研究者詳細 - 佐藤　しのぶ

論文 - 佐藤　しのぶ

分割表示140 件中 121 - 140 件目／全件表示 >>

Linker chain effect of ferrocenylnaphtalene diimide derivatives on a tetraplex DNA binding 査読有り

Shinobu Sato,Hiroki Kondo,Shigeori Takenaka

Nucleic Acids Symposium Series 50 107 - 108 2006年11月

Ferrocenylnaphthalene diimide-based electrochemical detection of methylated gene 査読有り

Shinobu Sato,Hiroki Kondo,Koji Hokazono,Tatsuya Irie,Takashi Ueki,Michinori Waki,Takahiko Nojima,Shigeori Takenaka

Analytica Chimica Acta 578 ( 18 ) 82 - 87 2006年09月

Electrochemical detection of telomeric quadruplex DNA using ferrocenyl naphthalene diimide. 招待有り査読有り国際誌

Sato S., Kondo H., Nojima T., Takenaka S.

Nucleic acids symposium series (2004) ( 49 ) 237 - 238 2005年12月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

Ferrocenylnaphthalene diimide (FND) could strongly bind to the synthetic telomere DNA, 5'-CAT GGT GGT TTG GGT TAG GGT TAG GGT TAG GGT TAC CAC-3', at 0.1 M KCl. The binding affinity of FND for the telomere DNA was ten times higher than that for calf thymus DNA under the conditions employed. Circular dichroism spectra suggested that the telomere DNA can form a tetraplex structure and FND can bind to it. Oligonucleotide extended by telomerase on the electrode could also be detected electrochemically by using FND, thereby suggesting the possibility that telomerase activity may be detected electrochemically.

DOI： 10.1093/nass/49.1.237

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Electrochamical detection of telomeric quadruplex DNA using ferrocenyl naphthalene diimide 査読有り

Shinobu Sato,Hiroki Kondo,Takahiko Nojima,Shigeori Takenaka

Nucleic Acids Symposium Series 49 237 - 238 2005年09月

Supramolecular complex formation by β-cyclodextrin and ferrocenylnaphthalene diimide-intercalated double stranded DNA and improved electrochemical gene detection 招待有り査読有り

Sato S., Nojima T., Waki M., Takenaka S.

Molecules 10 ( 6 ) 693 - 707 2005年06月

記述言語：英語掲載種別：研究論文（学術雑誌）

Ferrocenylnaphthalene diimide 1 can bind to double stranded DNA (dsDNA) by the threading intercalation mode and the resulting complex was stabilized further by β-cyclodextrin (CD) by forming a supramolecular complex. These complex formation processes were studied by spectroscopic, viscometric, and electrochemical means in the absence or presence of β-CD, Quantitative analysis by quartz crystal microbalance (QCM) and electrochemical experiments strongly suggested a 2:1 binding stoichiometry for β-CD to 1 threading-intercalated to the dsDNA-immobilized electrode. Owing to this supramolecular complex formation, electrochemical DNA detection based on 1 was improved considerably. © 2005 by MDPI.

DOI： 10.3390/10060693

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Supramolecular complex formationby be-ta-cyclodextrin and ferrocenylnaphthalene diimide-intercalated double stranded DNA and improved electrochemical gene detection 査読有り

Shinobu Sato,Takahiko Nojima,Michinori Waki,Shigeori Takenaka

Molecules 10 ( 6 ) 693 - 707 2005年06月

Electrochemical Telomerase Assay with Ferrocenylnaphthalene Diimide as a Tetraplex DNA-Specific Binder 査読有り

Shinob Sato,Hiroki Kondo,Takahiko Nojima,Shigeori Takenaka

Analytical Chemistry 77 ( 22 ) 7304 - 7309 2005年04月

Electrochemical gene detection based on supramolecular complex formation by ferrocenyl-β-cyclodextrin and adamantylnaphthalene diimide bound to double stranded DNA 査読有り国際誌

Sato S., Nojima T., Takenaka S.

Journal of Organometallic Chemistry 689 ( 25 SPEC. ISS. ) 4722 - 4728 2004年12月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）

Adamantylnaphthalene diimide 1 was synthesized as a highly selective double stranded DNA (dsDNA) binding reagent. The binding studies with sonicated calf thymus DNA as a model of dsDNA revealed that 1 can bind to dsDNA by the threading mode, where the two adamantyl moieties are located in the major and minor grooves of dsDNA separately and the complex of 1 with DNA duplex was stabilized by capping of the adamantyl moieties of 1 bound to dsDNA by β-cyclodextrin. The adamantyl moieties of 1 could be incorporated also into the cavity of ferrocenyl-β-cyclodextrin (Fc-β-CD), resulting in the formation of a supramolecular complex. When this complex is formed on the DNA probe-immobilized electrode, electrochemical DNA detection was feasible: the electrode hybridized with target DNA gave rise to a current peak corresponding to the ferrocene oxidation upon treatment with 1 and Fc-β-CD. © 2004 Elsevier B.V. All rights reserved.

