研究者詳細 - 玉川　雅章

論文 - 玉川　雅章

分割表示219 件中 181 - 200 件目／全件表示 >>

Deformation process of a bubble near curved elastic wall 査読有り

Masaaki TAMAGAWAM,I.chiro YAMANOI,Atsushi MATSUMOTO

10th International Symposium on Flow Visualization 264 - 268 2002年07月

Fundamental investigation for developing drug delivery systems and bioprocess with shock waves and bubbles (Numerical analysis of deformation of cell model and observation of bubble behavior near the cell-membrane model) 査読有り国際誌

Tamagawa M., Yamanoi I., Matsumoto A., Wada H.

JSME International Journal, Series C: Mechanical Systems, Machine Elements and Manufacturing 44 ( 4 ) 1031 - 1040 2001年12月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

This paper describes the fundamental investigations for developing new technology using shock waves and bubbles, such as drug delivery systems (DDS) and bioprocess for environmental protection. To understand the fundamental phenomena, the coupling oscillation problems between the deformations of the cell including a bubble and the flow when underwater shock waves propagating are analyzed using computational fluid dynamics (CFD) and optical visualization. For this analysis, the cell is modeled as a liquid droplet including a gas bubble. The effects of (1) the differences of acoustic impedance between internal and surrounding fluid and (2) the boundary motion of the cell on the flow field (density) are discussed using ALE (Arbitrary Lagragian-Eulerian) computational method. The result shows that the effects of the differences of the acoustic impedance and the existence of a bubble in a cell are large for the deformation process of the cell itself. For the optical visualization, deformation process of a bubble near the elastic wall is observed as a model of cell membrane by shock waves to analyze the behavior of the bubble in the cell or microcapsule. From this result, it is suggested that there should be optimized or critical point to have large deformation of the bubble while changing initial position and initial diameter of the bubble in the cell and relative curvature of the wall (cell diameter), which may be enough to have large deformation to cracking the cell membrane. From these two results, it is found that if the proper parameters are selected, there are possibilities to make the large deformation enough to crack the cell membrane efficiently comparing with that has no bubbles when the shock waves and bubbles are applied to the fields of DDS or bioprocess.

DOI： 10.1299/jsmec.44.1031

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Predictions for hemolysis properties in turbulent shear blood flows by using computational fluid dynamics and their verification 査読有り国際誌

Tamagawa M., Minakawa S.

Nihon Kikai Gakkai Ronbunshu, B Hen/Transactions of the Japan Society of Mechanical Engineers, Part B 67 ( 664 ) 3119 - 3126 2001年12月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

This paper describes a numerical prediction method for hemolysis properties in orifice-pipe blood flows. In this study, several types of orifice-pipe flows by using two turbulence models are computed, which are ( 1 ) standard low Reynolds number k-ε model and (2 ) the k-ε model with partly patched Launder-Kato model (LK-Zonal model) to improve computational accuracy. These predicted flows are compared with (a) measuring pressure loss and (b) measuring reattachment length, and it is found that the flow using LK-Zonal model has good agreement with experiments. Then the hemolysis properties are estimated from the predicted flows. The results are 1) computational accuracy of orifice-pipe flow is improved by using LK-Zonal model, 2) accuracy of predicted hemolysis is also improved especially in orifice-pipe that have long contracted part.

DOI： 10.1299/kikaib.67.3119

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Deformation Process and Disintegration for Microcapsules including Gas Bubbles by Shock Waves in Drug Delivery Systems 査読有り

M. Tamagawa,I.Yamanoi,A. Matsumoto

Proc. of 23 rd International Symposium on Shock Waves 2001年07月

Fundamental Investigation for Developing Drug Delivery Systems and Bioprocess with Shock Waves and Bubbles 査読有り

M. Tamagawa,I. Yamanoi

JSME International Journal, C 44 ( 4 ) 1031 - 1040 2001年04月

せん断乱流場での数値流体力学を用いた溶血予測とその検証査読有り

皆川重治，玉川雅章

日本機械学会論文集Ｂ編 67 ( 664 ) 3119 - 3126 2001年04月

Analysis of deformation process for cell model including a gas bubble by shock waves 査読有り

M. Tamagawa,I.Yamanoi,A. Matsumoto

J. of Acoust. Soc. America 108 ( 5 ) 2547 - 2547 2000年12月

Predictions of index of hemolysis in shear blood flow (Improvement of accuracy for prediction by modifying turbulence model for orifice-pipe flow) 査読有り国際誌

Tamagawa M., Minakawa S.

JSME International Journal, Series C: Mechanical Systems, Machine Elements and Manufacturing 43 ( 4 ) 853 - 861 2000年12月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

This paper describes the improvement of accuracy for prediction of index of hemolysis in shear blood flow by computational fluid dynamics (CFD) with modified turbulence model, applying to orifice-pipe blood flow, which is simple model of turbulent shear stress induced hemolysis in the high speed rotary blood pump. Using CFD with partially patched modified κ-ε model (Launder-Kato partially patched model; LK-Zonal), results of the flow field in the orifice-pipe flow are compared with standard low Reynolds number κ-ε model at whole region (STD), and it is found that the shear stress by LK-Zonal model is predicted more precisely than that by STD model near the impinging flow region. As for hemolysis, from the computational data of orifice-pipe flow, the index of hemolysis is estimated in the same way as our previous paper(1), and it is found that the accuracy for prediction of index of hemolysis is also improved using LK-Zonal model in comparison with STD model, particularly in case of the orifice-pipe flow with large and long contracted part. From these results, the design method using CFD for the rotary blood pumps, that have impinging flow region to the wall, for suppressing the hemolysis can be proposed.

