2022/07/27 更新

フジイ サトシ
藤井 聡
FUJII Satoshi
Scopus 論文情報  
総論文数: 0  総Citation: 0  h-index: 9

Citation Countは当該年に発表した論文の被引用数

所属
大学院情報工学研究院 生命化学情報工学研究系
職名
助教
メールアドレス
メールアドレス
研究室電話
0948-29-7841
研究室FAX
0948-29-7841
外部リンク

研究キーワード

  • バイオインフォマティクス

  • 分析化学

  • 生物物理

研究分野

  • ナノテク・材料 / 分析化学

  • 自然科学一般 / 生物物理、化学物理、ソフトマターの物理

出身学校

  • 2001年03月   九州大学   工学部   物質科学工学科   卒業   日本国

出身大学院

  • 2006年03月   九州大学   工学研究科   化学システム工学専攻   博士課程・博士後期課程   修了   日本国

取得学位

  • 九州大学  -  博士(工学)   2006年03月

学内職務経歴

  • 2019年04月 - 現在   九州工業大学   大学院情報工学研究院   生命化学情報工学研究系     助教

  • 2008年04月 - 2019年03月   九州工業大学   大学院情報工学研究院   生命情報工学研究系     助教

所属学会・委員会

  • 2004年07月 - 現在   生物物理学会   日本国

論文

  • Naphthalene Diimides Carrying Two β-Cyclodextrins Prefer Telomere RNA G-Quadruplex Recognition 査読有り 国際誌

    Zou T., Sato Y., Kaneyoshi S., Mano K., Yasukawa R., Nakano Y., Fujii S., Sato S., Takenaka S.

    Molecules   27 ( 13 )   2022年07月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)

    Newly synthesized naphthalene diimide carrying two β-cyclodextrins (NDI-β-CyDs) showed improved specificity for the parallel G-quadruplex structure alongside the hybrid G-quadruplex structure. Specifically, the highest binding affinity of NDI-β-CyDs for the telomere RNA G-quadruplex was observed. The binding simulation indicated that β-cyclodextrins might be available for loop nucleobase inclusion under its complex.

    DOI: 10.3390/molecules27134053

    Scopus

    その他リンク: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85133131763&origin=inward

  • Cyclic ferrocenylnaphthalene diimides as a probe for electrochemical telomerase assay 査読有り

    Kaneyoshi S., Eguchi N., Fujimoto K., Fujii S., Sato S., Takenaka S.

    Journal of Inorganic Biochemistry   230   2022年05月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)

    Novel cyclic naphthalene diimides, 8 and 12, containing ferrocene in the cyclic linker were synthesized as G-quartet (G4) specific electrochemical ligands via the reaction of 1,1′-ferrocenedipropanoic acid and the terminal amine moieties of naphthalene diimides with varying linker lengths. The redox potentials of 8 and 12 were ca. 0.2 V (vs. Ag/AgCl), and the background current in an electrolyte was successfully suppressed. Both 8 and 12 bound to TA-core, representing human telomere G4, with K = 4.4 and 38 × 105 M−1, respectively. The current response of 12 to an electrode immobilized with G4 was the highest among the acyclic derivatives, suggesting its potential application in electrochemical telomerase assays.

    DOI: 10.1016/j.jinorgbio.2022.111746

    Scopus

    その他リンク: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85124248729&origin=inward

  • LSTM-PHV: prediction of human-virus protein-protein interactions by LSTM with word2vec 査読有り 国際誌

    Tsukiyama S., Hasan M.M., Fujii S., Kurata H.