DOI： 10.1016/j.jorganchem.2004.08.039

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Electrochemical gene detection by using adamantyl naphthalene diimide coupled with ferrocenyl-beta-cyclodextrin. 査読有り国際誌

Sato S., Nojima T., Kondo H., Takenaka S.

Nucleic acids symposium series (2004) ( 48 ) 103 - 104 2004年12月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

The adamantyl moieties of adamantylnaphthalene diimide (AND) can be incorporated into the cavity of ferrocenyl-beta-cyclodextrin even where they are bound to double stranded DNA by threading intercalation. When this ternary complex is formed on the DNA probe-immobilized electrode, electrochemical DNA detection is feasible: the electrode hybridized with target DNA gave rise to a current peak corresponding to the ferrocene oxidation upon treatment with AND and ferrocenyl-beta-cyclodextrin (Fc-beta-CD).

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Electrochemical gene detection by using adamanthyl naphthalene diimide coupled with ferrocenyl-beta-cyclodextrin 査読有り

Shinobu Sato,Takahiko Nojima,Hiroki Kondo,Shigeori Takenaka

Nucleic Acids Symposium Series 48 103 - 104 2004年11月

Electrochemical gene detection based on supramolecular complex formation by ferrocenyl-β-cyclodextrin and adamantylnaphthalene diimide bound to double stranded DNA 査読有り

Shinobu Sato,Takahiko Nojima,Shigeori Takenaka

Journal of Organometallic Chemistry 689 ( 25 ) 4722 - 4728 2004年04月

SNP analysis by using ferrocenyl naphthalene diimide (FND)-based electrochemical hybridization assay (EHA). 招待有り査読有り国際誌

Sato S., Maeda Y., Nojima T., Kondo H., Takenaka S.

Nucleic acids research. Supplement (2001) ( 3 ) 169 - 170 2003年01月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

Ferrocenylnaphthalene diimide (FND) having double-stranded DNA preference was used as an electrochemical hybridization indicator and applied to the electrochemical hybridization assay (EHA) coupled with a DNA probe-immobilized gold electrode. The effect of DNA probe length and the position of SNP (single nucleotide polymorphism) site on the DNA probe were studied in the SNP analysis concerned with the side effect of an anticancer drug, irinotecan. SNP analysis was achieved with high precision when a DNA probe carrying the SNP site near the terminus of a DNA probe was used in the EHA.

DOI： 10.1093/nass/3.1.169

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Binding of threading intercalator to nucleic acids: thermodynamic analyses. 査読有り国際誌

Torigoe H., Sato S., Yamashita K., Obika S., Imanishi T., Takenaka S.

Nucleic acids research. Supplement (2001) ( 2 ) 55 - 56 2002年01月

記述言語：英語掲載種別：研究論文（学術雑誌）

The constant melting temperature upon the change in the oligonucleotide concentration showed that the oligonucleotide d(CGCTTTGCG) formed a intramolecular hairpin rather than a duplex with an internal loop. We examined the thermodynamic properties of the interaction between the threading intercalator, naphthalene diimides designated as NDI, and a series of hairpin oligonucleotides, d(CGCTnGCG) (n = 3, 4, 5, and 6) designated as CGCn. A complex with a molar ratio of 1:1 was formed between NDI and CGCn. Because the observed negative entropy change was unfavorable for the binding of NDI to CGCn, the binding was driven by the large negative enthalpy change. All of the thermodynamic parameters for the threading intercalation were not significantly changed by the difference in the loop length n. The stem region rather than the loop region of CGCn is mainly involved in the binding of NDI.

DOI： 10.1093/nass/2.1.55

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Synthesis of adamantyl naphthalene diimide and its interaction with double stranded DNA. 査読有り国際誌

Sato S., Nojima T., Takagi M., Kondo H., Takenaka S.

Nucleic acids research. Supplement (2001) ( 2 ) 213 - 214 2002年01月

担当区分：最終著者記述言語：英語掲載種別：研究論文（学術雑誌）

An adamantyl naphthalene diimide derivative (AND) was synthesized as a highly selective double stranded DNA binding reagent. The binding studies with sonicated calf thymus DNA revealed that AND can bind to double stranded DNA by the threading mode, where the two adamantyl moieties are located in the major and minor grooves of DNA duplex separately. In the presence of beta-cyclodextrin (beta-CD), the complex of AND with DNA duplex was stabilized by capping of the adamantyl moieties of AND by beta-CD. In other words, beta-CD serves as a stabilizer for the complex of AND with DNA duplex to result in an enhanced selectivity of AND for double stranded DNA over single stranded DNA.