DOI： 10.1299/jsmec.43.853

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生体内の衝撃波のバイオメカニクス(コンピューテーショナル・バイオメカニクス) 査読有り

玉川　雅章

日本ME学会誌 BME 14 ( 10 ) 41 - 44 2000年10月

Predictions of Index of Hemolysis in Shear Blood Flow 査読有り

(M. Tamagawa,T.Akamatsu

JSME International Journal Series B 43 ( 2 ) 225 - 232 2000年05月

Predictions of index of hemolysis in shear blood flow (Effects of contact with wall and particle inertia) 査読有り国際誌

Tamagawa M., Akamatsu T., Sano T.

JSME International Journal, Series B: Fluids and Thermal Engineering 43 ( 2 ) 225 - 232 2000年05月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

This paper describes the effects of the particle inertia and the contact with the wall on hemolysis properties. The newly proposed methods of examining the inertia of red blood cells (particle) on particle path are discussed using computational fluid dynamics (CFD). In these methods, the particles are moved by Stokes drag including effects of difference of density between plasma and internal liquid in the blood. The results of computational analysis using these methods show that (1) the diameter of the particle (red blood cell), that is inertia of the cells, (2) the configuration of the objective wall boundary are important factors for this prediction. The results also show that if the inertia and the contact with the wall are considered, the precision of the prediction of the hemolysis properties will be improved comparing with that they are not considered.

DOI： 10.1299/jsmeb.43.225

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Effects of Shock Waves on Living Tissue Cells and its Deformation Process Using a Mathematical Model 査読有り

M. Tamagawa,T.Akamatsu

JSME International Journal Series C, 42 ( 3 ) 640 - 647 1999年11月

Hemolysis (Erthrocyte Damage) Model for Prediction in Turbulent Shear Blood Flow 査読有り

M. Tamagawa,T.Akamatsu

Turbulence and Shear Flow-1(1-st International Symposium) 837 - 842 1999年09月

Effects of shock waves on living tissue cells and its deformation process using a mathematical model 査読有り国際誌

Tamagawa M., Akamatsu T.

JSME International Journal, Series C: Mechanical Systems, Machine Elements and Manufacturing 42 ( 3 ) 640 - 647 1999年09月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

In this study, damage of living tissue cells (red blood cells and cancer cells) and experimental cell models (microcapsules) by plane shock waves is carried out experimentally. In addition, the effects of physical condition on the degree of damage are evaluated by constructing an appropriate mathematical model. To explain these phenomena, the red blood cells and the microcapsules are modeled mathematically as two spherical elastic shells filled with liquid. The fundamental equations express the oscillation of the spherical elastic shell in response to the incident pressure wave in the surrounding fluid. Frequency responses of the elastic shell model of two living tissue cells with mutual interaction in water are analyzed. From the results of this analysis, the effects of (1) the rise time of shock waves, (2) the distance between cells on shock-induced damage, (3) the concentration of suspended cells and (4) the incidence angle of shock waves are discussed. It is found that effects of these parameters are large in certain cases.

DOI： 10.1299/jsmec.42.640

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Modeling of Deformation for Living Tissue Cells with Structure by Propagating Shock Wave 査読有り

M. Tamagawa,T.Akamatsu

Proc. of 22nd International Symposium on Shock Waves 595 - 600 1999年07月

Predictions for hemolysis properties in shear blood flows of the pipe-orifice (2nd report, effects of particle inertia and contact with wall) 査読有り国際誌

Tamagawa M., Sano T., Akamatsu T.

Nihon Kikai Gakkai Ronbunshu, B Hen/Transactions of the Japan Society of Mechanical Engineers, Part B 65 ( 633 ) 1621 - 1628 1999年05月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

This paper describes the particle inertia and the contact with the wall of red blood cells on the variance of particle path, that should depend on the hemolysis properties. The new methods of examining the inertia of red blood cells (particle) on particle path are discussed using computational fluid dynamics (CFD). In this method, the particles are moved by Stokes drag including effects of difference between density of plasma and internal liquid in the blood. The results of analysis by this method show that (1) the diameter of the particle (red blood cell) that means inertia of the cells, (2) the configuration of the objective wall boundary are important factor. These results also show that if the inertia and the contact with the wall are considered, the precision of the prediction of the hemolysis properties will be progressed.

DOI： 10.1299/kikaib.65.1621

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オリフィス管内せん断血流の溶血特性予測（第２報，粒子の慣性力と壁面接触の影響）査読有り

玉川雅章，佐野貴司，赤松映明

日本機械学会論文集 B編 98 ( 1217 ) 1621 - 1628 1999年02月

Deformation of Spherical Living Tissue Cells by Using Shock Waves 査読有り

M.Tamagawa,T.Akamatsu

Proc. of the 3rd World Congress of Biomechanics 405 - 405 1998年10月