    Briefings in bioinformatics   22 ( 6 )   2021年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)

    Viral infection involves a large number of protein-protein interactions (PPIs) between human and virus. The PPIs range from the initial binding of viral coat proteins to host membrane receptors to the hijacking of host transcription machinery. However, few interspecies PPIs have been identified, because experimental methods including mass spectrometry are time-consuming and expensive, and molecular dynamic simulation is limited only to the proteins whose 3D structures are solved. Sequence-based machine learning methods are expected to overcome these problems. We have first developed the LSTM model with word2vec to predict PPIs between human and virus, named LSTM-PHV, by using amino acid sequences alone. The LSTM-PHV effectively learnt the training data with a highly imbalanced ratio of positive to negative samples and achieved AUCs of 0.976 and 0.973 and accuracies of 0.984 and 0.985 on the training and independent datasets, respectively. In predicting PPIs between human and unknown or new virus, the LSTM-PHV learned greatly outperformed the existing state-of-the-art PPI predictors. Interestingly, learning of only sequence contexts as words is sufficient for PPI prediction. Use of uniform manifold approximation and projection demonstrated that the LSTM-PHV clearly distinguished the positive PPI samples from the negative ones. We presented the LSTM-PHV online web server and support data that are freely available at http://kurata35.bio.kyutech.ac.jp/LSTM-PHV.

    DOI: 10.1093/bib/bbab228

    Scopus

    その他リンク: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85121953622&origin=inward

  • Genome-wide screening reveals a role for subcellular localization of CRBN in the anti-myeloma activity of pomalidomide 査読有り

    Tateno S., Iida M., Fujii S., Suwa T., Katayama M., Tokuyama H., Yamamoto J., Ito T., Sakamoto S., Handa H., Yamaguchi Y.

    Scientific Reports   10 ( 1 )   2020年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)

    © 2020, The Author(s). Pomalidomide, a derivative of thalidomide, is an effective treatment for multiple myeloma. The drug exerts its effects through CRBN, a component of the E3 ubiquitin ligase complex CRL4CRBN. To search for novel factors involved in the anti-cancer activity of pomalidomide, we performed a genome-wide shRNA library screen and identified 445 genes as those affecting pomalidomide sensitivity. Genes encoding components of the ubiquitin-proteasome pathway, such as subunits of the CRL4CRBN complex, the COP9 signalosome, and the 26S proteasome, were among the pomalidomide-affecting genes. Karyopherin beta 1 (KPNB1) was identified as a novel pomalidomide-affecting gene. KPNB1 was required for the nuclear import of CRBN and for the CRBN-directed, pomalidomide-dependent degradation of a clinically relevant substrate, the transcription factor Aiolos. By contrast, the cytoplasmic translation factor GSPT1 was degraded following treatment with the thalidomide derivative CC-885 only when CRBN was present in the cytoplasm, indicating that subcellular distribution of CRBN is critical for the efficacy of thalidomide-based medications.

    DOI: 10.1038/s41598-020-61027-w

    Scopus

    その他リンク: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85081211410&origin=inward

  • The role of Mediator and Little Elongation Complex in transcription termination 査読有り

    Takahashi H., Ranjan A., Chen S., Suzuki H., Shibata M., Hirose T., Hirose H., Sasaki K., Abe R., Chen K., He Y., Zhang Y., Takigawa I., Tsukiyama T., Watanabe M., Fujii S., Iida M., Yamamoto J., Yamaguchi Y., Suzuki Y., Matsumoto M., Nakayama K.I., Washburn M.P., Saraf A., Florens L., Sato S., Tomomori-Sato C., Conaway R.C., Conaway J.W., Hatakeyama S.

    Nature Communications   11 ( 1 )   2020年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)

    © 2020, The Author(s). Mediator is a coregulatory complex that regulates transcription of Pol II-dependent genes. Previously, we showed that human Mediator subunit MED26 plays a role in the recruitment of Super Elongation Complex (SEC) or Little Elongation Complex (LEC) to regulate the expression of certain genes. MED26 plays a role in recruiting SEC to protein-coding genes including c-myc and LEC to small nuclear RNA (snRNA) genes. However, how MED26 engages SEC or LEC to regulate distinct genes is unclear. Here, we provide evidence that MED26 recruits LEC to modulate transcription termination of non-polyadenylated transcripts including snRNAs and mRNAs encoding replication-dependent histone (RDH) at Cajal bodies. Our findings indicate that LEC recruited by MED26 promotes efficient transcription termination by Pol II through interaction with CBC-ARS2 and NELF/DSIF, and promotes 3′ end processing by enhancing recruitment of Integrator or Heat Labile Factor to snRNA or RDH genes, respectively.