DOI： 10.1093/nass/2.1.213

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Ferrocenyl naphthalene diimide can bind to DNA·RNA hetero duplex: Potential use in an electrochemical detection of mRNA expression 査読有り

Sato S., Fujii S., Yamashita K., Takagi M., Kondo H., Takenaka S.

Journal of Organometallic Chemistry 637-639 476 - 483 2001年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

The novel ferrocenyl naphthalene diimide derivative 1 was synthesized by the condensation reaction between ferroceneacetic acid and terminal amino moieties of two imide substituents of naphthalene diimide. Stopped-flow analysis of the ligand 1 and DNA interaction revealed the following results: (i) the ligand binds to double stranded DNA more strongly than to single stranded DNA; (ii) the ligand does not have a bias against DNA sequence; (iii) the ligand can bind to the DNA·RNA hetero duplex more strongly than to the DNA·DNA duplex. These properties of 1 make it a suitable ligand for analysis of not only DNA but RNA. In fact, a current due to 1 was observed at 269 mV in the differential pulse voltammetric analysis of dA20-immobilized electrode in an electrolyte containing 1. The current increased markedly upon hybridization with polyU, whereas no current increase was obtained for polyA. Since the DNA·RNA hetero duplex is formed between sample RNA and DNA on the electrode, 1 may be used for the electrochemical detection of mRNA expression. © 2001 Elsevier Science B.V.

DOI： 10.1016/S0022-328X(01)00951-2

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Analysis of the complex of oligonucleotide duplexes with ligands by MALDI-TOF mass spectroscopy 査読有り国際誌

Yamashita K., Sato S., Takamiya H., Takagi M., Takenaka S.

Chemistry Letters ( 7 ) 680 - 681 2001年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

The peaks for a complex of DNA-interacting ligands naphthalene monoimide (NMI), naphthalene diimide (NDI) and ethidium bromide and groove binding ligand Hoechst 33258 with a duplex of oligonucleotide 5′-CCCCGGGG-3′ were observed successfully in MALDI-TOF mass spectroscopy. The appearance of the peak of the complex depended on both the binding mode (classical intercalation, threading intercalation, or groove binding) and the duplex structure (fully matched or mismatched).

DOI： 10.1246/cl.2001.680

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Analysis of the Complex of Oligonucleotide Duplexes of with Ligands by MALDI-TOF Mass Spectroscopy 査読有り

Kenichi Yamashita,Shinobu Sato,Hiroki Takamiya,Makoto Takagi,Shigeori Takenaka

Chemistry Letters 30 680 - 681 2001年04月

Ferrocenyl naphthalene diimide can bind to DNA-RNA hetero duplex: potential use in an electrochemical detection of mRNA expression 査読有り

Shinobu Sato,Satoshi Fujii,Kenichi Yamashita,Makoto Takagi,Hiroki Kondo,Shigeori Takenaka

Journal of Organometallic Chemistry 637639 476 - 483 2001年04月

Linker chain effect of ferrocenyl naphthalene diimide on a double stranded DNA preference. 査読有り国際誌

Sato S., Takamiya H., Yamashita K., Takagi M., Kondo H., Takenaka S.

Nucleic acids research. Supplement (2001) ( 1 ) 269 - 270 2001年01月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

Naphthalene diimide derivative 1 carrying two 3-(ferrocenyl-methylamino)-propyl substituents was synthesized as a new hybrid indicator for electrochemical gene sensing. Ligand 1 showed a preference for double stranded DNA four-times larger than 2 previously described. The peak potential of 1 shifted 30 mV toward the negative side from that of 2, thereby shortening the time required for gene detection.

DOI： 10.1093/nass/1.1.269

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Ferroceneacetyl naphthalene diimide as a new electrochemical ligand for DNA sensing. 査読有り国際誌

Sato S., Yamashita K., Takagi M., Takenaka S.

Nucleic acids symposium series ( 44 ) 171 - 172 2000年01月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

New electrochemically active DNA ligand 1 was synthesized by the connection of ferroceneacetic acid at the terminal amino moieties of two imide substituents of naphthalene diimide. Electrochemical experiments in aqueous solution containing DMSO showed that the selectivity for double stranded DNA of 1 has increased from that of ligand 2 previously reported. The peak current of 1 shifted toward the negative side from that of 2, thereby shortening the time required for gene detection.

DOI： 10.1093/nass/44.1.171

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