−マイクロニードル/デバイスの実用化に向けて−

    令和元年度メディショナルナノテク研究会  2019.10 

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    Language:Japanese   Presentation type:Invited lecture  

  • 九工大マイクロニードル研究の進捗について

    令和元年度メディショナルナノテク研究会  2019.10 

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    Language:Japanese   Presentation type:Invited lecture  

  • 皮膚内送達&次世代経皮治療システムに向けて

    平成30年度「メディショナルナノテク研究会」  2018.07  メディショナルナノテク研究会

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    Presentation type:Invited lecture   Venue:九州工業大学  

  • 次世代経皮治療システムの開発

    平成29年度「メディショナルナノテク研究会」第1回例会  2017.07  メディショナルナノテク研究会

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    Presentation type:Invited lecture   Venue:広島市立大学  

  • 化粧品分野への経皮治療システム研究の応用

    第3回JCC産学交流セミナー  2017.03  ジャパンコスメティックセンター

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    Presentation type:Invited lecture   Venue:唐津  

  • 経皮吸収製剤のin silico薬物動態評価

    第29回日本実験動物代替法学会  2016.11 

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    Language:Japanese   Presentation type:Invited lecture  

  • 経皮治療システム研究への再生培養皮膚応用の試み

    日本DDS学会  2005.07  日本DDS学会

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    Presentation type:Invited lecture   Venue:長崎  

  • 薬物の皮膚内代謝:実験動物とヒトとの相関

    経皮治療システムシンポジウム  2003.01 

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    Presentation type:Invited lecture   Venue:福岡  

  • 経皮治療システム研究における皮膚モデル

    シンポジウム:ヒト細胞培養法による最新の治療システム  1998.05 

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    Presentation type:Keynote lecture  

  • 経皮治療システムの最近の進歩

    第5回経皮治療システムシンポジウム  1998.01 

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    Presentation type:Invited lecture  

  • 薬物の皮膚代謝と結合

    第4回経皮治療システムシンポジウム  1997.01 

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    Presentation type:Invited lecture  

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Contracts

  • ジアシルグルタミン酸リシンNa塩を含む新規ジェミニ型界面活性剤の皮膚への浸透性及び浸透促進剤としての機能に関する研究

    2009.06 - 2012.05

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    Grant type:Consigned research

  • 培養皮膚の経皮治療システム研究への応用

    2006.11

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    Grant type:Consigned research

Other External Funds

  • 非溶解型美容用マイクロニードルの実用化

    2022.08 - 2023.03

    令和4年度研究開発プロジェクト支援事業(実用化研究開発事業)  

  • 穿刺性を薬剤供給量に優れ、安価かつ手軽に使用出来る新型マイクロニードルシステムの開発

    2021.05 - 2022.03

    2021年度/A-STEP 令和2年度追加公募(トライアウトタイプ)標準  

  • 大容量薬剤コーティング型マイクロニードルの医療用途としての優位性の検証と実用化可能なアプリケータの開発と性能把握

    2020.04 - 2021.02

    新成長戦略推進研究開発事業(実用化研究開発事業)  

  • 大容量コーティング型医療用マイクロニードルアレイ製造、穿刺技術の確立と薬剤効果の検証

    2019.04 - 2020.02

    新成長戦略推進研究開発事業(実用化研究開発事業)  

  • 新型医療用マイクロニードルの実用化開発

    2018.04 - 2019.03

    公益財団法人金型技術振興財団助成金  

  • 医療用マイクロニードルの開発

    2015.04 - 2016.03

    北九州市環境未来技術開発助成事業  

  • 皮膚内送達を目指した新規ペプチド粒子の合成

    2014.06 - 2015.03

    部局長裁量経費による研究グループ支援  

  • 医療用マイクロニードルの開発

    2014.04 - 2015.03

    北九州市環境未来技術開発助成事業  

  • 皮膚内送達を目指した新規ペプチド粒子の合成

    2013.06 - 2014.03

    部局長裁量経費による研究グループ支援  

  • 医療用マイクロニードルの実用化開発

    2013.04 - 2014.03

    医療・保健・介護分野製品開発事業  

  • 皮膚内送達を目指した新規ペプチド粒子の合成

    2012.06 - 2013.03

    部局長裁量経費による研究グループ支援  

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Other Research Activities

  • 研究成果の展示会への出展

    2018.08

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    イノベーションジャパン2018への出店

  • 研究成果の展示会への出展

    2015.06

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    CITE Japan 2015への出展

Charge of off-campus class subject

  • 2022.09 - 2023.03   Institution:福岡大学

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    Level:undergraduate_liberal_arts 

  • 2021.09 - 2022.03   Institution:福岡大学

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    Level:undergraduate_liberal_arts 

  • 2020.09 - 2021.03   Institution:福岡大学

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    Level:undergraduate_liberal_arts 

  • 2019.09 - 2020.03   Institution:福岡大学

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    Level:undergraduate_liberal_arts 

Activities of Academic societies and Committees

  • The Academy of Pharmaceutical Science and Technology, Japan  

    2018.04

Social activity outside the university

  • 九州工業大学オープンキャンパス公開講義

    2014.07.19 - 2014.07.20

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    Type:University open house

  • 経皮吸収研究の基礎 薬物の膜透過について

    2014.04.21

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    Type:Other

  • 九州工業大学情報技術セミナー

    2010.08.23 - 2010.08.27

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    Type:Seminar, workshop

    講師:東條角治,引間知広
    主催者:九州工業大学
    役割:講師
    会場:九州工業大学情報工学部