    DOI: 10.1038/s41467-020-14849-1

    Scopus

    その他リンク: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85080098899&origin=inward

  • The interaction of cyclic naphthalene diimide with G-quadruplex under molecular crowding condition 査読有り

    Zou T., Sato S., Yasukawa R., Takeuchi R., Ozaki S., Fujii S., Takenaka S.

    Molecules   25 ( 3 )   2020年02月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)

    © 2020 by the authors. G-quadruplex specific targeting molecules, also termed as G4 ligands, are attracting increasing attention for their ability to recognize and stabilize G-quadruplex and high potentiality for biological regulation. However, G4 ligands recognizing G-quadruplex were generally investigated within a dilute condition, which might be interfered with under a cellular crowding environment. Here, we designed and synthesized several new cyclic naphthalene diimide (cNDI) derivatives, and investigated their interaction with G-quadruplex under molecular crowding condition (40% v/v polyethylene glycol (PEG)200) to mimic the cellular condition. The results indicated that, under molecular crowding conditions, cNDI derivatives were still able to recognize and stabilize G-quadruplex structures based on circular dichroism measurement. The binding affinities were slightly decreased but still comparatively high upon determination by isothermal titration calorimetry and UV-vis absorbance spectroscopy. More interestingly, cNDI derivatives were observed with preference to induce a telomere sequence to form a hybrid G-quadruplex under cation-deficient molecular crowding conditions.

    DOI: 10.3390/molecules25030668

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    その他リンク: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85079081249&origin=inward

  • Cyclic Naphthalene Diimide with a Ferrocene Moiety as a Redox-Active Tetraplex-DNA Ligand 査読有り

    Kaneyoshi S., Zou T., Ozaki S., Takeuchi R., Udou A., Nakahara T., Fujimoto K., Fujii S., Sato S., Takenaka S.

    Chemistry - A European Journal   26 ( 1 )   139 - 142   2020年01月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)

    © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Cyclic naphthalene diimides (cNDIs), with a ferrocene moiety (cFNDs) and different linker lengths between the ferrocene and cNDI moieties, were designed and synthesized as redox-active, tetraplex-DNA ligands. Intramolecular stacking was observed between ferrocene and the NDI planes, which could affect the binding properties for G-quadruplexes. Interestingly, the circular dichroism spectrum of one of these compounds clearly shows new Cotton effects around 320–380 and 240 nm, which can be considered a direct evidence of intramolecular stacking of ferrocene and the NDI. Regarding recognition of hybrid G-quadruplexes, the less rigid structures (longer linkers) show higher binding affinity (106 m−1 order of magnitude). All new compounds show higher selectivity for G4 during electrochemical detection than noncyclic FND derivatives, which further identifies the redox-active potentiality of the cFNDs. Two of the three compounds tested even show preferential inhibition of cell growth in cancer cells over normal cells in a low concentration range, highlighting the potential for bioapplications of these cFNDs.

    DOI: 10.1002/chem.201903883

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    その他リンク: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85076108396&origin=inward

  • A simple and practical workflow for genotyping of CRISPR–Cas9-based knockout phenotypes using multiplexed amplicon sequencing 査読有り

    Iida M., Suzuki M., Sakane Y., Nishide H., Uchiyama I., Yamamoto T., Suzuki K.i.T., Fujii S.

    Genes to Cells   25 ( 7 )   498 - 509   2020年01月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)

    © 2020 Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd Founder animals carrying high proportions of somatic mutation induced by CRISPR–Cas9 enable a rapid and scalable strategy for the functional screening of numerous target genes in vivo. In this functional screening, genotyping using pooled amplicons with next-generation sequencing is the most suitable approach for large-scale management of multiple samples and accurate evaluation of the efficiency of Cas9-induced somatic mutations at target sites. Here, we present a simple workflow for genotyping of multiple CRISPR–Cas9-based knockout founders by pooled amplicon sequencing. Using custom barcoded primers, pooled amplicons from multiple individuals can be run in a single-indexed library on the Illumina MiSeq platform. Additionally, a user-friendly web tool, CLiCKAR, is available to simultaneously perform demultiplexing of pooled sequence data and evaluation of somatic mutation in each phenotype. CLiCKAR provides users with practical reports regarding the positions of insertions/deletions, as well as the frameshift ratio and tables containing mutation sequences, and read counts of each phenotype, with just a few clicks by the implementation of demultiplexing for pooled sample data and calculation of the frameshift ratio. This genotyping workflow can be harnessed to evaluate genotype–phenotype correlations in CRISPR–Cas9-based loss-of-function screening of numerous target genes in various organisms.

    DOI: 10.1111/gtc.12775

    Scopus

    その他リンク: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85085561481&origin=inward

  • Functional analysis of thyroid hormone receptor beta in Xenopus tropicalis founders using CRISPR-Cas 査読有り

    Y Sakane, M Iida, T Hasebe, S Fujii, DR Buchholz, A Ishizuya-Oka, T Yamamoto, KT Suzuki

    Biology Open   7   2018年01月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)

    DOI: 10.1242/bio.030338

    その他リンク: http://bio.biologists.org/content/7/1/bio030338

  • Effects of 4-Hydroxy-2,3,3 <sup>0</sup> ,4 <sup>0</sup> ,5-Pentachlorobiphenyl (4-OH-CB107) on liver transcriptome in rats: Implication in the disruption of circadian rhythm and fatty acid metabolism 査読有り

    Ochiai M., Iida M., Agusa T., Takaguchi K., Fujii S., Nomiyama K., Iwata H.

    Toxicological Sciences   165 ( 1 )   118 - 130   2018年01月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)

    © The Author(s) 2018. Polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (OH-PCBs) have been detected in tissues of both wild animals and humans. Several previous studies have suggested adverse effects of OH-PCBs on the endocrine and nervous systems in mammals. However, there have been no studies on transcriptome analysis of the effects of OH-PCBs, and thus, the whole picture and mechanisms underlying the adverse effects induced by OH-PCBs are still poorly understood. We therefore investigated the mRNA expression profile in the liver of adult male Wistar rats treated with 4-hydroxy-2,3,3 0 ,4 0 ,5-pentachlorobiphenyl (4-OH-CB107) to explore the genes responsive to OH-PCBs and to understand the potential effects of the chemical. Next-generation RNA sequencing analysis revealed changes in the expression of genes involved in the circadian rhythm and fatty acid metabolism, such as nuclear receptor subfamily 1, group D, member 1, aryl hydrocarbon receptor nuclear translocator-like protein 1, cryptochrome circadian clock 1, and enoyl-CoA hydratase and 3-hydroxyacyl-CoA dehydrogenase, in 4-OH-CB107-treated rats. In addition, biochemical analysis of the plasma revealed a dose-dependent increase in the leucine aminopeptidase, indicating the onset of liver damage. These results suggest that OH-PCB exposure May induce liver injury as well as disrupt the circadian rhythm and peroxisome proliferator-activated receptor-related fatty acid metabolism.

    DOI: 10.1093/toxsci/kfy123

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  • Identification of aryl hydrocarbon receptor signaling pathways altered in TCDD-treated red seabream embryos by transcriptome analysis 査読有り

    Iida M., Iida M., Fujii S., Uchida M., Nakamura H., Kagami Y., Agusa T., Hirano M., Bak S., Kim E., Iwata H.

    Aquatic Toxicology   177   156 - 170   2016年08月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)

    © 2016 Elsevier B.V.2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces a broad spectrum of toxic effects including craniofacial malformation and neural damage in fish embryos. These effects are mainly mediated by the aryl hydrocarbon receptor (AHR). However, the mode of action between TCDD-induced AHR activation and adverse outcomes is not yet understood. To provide a comprehensive picture of the AHR signaling pathway in fish embryos exposed to TCDD, red seabream (Pagrus major) embryos were treated with graded concentrations of TCDD (0.3–37 nM) in seawater, or with a mixture of TCDD and 500 nM CH223191, an AHR-specific antagonist. The transcriptome of red seabream embryos was analyzed using a custom-made microarray with 6000 probes specifically prepared for this species. A Jonckheere-Terpstra test was performed to screen for genes that demonstrated altered mRNA expression levels following TCDD exposure. The signals of 1217 genes (as human homologs) were significantly altered in a TCDD concentration-dependent manner (q-value < 0.2). Notably, the TCDD-induced alteration in mRNA expression was alleviated by co-exposure to CH223191, suggesting that the mRNA expression level of these genes was regulated by AHR. To identify TCDD-activated pathways, the microarray data were further subjected to gene set enrichment analysis (GSEA) and functional protein–protein interaction (PPI) network analysis. GSEA demonstrated that the effects of TCDD on sets of genes involved calcium, mitogen-activated protein kinase (MAPK), actin cytoskeleton, chemokine, T cell receptor, melanoma, vascular endothelial growth factor (VEGF), axon guidance, and renal cell carcinoma signaling pathways. These results suggest the hypotheses that TCDD induces immunosuppression via the calcium, MAPK, chemokine, and T cell receptor signaling pathways, neurotoxicity via VEGF signaling, and axon guidance alterations and teratogenicity via the dysregulation of the actin cytoskeleton and melanoma and renal cell carcinoma signaling pathways. Furthermore, the PPI network analysis indicated that the adverse outcome pathways of TCDD in the embryos might be propagated through several hub genes such as cell division control protein 42, phosphoinositide-3-kinase regulatory subunit 1, and guanine nucleotide-binding proteins. Understanding these pathways potentially allows for exploring the adverse outcome pathway of the effects of TCDD on the red seabream embryos.

    DOI: 10.1016/j.aquatox.2016.05.014

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    その他リンク: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84976592339&origin=inward

  • Rapid and efficient analysis of gene function using CRISPR-Cas9 in Xenopus tropicalis founders 査読有り

    Shigeta M., Sakane Y., Iida M., Suzuki M., Kashiwagi K., Kashiwagi A., Fujii S., Yamamoto T., Suzuki K.

    Genes to Cells   21 ( 7 )   755 - 771   2016年07月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)

    © 2016 Molecular Biology Society of Japan and John Wiley & Sons Australia, LtdRecent advances in genome editing using programmable nucleases, such as zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) and the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas system, have facilitated reverse genetics in Xenopus tropicalis. To establish a practical workflow for analyzing genes of interest using CRISPR-Cas9, we examined various experimental procedures and conditions. We first compared the efficiency of gene disruption between Cas9 protein and mRNA injection by analyzing genotype and phenotype frequency, and toxicity. Injection of X. tropicalis embryos with Cas9 mRNA resulted in high gene-disrupting efficiency comparable with that produced by Cas9 protein injection. To exactly evaluate the somatic mutation rates of on-target sites, amplicon sequencing and restriction fragment length polymorphism analysis using a restriction enzyme or recombinant Cas9 were performed. Mutation rates of two target genes (slc45a2 and ltk) required for pigmentation were estimated to be over 90% by both methods in animals exhibiting severe phenotypes, suggesting that targeted somatic mutations were biallelically introduced in almost all somatic cells of founder animals. Using a heteroduplex mobility assay, we also showed that off-target mutations were induced at a low rate. Based on our results, we propose a CRISPR-Cas9-mediated gene disruption workflow for a rapid and efficient analysis of gene function using X. tropicalis founders.

    DOI: 10.1111/gtc.12379

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  • SMARCAD1 is an ATP-dependent stimulator of nucleosomal H2A acetylation via CBP, resulting in transcriptional regulation 査読有り

    M. Doiguchi, T. Nakagawa T, Y. Imamura, M. Yoneda, M. Higashi, K Kubota, S. Yamashita, H. Asahara, M. Iida, S. Fujii, T. Ikura, Z. Liu, T. Nandu, WL. Kraus, H. Ueda, T. Ito

    Scientific Reports   6   20179   2016年02月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)

    DOI: 10.1038/srep20179

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    その他リンク: http://www.nature.com/articles/srep20179

  • Diagnosis of Periodontal Disease from Saliva Samples Using Fourier Transform Infrared Microscopy Coupled with Partial Least Squares Discriminant Analysis 査読有り

    S. Fujii, S Sato, K. Fukuda, T. Okinaga, W. Ariyoshi, M. Usui, K. Nakashima, T. Nishihara, S. Takenaka

    Analytical Sciences   32 ( 2 )   225 - 231   2016年02月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)

    DOI: 10.2116/analsci.32.225

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    CiNii Article

    その他リンク: http://www.mdpi.com/1420-3049/20/6/10963

  • Dzip3 regulates developmental genes in mouse embryonic stem cells by reorganizing 3D chromatin conformation 査読有り

    D. Inoue, H. Aihara, T. Sato, H. Mizusaki, M. Doiguchi, M. Higashi, Y. Imamura, M. Yoneda, T. Miyanishi, S. Fujii, A. Okuda, T. Nakagawa, T. Ito

    Scientific Reports   5   16567   2015年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)

    DOI: 10.1038/srep16567

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    その他リンク: http://www.nature.com/articles/srep16567

  • A Selective G-Quadruplex DNA-Stabilizing Ligand Based on a Cyclic Naphthalene Diimide Derivative 査読有り

    M. M. Islam, S. Fujii, S. Sato, T. Okauchi, S. Takenaka

    Molecules   20 ( 6 )   10963 - 10979   2015年06月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)

    DOI: 10.3390/molecules200610963

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    その他リンク: http://www.mdpi.com/1420-3049/20/6/10963

  • Thermodynamics and kinetic studies in the binding interaction of cyclic naphthalene diimide derivatives with double stranded DNAs 査読有り

    M. M. Islam, S. Fujii, S. Sato, T. Okauchi, S. Takenaka

    Bioorganic & Medicinal Chemistry   23 ( 15 )   4769 - 4776   2015年06月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)

    DOI: 10.1016/j.bmc.2015.05.046

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    その他リンク: http://www.sciencedirect.com/science/article/pii/S0968089615004563

  • Erratum: Cooperative binding of ferrocenylnaphthalene diimide carrying β-cyclodextrin converts double-stranded DNA to a rod-like structure (Bioconjugate Chemistry (2015) 26:3 (379-382) DOI: 10.1021/bc500535n) 査読有り

    Sato S., Umeda Y., Fujii S., Takenaka S.

    Bioconjugate Chemistry   26 ( 4 )   2015年04月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)

    DOI: 10.1021/acs.bioconjchem.5b00149

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    その他リンク: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84927762176&origin=inward

  • Cooperative Binding of Ferrocenylnaphthalene Diimide Carrying β-Cyclodextrin Converts Double-Stranded DNA to a Rod-Like Structure 査読有り

    S. Sato, Y. Ueda, S. Fujii, S. Takenaka

    Bioconjugate Chemistry   26 ( 3 )   379 - 382   2015年03月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)

    DOI: 10.1021/bc500535n

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    その他リンク: http://www.mdpi.com/1420-3049/20/6/10963

  • Design of tetraplex specific ligands: cyclic naphthalene diimide 査読有り

    Y. Esaki, MM. Islam, S. Fujii, S. Sato, S. Takenaka

    Chemical Communications   50 ( 45 )   5967 - 5969   2014年04月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)

    DOI: 10.1039/c4cc01005a

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    その他リンク: http://pubs.rsc.org/en/Content/ArticleLanding/2014/CC/C4CC01005A

  • NF-E2 p45 is important for establishing normal function of platelets 査読有り

    R. Fujita, M. Takayama-Tsujimoto, H. Satoh, L. Gutiérrez, H. Aburatani, S. Fujii, A. Sarai, EH. Bresnick, M. Yamamoto, H. Motohashi

    Molecular and Cellular Biology   33 ( 14 )   2659 - 2670   2013年05月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)

    DOI: 10.1128/MCB.01274-12

    Scopus

    その他リンク: http://mcb.asm.org/content/33/14/2659

  • Evaluation of DNA intramolecular interactions for nucleosome positioning in yeast 査読有り

    M. Fernandez, S. Fujii, H. Kono and A. Sarai

    Genome Informatics   23 ( 1 )   13 - 20   2009年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)

  • DNA deformability and hydration studied by molecular dynamics simulation 査読有り

    Y. Yonetani,H. Kono,S. Fujii,A. Sarai,N. Go

    Mol. Simulation   33   103 - 107   2007年04月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)

  • Sequence-dependent DNA deformability studied using molecular dynamics simulations 査読有り

    S. Fujii,H. Kono,S. Takenaka,N. Go & A. Sarai

    Nucleic Acid Research   35 ( 18 )   6063 - 6074   2007年04月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)

    代表的研究業績

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口頭発表・ポスター発表等

  • The gene regulation by the combination of transcription factors: analysis of co-occurrence of small maf family and the other transcription factors

    Satoshi Fujii

    2010年日本バイオインフォマティクス学会年会 

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    開催期間: 2010年12月13日 - 2010年12月15日   記述言語:英語  

  • The difference of the A-B form transition of DNA between the different sequences and environments studied by molecular dynamics simulations

    Satoshi Fujii

    第48回日本生物物理学会年会 

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    開催期間: 2010年09月20日 - 2010年09月22日   記述言語:英語   開催地:東北大学川内キャンパス  

  • The effect of environment on the conformational transition of DNA studied by molecular dynamics simulations

    Satoshi Fujii

    第47回日本生物物理学会年会 

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    開催期間: 2009年10月30日   記述言語:英語   開催地:アスティ徳島  

  • The conformational transition of DNA by the environment in molecular dynamics simulation

    Satoshi Fujii

    第46回日本生物物理学会年会 

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    開催期間: 2008年12月03日   記述言語:英語   開催地:福岡国際会議場  

  • タンパク質-DNA認識におけるDNA backbone構造の役割

    藤井 聡

    日本生物物理学会第45回年会 

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    開催期間: 2007年12月21日 - 2007年12月23日   記述言語:日本語   開催地:パシフィコ横浜  

  • 蛋白質-DNA認識における配列依存的DNA backboneコンフォーメーションの役割

    Satoshi Fujii

    第7回日本蛋白質科学会年会 

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    開催期間: 2007年05月24日 - 2007年05月26日   記述言語:日本語   開催地:仙台国際センター  

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講演

  • プール型shRNAシークエンス(shRNA-seq)スクリーニングデータ解析法の開発

    NGS現場の会第四回研究会  2015年07月 

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    開催期間: 2015年07月01日 - 2015年07月03日   発表言語:日本語   講演種別:特別講演   開催地:つくば国際会議場  

担当授業科目(学内)

  • 2021年度   医用分子シミュレーション

  • 2021年度   バイオデータベース演習

  • 2020年度   医用分子シミュレーション

  • 2020年度   バイオデータベース演習

  • 2019年度   分子設計基礎

  • 2019年度   データベース演習

  • 2018年度   データベース演習

  • 2018年度   分子設計基礎

  • 2017年度   分子設計基礎

  • 2017年度   データベース演習

  • 2016年度   分子設計基礎

  • 2016年度   データベース演習

  • 2015年度   データベース演習

  • 2015年度   分子設計基礎

  • 2014年度   データベース演習

  • 2014年度   分子設計基礎

  • 2012年度   分子設計基礎

  • 2012年度   数値計算演習

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